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Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections

  1. Jennifer R Shiu1,
  2. Erica Wang2,
  3. Aaron M Tejani3,*,
  4. Michael Wasdell4

Editorial Group: Cochrane Injuries Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 13 SEP 2012

DOI: 10.1002/14651858.CD008481.pub2


How to Cite

Shiu JR, Wang E, Tejani AM, Wasdell M. Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD008481. DOI: 10.1002/14651858.CD008481.pub2.

Author Information

  1. 1

    Alberta Health Services, Edmonton, Canada

  2. 2

    Interior Health Authority, Kelowna General Hospital, Kelowna, Canada

  3. 3

    University of British Columbia, Therapeutics Initiative, Vancouver, BC, Canada

  4. 4

    Bridgepoint Collaboratory for Research and Innovation Bridgepoint Health, Toronto, Canada

*Aaron M Tejani, Therapeutics Initiative, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada. Aaron.Tejani@fraserhealth.ca.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 28 MAR 2013

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[Figure 1]
Figure 1. Continuous vs intermittent study flow diagram.
[Figure 2]
Figure 2. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 3]
Figure 3. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 4]
Figure 4. Funnel plot of comparison: continuous vs intermittent antibiotic infusions, outcome. All-cause mortality.
[Figure 5]
Figure 5. Funnel plot of comparison: continuous vs intermittent antibiotic infusions. Outcome: infection recurrence.
[Figure 6]
Figure 6. Funnel plot of comparison: continuous vs intermittent antibiotic infusions. Outcome: clinical cure.
[Figure 7]
Figure 7. Funnel plot of comparison: continuous vs intermittent antibiotic infusions. Outcome: super-infection.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Continuous vs intermittent, Outcome 1 All cause mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Continuous vs intermittent, Outcome 2 Infection recurrence.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Continuous vs intermittent, Outcome 3 Clinical Cure.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Continuous vs intermittent, Outcome 4 Superinfection.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Continuous vs intermittent, Outcome 5 Serious Adverse Events.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Continuous vs intermittent, Outcome 6 Withdrawal due to Adverse Events.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Continuous vs intermittent, Outcome 7 Adverse Events.