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Diagnostic Test Accuracy Protocol

Red flags to screen for malignancy in patients with low-back pain

  1. Nicholas Henschke1,*,
  2. Christopher G. Maher2,
  3. Raymond WJG Ostelo3,
  4. Henrica CW de Vet4,
  5. Petra Macaskill5,
  6. Les Irwig6

Editorial Group: Cochrane Back Group

Published Online: 8 SEP 2010

DOI: 10.1002/14651858.CD008686


How to Cite

Henschke N, Maher CG, Ostelo RWJG, de Vet HCW, Macaskill P, Irwig L. Red flags to screen for malignancy in patients with low-back pain (Protocol). Cochrane Database of Systematic Reviews 2010, Issue 9. Art. No.: CD008686. DOI: 10.1002/14651858.CD008686.

Author Information

  1. 1

    The George Institute for International Health, Sydney, NSW, Australia

  2. 2

    The George Institute of International Health, Musculoskeletal Division, Sydney, NSW, Australia

  3. 3

    VU University, Department of Health Sciences, EMGO Institute for Health and Care Research, Amsterdam, Netherlands

  4. 4

    VU University Medical Center, Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, Amsterdam, Netherlands

  5. 5

    School of Public Health, Screening and Test Evaluation Program (STEP), Sydney, NSW, Australia

  6. 6

    University of Sydney, School of Public Health, Sydney, NSW, Australia

*Nicholas Henschke, The George Institute for International Health, Level 7, 341 George Street, Sydney, NSW, 2000, Australia. nhenschke@georgeinstitute.org.au.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 8 SEP 2010

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

The general aim of this review is to provide information that may assist clinicians to make decisions about appropriate management in patients with LBP. More specifically, the objective of this systematic review is to assess the diagnostic performance of clinical characteristics identified by taking a clinical history and conducting a physical examination ("red flags") to screen for spinal malignancy in patients presenting with LBP.

The secondary objective of this review is to assess the influence of sources of heterogeneity on the diagnostic accuracy of "red flags", in particular, the health care setting (e.g. primary or secondary care), the study design (e.g. consecutive series or case-control), the timing of "red flag" assessment, and aspects of study quality as reflected in the assessment of the items of the QUADAS checklist (Appendix 1).