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Intervention Review

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Baclofen for alcohol withdrawal

  1. Jia Liu*,
  2. Lu-Ning Wang

Editorial Group: Cochrane Drugs and Alcohol Group

Published Online: 28 FEB 2013

DOI: 10.1002/14651858.CD008502.pub3


How to Cite

Liu J, Wang LN. Baclofen for alcohol withdrawal. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD008502. DOI: 10.1002/14651858.CD008502.pub3.

Author Information

  1. Chinese PLA General Hospital, Department of Geriatric Neurology, Beijing, China

*Jia Liu, Department of Geriatric Neurology, Chinese PLA General Hospital, Fuxing Road 28, Beijing, 100853, China. Jason_liu1984@yahoo.cn.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 28 FEB 2013

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This is not the most recent version of the article. View current version (20 AUG 2017)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Addolorato 2006 {published data only}
  • Addolorato G, Leggio L, Abenavoli L, Agabio R, Caputo F, Capristo E, et al. Baclofen in the treatment of alcohol withdrawal syndrome: a comparative study vs diazepam. American Journal of Medicine 2006;119:276.e13-8.
Lyon 2011 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Addolorato 2002 a {published data only}
  • Addolorato G, Caputo F, Capristo E, Domenicali M, Bernardi M, Janiri L, et al. Baclofen efficacy in reducing alcohol craving and intake: a preliminary double-blind randomised controlled study. Alcohol and Alcoholism 2002;37:504-8.
Addolorato 2007 {published data only}
  • Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, et al. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet 2007;370:1915-22.
Addolorato 2011 {published data only}
  • Addolorato G, Leggio L, Ferrulli A, Cardone S, Bedogni G, Caputo F, et al. Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial. Alcohol and Alcoholism 2011;46:312-7.
Garbutt 2007 {published data only}
Garbutt 2010 {published data only}
Krupitskiī 1995 {published data only}
  • Krupitskiī EM, Burakov AM, Grinenko AIa, Borodkin IuS. Effect of pharmacotherapy of affective disorders on the psycho-semantics of alcoholic patients. Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova 1995;95:67-71.
Krupitsky 1993 {published data only}
  • Krupitsky EM, Burakov AM, Ivanov VB, Krandashova GF, Lapin IP, Grinenko AJ, et al. Baclofen administration for the treatment of affective disorders in alcoholic patients. Drug and Alcohol Dependence 1993;33:157-63.
Leggio 2012 {published data only}
  • Leggio L, Ferrulli A, Zambon A, Caputo F, Kenna GA, Swift RM, et al. Baclofen promotes alcohol abstinence in alcohol dependent cirrhotic patients with hepatitis C virus (HCV) infection. Addictive Behaviors 2012;37:561-4.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Addolorato 2002
  • Addolorato G, Caputo F, Capristo E, Janiri L, Bernardi M, Agabio R, et al. Rapid suppression of alcohol withdrawal syndrome by baclofen. American Journal of Medicine 2002;112:226-9.
Addolorato 2003
  • Addolorato G, Leggio L, Abenavoli L, DeLorenzi G, Parente A, Caputo F, et al. Suppression of alcohol delirium tremens by baclofen administration: a case report. Clinical Neuropharmacology 2003;26:258-62.
Amato 2010
  • Amato L, Minozzi S, Vecchi S, Davoli M. Benzodiazepines for alcohol withdrawal. Cochrane Database of Systematic Reviews 2010;3:CD005063.
Amato 2011
  • Amato L, Minozzi S, Davoli M. Efficacy and safety of pharmacological interventions for the treatment of the alcohol withdrawal syndrome. Cochrane Database of Systematic Reviews 2011;6:CD008537.
American Psychiatric Association 1994
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Bowery 1987
Carter 2009
Colombo 2000
  • Colombo G, Agabio R, Carai MA, Lobina C, Pani M, Reali R, et al. Ability of baclofen in reducing alcohol intake and withdrawal severity: I-preclinical evidence. Alcoholism, Clinical and Experimental Research 2000;24:58-66.
Davidoff 1985
Dissanaike 2006
Dodd 2000
Fiellin 2002
  • Fiellin DA, O'Connor PG, Holmboe ES, Horwitz RI. Risk for delirium tremens in patients with alcohol withdrawal syndrome. Substance Abuse 2002;23:83-94.
Higgins 2011
  • Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Knapp 2007
  • Knapp DJ, Overstreet DH, Breese GR. Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal. Alcoholism, Clinical and Experimental Research 2007;31:582-95.
Leggio 2008
  • Leggio L, Kenna GA, Swift RM. New developments for the pharmacological treatment of alcohol withdrawal syndrome. A focus on non-benzodiazepine GABAergic medications. Biological Psychiatry 2008;32:1106-17.
Lejoyeux 1998
Lerner 1985
Liang 2004
  • Liang J, Cagetti E, Olsen RW, Spigelman I. Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence. Journal of Pharmacology and Experimental Therapeutics 2004;310:1234-45.
Mayo-Smith 1997
  • Mayo-Smith MF. Pharmacological management of alcohol withdrawal. A meta analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA 1997;278:144-51.
McDonald 2008
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Review Manager 2011 [Computer program]
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Room 2005
Stallings 2007
  • Stallings W, Schrader S. Baclofen as prophylaxis and treatment for alcohol withdrawal: a retrospective chart review. Journal of Oklahoma State Medical Association 2007;100:354-60.
Weiss 2002
Westerink 1996
  • Westerink BHC, Kwint H-F, deVries JB. The pharmacology of mesolimbic dopamine neurons: a dual-probe micro dialysis study in the ventral tegmental area and nucleus accumbens of the rat brain. Journal of Neuroscience 1996;16:2605-11.