This is the protocol for a review and there is no abstract. The objectives are as follows:
To assess the diagnostic accuracy of RDTs for detecting typhoid and paratyphoid fever in persons living in endemic areas presenting to a healthcare facility with fever.
In the primary analysis, the studies will be grouped by:
Salmonella enterica serovars (Typhi or Paratyphi A);
study design (see 'Types of studies');
test population (clinically-suspected typhoid / paratyphoid or unselected febrile patients)
index test type (individual commercial test / test format - see 'Index tests'); and
reference test (Grade 1 or Grade 2 - see 'Reference standards').
We plan to investigate the following sources of heterogeneity (see 'Investigations of heterogeneity'):
degree of typhoid endemicity (low / medium /high as per Crump 2004);
patient age (adults / children / mixed);
geographical area (sub-Saharan Africa / rest of the world). Non-typhoidal Salmonella (NTS) are emerging as a prominent cause of bacteraemia in sub-Saharan Africa. Endemicity may affect RDT performance in this compared to other locations.