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Single dose oral analgesics for acute postoperative pain in adults

  1. R Andrew Moore1,
  2. Sheena Derry1,
  3. Henry J McQuay1,
  4. Philip J Wiffen2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 7 SEP 2011

Assessed as up-to-date: 11 JUL 2011

DOI: 10.1002/14651858.CD008659.pub2

How to Cite

Moore RA, Derry S, McQuay HJ, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2011, Issue 9. Art. No.: CD008659. DOI: 10.1002/14651858.CD008659.pub2.

Author Information

  1. 1

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

  2. 2

    UK Cochrane Centre, Oxford, UK

*Maura Moore, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK. maura.moore@pru.ox.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 7 SEP 2011

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[Figure 1]
Figure 1. All types of surgery: NNT for at least 50% maximum pain relief over four to six hours compared with placebo, by rank order.
[Figure 2]
Figure 2. Dental pain: NNT for at least 50% maximum pain relief over four to six hours compared with placebo, by rank order.
[Figure 3]
Figure 3. Other painful conditions: NNT for at least 50% maximum pain relief over four to six hours compared with placebo, by rank order.
[Figure 4]
Figure 4. Percentage of patients achieving at least 50% maximum pain relief (dental pain).
[Figure 5]
Figure 5. Mean time to remedication in painful dental conditions.
[Figure 6]
Figure 6. Plot of percentage of participants reporting at least one adverse event with active drug and placebo. Each symbol represents results from one drug/dose combination, and the size of the size of the symbol is proportional to the number of participants (inset scale).
[Figure 7]
Figure 7. Plot of percent with outcome with placebo versus number of participants given placebo - dental only.
[Figure 8]
Figure 8. Plot of percent with outcome with placebo versus number of participants given placebo - other conditions only.
[Figure 9]
Figure 9. Plot of percent with outcome with placebo versus number of participants given placebo - all types of surgery.
[Figure 10]
Figure 10. Plot of NNT over four to six hours versus mean time to remedication.