Get access

Fibrinogen concentrate in severely bleeding patients for acquired hypofibrinogenaemia

  • Protocol
  • Intervention

Authors

  • Anne Wikkelsø,

    Corresponding author
    1. Herlev University Hospital, Department of Anaesthesiology, Herlev, Denmark
    • Anne Wikkelsø, Department of Anaesthesiology, Herlev University Hospital, Herlev, Denmark. wikkelso@gmail.com.

    Search for more papers by this author
  • Arash Afshari,

    1. Rigshospitalet, The Cochrane Anaesthesia Review Group & Copenhagen Trial Unit and Department of Paediatric and Obstetric Anaesthesia, Copenhagen, Denmark
    Search for more papers by this author
  • Ann Merete Møller

    1. Herlev University Hospital, The Cochrane Anaesthesia Review Group, Rigshospitalet & Department of Anaesthesiology, Herlev, Denmark
    Search for more papers by this author

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

We will assess the benefits and harms of fibrinogen concentrate compared to placebo or usual treatment for bleeding patients. We will look at various outcomes, predefined subgroups and perform sensitivity analyses. We will also examine the role of bias and apply trial sequential analyses (TSA) (Wetterslev 2008) to examine the level of evidence. We will provide a 'Risk of bias' (ROB) table and a 'Summary of findings' (SOF) table in order to list important outcomes and quality of evidence (Guyatt 2008).

Get access to the full text of this article