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Acetaminophen (paracetamol) for the common cold in adults

  1. Siyuan Li1,
  2. Jirong Yue1,
  3. Bi Rong Dong1,*,
  4. Ming Yang1,
  5. Xiufang Lin1,
  6. Taixiang Wu2

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 1 JUL 2013

Assessed as up-to-date: 13 FEB 2013

DOI: 10.1002/14651858.CD008800.pub2

How to Cite

Li S, Yue J, Dong BR, Yang M, Lin X, Wu T. Acetaminophen (paracetamol) for the common cold in adults. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD008800. DOI: 10.1002/14651858.CD008800.pub2.

Author Information

  1. 1

    West China Hospital, Sichuan University, Department of Geriatrics, Chengdu, Sichuan, China

  2. 2

    West China Hospital, Sichuan University, Chinese Clinical Trial Registry, Chinese Ethics Committee of Registering Clinical Trials, Chengdu, Sichuan, China

*Bi Rong Dong, Department of Geriatrics, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, 610041, China. birongdong@163.com.

Publication History

  1. Publication Status: Edited (no change to conclusions), comment added to review
  2. Published Online: 1 JUL 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Bachert 2005 {published data only}
  • Bachert C, Chuchalin AG, Eisebitt R, Netayzhenko VZ, Voelker M. Aspirin compared with acetaminophen in the treatment of fever and other symptoms of upper respiratory tract infection in adults: a multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group, single-dose, 6-hour dose-ranging study. Clinical Therapeutics 2005;27(7):993-1003.
Graham 1990 {published data only}
  • Graham NMH, Burrell CJ, Douglas RM, Debelle P, Davies L. Adverse effects of aspirin, acetaminophen, and ibuprofen on immune function,viral shedding, and clinical status in rhinovirus-infected volunteers. Journal of Infectious Diseases 1990;162:1277-82.
Ryan 1987 {published data only}
  • Ryan PB, Rush DR, Nicholas TA, Graham DG. A double-blind comparison of fenoprofen, acetaminophen, and placebo in the palliative treatment of common nonbacterial upper respiratory infections. Current Therapeutic Research 1987;41(1):17-23.
Sperber 2000 {published data only}
  • Sperber SJ, Turner RB, Sorrentino JV, Connor RR, Rogers J, Gwaltney JM. Effectiveness of pseudoephedrine plus acetaminophen for treatment of symptoms attributed to the paranasal sinuses associated with the common cold. Archives of Family Medicine 2000;9:979-85.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Eccles 2006a {published data only}
  • Eccles R, Jawad M, Jawad S, Ridge D, North M, Jones E, et al. Efficacy of a paracetamol-pseudoephedrine combination for treatment of nasal congestion and pain-related symptoms in upper respiratory tract infection. Current Medical Research & Opinion 2006;22(12):2411-8.
Koytchev 2003 {published data only}
  • Koytchev R, Vlahov V, Bacratcheva N, Giesel B, Gawronska-szklarz B, Wojcicki J, et al. Evaluation of the efficacy of a combined formulation (Grippostad-C) in the therapy of symptoms of common cold: a randomised, double-blind, multicenter trial. International Journal of Clinical Pharmacology & Therapeutics 2003;41(3):114-25.
Sedinkin 2004 {published data only}
  • Sedinkin AA, Balandin AV, Dimova AD. Results of an open prospective controlled randomised comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain. Vestnik Otorinolaringologii 2004;1(5):52-4.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Blanco de la Mora 2000 {published data only}
  • Blanco de la Mora E, Loose I. Efficacy and safety of loratadin, pseudoephedrine & acetaminophen new formulation design for the symptomatic treatment of common cold. Investigation Medical International 2000;27(1):14-25.
Mizoguchi 2007 {published data only}
  • Mizoguchi H, Wilson A, Jerdack GR, Hull JD, Goodale M, Grender JM, et al. Efficacy of a single evening dose of syrup containing paracetamol, dextromethorphan hydrobromide, doxylamine succinate and ephedrine sulfate in subjects with multiple common cold symptoms. International Journal of Clinical Pharmacology & Therapeutics 2007;45(4):230-6.
Schachtel 1999 {published data only}
  • Schachtel BP, Loose I. Gastrointestinal tolerability of single doses of acetylsalicylic acid, paracetamol, and placebo in adults with upper respiratory tract infection. Gut 1999;45(Suppl V):A95.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
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Lucas 2005
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Mizoquchi 2007
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