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Overview of Reviews

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Single dose oral analgesics for acute postoperative pain in adults

  1. R Andrew Moore1,
  2. Sheena Derry1,
  3. Henry J McQuay1,
  4. Philip J Wiffen2

Editorial Group: Cochrane Pain, Palliative and Supportive Care Group

Published Online: 7 SEP 2011

Assessed as up-to-date: 11 JUL 2011

DOI: 10.1002/14651858.CD008659.pub2


How to Cite

Moore RA, Derry S, McQuay HJ, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database of Systematic Reviews 2011, Issue 9. Art. No.: CD008659. DOI: 10.1002/14651858.CD008659.pub2.

Author Information

  1. 1

    University of Oxford, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), Oxford, Oxfordshire, UK

  2. 2

    UK Cochrane Centre, Oxford, UK

*Maura Moore, Pain Research and Nuffield Department of Clinical Neurosciences (Nuffield Division of Anaesthetics), University of Oxford, Pain Research Unit, Churchill Hospital, Oxford, Oxfordshire, OX3 7LJ, UK. maura.moore@pru.ox.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 7 SEP 2011

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Table 1. Characteristics of included reviews

ReviewDate assessed as

up to date
PopulationInterventionsComparison

interventions
Outcomes for which

data were reported
Review limitations

Aceclofenac 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Acemetacin 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboNoneNo studies found

Aspirin 1999 2011

(update in progress)
Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Celecoxib 20082008Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Codeine 2010 2010Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Dexibuprofen 2009  2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
Limited numbers

Dextropropoxyphene ± Paracetamol 19992011

(additional searches)
Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Diclofenac 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Diflunisal 2010 2010Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Dihydrocodeine 20002011

(additional searches)
Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Dipyrone 20102010Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Etodolac 2009 2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Etoricoxib 2009 2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Fenbufen 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Fenoprofen 20112011Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
Limited numbers

Flurbiprofen 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Gabapentin 20102010Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Ibuprofen 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Indometacin 2004  2011

(additional searches)
Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
Limited numbers

Ketoprofen and Dexketoprofen 2009 2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Lornoxicam 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Lumiracoxib 2010 2010Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Mefenamic acid 20112011Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Meloxicam 2009 2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboNoneNo studies found

Nabumetone 2009 2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboNoneNo studies found

Naproxen 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Nefopam 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboNoneNo studies found

Oxycodone ± Paracetamol 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Paracetamol + Codeine 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Paracetamol 2008 2008Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Piroxicam 20002011

(additional searches)
Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Rofecoxib 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboTOTPAR, SPID,

remedication time, AE
None

Sulindac 2009  2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboNoneNo studies found

Tenoxicam 2009 2009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboNoneNo studies found

Tiaprofenic acid 20092009Adults with at least

moderate pain
Analgesic,

various doses
PlaceboNoneNo studies found

 AE = adverse event; SPID = summed pain intensity difference; TOTPAR = total pain relief