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Somatostatin analogues for pancreatic surgery

  1. Kurinchi Selvan Gurusamy*,
  2. Rahul Koti,
  3. Giuseppe Fusai,
  4. Brian R Davidson

Editorial Group: Cochrane Upper GI and Pancreatic Diseases Group

Published Online: 30 APR 2013

Assessed as up-to-date: 14 FEB 2013

DOI: 10.1002/14651858.CD008370.pub3


How to Cite

Gurusamy KS, Koti R, Fusai G, Davidson BR. Somatostatin analogues for pancreatic surgery. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD008370. DOI: 10.1002/14651858.CD008370.pub3.

Author Information

  1. Royal Free Campus, UCL Medical School, Department of Surgery, London, UK

*Kurinchi Selvan Gurusamy, Department of Surgery, Royal Free Campus, UCL Medical School, Royal Free Hospital,, Rowland Hill Street, London, NW3 2PF, UK. kurinchi2k@hotmail.com.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 30 APR 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Beguiristain 1995 {published data only}
  • Beguiristain A, Espi A, Balen E, Pardo F, Hernandez Lizoain JL, Alvarez Cienfuegos J. Somatostatin prophylaxis following cephalic duodenopancreatectomy. Revista Espanola de Enfermedades Digestivas 1995;87(3):221-4.
Briceño Delgado 1998 {published data only}
  • Briceño Delgado FJ, López Cillero P, Rufián Peña S, Solórzano Peck G, Miño Fugarolas G, Pera Madrazo C. Prospective and randomized study on the usefulness of octreotide in the prevention of complications after cephalic duodeno-pancreatectomy. Revista Espanola de Enfermedades Digestivas 1998;90(10):687-94.
Buccoliero 1992 {published and unpublished data}
  • Buccoliero F, Pansini GC, Mascoli F, Mari C, Donini A, Navarra G. Somatostatin in duodenocephalopancreatectomy for neoplastic pathology. Minerva Chirurgica 1992;47(8):713-6.
Buchler 1992 {published data only}
  • Buchler M, Friess H. Inhibition of pancreatic secretion to prevent postoperative complications following pancreatic resection. Acta Gastroenterologica Belgica 1993; Vol. 56, issue 3-4:271-8.
  • Buchler M, Friess H. Prevention of postoperative complications following pancreatic surgery. Digestion 1993;54(Suppl 1):41-6.
  • Buchler M, Friess H, Klempa I, Hermanek P, Sulkowski U, Becker H, et al. Role of octreotide in the prevention of postoperative complications following pancreatic resection. American Journal of Surgery 1992;163(1):125-31.
  • Friess H, Klempa I, Hermanek P, Sulkowski U, Uhl W, Beger HG, et al. Prophylaxis of complications after pancreatic surgery: results of a multicenter trial in Germany. Digestion 1994; Vol. 55, issue Suppl 1:35-40.
Fernandez-Cruz 2012 {published data only}
  • Fernandez-Cruz L, Chavarria EJ, Taura P, Vallejos R, Lopez-Boado MA, Ferrer J. Prospective, randomized trial of the effect of octreotide on pancreatic juice output after pancreatoduodenectomy in relation to histological diagnosis, duct size and leakage. HPB 2012;14:91-2.
Friess 1995 {published data only}
  • Buchler MM, Gaus W. Randomized controlled multicentre study of the prevention of complications by octreotide in patients undergoing surgery for chronic pancreatitis. authors' reply. British Journal of Surgery 1996; Vol. 83, issue 3:422-3.
  • Friess H, Beger HG, Sulkowski U, Becker H, Hofbauer B, Dennler HJ, et al. Randomized controlled multicentre study of the prevention of complications by octreotide in patients undergoing surgery for chronic pancreatitis. British Journal of Surgery 1995;82(9):1270-3.
  • Friess H, Beger HG, Sulkowski U, Becker H, Hofbauer B, Dennler HJ, et al. Randomized controlled multicentre study of the prevention of complications by octreotide in patients undergoing surgery for chronic pancreatitis (vol 82, pg 1270, 1995). British Journal of Surgery 1996; Vol. 83, issue 1:126.
  • Friess H, Hofbauer B, Buchler MW. The role of somatostatin and octreotide in pancreatic surgery and in acute and chronic pancreatitis. Digestive Surgery 1994;11(3-6):445-50.
Gouillat 2001 {published and unpublished data}
Hesse 2005 {published data only}
  • Hesse UJ, De Decker C, Houtmeyers P, Demetter P, Ceelen W, Pattyn P, et al. Prospectively randomized trial using perioperative low dose octreotide to prevent organ related and general complications following pancreatic surgery and pancreatico-jejunostomy. Acta Chirurgica Belgica 2005; Vol. 105, issue 4:383-7.
  • Hesse UJ, De Decker C, Houtmeyers P, Demetter P, Ceelen W, Pattyn P, et al. Prospectively randomized trial using perioperative low-dose octreotide to prevent organ-related and general complications after pancreatic surgery and pancreatico-jejunostomy. World Journal of Surgery 2005;29(10):1325-8.
Katsourakis 2010 {published data only}
  • Katsourakis A, Oikonomou L, Chatzitheoklitos E, Noussios G, Pitiakoudis M, Polychronidis A, et al. The role of somatostatin in 67 consecutive pancreatectomies: a randomized clinical trial. Clinical and Experimental Gastroenterology 2010;3(1):179-83.
  • Katsourakis A, Zezos P, Noussios G, Kouklakis G, Chatzitheoklitos E, Simopoulos K, et al. Does prophylactic administration of somatostatin decrease the rates of complications after pancreatic resection?: a clinical and electron microscopy study. Pancreas 2013;42(1):37-41.
Klempa 1991 {published data only}
  • Klempa I, Baca I, Menzel J, Schuszdiarra V. Effect of somatostatin on basal and stimulated exocrine pancreatic secretion after partial duodenopancreatectomy. A clinical experimental study. Der Chirurg 1991; Vol. 62, issue 4:293-9.
Kollmar 2008 {published and unpublished data}
  • Kollmar O, Moussavian MR, Richter S, de Roi P, Maurer CA, Schilling MK. Prophylactic octreotide and delayed gastric emptying after pancreaticoduodenectomy: results of a prospective randomized double-blinded placebo-controlled trial. European Journal of Surgical Oncology 2008;34(8):868-75.
Kurumboor 2012 {published data only}
  • Kurumboor P, Kamalesh NP, Pramil K, Vipin IS, Shylesh A, Varma D, et al. A prospective randomized controlled trial on use of octreotide in patients with soft pancreas undergoing pancreaticoduodenectomy: interim analysis. HPB 2012;14:225.
Lange 1992 {published data only}
  • Lange JR, Steinberg SM, Doherty GM, Langstein HN, White DE, Shawker TH, et al. A randomized, prospective trial of postoperative somatostatin analogue in patients with neuroendocrine tumors of the pancreas. Surgery 1992;112(6):1033-8.
Matheus 2009 {published data only}
  • Matheus A, Montagnini A, Abe E, Haddad L, Penteado S, Abdo E, et al. Octreotide in patients with high risk to develop pancreatic fistula after pancreaticoduodenectomy: a prospective randomized trial. HPB 2010;12(Suppl S1):218-9.
  • Matheus AS, Montagnini AL, Jukemura J, Abe ES, Penteado S, Haddad LB, et al. Octreotide in patients with high risk to develop pancreatic fistula after pancreaticoduodenectomy - a prospective randomized trial. European Journal of Surgical Oncology 2010;36(9):814.
  • Matheus AS, Montagnini AL, Jukemura J, Perini MV, Haddad LB, Abe ES, et al. Does octreotide have any beneficial effect in patients with high risk to develop pancreatic fistula after pancreaticoduodenectomy: a prospective randomized trial. Gastroenterology 2009;136(5 Suppl 1):A-881.
Montorsi 1995 {published data only}
  • Montorsi M, Zago M, Mosca F, Capussotti L, Zotti E, Ribotta G, et al. Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery 1995;117(1):26-31.
Pederzoli 1994 {published data only}
  • Bassi C, Falconi M, Lombardi D, Briani G, Vesentini S, Camboni MG, et al. Prophylaxis of complications after pancreatic surgery: results of a multicenter trial in Italy. Italian Study Group. Digestion 1994;55(Suppl 1):41-7.
  • Pederzoli P, Bassi C, Falconi M, Camboni MG. Efficacy of octreotide in the prevention of complications of elective pancreatic surgery. British Journal of Surgery 1994;81(2):265-9.
Sarr 2003 {published data only}
  • Ramos-De la Medina A, Sarr MG. Somatostatin analogues in the prevention of pancreas-related complications after pancreatic resection. Journal of Hepatobiliary Pancreatic Surgery 2006;13(3):190-3.
  • Sarr MG. The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial. Journal of the American College of Surgeons 2003;196(4):556-65.
Shan 2005 {published data only}
  • Shan YS, Sy ED, Lin PW. Role of somatostatin in the prevention of pancreatic stump-related morbidity following elective pancreaticoduodenectomy in high-risk patients and elimination of surgeon-related factors: prospective, randomized, controlled trial. World Journal of Surgery 2003;27(6):709-14.
  • Shan YS, Sy ED, Tsai ML, Tang LY, Li PS, Lin PW. Effects of somatostatin prophylaxis after pylorus-preserving pancreaticoduodenectomy: increased delayed gastric emptying and reduced plasma motilin. World Journal of Surgery 2005;29(10):1319-24.
Suc 2004 {published data only}
  • Oberlin P, Suc B, Pezet D, Fagniez PL, Hay JM. Prevention of intra-abdominal complications after pancreatic resection by octreotide. A prospective, multicenter, randomized trial. Gastroenterology 2000;118(4):A463.
  • Suc B, Msika S, Piccinini M, Fourtanier G, Hay JM, Flamant Y, et al. Octreotide in the prevention of intra-abdominal complications following elective pancreatic resection: a prospective, multicenter randomized controlled trial. Archives of Surgery 2004;139(3):288-94.
Tulassay 1993 {published data only}
  • Tulassay Z, Flautner L, Fehervari I, Sandor Z, Nemeth J. Somatostatin in the prevention of postoperative increase of pancreatic enzyme after pancreatic surgery. Orvosi Hetilap 1992;133(13):777-80.
  • Tulassay Z, Flautner L, Sandor Z, Fehervari I. Perioperative use of somatostatin in pancreatic surgery. Acta Biomedica Ateneo Parmense 1993;64(5-6):205-11.
Yeo 2000 {published data only}
  • Yeo CJ, Cameron JL, Lillemoe KD, Sauter PK, Coleman J, Sohn TA, et al. Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial. Annals of Surgery 2000;232(3):419-29.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Barnett 2004 {published data only}
  • Barnett SP, Hodul PJ, Creech S, Pickleman J, Arahna GV. Octreotide does not prevent postoperative pancreatic fistula or mortality following pancreaticoduodenectomy. The American Surgeon 2004;70(3):222-7.
Bassi 1994 {published data only}
  • Bassi C, Falconi M, Pederzoli P. Role of somatostatin and somatostatin analogs in the treatment of gastrointestinal-diseases - prevention of complications after pancreatic surgery. Gut 1994;35:S20-2.
Brennan 2000 {published data only}
  • Brennan MF, Yeo CJ, Warshaw AL, O'Leary P, Warren KW, Way LW, et al. Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy? Results of a prospective randomized placebo-controlled trial - discussion. Annals of Surgery 2000;232(3):426-9.
Büchler 2001 {published data only}
  • Büchler MW, Bassi C, Fingerhut A, Klempa I. Does prophylactic octreotide decrease the rates of pancreatic fistula and other complications after pancreaticoduodenectomy?. Annals of Surgery 2001;234(2):262-3.
Droeser 2013 {published data only}
  • Droeser RA, Jeanmonod P, Schuld J, Moussavian MR, Schilling MK, Kollmar O. Octreotide prophylaxis is not beneficial for biochemical activity and clinical severity of postoperative pancreatic fistula after pancreatic surgery. Digestive Surgery 2013;29(6):484-91.
Elhadad 1998 {published data only}
  • Elhadad A, Rounanier G, Chippoini J. Octreotide in the prevention of surgical complications after pancreatectomy. A prospective randomised multicenter study. Hepatogastroenterology 1998;45(Suppl 2):152.
Falconi 2002 {published data only}
  • Falconi M, Contro C, Ballabio M, Bassi C, Salvia R, Pederzoli P. Evaluation of lanreotide effects on human exocrine pancreatic secretion after a single dose: preliminary study. Digestive and Liver Disease 2002;34(2):127-32.
Frick 1996 {published data only}
Friess 1989 {published data only}
  • Friess H, Buchler M, Meschenmoser L. Effect of octreotide (SMS 201-995) on exocrine pancreatic function in man. Pancreas 1989;4:616.
Friess 1996 {published data only}
Habib 1998 {published data only}
  • Habib E, Elhadad A, Fourtanier G, Chipponi J, Faniez P L, Hay JM, et al. Octreotide in prevention of surgical complication after pancreatectomy. Annales de Chirurgie 1998;52(7):671-2.
Klempa 1979 {published data only}
  • Klempa I, Schwedes U, Usadel KH. Prevention of postoperative pancreatic complications following duodenopancreatectomy using somatostatin. Der Chirurg 1979;50(7):427-31.
Lowy 1997 {published data only}
  • Lowy AM, Lee JE, Davidson BS, Pisters PWT, Evans DB. The role of octreotide in the prevention of pancreatic fistula after pancreaticoduodenectomy for periampullary malignancy: a prospective randomized trial. Gastroenterology 1996;110(4):A1401.
  • Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, et al. Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Annals of Surgery 1997;226(5):632-41.
Shatverian 2004 {published data only}
  • Shatverian GA, Ratnikova NP, Mikhailov Iu E, Bedzhanian AL, Sidorov AN, Fisenko EP, et al. Role octreotide in prevention of complications after pancreatoduodenal resections [Rol' oktreotida v profilaktuke oslozhnenii posle pankreatoduodenal'nykh rezektsii]. Khirurgiia 2004;2:56-60.
Van Berge 1997 {published data only}
  • Van Berge Henegouvven MI, Van Gulik TM, Akkermans LMA, Jansen JBMJ, Gouma DJ. The effect of octreotide on gastric emptying at a dosage used to prevent complications after pancreatic surgery: a randomised, placebo controlled study in volunteers. Gut 1997;41(6):758-62.
Van Hee 1998 {published data only}
  • Van Hee R, De Laet I, Salgado R, Ysebaert D. The influence of somatostatin on postoperative outcome after elective pancreatic surgery. Acta Chirurgica Belgica 1998;98(2):62-5.
Wang 2012 {published data only}
  • Tian BL, Su AP, Wang WG, Zhang Y. Does preoperative somatostatin administration decrease the rate of postoperative pancreatic fistula following pancreaticoduodenectomy? A randomized placebo-controlled trial. Journal of Gastroenterology and Hepatology 2012;27 Suppl 5:359.
  • Wang W, Tian B, Babu SR, Zhang Y, Yang M. Randomized, placebo-controlled study of the efficacy of preoperative somatostatin administration in the prevention of postoperative complications following pancreaticoduodenectomy. Hepatogastroenterology 2012;60(123):e1. [DOI: 10.5754/hge12669]
Woltering 2003 {published data only}
  • Woltering EA. The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial - invited commentary. Journal of the American College of Surgeons 2003;196(4):564-5.
Yeo 1999 {published data only}

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Alexakis 2004
Alghamdi 2007
  • Alghamdi AA, Jawas AM, Hart RS. Use of octreotide for the prevention of pancreatic fistula after elective pancreatic surgery: a systematic review and meta-analysis. Canadian Journal of Surgery 2007;50(6):459-66.
Bassi 2005
Clavien 2009
  • Clavien PA, Barkun J, de Oliveira ML, Vauthey JN, Dindo D, Schulick RD, et al. The Clavien-Dindo classification of surgical complications: five-year experience. Annals of Surgery 2009;250(2):187-96.
Connor 2005
DeMets 1987
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Egger 1997
Forman 2009
  • Forman D, Delaney B, Kuipers E, Malthaner R, Moayyedi P, Gardener E, et al. Cochrane Upper Gastrointestinal and Pancreatic Diseases Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)) 2009, Issue 2. Art. No.: UPPERGI.
Gouma 2000
  • Gouma DJ, van Geenen RC, van Gulik TM, de Haan RJ, de Wit LT, Busch OR, et al. Rates of complications and death after pancreaticoduodenectomy: risk factors and the impact of hospital volume. Annals of Surgery 2000;232(6):786-95. [PUBMED: 11088073]
Gurusamy 2009
Higgins 2002
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Kjaergard 2001
Lembcke 1987
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Macaskill 2001
Mayo 2009
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Ohwada 1998
  • Ohwada S, Ogawa T, Tanahashi Y, Nakamura S, Takeyoshi I, Ohya T, et al. Fibrin glue sandwich prevents pancreatic fistula following distal pancreatectomy. World Journal of Surgery 1998;22(5):494-8.
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Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273(5):408-12.
Sohn 2000
  • Sohn TA, Yeo CJ, Cameron JL, Koniaris L, Kaushal S, Abrams RA, et al. Resected adenocarcinoma of the pancreas - 616 patients: results, outcomes, and prognostic indicators. Journal of Gastrointestinal Surgery 2000;4(6):567-79.
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Gurusamy 2010
Koti 2010
Wente 2003
  • Morris E, Wente MN, Seiler CM, Finch-Jones M, Büchler MW, Alderson D. Somatostatin and its analogues in the prevention of complications following pancreatic surgery. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD004521]