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Intervention Review

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Vitamin D supplementation for women during pregnancy

  1. Luz Maria De-Regil1,*,
  2. Cristina Palacios2,
  3. Ali Ansary3,
  4. Regina Kulier4,
  5. Juan Pablo Peña-Rosas1

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 15 FEB 2012

Assessed as up-to-date: 16 DEC 2011

DOI: 10.1002/14651858.CD008873.pub2


How to Cite

De-Regil LM, Palacios C, Ansary A, Kulier R, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No.: CD008873. DOI: 10.1002/14651858.CD008873.pub2.

Author Information

  1. 1

    World Health Organization, Evidence and Programme Guidance, Department of Nutrition for Health and Development, Geneva, Switzerland

  2. 2

    University of Puerto Rico, Nutrition Program, Department of Human Development, Graduate School of Public Health, San Juan, Puerto Rico

  3. 3

    Children's Hospital of Orange County, Orange, CA, USA

  4. 4

    Geneva, Switzerland

*Luz Maria De-Regil, Evidence and Programme Guidance, Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, Geneva, 1211, Switzerland. deregillu@who.int.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 15 FEB 2012

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This is not the most recent version of the article. View current version (14 JAN 2016)

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Brooke 1980 {published data only}
  • Brooke OG, Brown IRF, Bone CDM, Carter ND, Cleeve HJW, Maxwell JD, et al. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. British Medical Journal 1980;1:751-4.
  • Brooke OG, Butters F, Wood C. Intrauterine vitamin D nutrition and postnatal growth in Asian infants. British Medical Journal 1981;283:1024.
  • Maxwell JD, Ang L, Brooke OG, Brown IRF. Vitamin D supplements enhance weight gain and nutritional status in pregnant Asians. British Journal of Obstetrics and Gynaecology 1981;88:987-91.
Delvin 1986 {published data only}
Mallet 1986 {published data only}
Marya 1987 {published data only}
Marya 1988 {published data only}
  • Marya RK, Rathee S, Dua V, Sangwan K. Effect of vitamin D supplementation during pregnancy on foetal growth. Indian Journal of Medical Research 1988;88:488-92.
Yu 2008 {published data only}
  • Yu C, Newton L, Robinson S, Teoh TG, Sethi M. Vitamin D deficiency and supplementation in pregnant women of four ethnic groups. Archives of Disease in Childhood. Fetal and Neonatal Edition 2008;93(Suppl 1):Fa68.
  • Yu CK, Sykes L, Sethi M, Teoh TG, Robinson S. Vitamin D deficiency and supplementation during pregnancy. Clinical Endocrinology 2009;70(5):685-90.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Ala-Houhala 1986 {published data only}
Cockburn 1980 {published data only}
  • Cockburn F, Belton NR, Purvis RJ, Giles MM, Brown JK, Turner TL, et al. Maternal vitamin D intake and mineral metabolism in mothers and their newborn infants. British Medical Journal 1980;281(6232):11-4.
Das 2009 {published data only}
  • Bhatia V. A study of the effect of vitamin D supplementation in pregnant women, on the growth and biochemical features of the newborn baby and infant. Clinical Trials Registry - India (http://ctri.nic.in/Clinicaltrials/login.php) (accessed 2010).
  • Das V, Agarwal A, Bhatia V, Pandey A, Agarwal S, Saxena P, et al. Evaluation of vitamin d status and need for supplementation in pregnant women of a rural area of North India. International Journal of Gynecology & Obstetrics 2009;107(Suppl 2):S151.
  • Sahu M, Das V, Aggarwal A, Rawat V, Saxena P, Bhatia V. Vitamin D replacement in pregnant women in rural north India: a pilot study. European Journal of Clinical Nutrition 2009;63(9):1157-9.
Ito 1994 {published data only}
  • Ito M, Koyama H, Ohshige A, Maeda T, Yoshimura T, Okamura H. Prevention of preeclampsia with calcium supplementation and vitamin D3 in an antenatal protocol. International Journal of Gynecology & Obstetrics 1994;47(2):115-20.
MacDonald 1986 {published data only}
  • MacDonald HN. Fetal and maternal benefits from calcium and vitamin D supplementation of pregnant Asians. Personal communication 1986.
Marya 1981 {published data only}
von Hurst 2009 {published data only}
  • von Hurst PR. The role of vitamin D in metabolism and bone health. A thesis presented in partial fulfilment of the requirements for the degree of doctor of philosophy in nutritional science, Massey University, Albany New Zealand. Vol. 1, Albany: Massey University, 2009.
  • von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. British Journal of Nutrition 2010;103(4):549-55.
  • von Hurst PR, Stonehouse W, Matthys C, Conlon C, Kruger MC, Coad J. Study protocol--metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: a randomised, placebo-controlled, double-blind vitamin D intervention. BMC Public Health 2008;8:267.
Wagner 2006 {published data only (unpublished sought but not used)}
  • Appelgren KE, Nietert PJ, Hulsey TC, Hollis BW, Wagner CL. Analyzing adherence to prenatal supplement: does pill count measure up?. International Journal of Endocrinology 2010;2010:1-8.
  • Hollis BW, Johnson D, Hulsey TC, Ebeling M, Wagner CL. Vitamin D supplementation during pregnancy: Double-blind, randomized clinical trial of safety and effectiveness. Journal of Bone and Mineral Research 2011;26(10):2341-57.
  • Wagner CL. Evaluation of vitamin D requirements during pregnancy (ongoing trial). ClinicalTrials.gov (http://clinicaltrials.gov/) (accessed 21 March 2006).
  • Wagner CL, Johnson D, Hulsey TC, Ebeling M, Shary J,  Smith PG, et al. Vitamin D supplementation during pregnancy Part I NICHD/CTSA randomized clinical trial (RCT): safety consideration. Pediatric Academic Societies Annual Meeting; 2010 May 1-4; Vancouver, Canada . 2010.
  • Wagner CL, McNeil R, Hamilton SA, Davis DJ, Prudgen C, Winkler J, et al. Vitamin D (vitD) supplementation during pregnancy: Thrasher Research Fund RCT in SC community center networks. Pediatric Academic Societies 2010 Annual Meeting; 2010 May 1-4; Vancouver, Canada. 2010.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Bisgaard 2009 {published data only}
  • Bisgaard H. Vitamin D supplementation during pregnancy for prevention of asthma in childhood (ABCvitaminD). ClinicalTrials.gov (http://clinicaltrials.gov) (accessed 31 July 2009).
Das 2010 {published data only}
  • Das V. Vitamin D and calcium nutrition in pregnancy-evaluation of optimal supplementation dose of vitamin D during antenatal period. Clinical Trials Registry - India (http://ctri.nic.in/Clinicaltrials/login.php) (accessed 2010).
Goldring 2010 {published data only}
  • Goldring S. Effects of prenatal vitamin D supplementation on respiratory and allergic phenotypes and bone density in the first three years of life. UKCRN (http://public.ukcrn.org.uk) (accessed 6 April 2011).
Grant 2010 {published data only}
  • Grant C. Randomised placebo controlled study of vitamin D during pregnancy and infancy. Australian New Zealand Clinical Trials Register (www.anzctr.org.au) (accessed 17 August 2010).
Habib 2010 {published data only}
  • Habib MA. Evaluation of the effectiveness of vitamin D supplementation to pregnant women and their infants in Pakistan. ClinicalTrials.gov (http://clinicaltrials.gov/) (accessed 15 February 2011).
Hacker 2010 {published data only}
  • Hacker AN. Bone Health in Pregnancy (B-Hip). ClinicalTrials.gov (http://clinicaltrials.gov) (accessed 2010).
Judkins 2011 {published data only}
  • Judkins A. A randomised double blinded interventional trial to determine the effect of 50,000 IU vitamin D supplementation monthly or twice monthly from 20 weeks gestation.. ACTRN12610001044011 2011.
Rasmussen 2009 {published data only}
  • Rasmussen G. Additional information on registered trial. Effects of vitamin D supplement before, during and after pregnancy on complications, birth weight and bone mineral density during lactation (gravita). Personal communication 2011.
  • Rasmussen GB. Effects of vitamin D supplement before and during pregnancy on birth weight (gravita). ClinicalTrials.gov (http://clinicaltrials.gov/) (accessed 17 August 2010).
Roth 2010 {published data only}
  • Roth D. Antenatal vitamin D3 supplementation in Bangladesh: randomized controlled trial (AViDD-2). ClinicalTrials.gov (http://clinicaltrials.gov) (accessed 6 April 2011).
Soheilykhah 2011 {published data only}
  • Soheilykhah S. Effect of different doses of vitamin D on insulin resistance in pregnant women attending in Shahid Sadoughi and Mojibian prenatal clinics. Iranian registry of clinical trials 2011.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
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References to other published versions of this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
  5. References to other published versions of this review
Mahomed 1999
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