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Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age

  1. Aamer Imdad1,
  2. Kurt Herzer2,
  3. Evan Mayo-Wilson3,
  4. Mohammad Yawar Yakoob1,
  5. Zulfiqar A Bhutta1,*

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group

Published Online: 8 DEC 2010

Assessed as up-to-date: 26 OCT 2010

DOI: 10.1002/14651858.CD008524.pub2


How to Cite

Imdad A, Herzer K, Mayo-Wilson E, Yakoob MY, Bhutta ZA. Vitamin A supplementation for preventing morbidity and mortality in children from 6 months to 5 years of age. Cochrane Database of Systematic Reviews 2010, Issue 12. Art. No.: CD008524. DOI: 10.1002/14651858.CD008524.pub2.

Author Information

  1. 1

    Aga Khan University Hospital, Division of Women and Child Health, Karachi, Pakistan

  2. 2

    Johns Hopkins School of Medicine, Baltimore, MD, USA

  3. 3

    University of Oxford, The Centre for Evidence-Based Intervention, Oxford, UK

*Zulfiqar A Bhutta, Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, 74800, Pakistan. zulfiqar.bhutta@aku.edu.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 8 DEC 2010

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[Figure 1]
Figure 1. Flow diagram for selection of studies
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Forest plot of comparison: 1 Vitamin A versus Control, outcome: 1.1 Mortality (all-cause) at Longest Follow-up.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Vitamin A versus Control, outcome: 1.5 Mortality due to Diarrhoea at Longest Follow-up.
[Figure 5]
Figure 5. Forest plot of comparison: 1 Vitamin A versus Control, outcome: 1.6 Mortality due to Measles at Longest Follow-up.
[Figure 6]
Figure 6. Forest plot of comparison: 1 Vitamin A versus Control, outcome: 1.9 Diarrhoea Incidence at Longest Follow-up.
[Figure 7]
Figure 7. Forest plot of comparison: 1 Vitamin A versus Control, outcome: 1.12 Measles Incidence at Longest Follow-up.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Vitamin A versus Control, Outcome 1 Mortality (all-cause) at Longest Follow-up.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Vitamin A versus Control, Outcome 2 Mortality (all-cause) at Longest Follow-up (by Age).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Vitamin A versus Control, Outcome 3 Mortality (all-cause) at Longest Follow-up (by Sex).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Vitamin A versus Control, Outcome 4 Mortality (all-cause) at Longest Follow-up (Sensitivity Analysis including DEVTA trial).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Vitamin A versus Control, Outcome 5 Mortality due to Diarrhoea at Longest Follow-up.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Vitamin A versus Control, Outcome 6 Mortality due to Measles at Longest Follow-up.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Vitamin A versus Control, Outcome 7 Mortality due to Meningitis at Longest Follow-up.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Vitamin A versus Control, Outcome 8 Mortality due to LRTI at Longest Follow-up.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Vitamin A versus Control, Outcome 9 Diarrhoea Incidence at Longest Follow-up.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Vitamin A versus Control, Outcome 10 Diarrhoea Prevalence at Longest Follow-up.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Vitamin A versus Control, Outcome 11 Measles Incidence at Longest Follow-up.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Vitamin A versus Control, Outcome 12 Malaria Incidence at Longest Follow-up.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Vitamin A versus Control, Outcome 13 Malaria Prevalence at Longest Follow-up.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Vitamin A versus Control, Outcome 14 Lower Respiratory Tract Infection Incidence at Longest Follow-up.
[Analysis 1.15]
Analysis 1.15. Comparison 1 Vitamin A versus Control, Outcome 15 Bitot's Spots Prevalence at Longest Follow-up.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Vitamin A versus Control, Outcome 16 Night Blindness Incidence at Longest Follow-up.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Vitamin A versus Control, Outcome 17 Night Blindness Prevalence at Longest Follow-up.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Vitamin A versus Control, Outcome 18 Xerophthalmia Incidence at Longest Follow-up.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Vitamin A versus Control, Outcome 19 Xerophthalmia Prevalence at Longest Follow-up.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Vitamin A versus Control, Outcome 20 Vitamin A Deficient at Longest Follow-up.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Vitamin A versus Control, Outcome 21 Vitamin A Serum Level at Longest Follow-up.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Vitamin A versus Control, Outcome 22 Hospitalisation, Number of Children Hospitalised Once or More at Longest Follow-up.
[Analysis 1.23]
Analysis 1.23. Comparison 1 Vitamin A versus Control, Outcome 23 Hospitalisation due to Diarrhoea at Longest Follow-up.
[Analysis 1.24]
Analysis 1.24. Comparison 1 Vitamin A versus Control, Outcome 24 Hospitalisation due to Lower Respiratory Tract Infection at Longest Follow-up.
[Analysis 1.25]
Analysis 1.25. Comparison 1 Vitamin A versus Control, Outcome 25 Side effect - Bulging Fontanelle.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Vitamin A versus Control, Outcome 26 Side effect - Vomiting.