The effects of high perioperative inspiratory oxygen fraction for adult surgical patients

  • Protocol
  • Intervention

Authors

  • Jørn Wetterslev,

    Corresponding author
    1. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
    • Jørn Wetterslev, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, DK-2100, Denmark. wetterslev@ctu.rh.dk.

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  • Christian S Meyhoff,

    1. Copenhagen University Hospital, Rigshospitalet, Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen, Denmark
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  • Lars N Jørgensen,

    1. Bispebjerg Hospital, University of Copenhagen, Department of Surgery K, Copenhagen, Denmark
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  • Christian Gluud,

    1. Copenhagen Trial Unit, Centre for Clinical Intervention Research, Department 3344, Rigshospitalet, Copenhagen University Hospital, Cochrane Hepato-Biliary Group, Copenhagen, Denmark
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  • Lars S Rasmussen

    1. Copenhagen University Hospital, Rigshospitalet, Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen, Denmark
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Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

We will assess the benefits and harms of an FIO2 equal to or higher than 60% compared with a control FIO2 of 40% or below in the perioperative setting.

We will look at various outcomes, conduct subgroup and sensitivity analyses, examine the role of bias and apply trial sequential analyses (TSA) (Brok 2008; Brok 2009; Thorlund 2009; Wetterslev 2008) to examine the level of evidence for this intervention.