Intervention Protocol

Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates

  1. Stephanie Ardell1,*,
  2. Martin Offringa2,
  3. Roger Soll3

Editorial Group: Cochrane Neonatal Group

Published Online: 20 JAN 2010

Assessed as up-to-date: 10 NOV 2009

DOI: 10.1002/14651858.CD008342


How to Cite

Ardell S, Offringa M, Soll R. Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates (Protocol). Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD008342. DOI: 10.1002/14651858.CD008342.

Author Information

  1. 1

    Fletcher Allen Health Care, Division of Neonatal Perinatal Medicine, Burlington, Vermont, USA

  2. 2

    Academic Medical Center, Pediatrics, H3-145, Amsterdam, Netherlands

  3. 3

    University of Vermont, Division of Neonatal-Perinatal Medicine, Burlington, Vermont, USA

*Stephanie Ardell, Division of Neonatal Perinatal Medicine, Fletcher Allen Health Care, McClure 7, 111 Colchester Avenue, Burlington, Vermont, 05401, USA. Stephanie.Ardell@vtmednet.org.

Publication History

  1. Publication Status: New
  2. Published Online: 20 JAN 2010

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

Primary objective:
To determine the effectiveness of vitamin K prophylaxis in the prevention of vitamin K deficiency bleeding in preterm infants.

Main comparisons:

1. Vitamin K (via any route of administration) vs. no vitamin K
a. Intramuscular vitamin K vs. no vitamin K
b. Oral vitamin K vs. no vitamin K

2. Intramuscular vitamin K vs. oral vitamin K

3. Intramuscular vitamin K vs. intravenous vitamin K

Subgroup analyses will include studies that used single vs. multiple doses of vitamin K and studies of different vitamin K preparations [(vitamin K1 (phylloquinone) vitamin K2 (menaquinone) or vitamin K3 (menadione)].