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Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage

  1. Richard Marigold1,
  2. Albrecht Günther2,
  3. Divya Tiwari3,
  4. Joseph Kwan4,*

Editorial Group: Cochrane Epilepsy Group

Published Online: 5 JUN 2013

Assessed as up-to-date: 12 MAR 2013

DOI: 10.1002/14651858.CD008710.pub2

How to Cite

Marigold R, Günther A, Tiwari D, Kwan J. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD008710. DOI: 10.1002/14651858.CD008710.pub2.

Author Information

  1. 1

    Royal Bournemouth Hospital, Department of Stroke Medicine, Bournemouth, UK

  2. 2

    Jena University Hospital, Department of Neurology, Jena, Germany

  3. 3

    Royal Bournemouth Hospital, Bournemouth, Dorset, UK

  4. 4

    Bournemouth University, School of Health and Social Care, Bournemouth, Dorset, UK

*Joseph Kwan, School of Health and Social Care, Bournemouth University, Royal London House, Christchurch Road, Bournemouth, Dorset, BH1 3LT, UK.

Publication History

  1. Publication Status: New
  2. Published Online: 5 JUN 2013


Characteristics of excluded studies [ordered by study ID]

StudyReason for exclusion

Chumnanvej 2007Not a randomised controlled trial. Patients allocated to short (3 days) or longer-term (until hospital discharge) phenytoin treatment with no comparison with placebo

Lewis 2009Retrospective analysis examining levetiracetam and phenytoin in seizure prophylaxis

Murphy-Human 2011Not a randomised controlled study, retrospective analysis of seizure recurrence based on extended phenytoin use versus 3 days of levetiracetam

Naidech 2005Not a randomised controlled trial. Calculation of phenytoin "burden" based on average serum levels and functional and cognitive outcomes then assessed

Rapaport 2012Retrospective analysis of the outcome of antiepileptics used in non-traumatic intracranial haemorrhage, not a randomised controlled trial

Rhoney 2000Retrospective analysis of patient charts, not a randomised controlled trial

Rosengart 2007Retrospective analysis of AED prescribing patterns in patients randomised to tirilizad assessing neurological outcome and in-hospital complications. Not a randomised controlled trial of AED medication

Szaflarski 2010Randomised single blind trial, but compared levetiracetam with phenytoin rather than placebo; 89% of patients with traumatic brain injury rather than subarachnoid haemorrhage