This is the protocol for a review and there is no abstract. The objectives are as follows:
The objective of this review is to compare the use of single chemotherapy agents given sequentially with regimens using a combination of the same agents for the management of women with metastatic breast cancer to determine their effect on survival. This involves examining two different chemotherapy schemata:
Schema 1: sequential single agents given on disease progression, eg cycles of drug A until disease progression followed by cycles of drug B until disease progression versus cycles of combination AB until disease progression;
Schema 2: sequential single agents given as a set number of cycles versus the combination for the same total number of cycles, eg four cycles of A followed by four cycles of B versus eight cycles of AB.