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Vitamin A supplementation during pregnancy for maternal and newborn outcomes

  1. Nynke van den Broek1,*,
  2. Lixia Dou2,
  3. Mohammad Othman3,
  4. James P Neilson3,
  5. Simon Gates4,
  6. A Metin Gülmezoglu5

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 10 NOV 2010

Assessed as up-to-date: 4 OCT 2010

DOI: 10.1002/14651858.CD008666.pub2


How to Cite

van den Broek N, Dou L, Othman M, Neilson JP, Gates S, Gülmezoglu AM. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database of Systematic Reviews 2010, Issue 11. Art. No.: CD008666. DOI: 10.1002/14651858.CD008666.pub2.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, Liverpool, UK

  2. 2

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

  3. 3

    The University of Liverpool, Department of Women's and Children's Health, Liverpool, UK

  4. 4

    Warwick Medical School, University of Warwick, Warwick Clinical Trials Unit, Coventry, UK

  5. 5

    World Health Organization, UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research, Geneva, Switzerland

*Nynke van den Broek, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. vdbroek@liverpool.ac.uk.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 10 NOV 2010

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This is not the most recent version of the article. View current version (27 OCT 2015)

[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 1 Maternal mortality.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 2 Perinatal mortality.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 3 Neonatal mortality.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 4 Stillbirth.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 5 Maternal anaemia.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 6 Maternal clinical infection.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 7 Maternal night blindness.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 8 Preterm birth.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 9 Neonatal anaemia.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Vitamin A alone versus placebo or no treatment, Outcome 12 Low birthweight.
[Analysis 3.3]
Analysis 3.3. Comparison 3 Vitamin A with other micronutrients versus micronutrient supplements without vitamin A, Outcome 3 Neonatal mortality.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Vitamin A with other micronutrients versus micronutrient supplements without vitamin A, Outcome 4 Stillbirth.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Vitamin A with other micronutrients versus micronutrient supplements without vitamin A, Outcome 5 Maternal anaemia.
[Analysis 3.8]
Analysis 3.8. Comparison 3 Vitamin A with other micronutrients versus micronutrient supplements without vitamin A, Outcome 8 Preterm birth.
[Analysis 3.9]
Analysis 3.9. Comparison 3 Vitamin A with other micronutrients versus micronutrient supplements without vitamin A, Outcome 9 Neonatal anaemia.
[Analysis 3.12]
Analysis 3.12. Comparison 3 Vitamin A with other micronutrients versus micronutrient supplements without vitamin A, Outcome 12 Low birthweight.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 1 Maternal mortality (infant mortality level).
[Analysis 4.2]
Analysis 4.2. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 2 Perinatal mortality (infant mortality level).
[Analysis 4.3]
Analysis 4.3. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 3 Maternal mortality (maternal mortality level).
[Analysis 4.4]
Analysis 4.4. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 4 Perinatal mortality (maternal mortality level).
[Analysis 4.5]
Analysis 4.5. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 5 Maternal mortality (prevalence of vitamin A deficiency).
[Analysis 4.6]
Analysis 4.6. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 6 Perinatal mortality (prevalence of vitamin A deficiency).
[Analysis 4.7]
Analysis 4.7. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 7 Maternal mortality (prevalence of HIV in the general population).
[Analysis 4.8]
Analysis 4.8. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 8 Perinatal mortality (prevalence of HIV in the general population).
[Analysis 4.9]
Analysis 4.9. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 9 Maternal mortality (dose).
[Analysis 4.10]
Analysis 4.10. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 10 Perinatal mortality (dose).
[Analysis 4.11]
Analysis 4.11. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 11 Maternal mortality (regimen).
[Analysis 4.12]
Analysis 4.12. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 12 Perinatal mortality (regimen).
[Analysis 4.13]
Analysis 4.13. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 13 Maternal mortality (duration of intervention).
[Analysis 4.15]
Analysis 4.15. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 15 Maternal mortality (trimester of pregnancy).
[Analysis 4.16]
Analysis 4.16. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 16 Perinatal mortality (trimester of pregnancy).
[Analysis 4.17]
Analysis 4.17. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 17 Maternal mortality (randomisation).
[Analysis 4.18]
Analysis 4.18. Comparison 4 Vitamin A alone versus placebo or no treatment (subgroups), Outcome 18 Perinatal mortality (randomisation).