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Thromboprophylaxis for trauma patients

  1. Luis M Barrera1,*,
  2. Pablo Perel2,
  3. Katharine Ker2,
  4. Roberto Cirocchi3,
  5. Eriberto Farinella4,
  6. Carlos Hernando Morales Uribe1

Editorial Group: Cochrane Injuries Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 30 APR 2009

DOI: 10.1002/14651858.CD008303.pub2


How to Cite

Barrera LM, Perel P, Ker K, Cirocchi R, Farinella E, Morales Uribe CH. Thromboprophylaxis for trauma patients. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD008303. DOI: 10.1002/14651858.CD008303.pub2.

Author Information

  1. 1

    Universidad de Antioquia, Department of General Surgery, Medellin, Colombia

  2. 2

    London School of Hygiene & Tropical Medicine, Cochrane Injuries Group, London, UK

  3. 3

    University of Perugia, Department of General Surgery, Terni, Italy

  4. 4

    Lister Hospital - East and North Herts NHS Trust, General and Colorectal Surgery, Stevenage, Hertfordshire, UK

*Luis M Barrera, Department of General Surgery, Universidad de Antioquia, Street 67 N 53-108, Medellin, Colombia. luismbarrera@cable.net.co. bluis73@hotmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 28 MAR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Anglen 1998 {published data only}
  • Anglen JO, Bagby C, George R. A randomised comparison of sequential-gradient calf compression with intermittent plantar compression for prevention of venous thrombosis in orthopedic trauma patients: preliminary results. American journal of orthopedics 1998;27(1):53-8.
Cohn 1999 {published data only}
  • Cohn SM, Moller BA, Feinstein, AJ, Burns GA, Ginzburg E, Hammers LW. Prospective trial of low-molecular-weight heparin versus unfractionated heparin in moderately injured patients. Vascular Surgery 1999;33(2):219-23.
Dennis 1993 {published data only}
  • Dennis JW, Menawat S, Von Thron J, Fallon Jr WF, Vinsant GO, Laneve LM, et al. Efficacy of deep venous thrombosis prophylaxis in trauma patients and identification of high-risk groups. The Journal of Trauma-injury and Critical Care 1993;35(1):132-9.
Elliot 1999 {published data only}
  • Elliott CG, Dudney TM, Egger M, Orme JF, Clemmer TP, Horn SD, et al. Calf-thigh sequential pneumatic compression compared with plantar venous pneumatic compression to prevent deep-vein thrombosis after non-lower extremity trauma. The Journal of Trauma-injury and Critical Care 1999;47(1):25-32.
Fisher 1995 {published data only}
  • Fisher CG, Blachut PA, Salvian AJ, Meek RN, O'Brien PJ. Effectiveness of pneumatic leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients [Abstract]. Journal of Bone and Joint Surgery - British Volume 1991;73 Suppl 1:49-50.
  • Fisher CG, Blachut PA, Salvian AJ, Meek RN, O'Brien PJ. Effectiveness of pneumatic leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients: a prospective, randomised study of compression alone versus no prophylaxis. Journal of orthopaedic trauma 1995;9(1):1-7.
Fuchs 2005 {published data only}
  • Fuchs S, Heyse T, Rudofsky G, Gosheger G, Chylarecki C. Continuous passive motion in the prevention of deep-vein thrombosis: a randomised comparison in trauma patients. The Journal of bone and joint surgery. British volume. 2005;87(8):1117-22.
Geerts 1996 {published data only}
  • Geerts WH, Jay RM, Code KI, Chen E, Szalai JP, Saibil EA, Hamilton PA. A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma. The New England journal of medicine 1996;335(10):701-7.
Ginzburg 2003 {published data only}
Knudson 1992 {published data only}
Knudson 1994 All groups {published data only}
Knudson 1994 group I {published data only}
Knudson 1994 group II {published data only}
Knudson 1994 group III {published data only}
Knudson 1996 {published data only}
  • Knudson MM, Morabito D, Paiement GD, Shackleford S. Use of low molecular weight heparin in preventing thromboembolism in trauma patients.. Journal of Trauma-Injury Infection and Critical Care 1996;41(3):446-59.
Kurtoglu 2004 {published data only}
  • Kurtoglu M, Yanar H, Bilsel Y, Guloglu R, Kizilirmak S, Buyukkurt D, Granit V. Venous thromboembolism prophylaxis after head and spinal trauma: intermittent pneumatic compression devices versus low molecular weight heparin. World journal of surgery 2004;28(8):807-11.
Stannard 2001 {published data only}
  • Stannard JP, Riley RS, McClenney MD, Lopez Ben RR, Volgas DA, Alonso JE. Mechanical prophylaxis against deep-vein thrombosis after pelvic and acetabular fractures.. Journal of Bone and Joint Surgery - American Volume 2001;83 A(7):1047-51.
Stannard 2006 {published data only}
  • Stannard JP, Lopez-Ben RR, Volgas DA, Anderson ER, Busbee M, Karr DK, McGwin GR, Alonso JE. The Journal of bone and joint surgery. American volume. Prophylaxis against deep-vein thrombosis following trauma: a prospective, randomised comparison of mechanical and pharmacologic prophylaxis 2006;88(2):261-6.
Velmahos 2005 {published data only}
  • Velmahos GC, Petrone P, Chan LS, Hanks SE, Brown CV, Demetriades D. Electrostimulation for the prevention of deep venous thrombosis in patients with major trauma: a prospective randomised study. Surgery. 2005;137(5):493-8.
Yanar 2007 {published data only}
  • Yanar H, Kurtoglu M, Taviloglu K, Guloglu R, Ertekin C. Is intermittent pneumatic compression make low molecular weight heparin more efficient in the prophylaxis of venous thromboembolism in trauma patients. European Journal of Trauma and Emergency Surgery 2007;33(3 Suppl 2):79-80.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Breyer 1986 {published data only}
  • Breyer HG, Al-Therib J, Bacher P, Werner B. Thrombosis prophylaxis with low molecular weight heparin in trauma surgery [Abstract]. Thrombosis Research Supplement 1986;VI:84.
Greenfiel 1997 {published data only}
Haas 2003 {published data only}
  • Haas S, Lassen MR, Wolf H, Brom J, Weidinger G, Fareed J. Prevention of venous thromboembolism in orthopedic trauma patients receiving heparin thromboprophylaxis - a substudy analysis of autopsy-confirmed fatal pulmonary embolism. Journal of Thrombosis & Haemostasis 2003;1(Suppl 1):Abstract no: P1442.
Holzheimer 2004 {published data only}
Murakami 2003 {published data only}
  • Murakami M, McDill TL, Cindrick-Pounds L, Loran DB, Woodside KJ, Mileski WJ, et al. Deep venous thrombosis prophylaxis in trauma: improved compliance with a novel miniaturized pneumatic compression device. Journal of vascular surgery 2003;38(5):923-7.
Reilmann 1986 {published data only}
  • Reilmann H, Creutzig H, Tscherne H, Reilmann L. Langenbecks Archiv fur Chirurgie. Medicamental prophylaxis of thromboembolic complications with heparin and dihydroergotamine in trauma surgery 1986;369:753.
Wolf 1992 {published data only}
  • Wolf H, Kujath P, Spannagel U. Prevention of Thromboembolic Complications in Traumatized Patients - a Comparison Between Low-Molecular-Weight Heparin and Low-Dose Heparin. Perfusion 1992;5(7):210.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Acosta 1998
  • Acosta JA, Yang JC, Winchell RJ, Simons RK, Fortlage DL, Hollingsworth-Fridlund P, et al. Lethal injuries and time to death in a level I trauma center. Journal of the American College of Surgeons 1998;186:528-33.
Bani-Hani 2011
  • Bani-Hani M, Titi MA, Jaradat I, Al-Khaffaf H. Interventions for preventing venous thromboembolism following abdominal aortic surgery. Cochrane Database of Systematic Reviews 2011, Issue 3.
Bauer 1944
  • Bauer G. Thrombosis following leg injuries. Acta Chirurgica Scandinavica 1944;90:229-48.
Cipolle 2002
  • Cipolle MD, Wojcik R, Seislove E, Wasser TE, Pasquale MD. The role of surveillance duplex scanning in preventing venous thromboembolism in trauma patients. Journal of Trauma-Injury Infection & Critical Care 2002;52:453-62.
Cohn 1999
  • Cohn SM, Moller BA, Feinstein AJ, Burns GA, Ginzburg E, Hammers LW. Prospective trial of low-molecular-weight heparin versus unfractionated heparin in moderately injured patients. Vascular and Endovascular Surgery 1999;33:219-23.
Elliott 1999
  • Elliott CG, Dudney TM, Egger M, Orme JF, Clemmer TP, Horn SD, et al. Calf-thigh sequential pneumatic compression compared with plantar venous pneumatic compression to prevent deep-vein thrombosis after non-lower extremity trauma. Journal of Trauma-Injury Infection & Critical Care 1999;47:25-32.
Evans 2003
  • Evans SA, Airey MC, Chell SM, Connelly JB, Rigby AS, Tennant A. Disability in young adults following major trauma: 5 year follow up of survivors. BioMed Central Public Health 2003;3:8.
Fisher 1995
  • Fisher CG, Blachut PA, Salvian AJ, Meek RN, O'Brien PJ. Effectiveness of leg compression devices for the prevention of thromboembolic disease in orthopaedic trauma patients: a prospective, randomised study of compression alone versus no prophylaxis. Journal of Orthopedics Trauma 1995;9:1-7.
Frezza 1996
  • Frezza EE, Siram SM, van Thiel DH, Mezghebe MH. Venous thromboembolism after penetrating chest trauma is not a cause of early death. Journal of Cardiovascular Surgery 1996;37:521-4.
Geerts 1994
Geerts 1996
  • Geerts WH, Jay RM, Code KI, Chen E, Szalai JP, Saibil EA, et al. A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma. The New England Journal of Medicine 1996;335:701-7.
Geerts 2008
  • Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, et al. Prevention of venous thromboembolism: American college of chest physicians evidence-based clinical practice guidelines (8th edition). Chest 2008;133(6 Suppl):381-453.
Haentjens 1996
  • Haentjens P. Thromboembolic prophylaxis in orthopaedic trauma patients: a comparison between a fixed dose and an individually adjusted dose of a low molecular weight heparin (nadroparin calcium). Injury 1996;27:385-90.
Handoll 2008
  • Handoll HHG, Farrar MJ, McBirnie J, Tytherleigh-Strong GM, Milne AA, Gillespie WJ. Heparin, low molecular weight heparin and physical methods for preventing deep vein thrombosis and pulmonary embolism following surgery for hip fractures. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD000305]
Higgins 2008
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. Available from www.cochrane-handbook.org.
Hirsh 2004
  • Hirsh J, Raschke R. Heparin and Low-Molecular-Weight Heparin. The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(Supplement):188-203.
Hoffman 2001
Kahn 2012
  • Kahn SR, Lim W, Dunn AS, Cushman M, Dentali F, Akl EA, Cook DJ, Balekian AA, Klein RC, Le H, Schulman S, Murad MH. American College of Chest Physicians. Prevention of VTE in nonsurgical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012 Feb;141((2 Suppl)):195S-226S.
Kakkos 2008
  • Kakkos SK, Caprini JA, Geroulakos G, Nicolaides AN, Stansby GP, Reddy DJ. Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism in high-risk patients. Cochrane Database of Systematic Reviews 2008, Issue 4. [DOI: 10.1002/14651858.CD005258.pub2]
Kelsey 2000
  • Kelsey LJ, Fry DM, VanderKolk WE. Thrombosis risk in the trauma patient: prevention and treatment. Hematology/Oncology Clinics of North America April 2000; Vol. 14, issue 2:417-30.
Knudson 1994
Knudson 1996
  • Knudson MM, Morabito D, Paiement GD, Shackleford S. Use of low molecular weight heparin in preventing thromboembolism in trauma patients. Journal of Trauma-Injury Infection & Critical Care 1996;41:446-59.
McMurty 1999
  • McMurtry AL, Owings JT, Anderson JT, Battistella FD, Gosselin R. Increased use of prophylactic vena cava filters in trauma patients failed to decrease overall incidence of pulmonary embolism. Journal of the American College of Surgeons 1999;189:314-20.
Meissner 2003
  • Meissner MH, Chandler WL, Elliott JS. Venous thromboembolism in trauma: a local manifestation of systemic hypercoagulability?. Journal of Trauma-Injury Infection & Critical Care 2003;54:224-31.
Nijkeuter 2004
O'Malley 1990
RevMan 2008 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.0. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2008.
Rogers 1993
  • Rogers FB, Shackford SR, Wilson J, Ricci MA, Morris CS. Prophylactic vena cava filter insertion in severely injured trauma patients: indications and preliminary results. Journal of Trauma-Injury Infection & Critical Care 1993;35:637-41.
Rogers 1995
  • Rogers FB. Venous thromboembolism in trauma patients. Surgical Clinics of North America 1995; Vol. 75:279-91.
Rogers 2002
  • Rogers FB, Cipolle MD, Velmahos G, Rozycki G, Luchette FA. Practice Management Guidelines for the Prevention of Venous Thromboembolism in Trauma Patients: The EAST Practice Management Guidelines Work Group. Journal of Trauma-Injury, Infection and Critical Care 2002;53(1):142-64.
Sauaia 1995
Sevitt 1961
Shackford 1988
  • Shackford SR, Moser KM. Deep venous thrombosis and pulmonary embolism in trauma patients. Journal of Intensive Care Medicine 1988;3:87-98.
Smith 1994
  • Smith RM, Airey M, Franks AJ. Death after major trauma: can we affect it? The changing cause of death in each phase after injury [abstract]. Injury 1994;25:SB23-4.
Smith 2011
  • Smith TO, Taylor R, Hing CB. Thromboprophylaxis following major skeletal trauma:a systematic review. European Journal of Trauma and Emergency Surgery 2011;37:479-90.
Spaniolas 2008
  • Spaniolas K, Velmahos GC, Wicky S, Nussbaumer K, Petrovick L, Gervasini A, et al. Is upper extremity deep venous thrombosis underdiagnosed in trauma patients?. American Surgeon 2008;74(2):124-8.
Velmahos 2000
  • Velmahos GC, Kern J, Chan LS, Oder D, Murray JA, Shekelle P. Prevention of venous thromboembolism after injury: an evidence-based report: Part I. Analysis of risk factors and evaluation of the role of vena caval filters. Journal of Trauma-Injury Infection & Critical Care 2000;49:132-9.
Velmahos 2000a
  • Velmahos GC, Kern J, Chan LS, Oder D, Murray JA, Shekelle P. Prevention of venous thromboembolism after injury: an evidence-based report: Part II. Analysis of risk factors and evaluation of the role of vena caval filters. Journal of Trauma-Injury Infection & Critical Care 2000;49:140-4.
WHO 2008
  • World Health Organization. The global burden of disease: 2004 update. Vol. 1, Switzerland: WHO Library and cataloguing-data, 2008.
Wille-Jørgensen 2008
  • Wille-Jørgensen P, Rasmussen MS, Andersen BR, Borly L. Heparins and mechanical methods for thromboprophylaxis in colorectal surgery. The Cochrane Library 2008, Issue 4. [DOI: 10.1002/14651858.CD001217]