Repetitive transcranial magnetic stimulation for the treatment of amyotrophic lateral sclerosis or motor neuron disease

  • Review
  • Intervention




Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a progressive neurodegenerative disease without effective therapies. Several studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may have positive benefit in ALS. However, the efficacy and safety of this therapy remain uncertain. This is the first update of a review published in 2011.


To determine the clinical efficacy and safety of rTMS for treating ALS.

Search methods

On 30 July 2012, we searched the Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL (2012, issue 7 in The Cochrane Library), MEDLINE (1966 to July 2012), EMBASE (1980 to July 2012), CINAHL (1937 to July 2012), Science Citation Index Expanded (January 1945 to July 2012), AMED (January 1985 to July 2012). We searched the Chinese Biomedical Database (1979 to August 2012). We also searched for ongoing studies on (August 2012).

Selection criteria

Randomised and quasi-randomised controlled trials assessing the therapeutic efficacy and safety of rTMS for patients with a clinical diagnosis of ALS.

Comparisons eligible for inclusion were:

1. rTMS versus no intervention;

2. rTMS versus sham rTMS;

3. rTMS versus physiotherapy;

4. rTMS versus medications;

5. rTMS + other therapies or drugs versus sham rTMS + the same therapies or drugs;

6. different methods of application of rTMS such as high-frequency (> 1Hz) compared to low-frequency (≤ 1Hz) rTMS.

Data collection and analysis

Two authors independently selected papers, assessed risk of bias and extracted data. We resolved disagreements through discussion. We contacted study authors for additional information.

Main results

Three randomised, placebo-controlled trials with a total of 50 participants were included in the review. All three trials compared rTMS with sham TMS. All the trials were of poor methodological quality and were insufficiently homogeneous to allow the pooling of results. Moreover, the high rate of attrition further increased the risk of bias. None of the trials provided detailed data on the ALS Functional Rating Scale-Revised (ALSFRS-R) scores at six months follow-up which was pre-assigned as our primary outcome. One trial contained data in a suitable form for quantitative analysis of our secondary outcomes. No difference was seen between rTMS and sham rTMS using the ALSFRS-R scores and manual muscle testing (MMT) scores at 12 months follow-up in this trial. Additionally, none of the trials reported any adverse events associated with the use of rTMS. However, in view of the small sample size, the methodological limitations and incomplete outcome data, treatment with rTMS cannot be judged as completely safe.

Authors' conclusions

There is currently insufficient evidence to draw conclusions about the efficacy and safety of rTMS in the treatment of ALS. Further studies may be helpful if their potential benefit is weighed against the impact of participation in a randomised controlled trial on people with ALS.








2012年7月30日に、Cochrane Neuromuscular Disease Group Specialized Register、CENTRAL(2012年第7号 The Cochrane Library)、MEDLINE(1966年〜2012年7月)、EMBASE(1980年〜2012年7月)、CINAHL (1937年〜2012年7月)、Science Citation Index Expanded(1945年1月〜2012年7月)、AMED(1985年1月〜2012年7月)を検索した。Chinese Biomedical Database(1979年〜2012年8月)を検索した。また、clinicaltrials.govの進行中の研究も検索した(2012年8月)。




1. rTMSと無介入の比較

2. rTMSと偽rTMSの比較

3. rTMSと理学療法の比較

4. rTMSと薬物療法の比較

5. 「rTMS+他の療法または薬物」と「偽rTMS+同一の療法または薬物」の比較









《注意》この日本語訳は、臨床医、疫学研究者などによる翻訳のチェックを受けて公開していますが、訳語の間違いなどお気づきの点がございましたら、eJIM事務局までご連絡ください。なお、2013年6月からコクラン・ライブラリーのNew review, Updated reviewとも日単位で更新されています。eJIMでは最新版の日本語訳を掲載するよう努めておりますが、タイム・ラグが生じている場合もあります。ご利用に際しては、最新版(英語版)の内容をご確認ください。

Plain language summary

Repetitive transcranial magnetic stimulation (rTMS) for treating amyotrophic lateral sclerosis (ALS)

Amyotrophic lateral sclerosis (ALS), which is also known as motor neuron disease (MND), is a fatal disease in which the nerves in the brain and spinal cord that control movement degenerate. Treatments have little effect on how the disease progresses. People with ALS develop muscle weakness and paralysis of limb muscles and muscles involved in swallowing and breathing. Repetitive transcranial magnetic stimulation (rTMS) is a method for exciting nerve cells in superficial areas of the brain. It applies pulsed magnetic fields to the surface of the brain via an electrode on the scalp. There have been trials to see if rTMS is effective in people with ALS.

For this review we searched widely for clinical trials of rTMS in people with ALS and found three studies, which involved 50 participants in total. All three compared rTMS with sham (inactive) rTMS. None of the three studies reported on disability or limitation in activity as assessed by a specific ALS scale (ALSFRS-R) at six months follow-up, which was what we chose as our primary measure of the effectiveness of rTMS. Other outcome measures were only available from 12 participants in one poor quality trial, in which there was no difference between rTMS and sham rTMS in ALSFRS-R or a test of muscle strength at 12 months’ follow-up. None of the studies reported any adverse effects with rTMS. The trials in this review had small numbers of participants and some problems of design, so larger, well-designed trials should be considered, to determine the efficacy and safety of rTMS in ALS. However, the potential benefit should be balanced against the impact of taking part in trials for people with ALS.






《注意》この日本語訳は、臨床医、疫学研究者などによる翻訳のチェックを受けて公開していますが、訳語の間違いなどお気づきの点がございましたら、eJIM事務局までご連絡ください。なお、2013年6月からコクラン・ライブラリーのNew review, Updated reviewとも日単位で更新されています。eJIMでは最新版の日本語訳を掲載するよう努めておりますが、タイム・ラグが生じている場合もあります。ご利用に際しては、最新版(英語版)の内容をご確認ください。