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Intervention Review

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Vitamin D supplementation for women during pregnancy

  1. Luz Maria De-Regil1,*,
  2. Cristina Palacios2,
  3. Ali Ansary3,
  4. Regina Kulier4,
  5. Juan Pablo Peña-Rosas1

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 15 FEB 2012

Assessed as up-to-date: 16 DEC 2011

DOI: 10.1002/14651858.CD008873.pub2


How to Cite

De-Regil LM, Palacios C, Ansary A, Kulier R, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No.: CD008873. DOI: 10.1002/14651858.CD008873.pub2.

Author Information

  1. 1

    World Health Organization, Evidence and Programme Guidance, Department of Nutrition for Health and Development, Geneva, Switzerland

  2. 2

    University of Puerto Rico, Nutrition Program, Department of Human Development, Graduate School of Public Health, San Juan, Puerto Rico

  3. 3

    Children's Hospital of Orange County, Orange, CA, USA

  4. 4

    Geneva, Switzerland

*Luz Maria De-Regil, Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, Geneva, 1211, Switzerland. deregillu@who.int.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 15 FEB 2012

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This is not the most recent version of the article. View current version (14 JAN 2016)

[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 3 Maternal vitamin D levels at term (25-hydroxyvitamin D) (nmol/L) (ALL).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 4 Maternal vitamin D levels at term (25-hydroxyvitamin D) (nmol/L) by supplementation scheme/regimen.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 5 Maternal vitamin D levels at term (25-hydroxyvitamin D) (nmol/L) by total dose.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 6 Maternal vitamin D levels at term (25-hydroxyvitamin D) (nmol/L) by season at the start of pregnancy.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 8 Low birthweight (less than 2500 g) (ALL).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 12 Side effects (nephritic syndrome) (ALL).
[Analysis 1.14]
Analysis 1.14. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 14 Birth length (cm) (ALL).
[Analysis 1.15]
Analysis 1.15. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 15 Head circumference at birth (cm) (ALL).
[Analysis 1.16]
Analysis 1.16. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 16 Birthweight (g) (ALL).
[Analysis 1.18]
Analysis 1.18. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 18 Stillbirth (ALL).
[Analysis 1.19]
Analysis 1.19. Comparison 1 Vitamin D alone versus no treatment/placebo (no vitamins or minerals), Outcome 19 Neonatal death (ALL).
[Analysis 2.1]
Analysis 2.1. Comparison 2 Vitamin D + calcium versus no treatment/placebo (no vitamin or minerals), Outcome 1 Pre-eclampsia (ALL).