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Stavudine or zidovudine in three-drug combination therapy for initial treatment of HIV infection in antiretroviral-naïve individuals

  1. Alicen Spaulding1,*,
  2. George W Rutherford2,
  3. Nandi Siegfried3

Editorial Group: Cochrane HIV/AIDS Group

Published Online: 4 AUG 2010

Assessed as up-to-date: 8 JUL 2009

DOI: 10.1002/14651858.CD008651


How to Cite

Spaulding A, Rutherford GW, Siegfried N. Stavudine or zidovudine in three-drug combination therapy for initial treatment of HIV infection in antiretroviral-naïve individuals. Cochrane Database of Systematic Reviews 2010, Issue 8. Art. No.: CD008651. DOI: 10.1002/14651858.CD008651.

Author Information

  1. 1

    University of Minnesota, Division of Epidemiology and Community Health, Minneapolis, Minnesota, USA

  2. 2

    University of California, San Francisco, Global Health Sciences, San Francisco, California, USA

  3. 3

    University of Cape Town, Department of Public Health and Primary Health Care, Cape Town, South Africa

*Alicen Spaulding, Division of Epidemiology and Community Health, University of Minnesota, 1300 S. Second Street, Suite 300, Minneapolis, Minnesota, 55454-1015, USA. alicenspaulding@yahoo.com.

Publication History

  1. Publication Status: Stable (no update expected for reasons given in 'What's new')
  2. Published Online: 4 AUG 2010

SEARCH

[Figure 1]
Figure 1. Diagram of search results from overall ART systematic review.
[Figure 2]
Figure 2. Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
[Figure 3]
Figure 3. Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 d4T vs. AZT, outcome: 1.1 Mortality.
[Figure 5]
Figure 5. Forest plot of comparison: 1 d4T vs AZT, outcome: 1.2 Clinical response.
[Figure 6]
Figure 6. Forest plot of comparison: 1 d4T vs AZT, outcome: 1.3 Severe adverse events.
[Figure 7]
Figure 7. Forest plot of comparison: 1 d4T vs AZT, outcome: 1.4 Virologic response.
[Figure 8]
Figure 8. Forest plot of comparison: 1 d4T vs AZT, outcome: 1.5 Adherence/tolerability/retention.
[Figure 9]
Figure 9. Forest plot of comparison: 1 d4T vs AZT, outcome: 1.6 Immunologic response.
[Figure 10]
Figure 10. Forest plot of comparison: 1 d4T vs AZT, outcome: 1.7 Drug resistance.
[Analysis 1.1]
Analysis 1.1. Comparison 1 d4T vs. AZT, Outcome 1 Mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 d4T vs. AZT, Outcome 2 Clinical progression.
[Analysis 1.3]
Analysis 1.3. Comparison 1 d4T vs. AZT, Outcome 3 Severe adverse events.
[Analysis 1.4]
Analysis 1.4. Comparison 1 d4T vs. AZT, Outcome 4 Virologic response.
[Analysis 1.5]
Analysis 1.5. Comparison 1 d4T vs. AZT, Outcome 5 Adherence/tolerability/retention.
[Analysis 1.6]
Analysis 1.6. Comparison 1 d4T vs. AZT, Outcome 6 Immunologic response.
[Analysis 1.7]
Analysis 1.7. Comparison 1 d4T vs. AZT, Outcome 7 Drug resistance.