This is the protocol for a review and there is no abstract. The objectives are as follows:
To evaluate the use of tricyclic antidepressants in people with autism spectrum disorders. The objectives are to determine if treatment with tricyclic antidepressants:
improves the core features of autism, including restricted social interaction, restricted communication and stereotypical and repetitive behaviours;
improves non-core features such as challenging behaviours;
improves co-morbid states, such as depression and anxiety; and
causes adverse effects.