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Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T-cell lymphoma

  1. Max Schlaak1,†,*,
  2. Juliane Pickenhain1,‡,
  3. Sebastian Theurich2,§,
  4. Nicole Skoetz3,
  5. Michael von Bergwelt-Baildon2,¶,
  6. Peter Kurschat1,‖

Editorial Group: Cochrane Haematological Malignancies Group

Published Online: 29 AUG 2013

Assessed as up-to-date: 11 APR 2013

DOI: 10.1002/14651858.CD008908.pub3


How to Cite

Schlaak M, Pickenhain J, Theurich S, Skoetz N, von Bergwelt-Baildon M, Kurschat P. Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T-cell lymphoma. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD008908. DOI: 10.1002/14651858.CD008908.pub3.

Author Information

  1. 1

    University Hospital of Cologne, Department of Dermatology and Venerology, Cologne, Germany

  2. 2

    University Hospital of Cologne, Department I of Internal Medicine, Stem Cell Transplantation Program, Cologne, Germany

  3. 3

    University Hospital of Cologne, Cochrane Haematological Malignancies Group, Department I of Internal Medicine, Cologne, Germany

  1. authors have contributed equally (first author)

  2. authors have contributed equally (first author)

  3. §

    authors have contributed equally (first author)

  4. authors have contributed equally (last author)

  5. authors have contributed equally (last author)

*Max Schlaak, Department of Dermatology and Venerology, University Hospital of Cologne, Kerpener Str. 62, Cologne, 50924, Germany. max.schlaak@uk-koeln.de.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 29 AUG 2013

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References

References to studies excluded from this review

  1. References to studies excluded from this review
  2. Additional references
Alaibac 2005 {published data only}
  • Alaibac M, Berti E, Pigozzi B, Chiarion V, Aversa S, Marino F, et al. High-dose chemotherapy with autologous blood stem cell transplantation for aggressive subcutaneous panniculitis-like T-cell lymphoma. Journal of the American Academy of Dermatology 2005;52(5 Suppl 1):121-3. [PUBMED: 15858508]
Bertz 2002 {published data only}
  • Bertz H, Illerhaus G, Veelken H, Finke J. Allogeneic hematopoetic stem-cell transplantation for patients with relapsed or refractory lymphomas: comparison of high-dose conventional conditioning versus fludarabine-based reduced-intensity regimens. Annals of Oncology 2002;13(1):135-9. [PUBMED: 11863095]
Burt 2000 {published data only}
  • Burt RK, Guitart J, Traynor A, Link C, Rosen S, Pandolfino T, et al. Allogeneic hematopoietic stem cell transplantation for advanced mycosis fungoides: evidence of a graft-versus-tumor effect. Bone Marrow Transplantation 2000;25(1):111-3. [PUBMED: 10654025]
Chanan-Khan 2004 {published data only}
  • Chanan-Khan A, Islam T, Alam A, Miller KC, Gibbs J, Barcos M, et al. Long-term survival with allogeneic stem cell transplant and donor lymphocyte infusion following salvage therapy with anti-CD52 monoclonal antibody (Campath) in a patient with alpha/beta hepatosplenic T-cell non-Hodgkin's lymphoma. Leukemia & Lymphoma 2004;45(8):1673-5. [PUBMED: 15370223]
Corradini 2006 {published data only}
  • Corradini P, Tarella C, Zallio F, Dodero A, Zanni M, Valagussa P, et al. Long-term follow-up of patients with peripheral T-cell lymphomas treated up-front with high-dose chemotherapy followed by autologous stem cell transplantation. Leukemia 2006;20(9):1533-8. [PUBMED: 16871285]
Cudillo 2009 {published data only}
  • Cudillo L, Cerretti R, Baliva G, De Angelis G, Postorino M, Picardi A, et al. Sézary syndrome in relapse after reduced intensity allogeneic transplant successfully treated with donor lymphocyte infusion. Bone Marrow Transplantation 2009;43(4):347-8. [PUBMED: 18850017]
Duarte 2008 {published data only}
  • Duarte RF, Schmitz N, Servitje O, Sureda A. Haematopoietic stem cell transplantation for patients with primary cutaneous T-cell lymphoma. Bone Marrow Transplantation 2008;41(7):597-604. [PUBMED: 18176611]
Duarte 2010 {published data only}
  • Duarte RF, Canals C, Onida F, Gabriel IH, Arranz R, Arcese W, et al. Allogeneic hematopoietic cell transplantation for patients with mycosis fungoides and Sézary syndrome: a retrospective analysis of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation. Journal of Clinical Oncology 2010;28(29):4492-9. [PUBMED: 20697072]
Duvic 2010 {published data only}
  • Duvic M, Donato M, Dabaja B, Richmond H, Singh L, Wei W, et al. Total skin electron beam and non-myeloablative allogeneic hematopoietic stem-cell transplantation in advanced mycosis fungoides and Sézary syndrome. Journal of Clinical Oncology 2010;28(14):2365-72. [PUBMED: 20351328]
Fijnheer 2003 {published data only}
  • Fijnheer R, Sanders CJ, Canninga MR, de Weger RA, Verdonck LF. Complete remission of a radiochemotherapy-resistant cutaneous T-cell lymphoma with allogeneic non-myeloablative stem cell transplantation. Bone Marrow Transplantation 2003;32(3):345-7. [PUBMED: 12858211]
Gabriel 2007 {published data only}
  • Gabriel IH, Olavarria E, Jones RR, Whittaker S, Chaidos A, Apperley JF. Graft versus lymphoma effect after early relapse following reduced-intensity sibling allogeneic stem cell transplantation for relapsed cytotoxic variant of mycosis fungoides. Bone Marrow Transplantation 2007;40(4):401-3. [PUBMED: 17589536]
Ghobrial 2005 {published data only}
  • Ghobrial IM, Weenig RH, Pittlekow MR, Qu G, Kurtin PJ, Ristow K, et al. Clinical outcome of patients with subcutaneous panniculitis-like T-cell lymphoma. Leukemia & Lymphoma 2005;46(5):703-8. [PUBMED: 16019507]
Guitart 2002 {published data only}
  • Guitart J, Wickless SC, Oyama Y, Kuzel TM, Rosen ST, Traynor A, et al. Long-term remission after allogeneic hematopoietic stem cell transplantation for refractory cutaneous T-cell lymphoma. Archives of Dermatology 2002;138(10):1359-65. [PUBMED: 12374543]
Hamadani 2008 {published data only}
  • Hamadani M, Awan FT, Elder P, Lin TS, Porcu P, Blum KA, et al. Allogeneic hematopoietic stem cell transplantation for peripheral T cell lymphomas; evidence of graft-versus-T cell lymphoma effect. Biology of Blood & Marrow Transplantation 2008;14(4):480-3. [PUBMED: 18342792]
Hathaway 2007 {published data only}
Herbert 2004 {published data only}
  • Herbert KE, Spencer A, Grigg A, Ryan G, McCormack C, Prince HM. Graft-versus-lymphoma effect in refractory cutaneous T-cell lymphoma after reduced-intensity HLA-matched sibling allogeneic stem cell transplantation. Bone Marrow Transplantation 2004;34(6):521-5. [PUBMED: 15286686]
Hoff 2008 {published data only}
  • Hoff NP, Groffik A, Mota R, Pippirs U, Hengge UR, Kobbe G, et al. Successful use of allogeneic stem cell transplantation for treatment-refractory mycosis fungoides [Erfolgreicher Einsatz einer allogenen Stammzelltransplantation bei therapierefraktärer Mycosis fungoides]. Hautarzt 2008;59(10):779-82. [PUBMED: 18773178]
Horwitz 2008 {published data only}
  • Horwitz SM, Olsen EA, Duvic M, Porcu P, Kim YH. Review of the treatment of mycosis fungoides and Sézary syndrome: a stage-based approach. Journal of the National Comprehensive Cancer Network 2008;6(4):436-42. [PUBMED: 18433609]
Ichii 2006 {published data only}
  • Ichii M, Hatanaka K, Imakita M, Ueda Y, Kishino B, Tamaki T. Successful treatment of refractory subcutaneous panniculitis-like T-cell lymphoma with allogeneic peripheral blood stem cell transplantation from HLA-mismatched sibling donor. Leukemia & Lymphoma 2006;47(10):2250-2. [PUBMED: 17071503]
Kahata 2008 {published data only}
  • Kahata K, Hashino S, Takahata M, Fujisawa F, Kondo T, Kobayashi S, et al. Durable remission of Sézary syndrome after unrelated bone marrow transplantation by reduced-intensity conditioning. Acta Haematologica 2008;120(1):14-8. [PUBMED: 18716396]
Knobler 2001 {published data only}
Knobler 2002 {published data only}
Koch 2009 {published data only}
  • Koch R, Jaffe ES, Mensing C, Zeis M, Schmitz N, Sander CA. Cutaneous gamma/delta T-cell lymphoma [Primär kutanes Gamma/Delta-T-Zell-Lymphom]. Journal der Deutschen Dermatologischen Gesellschaft 2009;7(12):1065-7. [PUBMED: 19694889]
Majhail 2005 {published data only}
  • Majhail NS, Burns LJ. Hematopoietic stem cell transplantation in the treatment of peripheral T-cell lymphomas. Current Hematology Reports 2005;4(4):252-9. [PUBMED: 16009039]
Masood 2002 {published data only}
  • Masood N, Russell KJ, Olerud JE, Sabath DE, Sale GE, Doney KC, et al. Induction of complete remission of advanced stage mycosis fungoides by allogeneic hematopoietic stem cell transplantation. Journal of the American Academy of Dermatology 2002;47(1):140-5. [PUBMED: 12077596]
Molina 1999 {published data only}
  • Molina A, Nademanee A, Arber DA, Forman SJ. Remission of refractory Sézary syndrome after bone marrow transplantation from a matched unrelated donor. Biology of Blood & Marrow Transplantation 1999;5(6):400-4. [PUBMED: 10595818]
Molina 2005 {published data only}
  • Molina A, Zain J, Arber DA, Angelopolou M, O'Donnell M, Murata-Collins J, et al. Durable clinical, cytogenetic and molecular remissions after allogeneic hematopoietic cell transplantation for refractory Sézary syndrome and mycosis fungoides. Journal of Clinical Oncology 2005;23(25):6163-71. [PUBMED: 16135483]
Mukai 2003 {published data only}
Nakahashi 2009 {published data only}
  • Nakahashi H, Tsukamoto N, Yamane A, Saitoh T, Uchiumi H, Handa H, et al. Autologous peripheral blood stem cell transplantation to treat CHOP-refractory aggressive subcutaneous panniculitis-like T cell lymphoma. Acta Haematologica 2009;121(4):239-42. [PUBMED: 19556752]
Nishio 2000 {published data only}
  • Nishio M, Koizumi K, Endo T, Takashima H, Haseyama Y, Fujimoto K, et al. Effective high-dose chemotherapy combined with CD34+-selected autologous peripheral blood stem cell transplantation in a patient with cutaneous CD30-negative large T cell lymphoma. Bone Marrow Transplantation 2000;25(12):1315-7. [PUBMED: 10871740]
Okada 2010 {published data only}
Perez-Persona 2006 {published data only}
  • Perez-Persona E, Mateos-Mazon JJ, Lopez-Villar O, Arcos MJ, Encinas C, Graciani IF, et al. Complete remission of subcutaneous panniculitic T-cell lymphoma after allogeneic transplantation. Bone Marrow Transplantation 2006;38(12):821-2. [PUBMED: 17057727]
Poligone 2010 {published data only}
  • Poligone B, Heald P. Innovative therapy of cutaneous T-cell lymphoma: beyond psoralen and ultraviolet light and nitrogen mustard. Dermatologic Clinics 2010;28(3):501-10. [PUBMED: 20510760]
Rook 1994 {published data only}
Russell-Jones 2001 {published data only}
Shustov 2010 {published data only}
  • Shustov AR, Gooley TA, Sandmaier BM, Shizuru J, Sorror ML, Sahebi F, et al. Allogeneic haematopoietic cell transplantation after nonmyeloablative conditioning in patients with T-cell and natural killer-cell lymphomas. British Journal of Haematology 2010;150(2):170-8. [PUBMED: 20507311]
Soligo 2003 {published data only}
  • Soligo D, Ibatici A, Berti E, Morandi P, Longhi E, Venegoni L, et al. Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen. Bone Marrow Transplantation 2003;31(8):663-6. [PUBMED: 12692606]
Taylor 1992 {published data only}
  • Taylor A, Gasparro FP. Extracorporeal photochemotherapy for cutaneous T-cell lymphoma and other diseases. Seminars in Hematology 1992;29(2):132-41. [PUBMED: 1594945]
Tsuji 2010 {published data only}
Wu 2009 {published data only}
  • Wu PA, Kim YH, Lavori PW, Hoppe RT, Stockerl-Goldstein KE. A meta-analysis of patients receiving allogeneic or autologous hematopoietic stem cell transplant in mycosis fungoides and Sézary syndrome. Biology of Blood & Marrow Transplantation 2009;15(8):982-90. [PUBMED: 19589488]
Zain 2010 {published data only}
  • Zain J, Kaminetzky D, O'Connor OA. Emerging role of epigenetic therapies in cutaneous T-cell lymphomas. Expert Review of Hematology 2010;3(2):187-203. [PUBMED: 21083462]

Additional references

  1. References to studies excluded from this review
  2. Additional references
Aoudjhane 2005
  • Aoudjhane M, Labopin M, Gorin NC, Shimoni A, Ruutu T, Kolb HJ, et al. Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT). Leukemia 2005;19(12):2304-12. [PUBMED: 16193083]
Apisarnthanarax 2002
  • Apisarnthanarax N, Talpur R, Duvic M. Treatment of cutaneous T cell lymphoma: current status and future directions. American Journal of Clinical Dermatology 2002;3(3):193-215. [PUBMED: 11978140]
Dearden 2007
  • Dearden C. Is there a role for hemopoietic stem-cell transplantation in CTCL?. Oncology (Williston Park, N.Y.) 2007;21(2 Suppl 1):24-8. [PUBMED: 17474356]
Deeks 2011
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Egger 1997
Feinstein 2001
Foss 2004
  • Miller KB, Roberts TF, Chan G, Schenkein DP, Lawrence D, Sprague K, et al. A novel reduced intensity regimen for allogeneic hematopoietic stem cell transplantation associated with a reduced incidence of graft-versus-host disease. Bone Marrow Transplant 2004;33(9):881-9. [PUBMED: 14990986]
Gardner 2009
Giralt 2001
  • Giralt S, Thall PF, Khouri I, Wang X, Braunschweig I, Ippolitti C, et al. Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation. Blood 2001;97(3):631-7. [PUBMED: 11157478]
Higgins 2011a
  • Higgins JPT, Deeks JJ, Altman DG. Chapter 16: Special topics in statistics. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
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Hoff 2010
  • Hoff NP, Bruch-Gerharz D. The role of hematopoietic stem-cell transplantation in cutaneous T-cell lymphoma. Giornale Italiano di Dermatologia e Venereologia 2010;145(3):345-59. [PUBMED: 20461043]
Introcaso 2008
  • Introcaso CE, Leber B, Greene K, Ubriani R, Rook AH, Kim EJ. Stem cell transplantation in advanced cutaneous T-cell lymphoma. Journal of the American Academy of Dermatology 2008;58(4):645-9. [PUBMED: 18258335]
Karanes 2008
  • Karanes C, Nelson GO, Chitphakdithai P, Agura E, Ballen KK, Bolan CD, et al. Twenty years of unrelated donor hematopoietic cell transplantation for adult recipients facilitated by the National Marrow Donor Program. Biology of Blood and Marrow Transplantation 2008;14(9 Suppl):8-15. [PUBMED: 18721775]
Kim 2003
  • Kim YH, Liu HL, Mraz-Gernhard S, Varghese A, Hoppe RT. Long-term outcome of 525 patients with mycosis fungoides and Sézary syndrome: clinical prognostic factors and risk for disease progression. Archives of Dermatology 2003;139(7):857-66. [PUBMED: 12873880]
Knobler 2004
Koeppel 1994
  • Koeppel MC, Stoppa AM, Resbeut M, Blaise D, Coignet M, Coulier L, et al. Mycosis fungoides and allogenic bone marrow transplantation. Acta Dermato-Venereologica 1994;74(4):331-2. [PUBMED: 7976105]
Kolb 1998
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Lansigan 2010
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Stang 2006
Sterne 2008
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Whittaker 2003
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