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Antibiotic prophylaxis for preventing burn wound infection

  1. Leticia A Barajas-Nava1,*,
  2. Jesús López-Alcalde2,
  3. Marta Roqué i Figuls3,
  4. Ivan Solà3,
  5. Xavier Bonfill Cosp4

Editorial Group: Cochrane Wounds Group

Published Online: 6 JUN 2013

Assessed as up-to-date: 31 JAN 2013

DOI: 10.1002/14651858.CD008738.pub2


How to Cite

Barajas-Nava LA, López-Alcalde J, Roqué i Figuls M, Solà I, Bonfill Cosp X. Antibiotic prophylaxis for preventing burn wound infection. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD008738. DOI: 10.1002/14651858.CD008738.pub2.

Author Information

  1. 1

    Institute of Biomedical Research (IIB Sant Pau), Iberoamerican Cochrane Centre, Barcelona, Barcelona, Spain

  2. 2

    Laín Entralgo Agency (Cochrane Collaborating Centre), Health Technology Assessment Unit, Madrid, Madrid, Spain

  3. 3

    CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Iberoamerican Cochrane Centre, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Catalunya, Spain

  4. 4

    CIBER Epidemiología y Salud Pública (CIBERESP), Spain - Universitat Autònoma de Barcelona, Iberoamerican Cochrane Centre, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Catalonia, Spain

*Leticia A Barajas-Nava, Iberoamerican Cochrane Centre, Institute of Biomedical Research (IIB Sant Pau), C/ Sant Antoni Ma Claret 171, Casa de Convalescència, Barcelona, Barcelona, 08041, Spain. leticia.barajas@cochrane.es.

Publication History

  1. Publication Status: New
  2. Published Online: 6 JUN 2013

SEARCH

[Figure 1]
Figure 1. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 2]
Figure 2. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 3]
Figure 3. Flow diagram.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Topical antibiotic prophylaxis, Outcome 1 Burn wound infection.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Topical antibiotic prophylaxis, Outcome 2 Infections in the burned people (sepsis).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Topical antibiotic prophylaxis, Outcome 3 Infections in burned people (bacteraemia).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Topical antibiotic prophylaxis, Outcome 4 Infections in burned people (pneumonia).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Topical antibiotic prophylaxis, Outcome 5 Infections in burned people (urinary tract infection).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Topical antibiotic prophylaxis, Outcome 6 Adverse events.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Topical antibiotic prophylaxis, Outcome 7 Infection-related mortality.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Topical antibiotic prophylaxis, Outcome 8 Antibiotic resistance (MRSA).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Topical antibiotic prophylaxis, Outcome 9 All-cause mortality.
[Analysis 1.10]
Analysis 1.10. Comparison 1 Topical antibiotic prophylaxis, Outcome 10 Length of hospital stay (LOS).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 1 Burn wound infection.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 2 Infections in burned people (sepsis).
[Analysis 2.3]
Analysis 2.3. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 3 Infections in burned people (bacteraemia).
[Analysis 2.4]
Analysis 2.4. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 4 Infections in burned people (pneumonia).
[Analysis 2.5]
Analysis 2.5. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 5 Infections in burned people (urinary tract infection).
[Analysis 2.6]
Analysis 2.6. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 6 Infection-related mortality.
[Analysis 2.7]
Analysis 2.7. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 7 Antibiotic resistance (MRSA).
[Analysis 2.8]
Analysis 2.8. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 8 All-cause mortality.
[Analysis 2.9]
Analysis 2.9. Comparison 2 Systemic antibiotic prophylaxis (general), Outcome 9 Length of hospital stay (LOS).
[Analysis 3.1]
Analysis 3.1. Comparison 3 Systemic antibiotic prophylaxis (perioperative), Outcome 1 Burn wound infection.
[Analysis 3.2]
Analysis 3.2. Comparison 3 Systemic antibiotic prophylaxis (perioperative), Outcome 2 Infections in burned people (bacteraemia).
[Analysis 3.3]
Analysis 3.3. Comparison 3 Systemic antibiotic prophylaxis (perioperative), Outcome 3 Infections in burned people (pneumonia).
[Analysis 3.4]
Analysis 3.4. Comparison 3 Systemic antibiotic prophylaxis (perioperative), Outcome 4 Infections in burned people (urinary tract infection).
[Analysis 3.5]
Analysis 3.5. Comparison 3 Systemic antibiotic prophylaxis (perioperative), Outcome 5 Adverse events.
[Analysis 3.6]
Analysis 3.6. Comparison 3 Systemic antibiotic prophylaxis (perioperative), Outcome 6 All-cause mortality.
[Analysis 3.7]
Analysis 3.7. Comparison 3 Systemic antibiotic prophylaxis (perioperative), Outcome 7 Length of hospital stay (LOS).
[Analysis 4.1]
Analysis 4.1. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 1 Burn wound infection.
[Analysis 4.2]
Analysis 4.2. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 2 Infections in burned people (sepsis).
[Analysis 4.3]
Analysis 4.3. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 3 Infections in burned people (bacteraemia).
[Analysis 4.4]
Analysis 4.4. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 4 Infections in burned people (pneumonia).
[Analysis 4.5]
Analysis 4.5. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 5 Infections in burned people (urinary tract infection).
[Analysis 4.6]
Analysis 4.6. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 6 Adverse events.
[Analysis 4.7]
Analysis 4.7. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 7 Antibiotic resistance (MRSA).
[Analysis 4.8]
Analysis 4.8. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 8 All-cause mortality.
[Analysis 4.9]
Analysis 4.9. Comparison 4 Non-absorbable antibiotic prophylaxis (selective decontamination of the digestive tract), Outcome 9 Length of hospital stay (LOS).
[Analysis 5.1]
Analysis 5.1. Comparison 5 Local antibiotic prophylaxis (airway), Outcome 1 Infections in burned people (sepsis).
[Analysis 5.2]
Analysis 5.2. Comparison 5 Local antibiotic prophylaxis (airway), Outcome 2 All-cause mortality.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 1 Burn wound infection.
[Analysis 6.2]
Analysis 6.2. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 2 Infections in burned people (sepsis).
[Analysis 6.3]
Analysis 6.3. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 3 Infections in burned people (bacteraemia).
[Analysis 6.4]
Analysis 6.4. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 4 Infections in burned people (pneumonia).
[Analysis 6.5]
Analysis 6.5. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 5 Infections in burned people (urinary tract infection).
[Analysis 6.6]
Analysis 6.6. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 6 Infection-related mortality.
[Analysis 6.7]
Analysis 6.7. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 7 Adverse events.
[Analysis 6.8]
Analysis 6.8. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 8 Antibiotic resistance (MRSA).
[Analysis 6.9]
Analysis 6.9. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 9 All-cause mortality.
[Analysis 6.10]
Analysis 6.10. Comparison 6 Antibiotic prophylaxis vs control/placebo, Outcome 10 Length of hospital stay (LOS).