Intervention Protocol

The effects of high perioperative inspiratory oxygen fraction for adult surgical patients

  1. Jørn Wetterslev1,*,
  2. Christian S Meyhoff2,
  3. Lars N Jørgensen3,
  4. Christian Gluud4,
  5. Lars S Rasmussen2

Editorial Group: Cochrane Anaesthesia Group

Published Online: 8 DEC 2010

DOI: 10.1002/14651858.CD008884


How to Cite

Wetterslev J, Meyhoff CS, Jørgensen LN, Gluud C, Rasmussen LS. The effects of high perioperative inspiratory oxygen fraction for adult surgical patients (Protocol). Cochrane Database of Systematic Reviews 2010, Issue 12. Art. No.: CD008884. DOI: 10.1002/14651858.CD008884.

Author Information

  1. 1

    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

  2. 2

    Copenhagen University Hospital, Rigshospitalet, Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen, Denmark

  3. 3

    Bispebjerg Hospital, University of Copenhagen, Department of Surgery K, Copenhagen, Denmark

  4. 4

    Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Cochrane Hepato-Biliary Group, Copenhagen, Denmark

*Jørn Wetterslev, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, DK-2100, Denmark. wetterslev@ctu.rh.dk.

Publication History

  1. Publication Status: New
  2. Published Online: 8 DEC 2010

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Abstract

  1. Top of page
  2. Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

We will assess the benefits and harms of an FIO2 equal to or higher than 60% compared with a control FIO2 of 40% or below in the perioperative setting.

We will look at various outcomes, conduct subgroup and sensitivity analyses, examine the role of bias and apply trial sequential analyses (TSA) (Brok 2008; Brok 2009; Thorlund 2009; Wetterslev 2008) to examine the level of evidence for this intervention.