Immunomodulators and immunosuppressants for multiple sclerosis: a network meta-analysis

  • Protocol
  • Intervention



This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

To compare immunomodulators and immunosuppressants against placebo or against one another in terms of response and acceptability. Given the wide spectrum of available comparisons, we aim to use the methodology of multiple-treatments meta-analysis (MTM), a method that allows the integration of data from direct comparisons (when treatments are directly compared within a randomised trial) and indirect comparisons (when treatments are compared between trials by combining results against a common comparator treatment) (Lu 2004; Caldwell 2005; Salanti 2008).

In summary the aims of this overview are :

1. To estimate the relative effectiveness and acceptability of immunomodulators and immunosuppressants for MS;

2. To provide a ranking of the treatments according to their effectiveness and acceptability in order to inform clinical practice.