Intervention Review

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Antibiotic prophylaxis for preventing burn wound infection

  1. Leticia A Barajas-Nava1,*,
  2. Jesús López-Alcalde2,
  3. Marta Roqué i Figuls3,
  4. Ivan Solà3,
  5. Xavier Bonfill Cosp4

Editorial Group: Cochrane Wounds Group

Published Online: 6 JUN 2013

Assessed as up-to-date: 31 JAN 2013

DOI: 10.1002/14651858.CD008738.pub2


How to Cite

Barajas-Nava LA, López-Alcalde J, Roqué i Figuls M, Solà I, Bonfill Cosp X. Antibiotic prophylaxis for preventing burn wound infection. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD008738. DOI: 10.1002/14651858.CD008738.pub2.

Author Information

  1. 1

    Institute of Biomedical Research (IIB Sant Pau), Iberoamerican Cochrane Centre, Barcelona, Barcelona, Spain

  2. 2

    Laín Entralgo Agency (Cochrane Collaborating Centre), Health Technology Assessment Unit, Madrid, Madrid, Spain

  3. 3

    CIBER Epidemiología y Salud Pública (CIBERESP), Spain, Iberoamerican Cochrane Centre, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Catalunya, Spain

  4. 4

    CIBER Epidemiología y Salud Pública (CIBERESP), Spain - Universitat Autònoma de Barcelona, Iberoamerican Cochrane Centre, Institute of Biomedical Research (IIB Sant Pau), Barcelona, Catalonia, Spain

*Leticia A Barajas-Nava, Iberoamerican Cochrane Centre, Institute of Biomedical Research (IIB Sant Pau), C/ Sant Antoni Ma Claret 171, Casa de Convalescència, Barcelona, Barcelona, 08041, Spain. leticia.barajas@cochrane.es.

Publication History

  1. Publication Status: New
  2. Published Online: 6 JUN 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Alexander 1982 {published data only}
  • Alexander JW, MacMillan BG, Law EJ, Krummel R. Prophylactic antibiotics as an adjunct for skin grafting in clean reconstructive surgery following burn injury. Journal of Trauma 1982;22(8):687-90.
Alexander 1984 {published data only}
  • Alexander JW, MacMillan BG, Law EJ, Kern R. Lack of beneficial effects of restricted prophylactic antibiotics for debridement and/or grafting of seriously burned patients. Bulletin and Clinical Review of Burn Injuries 1984;1:20.
Ang 2001 {published data only}
  • Ang ES, Lee ST, Gan CS, See P, Chan YH, Ng LH, et al. The role of alternative therapy in the management of partial thickness burns of the face - experience with the use of moist exposed burn ointment (MEBO)compared with silver sulphadiazine. Annals of the Academy of Medicine 2002;29(1):7-10.
  • Ang ES, Lee ST, Gan CS, See PG, Chan YH, Ng LH, et al. Evaluating the role of alternative therapy in burn wound management: randomized trial comparing moist exposed burn ointment with conventional methods in the management of patients with second-degree burns. Medscape General Medicine 2001;3(12):3-18.
Barret 2000 {published data only}
  • Barret JP, Dziewulski P, Ramzy PI, Wolf SE, Desai MH, Herndon DN. Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns. Plastic and Reconstructive Surgery 2000;105(1):62-5.
Barret 2001 {published data only}
Bugmann 1998 {published data only}
  • Bugmann P, Taylor S, Gyger D, Lironi A, Genin B, Vunda A, et al. A silicone-coated nylon dressing reduces healing time in burned paediatric patients in comparison with standard sulfadiazine treatment: a prospective randomized trial. Burns 1998;24(7):609-12.
Caruso 2006 {published data only}
  • Caruso DM, Foster KN, Blome-Eberwein SA, Twomey JA, Herndon DN, Luterman A, et al. Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. Journal of Burn Care and Research 2006;27(3):298-309.
De La Cal 2005 {published data only}
  • De La Cal MA, Cerdá E, García-Hierro P, van Saene HK, Gómez-Santos D, Negro E, et al. Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: a randomized, placebo-controlled, double-blind trial. Annals of Surgery 2005;241(3):424-30.
Demling 1999 {published data only}
Demling 2003 {published data only}
  • Demling RH, DeSanti L. The potential benefits of a temporary bioactive skin substitute to treat partial-thickness burns of the feet. Wounds: A Compendium of Clinical Research and Practice 2003;15(1):10-5.
Desai 1991 {published data only}
  • Desai MH, Rutan RL, Heggers JP, Alvarado MI, McElroy K, Henrdon DN. The role of gentamicin iontophoresis in the treatment of burned ears. Journal of Burn Care and Rehabilitation 1991;12(6):521-4.
Durtschi 1982 {published data only}
  • Durtschi MB, Orgain C, Counts GW, Heimbach DM. A prospective study of prophylactic penicillin in acutely burned hospitalized patients. Journal of Trauma 1982;22(1):11-4.
Fisher 1968 {published data only}
  • Fisher AJ, Morrison G, van der Riet Rle S. A blind trial of two aerosol sprays in the exposure treatment of burns. South African Medical Journal  1968;42(34):903-5.
Gerding 1988 {published data only}
Gerding 1990 {published data only}
  • Gerding RL, Emerman CL, Effron D, Lukens T, Imbembo AL, Fratianne RB. Outpatient management of partial-thickness burns: Biobrane versus 1% silver sulfadiazine. Annals of Emergency Medicine 1990;19(2):121-4.
Glat 2009 {published data only}
  • Glat PM, Kubat WD, Hsu JF, Copty T, Burkey BA, Davis W, et al. Randomized clinical study of SilvaSorb gel in comparison to Silvadene silver sulfadiazine cream in the management of partial-thickness burns. Journal of Burn Care and Research 2009;30(2):262-67.
Gong 2009 {published data only}
  • Gong Z-H, Yao J, Ji J-F, Yang J, Xiang T. Effect of ionic silver dressing combined with hydrogel on degree II burn wound healing [in Chinese]. Journal of Clinical Rehabilitative Tissue Engineering Research 2009;13(42):8373-6.
Gotschall 1998 {published data only}
  • Gotschall CS, Morrison MIS, Eichelberger MR. Prospective randomized study of the efficacy of Mepitel on children with partial-thickness scalds. Journal of Burn Care and Rehabilitation 1998;19(4):279-83.
Hauser 2007 {published data only}
  • Hauser J, Rossbach O, Langer S, Vogt P, Germann G, Steinau HU, et al. Local therapy of grade IIa burns: Efficacy and tolerability of a new hydrosome wound gel for the local treatment of grade IIa burns as compared with silver sulfadiazine ointment [Lokale Behandlung von Grad-IIa-Verbrennungen. Wirksamkeit und Verträglichkeit eines neuartigen hydrosomalen Wundgels im Vergleich zu Silbersulfadiazin-Creme]. Unfallchirurg 2007;110(11):988-94.
Hosseini 2009 {published data only}
  • Hosseini SN, Karimian A, Mousavinasab SN, Rahmanpour H, Yamini M, Zahmatkesh SH. Xenoderm versus 1% silver sulfadiazine in partial-thickness burns. Asian Journal of Surgery 2009;32(4):234-9.
Khorasani 2009 {published data only}
  • Khorasani G, Hosseinimehr SJ, Azadbakht M, Zamani A, Mahdavi MR. Aloe versus silver sulfadiazine creams for second-degree burns: A randomized controlled study. Surgery Today 2009;39(7):587-91.
Kimura 1998 {published data only}
  • Kimura A, Mochizuki T, Nishizawa K, Mashiko K, Yamamoto Y, Otsuka T. Trimethoprim-sulfamethoxazole for the prevention of methicillin-resistant Staphylococcus aureus pneumonia in severely burned patients. Journal of Trauma 1998;45(2):383-7.
Levine 1978 {published data only}
  • Levine BA, Petroff PA, Slade CL, Pruitt BA Jr. Prospective trials of dexamethasone and aerosolized gentamicin in the treatment of inhalation injury in the burned patient. Journal of Trauma 1978;18(3):188-93.
Livingston 1990 {published data only}
  • Livingston DH, Cryer HG, Miller FB, Malangoni MA, Polk HC Jr, Weiner LJ. A randomized prospective study of topical antimicrobial agents on skin grafts after thermal injury. Plastic and Reconstructive Surgery 1990;86(6):1059-64; discussion 1065.
Maya 1986 {published data only}
  • Maya BJ, Covarrubias BA, Romero PA, Licona VL, Claesson BE, Filipsson S, et al. Spray rifamycin and amniotic membranes in second degree burns [Rifamicina spray y membranas amnióticas en quemaduras de segundo grado]. Compendium de Investigaciones Clinicas Latinoamericanas 1986;6(2):73-80.
Miller 1987 {published data only}
  • Miller LM, Carboll WB, Hansbrough JF. The effect of antimicrobial prophylaxis for burn wound excision: Ceforanide versus cefazolin. Current Therapeutic Research, Clinical and Experimental 1987;41(6):946-51.
Mohammadi 2009 {published data only}
  • Mohammadi AA, Riazi H, Hasheminasab MJ, Sabet B, Mohammadi MK, Abbasi S, et al. Amniotic membrane dressing vs conventional topical antibiotic dressing in hospitalized burn patients. Iranian Red Crescent Medical Journal 2009;11(1):66-70.
Moharamzad 2010 {published data only}
  • Moharamzad Y, Panahi Y, Beiraghdar F, Feizi I. Focused Conference Group: P16 - Natural products: Past and future? Clinical efficacy of a topical herbal cream (Aloe vera, Geranium robertianum and Lavandula stoechas) in second-degree burn wounds. Basic and Clinical Pharmacology and Toxicology 2010;107(Suppl. 1):162–69.
Muangman 2006 {published data only}
  • Muangman P, Chuntrasakul C, Silthram S, Suvanchote S, Benjathanung R, Kittidacha S, et al. Comparison of efficacy of 1% silver sulfadiazine and Acticoat for treatment of partial-thickness burn wounds. Journal of The Medical Association of Thailand 2006;89(7):953-8.
Munster 1986 {published data only}
Noordenbos 1999 {published data only}
  • Noordenbos J, Dore C, Hansbrough JF. Safety and efficacy of TransCyte for the treatment of partial-thickness burns. Journal of Burn Care and Rehabilitation 1999;20(4):275-81.
Rodgers 1997 {published data only}
  • Rodgers GL, Fisher MC, Lo A, Cresswell A, Long SS. Study of antibiotic prophylaxis during burn wound debridement in children. Journal of Burn Care and Rehabilitation 1997;18(4):342-6.
Silver 2007 {published data only}
  • Silver GM, Robertson SW, Halerz MM, Conrad P, Supple KG, Gamelli RL. A silver-coated antimicrobial barrier dressing used postoperatively on meshed autografts: a dressing comparison study. Journal of Burn Care and Research 2007;28(5):715-9.
Soroff 1994 {published data only}
  • Soroff HS, Sasvary DH. Collagenase ointment and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine cream in partial-thickness burns: a pilot study. Journal of Burn Care and Rehabilitation  1994;15(1):13-7.
Subrahmanyam 1998 {published data only}
Tayade 2006 {published data only}
  • Tayade MB, Bakhshi GD, Haobijam N. A comparative study of collagen sheet cover versus 1% silver sulphadiazine in partial thickness burns. Bombay Hospital Journal 2006;48(2):http://www.bhj.org/journal/2006_4802_april/html/org_res_263-267.html.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Abdel-Razek 2000 {published data only}
  • Abdel-Razek SM, Abdel-Khalek AH, Allam AM, Shalaby H, Mandoor S, Higazi M. Impact of selective gastrointestinal decontamination on mortality and morbidity in severely burned patients. Annals of Burns and Fire Disasters 2000;XIII(4):1-5.
Afilalo 1992 {published data only}
  • Afilalo M, Dankoff J, Guttman A, Lloyd J. DuoDERM hydroactive dressing versus silver sulphadiazine/Bactigras in the emergency treatment of partial skin thickness burns. Burns 1992;18(4):313-6.
Ahuja 2009 {published data only}
  • Ahuja RB, Gupta A, Gur R. A prospective double-blinded comparative analysis of framycetin and silver sulphadiazine as topical agents for burns: A pilot study. Burns 2009;35(5):672-6.
Baghel 2009 {published data only}
  • Baghel PS,  Shukla S,  Mathur RK,  Randa R. A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian Journal of Plastic Surgery 2009;42(2):176-81.
Branski 2008 {published data only}
Carneiro 2002 {published data only}
  • Carneiro PM, Rwanyuma LR, Mkony CA. A comparison of topical Phenytoin with Silverex in the treatment of superficial dermal burn wounds. Central African Journal of Medicine 2002;48(9-10):105-8.
Cason 1966 {published data only}
  • Cason JS, Jackson DM, Lowbury EJL, Ricketts CR. Antiseptic and aseptic prophylaxis for burns: use of silver nitrate and of isolators. British Medical Journal 1966;2(5525):1288-94.
De Gracia 2001 {published data only}
  • De Gracia CG. An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 2001;27(1):67-74.
Deutsch 1990 {published data only}
  • Deutsch DH, Miller SF, Finley RK. The use of intestinal antibiotics to delay or prevent infections in patients with burns. Journal of Burn Care and Rehabilitation 1990;11(5):436-42.
Donati 1994 {published data only}
Fang 1987 {published data only}
  • Fang CH, Nathan P, Robb EC, Alexander JW, MacMillan BG. Prospective clinical study of Hydron, a synthetic dressing, in delivery of an antimicrobial drug to second-degree burns. Journal of Burn Care and Rehabilitation  1987;8(3):206-9.
Grippaudo 2010 {published data only}
Huang 2006 {published data only}
  • Huang YS, Li XL, Liao ZJ, Zhang GA, Liu Q, Tang J, et al. Multi-center clinical study of acticoat (nanocrystalline silver dressing) for the management of residual burn wounds: Summary report. Zhonghua Shao Shang Za Zhi 2006;22(1):15-8.
Huang 2007 {published data only}
  • Huang Y, Li X, Liao Z, Zhang G, Liu Q, Tang J, et al. A randomized comparative trial between Acticoat and SD-Ag in the treatment of residual burn wounds, including safety analysis. Burns 2007;33(2):161-6.
Hunter 1976 {published data only}
Inman 1984 {published data only}
  • Inman RJ, Snelling CF, Roberts FJ, Shaw K, Boyle JC. Prospective comparison of silver sulfadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent (Silvazine) and silver sulfadiazine 1 per cent (Flamazine) as prophylaxis against burn wound infection. Burns, Including Thermal Injury  1984;11(1):35-40.
Li XL 2006 {published data only}
  • Li XL, Huang YS, Peng YZ, Liao ZJ, Zhang GA, Liu Q, et al. Multi-center clinical study of acticoat (nanocrystalline silver dressing) for the management of residual burn wounds. Zhonghua Shao Shang Za Zhi 2006;22(1):15-8.
Lowbury 1968 {published data only}
  • Lowbury EJ,  Jackson DM. Local chemoprophylaxis for burns with gentamicin and other agents. Lancet 1968;1(7544):654-7.
Malik 2010 {published data only}
Manuskiatti 1999 {published data only}
  • Manuskiatti W, Fitzpatrick RE, Goldman MP, Krejci-Papa N. Prophylactic antibiotics in patients undergoing laser resurfacing of the skin. Journal of the American Academy of Dermatology 1999;40(1):77-84.
Mashhood 2006 {published data only}
  • Mashhood AA, Khan TA, Sami AN. Honey compared with 1% silver sulfadiazine cream in the treatment of superficial and partial thickness burns. Journal of Pakistan Association of Dermatologists  2006;16(1):14-9.
Miller 1990 {published data only}
  • Miller L, Hansbrough J, Slater H, Goldfarb IW, Kealey P, Saffle J, et al. Sildimac: a new delivery system for silver sulfadiazine in the treatment of full-thickness burn injuries. Journal of Burn Care and Rehabilitation  1990;11(1):35-41.
Munster 1989 {published data only}
  • Munster AM, Xiao GX, Guo Y, Wong LA, Winchurch RA. Control of endotoxemia in burn patients by use of polymyxin B. Journal of Burn Care and Rehabilitation 1989;10(4):327-30.
Oen 2012 {published data only}
  • Oen IM,  van Baar ME,  Middelkoop E,  Nieuwenhuis MK. Facial Burns Group. Effectiveness of cerium nitrate-silver sulfadiazine in the treatment of facial burns: a multicenter, randomized,controlled trial. Plastic and Reconstructive Surgery 2012;130(2):274e-283e.
Ostlie 2012 {published data only}
  • Ostlie DJ,  Juang D,  Aguayo P,  Pettiford-Cunningham JP,  Erkmann EA,  Rash DE,  et al. Topical silver sulfadiazine vs collagenase ointment for the treatment of partial thickness burns in children: a prospective randomized trial. Journal of Pediatric Surgery 2012;47(6):1204-7.
Piel 1985 {published data only}
  • Piel P, Scarnati S, Goldfarb IW, Slater H. Antibiotic prophylaxis in patients undergoing burn wound excision. Journal of Burn Care and Rehabilitation 1985;6(5):422-4.
Proctor 1971 {published data only}
  • Proctor DS. The treatment of burns: a comparative trial of antibiotic dressings. South African Medical Journal 1971;45(2):231-6.
Ramos 2008 {published data only}
  • Ramos G, Resta M, Machare Delgado E, Durlach R, Fernandez Canigia L, Benaim F. Systemic perioperative antibiotic prophylaxis may improve skin autograft survival in patients with acute burns. Journal of Burn Care and Research 2008;29(6):917-23.
Steer 1997 {published data only}
  • Steer JA, Papini RP, Wilson AP, McGrouther DA, Nakhla LS, Parkhouse N. Randomized placebo-controlled trial of teicoplanin in the antibiotic prophylaxis of infection following manipulation of burn wounds. British Journal of Surgery 1997;84(6):848-53.
Subrahmanyam 1991 {published data only}
Ugburo 2004 {published data only}
  • Ugburo AO, Atoyebi OA, Oyeneyin JO, Sowemimo GO. An evaluation of the role of systemic antibiotic prophylaxis in the control of burn wound infection at the Lagos University Teaching Hospital. Burns 2004;30(1):43-8.
Varas 2005 {published data only}
  • Varas RP, O'Keeffe T, Namias N, Pizano LR, Quintana OD, Herrero Tellachea M, et al. A prospective, randomized trial of Acticoat versus silver sulfadiazine in the treatment of partial-thickness burns: which method is less painful?. Journal of Burn Care and Rehabilitation 2005;26(4):344-7.
Waffle 1988 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Maghsoudi 2011 {published data only}
  • Maghsoudi H, Salehi F, Khosrowshahi MK, Baghaei M, Nasirzadeh M, Shams R. Comparison between topical honey and mafenide acetate in treatment of burn wounds. Annals of Burns and Fire Disasters  2011;24(3):132-7.
Panahi 2012 {published data only}
  • Panahi Y, Beiraghdar F, Akbari H, Bekhradi H, Taghizadeh M, Sahebkar A. A herbal cream consisting of Aloe vera, Lavandulastoechas, and Pelargonium roseum as an alternative for silver sulfadiazine in burn management. Asian Biomedicine 2012;6(2):273-8.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Alexander 2009
Alp 2012
  • Alp E,  Coruh A,  Gunay GK,  Yontar Y,  Doganay M. Risk factors for nosocomial infection and mortality in burn patients: 10 years of experience at a university hospital. Journal of Burn Care and Research 2012;33(3):379-85.
Alsbjörn 2007
  • Alsbjörn B, Gilbert P, Hartmann B, Kaźmierski M, Monstrey S, Palao R, et al. Guidelines for the management of partial-thickness burns in a general hospital or community setting recommendations of a European working party. Burns 2007;33(2):155-60.
Altoparlak 2004
  • Altoparlak U, Erol S, Akcay MN, Celebi F, Kadanali A. The time-related changes of antimicrobial resistance patterns and predominant bacterial profiles of burn wounds and body flora of burned patients. Burns 2004;30(7):660-4.
Ansermino 2004
Atoyebi 1992
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  • Brychta P, Magnette A.  . European Practice Guidelines for Burn Care. The Netherlands, 2011.
Church 2006
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De Macedo 2005
  • De Macedo JL, Santos JB. Bacterial and fungal colonization of burn wounds. Memórias do Instituto Oswaldo Cruz 2005;100(5):535-9.
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Polavarapu 2008
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Still 2002
Wasiak 2008
Weber 2002
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Weber 2004
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WLDI 2008
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