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Anticonvulsants for alcohol dependence

  1. Pier Paolo Pani1,*,
  2. Emanuela Trogu1,
  3. Matteo Pacini2,
  4. Icro Maremmani3

Editorial Group: Cochrane Drugs and Alcohol Group

Published Online: 13 FEB 2014

Assessed as up-to-date: 19 DEC 2013

DOI: 10.1002/14651858.CD008544.pub2


How to Cite

Pani PP, Trogu E, Pacini M, Maremmani I. Anticonvulsants for alcohol dependence. Cochrane Database of Systematic Reviews 2014, Issue 2. Art. No.: CD008544. DOI: 10.1002/14651858.CD008544.pub2.

Author Information

  1. 1

    Health District 8 (ASL 8) Cagliari, Social-Health Division, Cagliari, Sardinia, Italy

  2. 2

    European Addiction Treatment Association (Europad), Policlinico Umberto I, University La Sapienza, Rome, Rome, Italy

  3. 3

    "Santa Chiara" University Hospital, University of Pisa, Italy, "Vincent P. Dole" Dual Diagnosis Unit, Department of Neurosciences, Pisa, Italy

*Pier Paolo Pani, Social-Health Division, Health District 8 (ASL 8) Cagliari, Via Logudoro 17, Cagliari, Sardinia, 09127, Italy. pallolo@tin.it.

Publication History

  1. Publication Status: New
  2. Published Online: 13 FEB 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Anton 2009 {published data only}
  • Anton RF, Myrick H, Baros AM, Latham PK, Randall PK, Wright TM, et al. Efficacy of a combination of flumazenil and gabapentin in the treatment of alcohol dependence: relationship to alcohol withdrawal symptoms. Journal of Clinical Psychopharmacology 2009;29:334-42.
Anton 2011 {published data only}
  • Anton RF, Myrick H, Wright TM, Latham PK, Baros AM, Waid LR, et al. Gabapentin combined with naltrexone for the treatment of alcohol dependence. American Journal of Psychiatry 2011;168:709-17.
Arias 2010 {published data only}
Baltieri 2008 {published data only}
Brady 2002 {published data only}
Brower 2008 {published data only}
Croissant 2006 {published data only}
De Sousa 2008 {published data only}
  • De Sousa AA, De Sousa J, Kapoor H. An open randomized trial comparing disulfiram and topiramate in the treatment of alcohol dependence. Journal of Substance Abuse Treatment 2008;34:460-3.
Fertig 2012 {published data only}
Florez 2008 {published data only}
Florez 2011 {published data only}
  • Florez G, Saiz PA, Garcia-Portilla P, Alvarez S, Nogueiras L, Bobes J. Topiramate for the treatment of alcohol dependence: comparison with naltrexone. European Addiction Research 2011;17:29-36.
Furieri 2007 {published data only}
  • Furieri FA, Nakamura-Palacios EM. Gabapentin reduces alcohol consumption and craving: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Psychiatry 2007;68:1691-700.
Johnson 2003 {published data only}
Johnson 2007 {published data only}
  • Johnson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, et al. Topiramate for Alcoholism Advisory Board, Topiramate for Alcoholism Study Group. Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial. Archives of Internal Medicine 2008;168:1188-99.
  • Johnson BA, Rosenthal N, Capece JA, Wiegand F, Mao L, Beyers K, et al. Topiramate for Alcoholism Advisory Board, Topiramate for Alcoholism Study Group. Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA 2007;298:1641-51.
Kampman 2013 {published and unpublished data}
  • Kampman KM. A Phase II, Randomized, Double-blind, Placebo-Controlled, Pilot Trial of Topiramate for Alcohol and Comorbid Cocaine Dependence. ClinicalTrials.gov 2005.
  • Kampman KM, Pettinati HM, Lynch KG, Spratt K, Wierzbicki MR, O'Brien CP. A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. Drug and Alcohol Dependence 2013;133:94-9.
Likhitsathian 2013 {published data only}
  • Likhitsathian S, Uttawichai K, Booncharoen H, Wittayanookulluk A, Angkurawaranon C, Srisurapanont M. Topiramate treatment for alcoholic outpatients recently receiving residential treatment programs: a 12-week, randomized, placebo-controlled trial. Drug and Alcohol Dependence 2013;133:440-6.
Martinotti 2007 {published data only}
Martinotti 2010 {published data only}
  • Martinotti G, Di Nicola M, Tedeschi D, Andreoli S, Reina D, Pomponi M, et al. Pregabalin versus naltrexone in alcohol dependence: a randomised, double-blind, comparison trial. Journal of Psychopharmacology 2010;24:1367-74.
Mueller 1997 {published data only}
  • Mueller TI, Stout RL, Rudden S, Brown RA, Gordon A, Solomon DA, et al. A double-blind, placebo-controlled pilot study of carbamazepine for the treatment of alcohol dependence. Alcoholism: Clinical and Experimental Research 1997;21:86-92.
Paparrigopoulos 2010 {published data only}
  • Paparrigopoulos T, Tzavellas E, Karaiskos D, Malitas P, Liappas I. An open pilot study of tiagabine in alcohol dependence: tolerability and clinical effects. Journal of Psychopharmacology 2010;24:1375-80.
Paparrigopoulos 2011 {published data only}
Richter 2012 {published data only}
  • Richter C, Effenberger S, Bschor T, Bonnet U, Haasen C, Preuss UW, et al. Efficacy and safety of levetiracetam for the prevention of alcohol relapse in recently detoxified alcohol-dependent patients: a randomized trial. Journal of Clinical Psychopharmacology 2012;32:558-62.
Rubio 2009 {published data only}
Salloum 2005 {published data only}
  • Salloum IM, Cornelius JR, Daley DC, Kirisci L, Himmelhoch JM, Thase ME. Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study. Archives of General Psychiatry 2005;62:37-45.
Trevisan 2008 {published data only}
  • Trevisan LA, Ralevski E, Keegan K, Oville A, Vuppalapati D, Gonzalez G, et al. Alcohol detoxification and relapse prevention using valproic acid versus gabapentin in alcohol-dependent patients. Addictive Disorders and Their Treatment 2008;7:119.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Karam-Hage 2003 {published data only}
Knapp 2010 {published data only}
  • Knapp CM, Sarid-Segal O, Richardson MA, Colaneri LS, Afshar M, Devine E, et al. Open label trial of the tolerability and efficacy of zonisamide in the treatment of alcohol dependence. American Journal of Drug and Alcohol Abuse 2010;36:102-5.
Le Strat 2012 {published data only}
Miranda 2008 {published data only}
Mitchell 2012 {published data only}
  • Mitchell JM, Grossman LE, Coker AR, Messing RO. The anticonvulsant levetiracetam potentiates alcohol consumption in non-treatment seeking alcohol abusers. Journal of Clinical Psychopharmacology 2012;32:269-72.
Myrick 2007 {published data only}
Narayana 2008 {published data only}
  • Narayana PL, Gupta AK, Sharma PK. Use of anti-craving agents in soldiers with alcohol dependence syndrome. Medical Journal of Armed Forces India 2008;64:320-4.
Schacht 2013 {published data only}
  • Schacht JP, Anton RF, Randall PK, Li X, Henderson S, Myrick H. Effects of a GABA-ergic medication combination and initial alcohol withdrawal severity on cue-elicited brain activation among treatment-seeking alcoholics. Psychopharmacology 2013;227:627-37.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Bajovic 2012 {published data only}
  • Bajovic B, Zivkovic N, Djokic G, Pavicevic D. Oxcarbazepine, topiramate and lamotrigine in the treatment of alcohol craving. European Neuropsychopharmacology 2012;22:S65-6.
De Vita 2012 {published data only}
  • De Vita O, Martinotti G, Di Nicola M, Tedeschi D, Hatzigiakoumis DS, Monetta M, et al. Topiramate at low dosage vs. placebo in alcohol dependence. European Psychiatry 2012;27:1.
MacKillop 2012 {published data only}
  • MacKillop J, Monti PM, Tidey J, Swift RM, Ray LA, Miranda R. Behavioral economic analysis of topirmate's effects on motivation for alcohol. Alcoholism: Clinical and Experimental Research 2012;36:247A.
Mason 2010 {published and unpublished data}
  • Mason BJ. Gabapentin Treatment of Alcohol Dependence. ClinicalTrials.gov 2006.
  • Mason BJ. Gabapentin in alcoholism: from laboratory study to clinical trial. Basic Clinical Pharmacology and Toxicology 2010:107.
  • Mason BJ. Human laboratory and clinical trial evidence for gabapentin treatment of alcohol dependence. Alcoholism: Clinical and Experimental Research 2010;34:64A.
Miranda 2011 {published data only (unpublished sought but not used)}
  • Miranda R, MacKillop J, Meehan J, Justus A, Tidey J, Ramirez J, et al. Biobehavioral effects of topiramate among heavy drinkers. Alcoholism: Clinical and Experimental Research. 2011; Vol. 35:21A.
Rubio 2002 {published data only}
  • Rubio G, Ponce G, Ortiz S, Oliva JM, Manzanares J, Jimenez-Arriero MA, et al. Comparison between gabapentine and acamprosate in the treatment of alcohol dependent patients. European Neuropsychopharmacology 2002;12:398.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Ait-Daoud 2010 {unpublished data only}
  • Ait-Daoud N, Anthenelli RM, Cinciripini PM, Johnson BA. New Pharmacotherapy for Alcohol and Co-morbid Disorders. ClinicalTrials.gov 2010.
Anthenelli 2008 {unpublished data only}
  • Anthenelli R, Heffner JL, Nolting S. Topiramate to Aid Smoking Cessation in Recovering Alcohol Dependent Men. ClinicalTrials.gov 2008.
Batki 2010 {unpublished data only}
  • Batki LS. Topiramate Treatment of Alcohol Use Disorders in Veterans With Post Traumatic Stress Disorder (PTSD): A Pilot Controlled Trial of Augmentation Therapy. ClinicalTrials.gov 2010.
Beresford 2011 {unpublished data only}
  • Beresford TP. A Double Blind Trial Of Divalproex Sodium For Affective Lability And Alcohol Use Following Traumatic Brain Injury. ClinicalTrials.gov 2011.
Ciraulo 2009 {unpublished data only}
  • Ciraulo DA, Sarid-Segal O, Afshar M. A Double-Blind, Placebo-Controlled, Parallel Group Design Trial of: Levetiracetam, Zonisamide, Topiramate, and Placebo Control for the Treatment of Alcohol Dependent Subjects. ClinicalTrials.gov 2009.
Del Bello 2007 {unpublished data only}
  • DelBello M. Quetiapine Plus Topiramate or Placebo for Bipolar Mania and Alcohol Use in Adolescents & Young Adults. ClinicalTrials.gov 2007.
Fischer 2011 {unpublished data only}
  • Fischer BA. A 14-week Randomized, Placebo-controlled Study of Topiramate for Alcohol Use Disorders in Veterans With Posttraumatic Stress Disorder. ClinicalTrials.gov 2011.
Frye 2005 {unpublished data only}
  • Frye MA. An Evaluation of Divalproex vs. Olanzapine for Alcohol Abuse Relapse Prevention in Patients With Bipolar Disorder. ClinicalTrials.gov 2005.
Johnson 2000 {unpublished data only}
  • Johnson BA, Ait-Daoud N. Combining Medications: Treatment for Alcoholism. ClinicalTrials.gov 2000.
Johnson 2007 b {unpublished data only}
  • Johnson B, Ait-Daoud N. Novel Pharmacotherapy for Dual Dependence. ClinicalTrials.gov 2007.
Jorge 2011 {unpublished data only}
  • Jorge RE. Treatment Strategy for Alcohol Use Disorders in Veterans With TBI. ClinicalTrials.gov 2011.
Kampman 2011 {unpublished data only}
  • Kampman KM. A Phase II, Double-Blind, Placebo-Controlled, Pilot Trial of Vigabatrin for the Treatment of Cocaine and Alcohol Dependence. ClinicalTrials.gov 2011.
Kranzler 2008 {unpublished data only}
  • Kranzler HR, Covault J, Arias A, Oncken C, Tennen H, Gelernter J, Armeli S, Drazinic C, Chamberlain S, Levine E, Jensen K, Lieberman R. Topiramate Treatment of Problem Drinkers. ClinicalTrials.gov 2008.
Mariani 2010 {unpublished data only}
  • Mariani J. Gabapentin for Abstinence Initiation in Alcohol Dependence. ClinicalTrials.gov 2010.
Mason 2009 {unpublished data only}
  • Mason BJ. Duloxetine Versus Pregabalin for Alcohol Dependence. ClinicalTrials.gov 2009.
Messing 2008 {unpublished data only}
  • Messing RO, Mitchell JM. Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake. ClinicalTrials.gov 2008.
Ostacher 2007 {unpublished data only}
  • Ostacher MJ. Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder. ClinicalTrials.gov 2007.
Petrakis 2007 {unpublished data only}
  • Petrakis IL. The Use of Anticonvulsants for Treatment of Patients With Alcohol Dependence and Post Traumatic Stress Disorder. ClinicalTrials.gov 2007.
Ralevski 2007 {unpublished data only}
  • Ralevski E. Topiramate for Treatment of Patients With Borderline Personality Disorder and Alcohol Dependence. ClinicalTrials.gov 2007.
Schaefer 2008 {unpublished data only}
  • Schaefer M. Efficacy and Safety of Levetiracetam in Prevention of Alcohol Relapse in Recently Detoxified Alcohol Dependent Patients. ClinicalTrials.gov 2008.
South Carolina 2001 {unpublished data only}
  • Alcohol Research Center—Treatment and Implications. ClinicalTrials.gov 2001.
Tolliver 2009 {unpublished data only}
  • Tolliver BK, Brady KT. A Double-Blind, Placebo-Controlled Trial of Lamotrigine In Individuals With Bipolar Disorder and Comorbid Alcohol Dependence. ClinicalTrials.gov 2009.

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  5. Additional references
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