Intervention Review

Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis

  1. Wanruchada Katchamart1,*,
  2. Judith Trudeau2,
  3. Veerapong Phumethum3,
  4. Claire Bombardier4

Editorial Group: Cochrane Musculoskeletal Group

Published Online: 14 APR 2010

Assessed as up-to-date: 16 FEB 2009

DOI: 10.1002/14651858.CD008495


How to Cite

Katchamart W, Trudeau J, Phumethum V, Bombardier C. Methotrexate monotherapy versus methotrexate combination therapy with non-biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis. Cochrane Database of Systematic Reviews 2010, Issue 4. Art. No.: CD008495. DOI: 10.1002/14651858.CD008495.

Author Information

  1. 1

    Siriraj Hospital, Mahidol University, Rheumatology Division, Department of Medicine, Bangkok, Thailand

  2. 2

    CHAUQ-Hôtel-Dieu de Lévis, Department of Rheumatology, Lévis, Quebec, Canada

  3. 3

    Prapokklao Hospital, Medicine, Muang district, Chantaburi, Thailand

  4. 4

    Institute for Work & Health, Toronto, Ontario, Canada

*Wanruchada Katchamart, Rheumatology Division, Department of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok road, Siriraj hospital, Bangkoknoi, Bangkok, 10700, Thailand. Wanda.katchamart@utoronto.ca.

Publication History

  1. Publication Status: New
  2. Published Online: 14 APR 2010

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  1. 1
    David L Scott, Fowzia Ibrahim, Vern Farewell, Aidan G O’Keeffe, Margaret Ma, David Walker, Margaret Heslin, Anita Patel, Gabrielle Kingsley, Randomised controlled trial of Tumour necrosis factor inhibitors Against Combination Intensive Therapy with conventional disease-modifying antirheumatic drugs in established rheumatoid arthritis: the TACIT trial and associated systematic reviews, Health Technology Assessment, 2014, 18, 66, 1

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    Licia Maria Henrique da Mota, Bóris Afonso Cruz, Claiton Viegas Brenol, Ivânio Alves Pereira, Lucila Stange Rezende-Fronza, Manoel Barros Bertolo, Max Vitor Carioca Freitas, Nilzio Antônio da Silva, Paulo Louzada-Junior, Rina Dalva Neubarth Giorgio, Rodrigo Aires Corrêa Lima, Wanderley Marques Bernardo, Geraldo da Rocha Castelar Pinheiro, Guidelines for the drug treatment of rheumatoid arthritis, Revista Brasileira de Reumatologia (English Edition), 2013, 53, 2, 158

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  3. 3
    John M. Davis, Eric L. Matteson, My Treatment Approach to Rheumatoid Arthritis, Mayo Clinic Proceedings, 2012, 87, 7, 659

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    Mark A Williams, Peter J Heine, Julie Bruce, Lucie Brosseau, Sallie Lamb, Exercise therapy for the rheumatoid hand, The Cochrane Library,
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    David S. Edwards, Is there an advantage in using methotrexate in combination with non-biologic disease modifying anti-rheumatic drugs over methotrexate monotherapy in people with rheumatoid arthritis??, Cochrane Clinical Answers,
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    Glen S Hazlewood, Cheryl Barnabe, George Tomlinson, Deborah Marshall, Claire Bombardier, Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis, The Cochrane Library,
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