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Sumatriptan plus naproxen for acute migraine attacks in adults

  1. Simon Law1,
  2. Sheena Derry2,*,
  3. R Andrew Moore2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 21 OCT 2013

Assessed as up-to-date: 3 OCT 2013

DOI: 10.1002/14651858.CD008541.pub2


How to Cite

Law S, Derry S, Moore RA. Sumatriptan plus naproxen for acute migraine attacks in adults. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD008541. DOI: 10.1002/14651858.CD008541.pub2.

Author Information

  1. 1

    Gloucester Hospitals NHS Foundation Trust, Department of Anaesthetics, Gloucestershire, UK

  2. 2

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences, Oxford, Oxfordshire, UK

*Sheena Derry, Pain Research and Nuffield Department of Clinical Neurosciences, University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LE, UK. sheena.derry@ndcn.ox.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 21 OCT 2013

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[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Forest plot of comparison: 1 Sumatriptan/naproxen versus placebo, outcome: 1.1 Pain-free at two hours.
[Figure 3]
Figure 3. L'Abbé plot showing results for sumatriptan + naproxen versus placebo for pain-free at two hours. Each circle represents a different study; blue circles are studies with moderate or severe baseline pain and cream circles are mild baseline pain; size of circle is proportional to size of study; diagonal is line of equivalence.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Sumatriptan/naproxen versus placebo, outcome: 1.2 Headache relief at two hours.
[Figure 5]
Figure 5. L'Abbé plot showing results for sumatriptan + naproxen versus placebo for headache relief at two hours in studies with moderate or severe baseline pain. Each circle represents a different study; size of circle is proportional to size of study; diagonal is line of equivalence.
[Figure 6]
Figure 6. L'Abbé plot showing results for sumatriptan + naproxen versus placebo for 24-hour sustained pain-free. Each circle represents a different study; blue circles are studies with moderate or severe baseline pain and cream circles are mild baseline pain; size of circle is proportional to size of study; diagonal is line of equivalence.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 1 Pain-free at 2 h.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 2 Headache relief at 2 h.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 3 24-h sustained pain-free.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 4 24-h sustained headache relief.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 5 Any adverse event.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 6 Rescue medication.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 7 Relief of associated symptoms at 2 h.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Sumatriptan/naproxen versus placebo, Outcome 8 Relief of functional disability at 2 h.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 1 Pain-free at 2 h.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 2 Headache relief at 2 h.
[Analysis 2.3]
Analysis 2.3. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 3 24-h sustained pain-free.
[Analysis 2.4]
Analysis 2.4. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 4 24-h sustained headache relief.
[Analysis 2.5]
Analysis 2.5. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 5 Any adverse event.
[Analysis 2.6]
Analysis 2.6. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 6 Rescue medication.
[Analysis 2.7]
Analysis 2.7. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 7 Relief of associated symptoms at 2 h.
[Analysis 2.8]
Analysis 2.8. Comparison 2 Sumatriptan/naproxen versus sumatriptan alone, Outcome 8 Relief of functional disability at 2 h.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 1 Pain-free at 2 h.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 2 Headache relief at 2 h.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 3 24-h sustained pain-free.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 4 24-h sustained headache relief.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 5 Any adverse event.
[Analysis 3.6]
Analysis 3.6. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 6 Rescue medication.
[Analysis 3.7]
Analysis 3.7. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 7 Relief of associated symptoms at 2 h.
[Analysis 3.8]
Analysis 3.8. Comparison 3 Sumatriptan/naproxen versus naproxen alone, Outcome 8 Relief of functional disability at 2 h.