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Tripterygium wilfordii Hook F (a traditional Chinese medicine) for primary nephrotic syndrome

  1. Yizhi Chen1,
  2. Zhixiang Gong2,
  3. Xiangmei Chen1,
  4. Li Tang1,
  5. Xuezhi Zhao3,
  6. Qing Yuan4,
  7. Guangyan Cai1,*

Editorial Group: Cochrane Kidney and Transplant Group

Published Online: 11 AUG 2013

Assessed as up-to-date: 13 AUG 2012

DOI: 10.1002/14651858.CD008568.pub2


How to Cite

Chen Y, Gong Z, Chen X, Tang L, Zhao X, Yuan Q, Cai G. Tripterygium wilfordii Hook F (a traditional Chinese medicine) for primary nephrotic syndrome. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD008568. DOI: 10.1002/14651858.CD008568.pub2.

Author Information

  1. 1

    Chinese People's Liberation Army (PLA) General Hospital (301 Hospital), Chinese PLA Medical Academy, Division of Nephrology, State Key Discipline and State Key Laboratory of Kidney Diseases (2011DAV00088), Beijing, China

  2. 2

    Chinese PLA 532 Hospital, Division of Infectious Diseases, Huangshan, Anhui, China

  3. 3

    Shanghai Chang Zheng Hospital, Division of Nephrology, Shanghai Kidney Disease Quality Control Center, Kidney Institute of Chinese PLA, Shanghai, Shanghai, China

  4. 4

    309th Hospital of the People's Liberation Army, Organ Transplant Center, Beijing, China

*Guangyan Cai, Division of Nephrology, State Key Discipline and State Key Laboratory of Kidney Diseases (2011DAV00088), Chinese People's Liberation Army (PLA) General Hospital (301 Hospital), Chinese PLA Medical Academy, Fuxing Road 28, Haidian District, Beijing, 100853, China. caiguangyan@sina.com.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 11 AUG 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
A-Da 2008 {published data only}
  • A-Da LT, Su JH, Wang ZC. Clinical random control observation of 18 cases of patients with primary IgA nephropathy syndrome treated with tripterygium glycosides tablet. Dangdai Yixue [China Contemporary Medicine] 2008;15(10):12-3.
Chen 2003 {published data only}
  • Chen ZM, Chen ZJ. Clinical analysis of 36 cases of refractory nephrotic syndrome treated by high-dosage Tripterygium glycosides. Zhongguo Quanke Yixue [Chinese General Practice] 2003;6(11):948.
Han 1999 {published data only}
  • Han JH, Mou ZL, Wang JP. Combination of Tripterygium glycosides and cyclosporin A for the treatment of refractory nephrotic syndrome. Linchuang Huicui [Clinical Focus] 1999;14(18):841-2.
Li 2000 {published data only}
  • Li Z, Zhang YF, Liu F. Clinical observation of 48 cases of nephrotic syndrome treated by combined treatment of Tripterygium wilfordii and quadruple chemotherapy. Hainan Yixue [Hainan Medical Journal] 1999;10(6):191-2.
  • Li Z, Zhang YF, Liu F. Clinical observation of 48 cases of nephrotic syndrome treated by combined treatment of Tripterygium wilfordii and quadruple chemotherapy. Yi Xue Wen Xuan [Anthology of Medicine] 2000;19(2):139-40.
Song 1998 {published data only}
  • Song HX, Wang ZT, Chen XT. Clinical study of combined treatment of cyclophosphamide and Tripterygium wilfordii for nephrotic syndrome. Lin Yi Yi Zhuan Xue Bao [Journal of Linyi Medical College] 1998;20(2):109-12.
Wen 1993 {published data only}
  • Wen YQ, Zhu QL, Wang MC, Ren ZQ, Liu ML, Hu GL. Clinical therapeutic analysis of primary nephrotic syndrome treated by prednisone and Tripterygium wilfordii. Zhonghua Shenzangbing Zazhi [Chinese Journal of Nephrology] 1993;9(3):190.
Yuan 2003 {published data only}
  • Yuan DS, Wang YR. Clinical therapeutic analysis of primary nephrotic syndrome in elderly treated by combination treatment of Tripterygium wilfordii and medium dosage prednisone. Zhong Hua Lin Chuang Yi Xue Yan Jiu Za Zhi [Chinese Magazine of Clinical Medicinal Professional Research] 2003;9(12):11475-6.
Zhang 2007a {published data only}
  • Zhang F. Comparison of effects of Tripterygium glycosides plus prednisone with prednisone alone on primary nephrotic syndrome. Zhong Wai Jian Kang Wen Zhai - Yi Yao Yue Kan [World Health Digest - Medical Monthly] 2007;4(8):96-8.
Zhao 1997 {published data only}
  • Zhao DG, Zhao X. Synergism of Tripterygium glycosides and prednisone for the complementary treatment of nephrotic syndrome. Changchun Zhongyiyao Daxue Xuebao [Journal of Changchun University of Traditional Chinese Medicine] 1997;13(4):20-1.
Zhao 2009 {published data only}
  • Zhao L. Comparative observation of effects of Tripterygium glycosides versus cyclophosphamide for the treatment of refractory nephrotic syndrome. Hebei Yi Yao [Hebei Medical Journal] 2009;31(16):2160-1.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chang 2005 {published data only}
  • Chang H, Li HP. Clinical analysis of 52 patients with nephrotic syndrome treated by Tripterygium glycosides and Fu Fang Dan Shen (active ingredients were Radix Salviae Miltiorrhizae and Lignum Dallbergiae Odoriferae). Zhong Guo Lin Chuang Yi Yao Yan Jiu Za Zhi [Chinese Journal of Clinical Medicine Research] 2005;11(4):14919-20.
Du 2008 {published data only}
  • Du XY. Clinical observation of effects of combined treatment for 50 patients with nephrotic syndrome. Zhong Guo Xian Dai Yao Wu Ying Yong [Chinese Journal of Modern Drug Application] 2008;2(11):98-9.
Han 2001 {published data only}
  • Han SL, Li GX, Zhou LH, Huang S, Ling YS. Clinical therapeutic observation of prednisone plus Tripterygium glycosides in the treatment of nephrotic syndrome (type I). Zhongguo Zhongxiyi Jiehe Shenbing Zazhi [Chinese Journal of Integrated Traditional and Western Nephrology] 2001;2(2):115-6.
Hu 2008 {published data only}
  • Hu GH, Yi ZW, Wang JH, Yao JC. Effect of triptergium wilfordii polyglycosidium on content of Th1 and Th2 in child recurrent nephrotic syndrome. Zhongguo Zhongyao Zazhi [China Journal of Chinese Materia Medica] 2008; Vol. 33, issue 4:441-3. [CN-00716138]
Huang 2003 {published data only}
  • Huang GH. Therapeutic effect analysis of Tripterygium wilfordii on the treatment of chronic nephrosis. Shiyong Linchuang Yixue [Practical Clinical Medicine] 2003;4(2):48.
Li 2003 {published data only}
  • Li Z, Meng H, Hong J. Clinical observation of 37 patients of nephrotic syndrome treated by combined treatment of Tripterygium wilfordii, Radix Astragali Mongolici, and quadruple chemotherapy. Zhongguo Quanke Yixue [Chinese General Practice] 2003;6(3):248.
Lin 2005 {published data only}
  • Lin X, Yang FF, You YW, Chen LX, Wang J, Li SL. Clinical efficacy of double dosage of Tripterygium wilfordii with intermittent maintenance therapy in treatment of primary nephrotic syndrome. Youjiang Minzu Yixueyuan Xuebao [Journal of Youjiang Medical College for Nationalities] 2005;27(3):282-4.
Liu 2003a {published data only}
  • Liu AM, Wang YP, Dai YW, Yang C, Tang HY. Clinical observation of the re-treatment after relapse in children with primary nephrotic syndrome. Zhejiang Zhongyi Zazhi [Zhejiang Journal of Traditional Chinese Medicine] 2003;38(3):334.
Liu 2003b {published data only}
  • Liu CM, Liu Y, Xu K. Clinical therapeutic observation of Tripterygium glycosides for the treatment of nephrotic syndrome. Guizhou Yiyao [Guizhou Medical Journal] 2003;27(5):442-4.
Liu 2010 {published data only}
  • Liu ZH, Yuan F, Wang YF. Tripterygium wilfordii combined with prednisone in the treatment of refractory primary nephrotic syndrome. Zhong Guo Yi Xue Chuang Xin [Medical Innovation of China] 2010;7(3):1-2.
Lu 2003 {published data only}
  • Lu XT. Combined Tripterygium wilfordii and prednisone for the treatment of nephrotic syndrome. Xiandai Zhongxiyijiehe Zazhi [Modern Journal of Integrated Traditional Chinese and Western Medicine] 2003;12(10):1058.
Ma 1991 {published data only}
  • Ma P. Effect of Tripterygium wilfordii combined with small-dosage prednisone on nephrosis syndrome. Linchuang Huicui [Clinical Focus] 1991;6(5):210-1.
Mo 2009 {published data only}
  • Mo XX. Effect of Tripterygium wilfordii combined with leflunomide on refractory nephrosis syndrome. Zhongguo Shequ Yishi [Chinese Community Doctors] 2009;11(10):54-5.
Pang 1999 {published data only}
  • Pang W, Fu HF, Tang DS. Clinical observation of integrated traditional Chinese and western medicine in treatment of nephrotic syndrome. Guangzhou Yixueyuan Xuebao [Academic Journal of Guangzhou Medical College] 1999;27(3):43-5.
Song 2008 {published data only}
  • Song B. Comparison between the therapeutic effects of cyclophosphamide and Tripterygium wilfordii hook on children refractory nephrotic syndrome. Zhong Guo Shi Yong Yi Yao [China Practical Medicine] 2008;3(14):7-8.
Sun 2008 {published data only}
  • Sun XH, Li HJ, Han W, Li BH. Observation on the therapeutic effect of the prednisone, Tripterygium wilfordii, ligustrazin in old age primary nephrotic syndrome. Xin Jiang Yi Ke Da Xue Xue Bao [Journal of Xinjiang Medical University] 2008;31(6):676-8.
Tang 2004 {published data only}
  • Tang XL, Hong SJ, Tang LL. Clinical therapeutic observation of combined Tripterygium wilfordii and ticlopidine in treatment of refractory nephrotic syndrome. Zhongguo Zhongxiyi Jiehe Shenbing Zazhi [Chinese Journal of Integrated Traditional and Western Nephrology] 2004;5(1):27.
Wang 1996 {published data only}
  • Wang KL, Wang DM. Effects of combination of prednisone and Tripterygium wilfordii in 30 patients with primary nephrotic syndrome. Da Li Yi Xue Yuan Xue Bao [Journal of Dali Medical College] 1996;5(4):36-7.
Wang 2000 {published data only}
  • Wang HW, Chen JH. Comparison of effects of Tripterygium wilfordii and prednisone in treatment of nephrotic syndrome in elderly. Youjiang Minzu Yixueyuan Xuebao [Journal of Youjiang Medical College for Nationalities] 2000;22(6):883-4.
Wang 2001 {published data only}
  • Wang QY, Zhao XH, Zhou WY, Wang XY. Clinical study of combined Tripterygium wilfordii and Shu Xue Tong injection in treatment of refractory nephrosis in adults. Zhongguo Zhongxiyi Jiehe Shenbing Zazhi [Chinese Journal of Integrated Traditional and Western Nephrology] 2001;2(10):606-7.
  • Wang QY, Zhou WY, Zhao XH. Clinical study of combined Tripterygium wilfordii and Shu Xue Tong injection in treatment of refractory nephrosis in adults. Heilongjiang Yi Xue [Heilongjiang Medical Journal] 2001;14(3):212.
Wang 2002 {published data only}
  • Wang LN, Tang XZ, Chen PP. Clinical therapeutic observation of prednisone plus Tripterygium wilfordii for the treatment of nephrotic syndrome. Zhongguo Zhongxiyi Jiehe Shenbing Zazhi [Chinese Journal of Integrated Traditional and Western Nephrology] 2002;3(7):418-9.
Wang 2005a {published data only}
  • Wang DY. Clinical therapeutic observation of combined Tripterygium wilfordii and lumbrokinase in the adjunctive treatment of primary nephrotic syndrome. Jiangxi Yiyao [Jiangxi Medical Journal] 2005;40(Suppl):694-6.
Wang 2005b {published data only}
  • Wang KM, Lai XH, Xu RF. Tripterygium wilfordii for the treatment of refractory primary nephrotic syndrome. Zhongguo Zhongxiyi Jiehe Zazhi [Chinese Journal of Integrated Traditional and Western Medicine] 2005;15(6):341-2.
Wang 2006 {published data only}
  • Wang YL. Clinical observation of integrated traditional Chinese and western medicine in treatment of nephrotic syndrome. Zhongyuan Yikan [Central Plains Medical Journal] 2006;33(10):60-1.
Wen 1996 {published data only}
  • Wen JF, Cao JX. Observation of effects of Tripterygium wilfordii and heparin on nephrotic syndrome. Zhongguo Xiandai Yixue Zazhi [China Journal of Modern Medicine] 1996;6(2):42.
Xiao 2003 {published data only}
  • Xiao HQ, Ding GH, Zhang JE, Zhang QH, Li T, Luo CX. Comparison between the therapeutic effects of Tripterygium wilfordii and cyclophosphamide on primary nephrotic syndrome. Linchuang Huicui [Clinical Focus] 2003;18(18):1039-40.
  • Xiao HQ, Zhang JE, Ye CY. Effects of Tripterygium wilfordii on primary nephrotic syndrome. Lin Chuang Shen Zang Bing Za Zhi [Journal of Clinical Nephrology] 2001;1(3):131-3.
Xiao 2007 {published data only}
  • Xiao YC. Clinical therapeutic observation of 56 patients with primary nephrotic syndrome treated by Tripterygium wilfordii. Shi Yong Quan Ke Yi Xue [Applied Journal of General Practice] 2007;5(4):312-3.
Xu 1998 {published data only}
  • Xu ZH, Hou CA, Chen Y, Xue QZ. Clinical observation of integrated traditional Chinese and western medicine in treatment of nephrotic syndrome. Shi Yong Zhong Xi Yi Jie He Za Zhi [The Practical Journal of Integrating Chinese with Modern Medicine] 1998;11(1):62.
Xu 2009b {published data only}
  • Xu YZ, Huang ZQ, Tang R. Effect of Tripterygium wilfordii together with prednisone in treatment of elderly primary nephrotic syndrome. Zhongguo Jiceng Yiyao [Chinese Journal of Primary Medicine and Pharmacy] 2009;16(5):781-2.
Yang 1995 {published data only}
  • Yang XH, Yu RF. Therapeutic observation of 40 patients with primary nephrotic syndrome and infection. Shiyong Yixue Zazhi [Journal of Practical Medicine] 1995;11(11):725-6.
Yang 2002 {published data only}
  • Yang LR. Combination of Tripterygium wilfordii and levamisole for the treatment of 41 patients with nephrotic syndrome. He Nan Yi Yao Xin Xi [Henan Medical Information] 2002;10(14):58-9.
Yang 2010 {published data only}
  • Yang J, Fan LH. Therapeutic observation of Tripterygium wilfordii and prednisone in the treatment of primary nephrotic syndrome. Zhong Guo Shi Yong Yi Yao [China Practical Medical] 2010;5(16):161-2.
Ye 2010 {published data only}
  • Ye YJ. Therapeutic observation of effect of combined leflunomide and tripterygium on refractory nephrotic syndrome. Jilin Yixue [Jilin Medical Journal] 2010;31(6):773.
Zhai 2004 {published data only}
  • Zhai XS, Zhou TG, Zou Y, Chen T. Clinical therapeutic analysis of 32 patients with nephrotic syndrome treated by Tripterygium wilfordii and prednisone. Xian Dai Yi Yao Wei Sheng [Modern Medicine Health] 2004;20(21):2246-7.
Zhang 2007b {published data only}
  • Zhang CF, Wang Z, Wang ML, Hua MN. Therapeutic analysis of 70 patients with nephrotic syndrome. Zhong Guo Shi Yong Yi Yao [China Practical Medical] 2007;2(36):137-8.
Zhang 2010 {published data only}
  • Zhang X, He XM, Du WB, Zhao CL. Effect of Tripterygium wilfordii combined with moiety prednisone on treatment of the aged nephrosis syndrome. Zhongguo Jiceng Yiyao [Chinese Journal of Primary Medicine and Pharmacy] 2010;17(5):623-5.
Zheng 1987 {published data only}
  • Zheng DH, Su P, Fang JY, Wei HM. Clinical therapeutic observation of 26 patients with nephrotic syndrome treated by Tripterygium wilfordii and urokinase. Huazhong Yixue Zazhi [Central China Medical Journal] 1987;11(2):77-8.
Zhong 2002 {published data only}
  • Zhong ZH, Lu JJ, Cai CD. Clinical analysis of 30 patients with refractory nephrotic syndrome treated by prednisone and Tripterygium wilfordii. Zhong Guo Zong He Lin Chuang [Clinical Medicine of China] 2002;18(5):435-6.
Zhou 1999 {published data only}
  • Zhou YC. Tripterygium wilfordii in combination with small-dosage prednisone for the treatment of nephrotic syndrome. Hebei Yixue [Hebei Medicine] 1999;5(4):14-6.
Zhou 2000 {published data only}
  • Zhou YZ. Clinical therapeutic observation of integrated traditional Chinese and western medicine in treatment of primary nephrotic syndrome. Hebei Zhongyi [Hebei Journal of Traditional Chinese Medicine] 2000;22(8):620-1.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Bao 2011
  • Bao J, Dai SM. A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety. Rheumatology International 2011;31(9):1123-9. [MEDLINE: 21365177]
Bonilla-Felix 1999
Chen 1985
  • Chen SY. Effect of Tripterygium wilfordii on the remission of proteinuria in patients with nephrotic syndrome. Zhongguo Zhongxiyi Jiehe Zazhi [Chinese Journal of Integrated Traditional and Western Medicine] 1985;5(3):164-6, 132. [MEDLINE: 3157498]
Chen 2010a
  • Chen YZ, Gao Q, Zhao XZ, Chen XM, Zhang F, Chen J, et al. Meta-analysis of Tripterygium wilfordii hook F in the immunosuppressive treatment of IgA nephropathy. Internal Medicine 2010;49(19):2049-55. [MEDLINE: 20930429]
Eddy 2003
Goldbach-Mansky 2009
  • Goldbach-Mansky R, Wilson M, Fleischmann R, Olsen N, Silverfield J, Kempf P, et al. Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. Annals of Internal Medicine 2009;151(4):229-40, W49-51. [MEDLINE: 19687490]
Gulati 1999
Haas 1997
  • Haas M, Meehan SM, Karrison TG, Spargo BH. Changing etiologies of unexplained adult nephrotic syndrome: A comparison of renal biopsy findings from 1976-1979 and 1995-1997. American Journal of Kidney Diseases 1997;30(5):621-31. [MEDLINE: 9370176]
Higgins 2011
  • Higgins JP, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hong 2002
Hull 2008
ISKD 1978
  • Anonymous. Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study of Kidney Disease in Children. Kidney International 1978;13(2):159-65. [MEDLINE: 713276]
Jiang 1994
KDIGO 2012
  • KDIGO. Idiopathic membranous nephropathy. Kidney International - Supplement 2012;2:186-97.
Korbet 1996
Kupchan 1972
  • Kupchan SM, Court WA, Dailey RG, Jr, Gilmore CJ, Bryan RF. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. Journal of the American Chemical Society 1972;94(20):7194-5. [MEDLINE: 5072337]
Moher 2010
  • Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, et al. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 2010;340:c869. [MEDLINE: 20332511]
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  • Pildal J, Hrobjartsson A, Jorgensen KJ, Hilden J, Altman DG, Gotzsche PC. Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. International Journal of Epidemiology 2007;36(4):847-57. [MEDLINE: 17517809]
Sharma 1997
  • Sharma M, Li JZ, Sharma R, Artero M, Ge X, McCarthy ET, et al. Inhibitory effect of Tripterygium wilfordii multiglycoside on increased glomerular albumin permeability in vitro. Nephrology Dialysis Transplantation 1997;12(10):2064-8. [MEDLINE: 9351066]
Srivastava 1999
Tao 1987
  • Tao XL, Dong Y, Zhang NZ. A double-blind study of T2 (tablets of polyglycosides of Tripterygium wilfordii hook) in the treatment of rheumatoid arthritis. Zhonghua Nei Ke Za Zhi [Chinese Journal of Internal Medicine] 1987;26(7):399-402, 44-5. [MEDLINE: 3322706]
Tao 1989
  • Tao XL, Sun Y, Dong Y, Xiao YL, Hu DW, Shi YP, et al. A prospective, controlled, double-blind, cross-over study of Tripterygium wilfordii hook F in treatment of rheumatoid arthritis. Chinese Medical Journal (English) 1989;102(5):327-32. [MEDLINE: 2509153]
Tao 1995
  • Tao X, Cai JJ, Lipsky PE. The identity of immunosuppressive components of the ethyl acetate extract and chloroform methanol extract (T2) of Tripterygium wilfordii Hook. F. Journal of Pharmacology & Experimental Therapeutics 1995;272(3):1305-12. [MEDLINE: 7891348]
Tao 1998
Tao 2001
  • Tao X, Cush JJ, Garret M, Lipsky PE. A phase I study of ethyl acetate extract of the Chinese antirheumatic herb Tripterygium wilfordii hook F in rheumatoid arthritis. Journal of Rheumatology 2001;28(10):2160-7. [MEDLINE: 11669150]
Tao 2002
Wan 2005
  • Wan Y, Gu L, Suzuki K, Karasawa T, Fujioka Y, Han GD, et al. Multi-glycoside of Tripterygium wilfordii Hook f. ameliorates proteinuria and acute mesangial injury induced by anti-Thy1.1 monoclonal antibody. Nephron. Experimental Nephrology 2005;99(4):e121-9. [MEDLINE: 15722645]
Wan 2010
  • Wan Y, Sun W, Zhang H, Yan Q, Chen P, Dou C, et al. Multi-glycoside of Tripterygium wilfordii Hook F. ameliorates prolonged mesangial lesions in experimental progressive glomerulonephritis. Nephron. Experimental Nephrology 2010;114(1):e7-14. [MEDLINE: 19816047]
Wen 1999
  • Wen ZH, Xu WH, Lai SL. Causal relationship of adverse reactions with tripterygium in 38 patients. Zhongyao Xinyao Yu Linchuang Yaoli [Traditional Chinese Drug Research & Clinical Pharmacology] 1999;10(1):50-3.
Xu 2009a
Zheng 2008

References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
  4. References to other published versions of this review
Chen 2010b
  • Chen YZ, Zhao XZ, Yuan Q. Tripterygium wilfordii Hook F (a traditional Chinese medicine) for primary nephrotic syndrome. Cochrane Database of Systematic Reviews 2010, Issue 7. [DOI: 10.1002/14651858.CD008568]