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Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T-cell lymphoma

  1. Max Schlaak1,†,*,
  2. Juliane Pickenhain1,‡,
  3. Sebastian Theurich2,§,
  4. Nicole Skoetz3,
  5. Michael von Bergwelt-Baildon2,¶,
  6. Peter Kurschat1,‖

Editorial Group: Cochrane Haematological Malignancies Group

Published Online: 29 AUG 2013

Assessed as up-to-date: 11 APR 2013

DOI: 10.1002/14651858.CD008908.pub3


How to Cite

Schlaak M, Pickenhain J, Theurich S, Skoetz N, von Bergwelt-Baildon M, Kurschat P. Allogeneic stem cell transplantation versus conventional therapy for advanced primary cutaneous T-cell lymphoma. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD008908. DOI: 10.1002/14651858.CD008908.pub3.

Author Information

  1. 1

    University Hospital of Cologne, Department of Dermatology and Venerology, Cologne, Germany

  2. 2

    University Hospital of Cologne, Department I of Internal Medicine, Stem Cell Transplantation Program, Cologne, Germany

  3. 3

    University Hospital of Cologne, Cochrane Haematological Malignancies Group, Department I of Internal Medicine, Cologne, Germany

  1. authors have contributed equally (first author)

  2. authors have contributed equally (first author)

  3. §

    authors have contributed equally (first author)

  4. authors have contributed equally (last author)

  5. authors have contributed equally (last author)

*Max Schlaak, Department of Dermatology and Venerology, University Hospital of Cologne, Kerpener Str. 62, Cologne, 50924, Germany. max.schlaak@uk-koeln.de.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 29 AUG 2013

SEARCH

 
Characteristics of excluded studies [ordered by study ID]

StudyReason for exclusion

Alaibac 2005Case report of a patient with SPTCL treated with autologous PBSCT and review of published cases of SPTCL treated with this therapeutic approach.

Bertz 2002Study not randomised, not controlled.

CTCL not included.

Burt 2000Case report of a patient with MF treated with allogeneic haematopoetic stem cell transplantation.

Chanan-Khan 2004Case report of a patient with alpha/beta hepatosplenic T-cell non-Hodgkin lymphoma treated with allogeneic stem cell transplantation and donor lymphocyte infusion.

Corradini 2006Patients with MF/SS or cutaneous lymphomas were excluded from the study.

Cudillo 2009Case report of a patient with SS.

Duarte 2008Review article of published data on the use of autologous and allogeneic HSCT for CTCL.

Duarte 2010Study not randomised, not controlled.

Retrospective analysis on the use of alloHSCT in a series of patients with advanced-stage MF/SS.

Duvic 2010Study not randomised, not controlled.

Single-arm study observing safety and efficacy of total skin electron beam with allogeneic stem cell transplantation in 19 patients with CTCL.

Fijnheer 2003Case report of a patient with cutaneous CD30-negative large T-cell lymphoma treated with non-myeloablative allogeneic peripheral stem cell transplantation.

Gabriel 2007Case report of a patient with a cytotoxic variant of MF treated with autologous stem cell transplantation followed by reduced-intensity sibling allogeneic stem cell transplantation in relapsed disease.

Ghobrial 2005Study not randomised, not controlled.

Retrospective analysis of diverse therapeutic approaches in 21 patients with SPTCL.

Guitart 2002Study not randomised, not controlled.

Case series of three patients with refractory tumour stage MF treated with allogeneic HLA-matched sibling transplantation after cytoreductive chemotherapy and total-body irradiation.

Hamadani 2008CTCL not included.

Hathaway 2007Study not randomised, not controlled.

Case series of two patients with SPTCL treated with corticosteroids and denileukin diftitox.

Herbert 2004Study not randomised, not controlled.

Case series of three patients with advanced, refractory (N = 2) or transformed (N = 1) CTCL who underwent reduced-intensity allogeneic stem cell transplantation.

Hoff 2008Case report of a patient with treatment-refractory MF treated with non-myeloablative allogeneic stem cell transplantation.

Horwitz 2008Review article discussing the importance of stage-based therapy in MF and SS.

Ichii 2006Case report of a patient with SPTCL treated with allogeneic PBSCT.

Kahata 2008Case report of a patient with SS with large cell transformation treated with reduced-intensity allogeneic bone marrow transplantation.

Knobler 2001Review article about clinical trials of extracorporeal photochemoimmunotherapy (ECP) in CTCL.

Knobler 2002Case report of a patient with CTCL treated with ECP, including an update on current status of ECP treatment.

Koch 2009Case report of a patient with cutaneous gamma/delta T-cell lymphoma treated with allogeneic stem cell transplantation.

Majhail 2005Review article on the current status of haematopoetic stem cell transplantation in CTCL.

Masood 2002Case report of a patient with stage IVA MF treated with HLA-matched allogeneic stem cell transplantation.

Molina 1999Case report of a patient with refractory SS treated with allogeneic unrelated donor bone marrow transplantation.

Molina 2005Study not randomised, not controlled.

Retrospective analysis of eight patients with advanced MF/SS evaluating the outcome of allogeneic haematopoetic stem cell transplantation in these patients.

Mukai 2003Case report of a patient with SPTCL treated with high-dose chemotherapy and total body irradiation with autologous peripheral stem cell rescue.

Nakahashi 2009Case report of a patient with refractory SPTCL treated with autologous peripheral blood stem cell transplantation.

Nishio 2000Case report of a patient with CD30-negative T-cell lymphoma treated with autologous peripheral blood stem cell transplantation.

Okada 2010Case report of a patient with MF treated with allogeneic bone marrow transplantation followed by relapse with a therapy-resistant immunophenotypic change (CD4+ to CD8+).

Perez-Persona 2006Case report.

Patient did not fit inclusion criteria (aged 15).

Poligone 2010Review article about the use of innovative therapies for CTCL.

Rook 1994Review article on the general use of extracorporeal photopheresis.

Russell-Jones 2001Study not randomised, not controlled.

Single-arm study observing the efficacy of autologous peripheral stem cell transplantation in nine patients with MF.

Shustov 2010Study not randomised, not controlled.

Single-arm study evaluating the outcome after non-myeloablative alloHSCT for patients with advanced T-cell and NK-cell lymphoma.

Soligo 2003Study not randomised, not controlled.

Case series of three patients with advanced MF treated with HLA-identical non-myeloablative allogeneic stem cell transplantation.

Taylor 1992Review article on the general use of extracorporeal photochemotherapy.

Tsuji 2010Case series of two patients with MF treated by reduced-intensity cord blood transplantation.

Wu 2009Meta-analysis of 39 patients to compare the outcome of allogeneic versus autologous stem cell transplantation in patients with MF/SS.

Zain 2010Review article about epigenetic therapies in cutaneous T-cell lymphomas.