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Rapid Diagnostic Tests for Typhoid and Paratyphoid (Enteric) Fever

  • Protocol
  • Diagnostic



This is the protocol for a review and there is no abstract. The objectives are as follows:

To assess the diagnostic accuracy of RDTs for detecting typhoid and paratyphoid fever in persons living in endemic areas presenting to a healthcare facility with fever.

In the primary analysis, the studies will be grouped by:

  • Salmonella enterica serovars (Typhi or Paratyphi A);

  • test population (clinically-suspected typhoid / paratyphoid or unselected febrile patients)

  • index test type (individual commercial test / test format - see 'Index tests'); and

We plan to investigate the following sources of heterogeneity (see 'Investigations of heterogeneity'):

  • degree of typhoid endemicity (low / medium /high as per Crump 2004);

  • patient age (adults / children / mixed);

  • geographical area (sub-Saharan Africa / rest of the world). Non-typhoidal Salmonella (NTS) are emerging as a prominent cause of bacteraemia in sub-Saharan Africa. Endemicity may affect RDT performance in this compared to other locations.