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Interventions for treating osteonecrosis of the jaw bones associated with bisphosphonates

  • Protocol
  • Intervention



This is the protocol for a review and there is no abstract. The objectives are as follows:

To determine the efficacy, safety and adverse events of any intervention (surgical or not) aimed at treating osteonecrosis of the jaws associated with bisphosphonate therapy.

Our purpose is to offer an extensive review of the published literature, including observational studies and case series or thoroughly described case reports, with an assessment of the quality of the data. We aim to review these non-randomised studies to draw conclusions for research and not for clinical management, unless we were to find a large cohort study showing a large clinical effect on an objective outcome.