Intervention Review

You have free access to this content

Osmotic therapies added to antibiotics for acute bacterial meningitis

  1. Emma CB Wall1,*,
  2. Katherine MB Ajdukiewicz2,
  3. Robert S Heyderman3,
  4. Paul Garner1

Editorial Group: Cochrane Acute Respiratory Infections Group

Published Online: 28 MAR 2013

Assessed as up-to-date: 30 NOV 2012

DOI: 10.1002/14651858.CD008806.pub2


How to Cite

Wall ECB, Ajdukiewicz KMB, Heyderman RS, Garner P. Osmotic therapies added to antibiotics for acute bacterial meningitis. Cochrane Database of Systematic Reviews 2013, Issue 3. Art. No.: CD008806. DOI: 10.1002/14651858.CD008806.pub2.

Author Information

  1. 1

    Liverpool School of Tropical Medicine, International Health Group, Liverpool, UK

  2. 2

    Pennine Acute Hospitals NHS Trust, Department of Infectious Diseases, Manchester, UK

  3. 3

    University of Malawi College of Medicine, Malawi-Liverpool-Wellcome Clinical Research Programme, Blantyre, Chichiri, Malawi

*Emma CB Wall, International Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. emma.wall@liv.ac.uk. emma.wall@doctors.org.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 28 MAR 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Ajdukiewicz 2011 {published data only}
  • Ajdukiewicz KM, Cartwright KE, Scarborough M, Mwambene JB, Goodson P, Molyneux ME, et al. Glycerol adjuvant therapy in adults with bacterial meningitis in a high HIV seroprevalence setting in Malawi: a double-blind, randomised controlled trial. Lancet Infect Diseases 2011;11(4):293-300.
Kilpi 1995 {published data only}
  • Kilpi T, Peltola H, Jauhiainen T, Kallio MJ. Oral glycerol and intravenous dexamethasone in preventing neurologic and audiologic sequelae of childhood bacterial meningitis. The Finnish Study Group. Pediatric Infectious Disease Journal 1995;14(4):270-8.
Peltola 2007 {published data only}
  • Peltola H, Roine I, Fernandez J, Zavala I, Ayala SG, Mata AG, et al. Adjuvant glycerol and/or dexamethasone to improve the outcomes of childhood bacterial meningitis: a prospective, randomized, double-blind, placebo-controlled trial [see comment]. Clinical Infectious Diseases 2007;45:1277-86.
Sankar 2007 {published data only}
  • Sankar J, Singhi P, Bansal A, Ray P, Singhi S. Role of dexamethasone and oral glycerol in reducing hearing and neurological sequelae in children with bacterial meningitis. Indian Pediatrics 2007;44(9):649-56.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Alimarante 1995 {published data only}
Herson 1977 {published data only}
Pecco 1991 {published data only}
  • Pecco P, Pavesio D, Peisino MG. Rational basis of modern therapy of bacterial meningitis. Review of the literature and our clinical experience of 122 pediatric cases. Panminerva Medica 1991;33(4):185-90.
Pelegrin 2012 {published data only}
  • Pelegrin I, Verdaguer R, Ariza J, Viladrich PF, Cabellos C. Effect of adjuvant therapy in pneumococcal meningitis: seizures and mortality. Clinical Microbiology and Infection 2012;19(Suppl):834.
Peltola 2010 {published data only}
  • Peltola H, Roine I, Fernandez J, Gonzlez MA, Zavala I, Gonzalez A, et al. Hearing impairment in childhood bacterial meningitis is little relieved by dexamethasone or glycerol. Paediatrics 2010;125(1):e1-8.
Singhi 2004 {published data only}
  • Singhi S, Khetarpal R, Baranwal AK, Singhi PD. Intensive care needs of children with acute bacterial meningitis: a developing country perspective. Annals of Tropical Paediatrics 2004;24(2):133-40.
Singhi 2007 {published data only}
  • Singhi S, Singhi P. Glycerol and dexamethasone in bacterial meningitis in low-income countries: response to the editorial commentary. Clinical Infectious Diseases 2007;47(5):732-3.
Singhi 2008 {published data only}
  • Singhi S, Jarvinen A, Peltola H. Increase in serum osmolality is possible mechanism for the beneficial effects of glycerol in childhood bacterial meningitis. Pediatric Infectious Diseases Journal 2008;27:892-6.
Urciuoli 1963 {published data only}
  • Urciuoloi R. A new osmotic drug: hypertonic solution of mannitol. Advantages as compared with urea. Use in the treatment of aseptic serous meningitis and postoperative cerebrospinal fluid fistulas. Gazzetta Medica Italiana 1963;122:234-6.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Molyneux 2012 {unpublished data only}
  • Glycerol and high dose paracetamol for paediatric meningitis. Ongoing study 2010.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Bereczki 2010
Blaser 2010
  • Blaser C, Klein M, Grandgirard D, Wittwer M, Peltola H, Weigand M, et al. Adjuvant glycerol is not beneficial in experimental pneumococcal meningitis. BMC Infectious Diseases 2010;10:84.
Brouwer 2010
Brouwer 2011
BTF 2000
  • Brain Trauma Foundation. The American association of neurological surgeons. The joint section on neurotrauma and critical care. Initial management. Journal of Neurotrauma 2000;17:463-9.
Choi 2005
  • Choi CW, Hwang JH, Chang JS, Park WS, Kim BI, Choi JH, et al. Effects of hypertonic (7%) saline on brain injury in experimental Escherichia coli meningitis. Journal of Korean Medical Science 2005;20:870-6.
de Gans 2002
Domingo 2009
  • Domingo P, Suarez-Lozano I, Torres F, Pomar V, Ribera E, Galindo MJ, et al. Bacterial meningitis in HIV-1-infected patients in the era of highly active antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes 2009;51:582-7.
GRADEpro 2008
  • Brozek J, Oxman A, Schünemann H. GRADEpro [Computer program]. Version 3.2 for Windows, 2008.
Harnden 2006
  • Harnden A, Ninis N, Thompson M, Perera R, Levin M, Mant D, et al. Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study. BMJ (Clinical research ed.) 2006;332:1295-8.
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Chichester, UK: Wiley-Blackwell, 2011.
Ichai 2009
  • Ichai C, Armando G, Orban JC, Berthier F, Rami L, Samat-Long C, et al. Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients. Intensive Care Medicine 2009;35:471-9.
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J. Chapter 6: Searching for studies. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration. Available from www.cochrane-handbook.org 2011.
Maconochie 2011
Mahdi 2012
  • Mahdi LK, Wang H, Van der Hoek M, Paton JC, Ogunniyi AD. Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice. Journal of Clinical Investigation 2012;122(6):2208-20.
Mathew 1972
  • Mathew NT, Rivera VM, Meyer JS, Charney JZ, Hartmann A. Double-blind evaluation of glycerol therapy in acute cerebral infarction. Lancet 1972;2:1327-9.
McCormick 2012
  • McCormick DW, Wilson ML, Mankhambo L, Phiri A, Chimalizeni Y, Kawaza K, et al. Risk factors for death and severe sequelae in Malawian children with bacterial meningitis, 1997-2010. Pediatric Infectious Diseases Journal 2012 Aug 20 [Epub ahead of print].
Meyer 1972
  • Meyer JS, Teraura T, Marx P, Hashi K, Sakamoto K. Brain swelling due to experimental cerebral infarction. Changes in vasomotor capacitance and effects of intravenous glycerol. Brain 1972;95:833-52.
Molyneux 2002
  • Molyneux EM, Walsh AL, Forsyth H, Tembo M, Mwenechanya J, Kayira K, et al. Dexamethasone treatment in childhood bacterial meningitis in Malawi: a randomised controlled trial. Lancet 2002;360:211-8.
Molyneux 2006
  • Molyneux E, Riordan FA, Walsh A. Acute bacterial meningitis in children presenting to the Royal Liverpool Children's Hospital, Liverpool, UK and the Queen Elizabeth Central Hospital in Blantyre, Malawi: a world of difference. Annals of Tropical Paediatrics 2006;26:29-37.
Namutangula 2007
Nguyen 2007
  • Nguyen TH, Tran TH, Thwaites G, Ly VC, Dinh XS, Ho Dang TN, et al. Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. New England Journal of Medicine 2007;357:2431-40.
Okoromah 2011
Pelkonen 2009
  • Pelkonen T, Roine I, Monteiro L, Correia M, Pitkaranta A, Bernardino L, et al. Risk factors for death and severe neurological sequelae in childhood bacterial meningitis in sub-Saharan Africa. Clinical Infectious Diseases. 2009;48:1107-10.
Peltola 2009
RevMan 2011
  • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2011.
Righetti 2005
  • Righetti E, Celani MG, Cantisani TA, Sterzi R, Boysen G, Ricci S. Glycerol for acute stroke. Cochrane Database of Systematic Reviews 2005, Issue 1. [DOI: 10.1002/14651858.CD000096.pub2]
Roine 2009
  • Roine I, Saukkoriipi A, Leinonen M, Peltola H. Microbial genome count in cerebrospinal fluid compared with clinical characteristics in pneumococcal and Haemophilus influenzae type B meningitis in children. Diagnostic Microbiology Infectious Diseases 2009;63(1):16-23.
Saez-Llorens 2007
Scarborough 2007
  • Scarborough M, Gordon SB, Whitty CJ, French N, Njalale Y, Chitani A, et al. Corticosteroids for bacterial meningitis in adults in sub-Saharan Africa. New England Journal of Medicine. 2007;357:2441-50.
Schmidt 1998
  • Schmidt H, Stuertz K, Chen V, Stringaris AK, Bruck W, Nau R. Glycerol does not reduce neuronal damage in experimental Streptococcus pneumoniae meningitis in rabbits. Inflammopharmacology 1998;6:19-26.
Schwarz 2002
Stoll 1998
  • Stoll J, Hagen M, Bartylla T, Weber K, Jost M, Treib V. Changes of cerebral perfusion after osmotherapy in acute cerebral edema assessed with perfusion weighted MRI. Neurological Research 1998;20(6):474-8.
Sudarsanam 2011
  • Sudarsanam TD, Rupali P, Tharyan P, Abraham OC, Thomas K. Pre-admission antibiotics for suspected cases of meningococcal disease. Cochrane Database of Systematic Reviews 2011, Issue 2. [DOI: 10.1002/14651858.CD005437.pub2]
UNDP 2009
  • United Nations Development Programme. Human Development Report. UNDP (http://hdr.undp.org/en/reports/global/hdr2009/) (accessed 20 December 2009).
van de Beek 2009
van de Beek 2010
  • van de Beek D, Farrar JJ, de Gans J, Mai NT, Molyneux EM, Peltola H, et al. Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. Lancet Neurology 2010;9:254-63.
van Well 2012
  • van Well GT, Sanders MS, Ouburg S, van Furth AM, Morré SA. Polymorphisms in toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis. PLoS One 2012;7(5):e35837.
Wakai 2008
  • Wakai A, Roberts I, Schierhout G. Mannitol for acute traumatic brain injury. Cochrane Database of Systematic Reviews 2008, Issue 1. [DOI: 10.1002/14651858.CD001049.pub4]
Yu 1992
  • Yu YL, Kumana CR, Lauder IJ, Cheung YK, Chan FL, Kou M, et al. Treatment of acute cerebral hemorrhage with intravenous glycerol. A double-blind, placebo-controlled, randomized trial. Stroke 1992;23:967-71.
Yu 1993
  • Yu YL, Kumana CR, Lauder IJ, Cheung YK, Chan FL, Kou M, et al. Treatment of acute cortical infarct with intravenous glycerol. A double-blind, placebo-controlled randomized trial. Stroke 1993;24:1119-24.