Intervention Review

You have free access to this content

Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer

  1. Sebastiaan L Knijnenburg1,*,
  2. Renée L Mulder2,
  3. Antoinette YN Schouten-Van Meeteren2,
  4. Arend Bökenkamp3,
  5. Hester Blufpand3,
  6. Eline van Dulmen-den Broeder4,
  7. Margreet A Veening4,
  8. Leontien CM Kremer2,
  9. Monique WM Jaspers1

Editorial Group: Cochrane Childhood Cancer Group

Published Online: 8 OCT 2013

Assessed as up-to-date: 20 MAY 2012

DOI: 10.1002/14651858.CD008944.pub2

How to Cite

Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AYN, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LCM, Jaspers MWM. Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD008944. DOI: 10.1002/14651858.CD008944.pub2.

Author Information

  1. 1

    Academic Medical Center, Medical Informatics, Amsterdam, Netherlands

  2. 2

    Emma Children's Hospital/Academic Medical Center, Department of Paediatric Oncology, Amsterdam, Netherlands

  3. 3

    VU University Medical Center, Department of Pediatric Nephrology, Amsterdam, Netherlands

  4. 4

    VU University Medical Center, Department of Pediatrics, Division of Oncology/Hematology, Amsterdam, Netherlands

*Sebastiaan L Knijnenburg, Medical Informatics, Academic Medical Center, P.O. Box 22660, Amsterdam, 1100 DD, Netherlands.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 8 OCT 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Aronson 2011 {published data only}
Bardi 2004 {published data only}
Bergeron 2005 {published data only}
Bolling 2010 {published data only}
  • Bolling T, Ernst I, Pape H, Martini C, Rube C, Timmermann B, et al. Dose-volume analysis of radiation nephropathy in children: preliminary report of the RiSK Consortium. International Journal of Radiation Oncology, Biology and Physics 2010;80(3):840-4.
Breslow 2005 {published data only}
  • Breslow NE, Collins AJ, Ritchey ML, Grigoriev YA, Peterson SM, Green DM. End stage renal disease in patients with Wilms tumor: results from the National Wilms Tumor Study Group and the United States Renal Data System. Journal of Urology 2005;174:1972-5.
Brock 1991 {published data only}
Cardous-Ubbink 2010 {published data only}
  • Cardous-Ubbink MC, Geenen MM, Schade KJ, Heinen RC, Caron HN, Kremer LC, et al. Hypertension in long-term survivors of childhood cancer: a nested case-control study. European Journal of Cancer 2010;46:782-90.
Chevallier 1997 {published data only}
  • Chevallier C, Hadj-Aissa A, Brunat-Mentigny M, Faraj G, Schell M, Cochat P. Renal function after nephrectomy for Wilms' tumor [Fonction rénale après néphrectomie pour tumeur de Wilms]. Archives de Pediatrie 1997;4:639-44.
Cosentino 1993 {published data only}
Cozzi 2005 {published data only}
  • Cozzi F, Schiavetti A, Morini F, Zani A, Gambino M, Donfrancesco C, et al. Renal function adaptation in children with unilateral renal tumors treated with nephron sparing surgery or nephrectomy. Journal of Urology 2005;174:1404-8.
de Graaf 1996 {published data only}
  • de Graaf SS, van Gent H, Reitsma-Bierens WC, van Luyk WH, Dolsma WV, Postma A. Renal function after unilateral nephrectomy for Wilms' tumour: the influence of radiation therapy. European Journal of Cancer 1996;32A:465-9.
Di Tullio 1996 {published data only}
English 1999 {published data only}
Ferrari 2005 {published data only}
  • Ferrari S, Pieretti F, Verri E, Tolentinis L, Cesari M, Versari M, et al. Prospective evaluation of renal function in pediatric and adult patients treated with high-dose ifosfamide, cisplatin and high-dose methotrexate. Anticancer Drugs 2005;16(7):733-8.
Finklestein 1993 {published data only}
  • Finklestein JZ, Norkool P, Green DM, Breslow N, D'Angio GJ. Diastolic hypertension in Wilms' tumor survivors: a late effect of treatment? A report from the National Wilms' Tumor Study Group. American Journal of Clinical Oncology 1993;16(3):201-5.
Frisk 2002 {published data only}
  • Frisk P, Bratteby LE, Carlson K, Lonnerholm G. Renal function after autologous bone marrow transplantation in children: a long-term prospective study. Bone Marrow Transplantation 2002;29(2):129-36.
Frisk 2007 {published data only}
Fujieda 2009 {published data only}
  • Fujieda M, Matsunaga A, Hayashi A, Tauchi H, Chayama K, Sekine T. Children's toxicology from bench to bed-Drug-induced renal injury (2): nephrotoxicity induced by cisplatin and ifosfamide in children. Journal of Toxicological Science 2009;34(Suppl 2):251-7.
Geenen 2010 {published data only}
Hamilton 2011 {published data only}
  • Hamilton TE, Ritchey ML, Haase GM, Argani P, Peterson SM, Anderson JR, et al. The management of synchronous bilateral Wilms tumor: a report from the National Wilms Tumor Study Group. Annals of Surgery 2011;253(5):1004-10.
Hoffmeister 2010 {published data only}
  • Hoffmeister PA, Hingorani SR, Storer BE, Baker KS, Sanders JE. Hypertension in long-term survivors of pediatric hematopoietic cell transplantation. Biology of Blood and Marrow Transplantion 2010;16(4):515-24.
Indolfi 2001 {published data only}
Kantor 1989 {published data only}
  • Kantor AF, Li FP, Janov AJ, Tarbell NJ, Sallan SE. Hypertension in long-term survivors of childhood renal cancers. Journal of Clinical Oncology 1989;7(7):912-5.
Kubiak 2004 {published data only}
  • Kubiak R, Gundeti M, Duffy PG, Ransley PG, Wilcox DT. Renal function and outcome following salvage surgery for bilateral Wilms' tumor. Journal of Pediatric Surgery 2004;39(11):1667-72.
Laverdiere 2005 {published data only}
Loebstein 1999 {published data only}
  • Loebstein R, Atanackovic G, Bishai R, Wolpin J, Khattak S, Hashemi G, et al. Risk factors for long-term outcome of ifosfamide-induced nephrotoxicity in children. Journal of Clinical Pharmacology 1999;39(5):454-61.
Makipernaa 1991 {published data only}
Mancini 1996 {published data only}
  • Mancini AF, Rosito P, Salmi S, Rondelli R, Alvisi P, Leopardi G, et al. Renal function in patients previously treated for Wilms tumor in infancy. Rivista Italiana di Pediatria 1996;22:882-8.
Mpofu 1992 {published data only}
Oberlin 2009 {published data only}
Othman 2002 {published data only}
Patzer 2001 {published data only}
  • Patzer L, Ringelmann F, Kentouche K, Fuchs D, Zintl F, Brandis M, et al. Renal function in long-term survivors of stem cell transplantation in childhood. A prospective trial. Bone Marrow Transplantion 2001;27(3):319-27.
Paulino 2000 {published data only}
  • Paulino AC, Wen BC, Brown CK, Tannous R, Mayr NA, Zhen WK, et al. Late effects in children treated with radiation therapy for Wilms' tumor. International Journal of Radiation Oncology, Biology and Physics 2000;46(5):1239-46.
Prasad 1996 {published data only}
Rossi 1993 {published data only}
  • Rossi R, Ehrich JH. Partial and complete de Toni-Debre-Fanconi syndrome after ifosfamide chemotherapy of childhood malignancy. European Journal of Clinical Pharmacology 1993;44 Suppl 1:S43-5.
Rossi 1994 {published data only}
Rossi 1994a {published data only}
  • Rossi R, Godde A, Kleinebrand A, Riepenhausen M, Boos J, Ritter J, et al. Unilateral nephrectomy and cisplatin as risk factors of ifosfamide-induced nephrotoxicity: analysis of 120 patients. Journal of Clinical Oncology 1994;12(1):159-65.
Rossi 1994b {published data only}
Rossi 1997 {published data only}
  • Rossi R, Schafers P, Pleyer J, Postler C, Boos J, Jurgens H. The influence of short versus continuous ifosfamide infusion on the development of renal tubular impairment. International Journal of Pediatric Hematology/Oncology 1997;4:393-9.
Rossi 1999 {published data only}
Sasso 2010 {published data only}
  • Sasso G, Greco N, Murino P, Sasso FS. Late toxicity in Wilms tumor patients treated with radiotherapy at 15 years of median follow-up. Journal of Pediatric Hematology and Oncology 2010;32(7):e264-7.
Schell 1995 {published data only}
  • Schell M, Cochat P, Hadj-Aissa A, Bouffet E, Dubourg L, Brunat-Mentigny M. Renal function following unilateral nephrectomy for neuroblastoma and Wilms' tumour. Pediatric Nephrology 1995;9:579-82.
Skinner 2009 {published data only}
  • Skinner R, Parry A, Price L, Cole M, Craft AW, Pearson AD. Persistent nephrotoxicity during 10-year follow-up after cisplatin or carboplatin treatment in childhood: relevance of age and dose as risk factors. European Journal of Cancer 2009;45(18):3213-9.
Skinner 2010 {published data only}
Srinivas 1998 {published data only}
  • Srinivas M, Agarwala S, Padhy AK, Gupta AK, Bajpai M, Bhatnagar V, et al. Somatic growth and renal function after unilateral nephrectomy for Wilms' tumor. Pediatric Surgery International 1998;14(3):185-8.
Stefanowicz 2009 {published data only}
  • Stefanowicz J, Owczuk R, Sierota D, Kaczorowska-Hac B, Balcerska A. Does antineoplasm treatment decrease the glomerular filtration rate in children?. Kidney and Blood Pressure Research 2009;32:194-9.
Stefanowicz 2010 {published data only}
Stefanowicz 2011 {published data only}
  • Stefanowicz J, Kosiak M, Romanowicz G, Owczuk R, Adamkiewicz-Drozynska E, Balcerska A. Glomerular filtration rate and prevalence of chronic kidney disease in Wilms' tumour survivors. Pediatric Nephrology 2011;26(5):759-66.
Stohr 2007 {published data only}
Stohr 2007a {published data only}
Trahair 2007 {published data only}
  • Trahair TN, Vowels MR, Johnston K, Cohn RJ, Russell SJ, Neville KA, et al. Long-term outcomes in children with high-risk neuroblastoma treated with autologous stem cell transplantation. Bone Marrow Transplantation 2007;40(8):741-6.
Trobs 2001 {published data only}
Van Dijk 2010 {published data only}
  • Van Dijk IWEM, Oldenburger F, Cardous-Ubbink MC, Geenen MM, Heinen RC, de Kraker J, et al. Evaluation of late adverse events in long-term Wilms' tumor survivors. International Journal of Radiation Oncology Biology Physics 2010;78:370-8.
Van Why 1991 {published data only}
  • Van Why SK, Friedman AL, Wei LJ, Hong R. Renal insufficiency after bone marrow transplantation in children. Bone Marrow Transplantation 1991;7(5):383-8.
von Schweinitz 1997 {published data only}
  • von Schweinitz D, Byrd DJ, Hecker H, Weinel P, Bode U, Burger D, et al. Efficiency and toxicity of ifosfamide, cisplatin and doxorubicin in the treatment of childhood hepatoblastoma. Study Committee of the Cooperative Paediatric Liver Tumour Study HB89 of the German Society for Paediatric Oncology and Haematology. European Journal of Cancer 1997;33(8):1243-9.
Weirich 2004 {published data only}
  • Weirich A, Ludwig R, Graf N, Abel U, Leuschner I, Vujanic GM, et al. Survival in nephroblastoma treated according to the trial and study SIOP-9/GPOH with respect to relapse and morbidity. Annals of Oncology 2004;15(5):808-20.
Wikstad 1986 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Abboud 2009 {published data only}
  • Abboud I, Porcher R, Robin M, de Latour RP, Glotz D, Socie G, et al. Chronic kidney dysfunction in patients alive without relapse 2 years after allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation 2009;15:1251-7.
Abd-El-Aal 2005 {published data only}
  • Abd-El-Aal HH, Mokhtar MM, Habib EE, El-Kashef AT, Fahmy ES. Medulloblastoma: conventional radiation therapy in comparison to chemo radiation therapy in the post-operative treatment of high-risk patients. Journal of the Egyptian National.Cancer Institute 2005;17:301-7.
Abedi 1990 {published data only}
  • Abedi MR, Backman L, Bostrom L, Lindback B, Ringden O. Markedly increased serum erythropoietin levels following conditioning for allogeneic bone marrow transplantation. Bone Marrow Transplantation 1990;6:121-6.
Aksnes 2009 {published data only}
Aleksa 2001 {published data only}
Aleksa 2004 {published data only}
  • Aleksa K, Ito S, Koren G. Renal-tubule metabolism of ifosfamide to the nephrotoxic chloroacetaldehyde: pharmacokinetic modeling for estimation of intracellular levels. Journal of Laboratory and Clinical Medicine 2004;143:159-62.
Amato 1995 {published data only}
Anderson 1979 {published data only}
  • Anderson T, Javadpour N, Schilsky R, Barlock A, Young RC. Chemotherapy for testicular cancer: current status of the National Cancer Institute Combined Modality Trial. Cancer Treatment Reports 1979;63:1687-92.
Anderson 2010 {published data only}
Antman 1989 {published data only}
  • Antman KH, Ryan L, Elias A, Sherman D, Grier HE. Response to ifosfamide and mesna: 124 previously treated patients with metastatic or unresectable sarcoma. Journal of Clinical Oncology 1989;7:126-31.
Arai 1998 {published data only}
  • Arai A, Sakamaki H, Tanikawa S, Akiyama H, Onozawa Y, Okamoto R, et al. [Hemolytic uremic syndrome after bone marrow transplantation]. Rinsho Ketsueki 1998;39:422-6.
Arakelyan 2010 {published data only}
  • Arakelyan N, Jais JP, Delwail V, Briere J, Moles-Moreau MP, Senecal D, et al. Reduced versus full doses of irradiation after 3 cycles of combined doxorubicin, bleomycin, vinblastine, and dacarbazine in early stage Hodgkin lymphomas: results of a randomized trial. Cancer 2010;116:4054-62.
Argueso 1992 {published data only}
  • Argueso LR, Ritchey ML, Boyle ET Jr, Milliner DS, Bergstralh EJ, Kramer SA. Prognosis of children with solitary kidney after unilateral nephrectomy. Journal of Urology 1992;148:747-51.
Ariceta 1997 {published data only}
Arjmandi-Rafsanjani 2008 {published data only}
  • Arjmandi-Rafsanjani K, Hooman N, Vosoug P. Renal function in late survivors of Iranian children with cancer: single centre experience. Indian Journal of Cancer 2008;45:154-7.
Arndt 1997 {published data only}
  • Arndt C, Tefft M, Gehan E, Anderson J, Jenson M, Link M, et al. A feasibility, toxicity, and early response study of etoposide, ifosfamide, and vincristine for the treatment of children with rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study (IRS) IV pilot study. Journal of Pediatric Hematology and Oncology 1997;19:124-9.
Arndt 1999 {published data only}
Arriagada 2009 {published data only}
Ashraf 1994 {published data only}
Bacci 2002 {published data only}
  • Bacci G, Ferrari S, Longhi A, Picci P, Mercuri M, Alvegard TA, et al. High dose ifosfamide in combination with high dose methotrexate, adriamycin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma: preliminary results of an Italian Sarcoma Group/Scandinavian Sarcoma Group pilot study. Journal of Chemotherapy 2002;14:198-206.
Baker 2010 {published data only}
  • Baker KS, Bresters D, Sande JE. The burden of cure: long-term side effects following hematopoietic stem cell transplantation (HSCT) in children. Pediatric Clinics of North America 2010;57:323-42.
Barahmani 2009 {published data only}
  • Barahmani N, Carpentieri S, Li XN, Wang T, Cao Y, Howe L, et al. Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma. Neuro-Oncology 2009;11:292-300.
Bardi 2004a {published data only}
Bardi 2007 {published data only}
  • Bardi E, Bobok I, Olah V, Kappelmayer J, Kiss C. Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer. Pathology & Oncology Research 2007;13:249-53.
Bashir 2007 {published data only}
Baudoin 1993 {published data only}
Berg 2006 {published data only}
Beyzadeoglu 2008 {published data only}
  • Beyzadeoglu M, Arpaci F, Surenkok S, Ozyigit G, Oysul K, Caglar K, et al. Acute renal toxicity of 2 conditoning regimens in patients undergoing autologous peripheral blood stem-cell transplantation: Total body irradiation-cyclophosphamide versus ifosfamide, carboplatin, etoposide. Saudi Medical Journal 2008;29:832-6.
Bhatia 2003 {published data only}
Bhisitkul 1991 {published data only}
Boddy 1996 {published data only}
  • Boddy AV, English M, Pearson AD, Idle JR, Skinner R. Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics. European Journal of Cancer 1996;32A:1179-84.
Bodei 2008 {published data only}
  • Bodei L, Cremonesi M, Ferrari M, Pacifici M, Grana CM, Bartolomei M, et al. Long-term evaluation of renal toxicity after peptide receptor radionuclide therapy with 90Y-DOTATOC and 177Lu-DOTATATE: the role of associated risk factors. European Journal of Nuclear Medicine and Molecular Imaging 2008;35:1847-56.
Bonsib 2010 {published data only}
Bosl 1988 {published data only}
  • Bosl GJ, Geller NL, Bajorin D, Leitner SP, Yagoda A, Golbey RB, et al. A randomized trial of etoposide + cisplatin versus vinblastine + bleomycin + cisplatin + cyclophosphamide + dactinomycin in patients with good-prognosis germ cell tumors. Journal of Clinical Oncology 1988;6:1231-8.
Brade 1991 {published data only}
  • Brade WP, Herdrich K, Kachel-Fischer U, Araujo CE. Dosing and side-effects of ifosfamide plus mesna. Journal of Cancer Research and Clinical Oncology 1991;117 Suppl 4:S164-86.
Bradley 1998 {published data only}
  • Bradley J, Reft C, Goldman S, Rubin C, Nachman J, Larson R, et al. High-energy total body irradiation as preparation for bone marrow transplantation in leukemia patients: treatment technique and related complications. International Journal of Radiation Oncology Biology Physics 1998;40:391-6.
Brock 1992 {published data only}
  • Brock PR, Yeomans EC, Bellman SC, Pritchard J. Cisplatin therapy in infants: short and long-term morbidity. British Journal of Cancer 1992;Suppl 18:S36-40.
Bunjes 2002 {published data only}
Bürger 1985 {published data only}
  • Bürger D, Moorman-Voestermans CG, Mildenberger H, Lemerle J, Voute PA, Tournade MF, et al. The advantages of preoperative therapy in Wilms' tumour. A summarised report on clinical trials conducted by the International Society of Paediatric Oncology (SIOP). Zeitschrift für Kinderchirurgie 1985;40:170-5.
Burk 1990 {published data only}
Cachat 1996 {published data only}
  • Cachat F, Guignard J-P. Chemotherapy in children and renal side-effects. Revue Medicale de la Suisse Romande 1996;116:985-93.
Cai 2010 {published data only}
Carlson 1993 {published data only}
  • Carlson K, Smedmyr B, Hagberg H, Oberg G, Simonsson B. Haemolytic uraemic syndrome and renal dysfunction following BEAC (BCNU, etoposide, ara-C, cyclophosphamide) +/- TBI and autologous BMT for malignant lymphomas. Bone Marrow Transplantation 1993;11:205-8.
Castleberry 1991 {published data only}
  • Castleberry RP, Kun LE, Shuster JJ, Altshuler G, Smith IE, Nitschke R, et al. Radiotherapy improves the outlook for patients older than 1 year with Pediatric Oncology Group stage C neuroblastoma. Journal of Clinical Oncology 1991;9:789-95.
Chen 2007 {published data only}
  • Chen XF, Zhou FJ, Han H, Qin ZK, Liu ZW, Yu SL, et al. [Transabdominal radical nephrectomy for renal cell carcinoma: an experience on 155 patients]. Ai.Zheng 2007;26:528-32.
Cheng 2008 {published data only}
  • Cheng JC, Schultheiss TE, Wong JY. Impact of drug therapy, radiation dose, and dose rate on renal toxicity following bone marrow transplantation. International Journal of Radiation Oncology, Biology, Physics 2008;71:1436-43.
Chow 2007 {published data only}
Chow 2010 {published data only}
  • Chow EJ, Simmons JH, Roth CL, Baker KS, Hoffmeister PA, Sanders JE, et al. Increased cardiometabolic traits in pediatric survivors of acute lymphoblastic leukemia treated with total body irradiation. Biology of Blood and Marrow Transplantation 2010;16(12):1674-81.
Chow 2011 {published data only}
  • Chow EJ, Mueller BA, Baker KS, Cushing-Haugen KL, Flowers ME, Martin PJ, et al. Cardiovascular hospitalizations and mortality among recipients of hematopoietic stem cell transplantation. Annals of Internal Medicine 2011;155(1):21-32.
Cohen 1995 {published data only}
Cohen 2008 {published data only}
  • Cohen EP, Irving AA, Drobyski WR, Klein JP, Passweg J, Talano JA, et al. Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. International Journal of Radiation Oncology, Biology, Physics 2008;70:1546-51.
Cole 1994 {published data only}
Conn 1972 {published data only}
  • Conn JW, Cohen EL, McDonald WJ, Blough WM Jr, Lucas CP, Mayor GH, et al. The syndrome of hypertension, hyperreninemia and secondary aldosteronism associated with renal juxtaglomerular cell tumor (primary reninism). Transactions of the Association of American Physicians 1972;85:353-68.
Cosset 1994 {published data only}
  • Cosset JM, Socie G, Dubray B, Girinsky T, Fourquet A, Gluckman E. Single dose versus fractionated total body irradiation before bone marrow transplantation: radiobiological and clinical considerations. International Journal of Radiation Oncology, Biology, Physics 1994;30:477-92.
Couto-Silva 2001 {published data only}
  • Couto-Silva AC, Trivin C, Thibaud E, Esperou H, Michon J, Brauner R. Factors affecting gonadal function after bone marrow transplantation during childhood. Bone Marrow Transplantation 2001;28:67-75.
Coze 1997 {published data only}
  • Coze C, Hartmann O, Michon J, Frappaz D, Dusol F, Rubie H, et al. NB87 induction protocol for stage 4 neuroblastoma in children over 1 year of age: a report from the French Society of Pediatric Oncology. Journal of Clinical Oncology 1997;15:3433-40.
Cozzi 1997 {published data only}
Cozzi 2001 {published data only}
Cozzi 2007 {published data only}
  • Cozzi F, Zani A, Schiavetti A, Morini F, DeGaetano V, Matrunola M, et al. Compensatory renal growth in children with unilateral renal tumor treated by nephron-sparing surgery or nephrectomy. European Journal of Pediatric Surgery 2007;17:382-6.
Crist 2001 {published data only}
  • Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. Journal of Clinical Oncology 2001;19:3091-102.
Crom 1981 {published data only}
Culine 1994 {published data only}
  • Culine S, Lhomme C, Kattan J, Duvillard P, Michel G, Droz J-P. Long-term results of two VAB-like regimens (vinblastine + actinomycin-D + bleomycin + cyclophosphamide + cisplatin) in malignant germ cell tumours of the ovary. European Journal of Cancer Part A: General Topics 1994;30:1239-44.
Curigliano 2009 {published data only}
  • Curigliano G, Spitaleri G, Magni E, Lorizzo K, De Cobelli O, Locatelli M, et al. Cisplatin, etoposide and continuous infusion bleomycin in patients with testicular germ cell tumors: efficacy and toxicity data from a retrospective study. Journal of Chemotherapy 2009;21:687-92.
D'Angio 1976 {published data only}
D'Aoust 1979 {published data only}
De Gislain 1990 {published data only}
  • De Gislain C, Dumas M, D'Athis P, Chapuis T, Mayer F, Fargeot P, et al. Plasma creatinine evolution in long term cisplatin therapy. Influence of drug addosications. Therapie 1990;45:423-7.
de Kraker 1989 {published data only}
  • de Kraker J, Voute PA. Experience with ifosfamide in paediatric tumours. Cancer Chemotherapy and Pharmacology 1989;24 Suppl 1:S28-9.
Delpassand 2008 {published data only}
  • Delpassand ES, Sims-Mourtada J, Saso H, Azhdarinia A, Ashoori F, Torabi F, et al. Safety and efficacy of radionuclide therapy with high-activity In-111 pentetreotide in patients with progressive neuroendocrine tumors. Cancer Biotherapy and Radiopharmaceuticals 2008;23:292-300.
Demchak 1991 {published data only}
  • Demchak PA, Mier JW, Robert NJ, O'Brien K, Gould JA, Atkins MB. Interleukin-2 and high-dose cisplatin in patients with metastatic melanoma: a pilot study. Journal of Clinical Oncology 1991;9:1821-30.
Detaille 2007 {published data only}
  • Detaille T, Anslot C, de Clety SC. Acute kidney injury in paediatric bone marrow patients. Acta Clinica Belgica 2007;2 Suppl:401-4.
Dhaliwal 1980 {published data only}
  • Dhaliwal RS, Adelman RD, Turner E, Russo JC, Ruebner B. Radiation nephritis with hypertension and hyperreninemia following chemotherapy: cure by nephrectomy. Journal of Pediatrics 1980;96:68-70.
Diavolitsis 2010 {published data only}
  • Diavolitsis VM, Rademaker A, Boyle J, Kang Z, Kiel K, Mulcahy M, et al. Change in creatinine clearance over time following upper abdominal irradiation: a dose-volume histogram multivariate analysis. American Journal of Clinical Oncology 2010;34(1):53-7.
Dome 1993 {published data only}
  • Dome JS, Huff V. Wilms tumor overview. In: Pagon RA,  Bird TD,  Dolan CR,  Stephens K,  Adam MP editor(s). GeneReviews™. Seattle, USA: University of Washington, 1993.
Doz 1994 {published data only}
Druley 2009 {published data only}
  • Druley TE, Hayashi R, Mansur DB, Zhang QJ, Barnes Y, Trinkaus K, et al. Early outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI. Bone Marrow Transplantation 2009;43:307-14.
Dunkel 2007 {published data only}
Edgar 2009 {published data only}
  • Edgar AB, Morris EMM, Kelnar CJH, Wallace HB. Endocrinopathy after childhood cancer treatment. Long-term Follow-up of Survivors of Childhood Cancer. Basel: S Karger AG, 2009:159-80.
Eghbali 1994 {published data only}
  • Eghbali H, Catry-Thomas I, Soubeyran P, Bonnel C, Hoerni B. Combination of etoposide, cisplatin and ifosfamide (VPH) in the salvage chemotherapy of relapsing or refractory aggressive malignant lymphoma. Study of 51 patients [Association d'etoposide, de cisplatine et d'ifosfamide (VPH) dans la chimiotherapie de "rattrapage" des lymphomes malins agressifs en progression ou en rechute. Etude sur 51 patients]. Bulletin du Cancer 1994;81:800-7.
Ehrlich 1974 {published data only}
Eklof 1976 {published data only}
  • Eklof O, Ringertz H. Kidney size and growth in unilateral renal agenesis and in the remaining kidney following nephrectomy for Wilms' tumor. Acta Radiologica: Diagnosis (Stockholm) 1976;17(5A):601-8.
Emminger 1992 {published data only}
  • Emminger W, Emminger-Schmidmeier W, Peters C, Hawliczek R, Hocker P, Gadner H. Limited tolerance of intensified conditioning regimens in children receiving methotrexate/cyclosporin A for graft-versus-host disease prophylaxis. Pediatric Hematology and Oncology 1992;9:1-9.
England 2011 {published data only}
Escobar 2006 {published data only}
  • Escobar MA, Grosfeld JL, Powell RL, West KW, Scherer LR III, Fallon RJ, et al. Long-term outcomes in patients with stage IV neuroblastoma. Journal of Pediatric Surgery 2006;41:377-81.
Esiashvili 2009 {published data only}
  • Esiashvili N, Chiang K-Y, Hasselle MD, Bryant C, Riffenburgh RH, Paulino AC. Renal toxicity in children undergoing total body irradiation for bone marrow transplant. Radiotherapy and Oncology 2009;90:242-6.
Feig 2009 {published data only}
Ferrari 2005a {published data only}
  • Ferrari S, Smeland S, Mercuri M, Bertoni F, Longhi A, Ruggieri P, et al. Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups. Journal of Clinical Oncology 2005;23:8845-52.
Feusner 2008 {published data only}
Feyer 1989 {published data only}
  • Feyer P, Hoffmann FA, Standke E, Kubel M, Helbig W. Acute and late effects in the course of and after total body irradiation with following bone marrow transplantation in patients with different forms of leukaemia. Folia Haematologica 1989;116:487-91.
Flentje 1998 {published data only}
  • Flentje M, Weirich A, Graf N, Potter R, Zimmerman H, Ludwig R. Abdominal irradiation in unilateral nephroblastoma and its impact on local control and survival. International Journal of Radiation Oncology, Biology, Physics 1998;40:163-9.
Fouladi 2009 {published data only}
Friedman 2007 {published data only}
Gallegos-Castorena 2007 {published data only}
  • Gallegos-Castorena S, Martinez-Avalos A, Mohar-Betancourt A, Guerrero-Avendano G, Zapata-Tarres M, Medina-Sanson A. Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. Pediatric Hematology and Oncology 2007;24:403-8.
Galsky 2007 {published data only}
  • Galsky MD, Iasonos A, Mironov S, Scattergood J, Boyle MG, Bajorin DF. Phase II trial of dose-dense doxorubicin plus gemcitabine followed by paclitaxel plus carboplatin in patients with advanced urothelial carcinoma and impaired renal function. Cancer 2007;109:549-55.
Garaventa 1994 {published data only}
Gaynon 1994 {published data only}
Geenen 2007 {published data only}
  • Geenen MM, Cardous-Ubbink MC, Kremer LCM, Van Den Bos C, Van Der Pal HJH, Heinen RC, et al. Medical assessment of adverse health outcomes in long-term survivors of childhood cancer. Journal of the American Medical Association 2007;297:2705-15.
Gerke 2000 {published data only}
  • Gerke P, Filejski W, Robins HI, Wiedemann GJ, Steinhoff J. Nephrotoxicity of ifosfamide, carboplatin and etoposide (ICE) alone or combined with extracorporeal or radiant-heat-induced whole-body hyperthermia. Journal of Cancer Research and Clinical Oncology 2000;126:173-7.
Gerstein 2009 {published data only}
  • Gerstein J, Meyer A, Sykora KW, Fruhauf J, Karstens JH, Bremer M. Long-term renal toxicity in children following fractionated total-body irradiation (TBI) before allogeneic stem cell transplantation (SCT). Strahlentherapie und Onkologie 2009;185(11):751-5.
Gillis 2007 {published data only}
  • Gillis AM, Sutton E, Dewitt KD, Matthay KK, Weinberg V, Fisch BM, et al. Long-term outcome and toxicities of intraoperative radiotherapy for high-risk neuroblastoma. International Journal of Radiation Oncology, Biology, Physics 2007;69:858-64.
Gobel 1993 {published data only}
  • Gobel U, Calaminus G, Teske C, Bamberg M, Bokkerink JP, Haas RJ, et al. BEP/VIP in children and adolescents with malignant non-testicular germ cell tumors. A comparison of the results of treatment of therapy studies MAKEI 83/86 and 89P/89 [BEP/VIP bei Kindern und Jugendlichen mit malignen nichttestikularen Keimzelltumoren. Ein Vergleich der Behandlungsergebnisse der Therapiestudien MAKEI 83/86 und 89P/89]. Klinische Pädiatrie 1993;205:231-40.
Goren 1986 {published data only}
Goren 2003 {published data only}
Goyal 2011 {published data only}
  • Goyal J, Sidana A, Georgiades CS, Rodriguez R. Renal function and oncologic outcomes after cryoablation or partial nephrectomy for tumors in solitary kidneys. Korean Journal of Urology 2011;52(6):384-9.
Graf 2003 {published data only}
  • Graf N, Reinhard H. Wilms tumors. Diagnosis and therapy. Urologe A 2003;42:391-409.
Gratton 2006 {published data only}
Green 1995 {published data only}
  • Green DM, Donckerwolcke R, Evans AE, D'Angio GJ. Late effects of treatment for Wilms tumor. Hematology/Oncology Clinics of North America 1995;9:1317-27.
Green 2008 {published data only}
Gronroos 2008 {published data only}
  • Gronroos MH, Jahnukainen T, Irjala K, Harkonen R, Hurme S, Mottonen M, et al. Comparison of glomerular function tests in children with cancer. Pediatric Nephrology 2008;23:797-803.
Gunes 2010 {published data only}
  • Gunes AM, Can E, Saglam H, Ilcol YO, Baytan B. Assessment of bone mineral density and risk factors in children completing treatment for acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology 2010;32:e102-7.
Haddy 2009 {published data only}
Hadley 2006 {published data only}
Hanly 2009 {published data only}
Hanna 2008 {published data only}
Hartmann 2000 {published data only}
  • Hartmann JT, Fels LM, Knop S, Stolt H, Kanz L, Bokemeyer C. A randomized trial comparing the nephrotoxicity of cisplatin/ifosfamide-based combination chemotherapy with or without amifostine in patients with solid tumors. Investigational New Drugs 2000;18:281-9.
Hayashi 2009 {published data only}
  • Hayashi K, Tsuchiya H, Yamamoto N, Shirai T, Yamauchi K, Takeuchi A, et al. Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma. Journal of Orthopaedic Science 2009;14:253-8.
Hayes-Jordan 2010 {published data only}
  • Hayes-Jordan A, Green H, Fitzgerald N, Xiao L, Anderson P. Novel treatment for desmoplastic small round cell tumor: hyperthermic intraperitoneal perfusion. Journal of Pediatric Surgery 2010;45:1000-6.
Hazar 2009 {published data only}
Hegde 2009 {published data only}
Heikens 1998 {published data only}
  • Heikens J, Somers R, Behrendt H, Oldenburger F, Langeveld NE, Bakker PJ. Late sequelae of oncologic treatment in children [Late gevolgen van oncologische behandeling bij kinderen]. Nederlands Tijdschrift voor Geneeskunde 1998;142:2191-5.
Heikens 2000 {published data only}
Helenglass 1988 {published data only}
  • Helenglass G, Powles RL, McElwain TJ, Lakhani A, Milan S, Gore M, et al. Melphalan and total body irradiation (TBI) versus cyclophosphamide and TBI as conditioning for allogeneic matched sibling bone marrow transplants for acute myeloblastic leukaemia in first remission. Bone Marrow Transplantation 1988;3:21-9.
Henderson 2008 {published data only}
  • Henderson T, Patel S, Levine J, Oeffinger KC. Follow-up of childhood cancer survivors: the role of the primary care physician. Consultant 2008;48:438-42.
Hingorani 2008 {published data only}
Horwich 1991 {published data only}
  • Horwich A, Dearnaley DP, Nicholls J, Jay G, Mason M, Harland S, et al. Effectiveness of carboplatin, etoposide, and bleomycin combination chemotherapy in good-prognosis metastatic testicular nonseminomatous germ cell tumors. Journal of Clinical Oncology 1991;9:62-9.
Hovi 1989 {published data only}
Hudson 2008 {published data only}
Iida 2008 {published data only}
  • Iida S, Kondo T, Amano H, Nakazawa H, Ito F, Hashimoto Y, et al. Minimal effect of cold ischemia time on progression to late-stage chronic kidney disease observed long term after partial nephrectomy. Urology 2008;72:1083-8.
Ippolito 2006 {published data only}
Janeway 2010 {published data only}
Jereb 1997 {published data only}
  • Jereb B. Radiotherapy in nephroblastoma. Pre- and postoperative combination treatment. Radiotherapy in localized (stage II, III, IV) and metastatic disease. Actue and long-term side effects. Radiology and Oncology 1997;31:48-53.
Jones 1995 {published data only}
  • Jones DP, Chesney RW. Renal toxicity of cancer chemotherapeutic agents in children: ifosfamide and cisplatin. Current Opinion in Pediatrics 1995;7:208-13.
Jones 2008 {published data only}
Kantarjian 1996 {published data only}
  • Kantarjian HM, Beran M, O'Brien S, Robertson L, Siddik Z, Yoshida M, et al. Evaluation of CI-973, a platinum analogue, in refractory or relapsed acute leukemia. Leukemia 1996;10:396-401.
Katzenstein 2009 {published data only}
  • Katzenstein HM, Chang KW, Krailo M, Chen Z, Finegold MJ, Rowland J, et al. Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group. Cancer 2009;115:5828-35.
Keaney 2005 {published data only}
  • Keaney CM, Springate JE. Cancer and the kidney. Adolescent Medicine Clinics 2005;16:121-48.
Kenney 2010 {published data only}
Kibirige 1988 {published data only}
Kim 1980 {published data only}
Kim 2009 {published data only}
  • Kim A, Gillespie A, Dombi E, Goodwin A, Goodspeed W, Fox E, et al. Characteristics of children enrolled in treatment trials for NF1-related plexiform neurofibromas. Neurology 2009;73:1273-9.
Kirch 1997 {published data only}
Kist-van Holthe 2002 {published data only}
  • Kist-van Holthe JE, Goedvolk CA, Brand R, van Weel MH, Bredius RG, van Oostayen JA, et al. Prospective study of renal insufficiency after bone marrow transplantation. Pediatric Nephrology 2002;17:1032-7.
Kist-van Holthe 2005 {published data only}
Koren 2007 {published data only}
Kourti 2005 {published data only}
  • Kourti M, Tragiannidis A, Makedou A, Papageorgiou T, Rousso I, Athanassiadou F. Metabolic syndrome in children and adolescents with acute lymphoblastic leukemia after the completion of chemotherapy. Journal of Pediatric Hematology/Oncology 2005;27:499-501.
Kremens 2002 {published data only}
  • Kremens B, Gruhn B, Klingebiel T, Hasan C, Laws HJ, Koscielniak E, et al. High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma. Bone Marrow Transplantation 2002;30:893-8.
Kremers 2003 {published data only}
  • Kremers A, Langer T, Stohr W, Beck JD, Rascher W. Late effects of oncological therapy in children. Padiatrische Praxis 2003;64:47-64.
Kumar 1996 {published data only}
  • Kumar M, Kedar A, Neiberger RE. Kidney function in long-term pediatric survivors of acute lymphoblastic leukemia following allogeneic bone marrow transplantation. Pediatric Hematology and Oncology 1996;13:375-9.
Kung 1995 {published data only}
  • Kung FH, Desai SJ, Dickerman JD, Goorin AM, Harris MB, Inoue S, et al. Ifosfamide/carboplatin/etoposide (ICE) for recurrent malignant solid tumors of childhood: a Pediatric Oncology Group Phase I/II study. Journal of Pediatric Hematology/Oncology 1995;17:265-9.
Kurt 2008 {published data only}
Kusumi 2008 {published data only}
  • Kusumi E, Kami M, Hara S, Hoshino J, Yamaguchi Y, Murashige N, et al. Postmortem examination of the kidney in allogeneic hematopoietic stem cell transplantation recipients: possible involvement of graft-versus-host disease. International Journal of Hematology 2008;87:225-30.
Landier 2008 {published data only}
Langer 2004 {published data only}
Leahey 1999 {published data only}
Le Bourgeois 1979 {published data only}
  • Le Bourgeois JP, Meignan M, Parmentier C, Tubiana M. Renal consequences of irradiation of the spleen in lymphoma patients. British Journal of Radiology 1979;52:56-60.
Lee 2001 {published data only}
Levi 1993 {published data only}
  • Levi JA, Raghavan D, Harvey V, Thompson D, Sandeman T, Gill G, et al. The importance of bleomycin in combination chemotherapy for good-prognosis germ cell carcinoma. Australasian Germ Cell Trial Group. Journal of Clinical Oncology 1993;11:1300-5.
Liesner 1994 {published data only}
  • Liesner RJ, Leiper AD, Hann IM, Chessells JM. Late effects of intensive treatment for acute myeloid leukemia and myelodysplasia in childhood. Journal of Clinical Oncology 1994;12:916-24.
Lonnerholm 1991 {published data only}
  • Lonnerholm G, Carlson K, Bratteby LE, Backlund L, Hagberg H, Rikner G, et al. Renal function after autologous bone marrow transplantation. Bone Marrow Transplantation 1991;8:129-34.
Ludwig 1992 {published data only}
  • Ludwig R, Weirich A, Potter R, Harms D, Burger D, Michaelis J, et al. Preoperative chemotherapy of nephroblastoma. Preliminary results of the SIOP-9/GPO therapy study [Praoperative Chemotherapie des Nephroblastoms. Vorlaufige Ergebnisse der Therapiestudie SIOP-9/GPO.]. Klinische Pediatrie 1992;204:204-13.
Macklis 1991 {published data only}
Macleod 1988 {published data only}
Majhail 2009 {published data only}
  • Majhail NS, Challa TR, Mulrooney DA, Baker KS, Burns LJ. Hypertension and diabetes mellitus in adult and pediatric survivors of allogeneic hematopoietic cell transplantation. Biology of Blood and Marrow Transplantation 2009;15:1100-7.
Makari 2010 {published data only}
Mandell 1999 {published data only}
  • Mandell LR, Kadota R, Freeman C, Douglass EC, Fontanesi J, Cohen ME, et al. There is no role for hyperfractionated radiotherapy in the management of children with newly diagnosed diffuse intrinsic brainstem tumors: results of a Pediatric Oncology Group phase III trial comparing conventional vs. hyperfractionated radiotherapy. International Journal of Radiation Oncology, Biology, Physics 1999;43:959-64.
Marina 1994 {published data only}
  • Marina NM, Wilimas JA, Meyer WH, Jones DP, Douglass EC, Pratt CB. Refining therapeutic strategies for patients with resistant Wilm's tumor. American Journal of Pediatric Hematology/Oncology 1994;16:296-300.
Marina 2000 {published data only}
  • Marina NM, Poquette CA, Cain AM, Jones D, Pratt CB, Meyer WH. Comparative renal tubular toxicity of chemotherapy regimens including ifosfamide in patients with newly diagnosed sarcomas. Journal of Pediatric Hematology/Oncology 2000;22:112-8.
Marina 2004 {published data only}
Mashhadi 2011 {published data only}
  • Mashhadi MA, Sanadgol H, Keikhaei M. Ifosfamide nephropathy in patients with sarcoma. Iranian Journal of Kidney Disease 2011;5(4):238-41.
Massimi 2007 {published data only}
McCune 2004 {published data only}
McCune 2009 {published data only}
  • McCune JS, Batchelder A, Guthrie KA, Witherspoon R, Appelbaum FR, Phillips B, et al. Personalized dosing of cyclophosphamide in the total body irradiation-cyclophosphamide conditioning regimen: a phase II trial in patients with hematologic malignancy. Clinical Pharmacology & Therapeutics 2009;85:615-622.
McDonald 1993 {published data only}
  • McDonald GB, Hinds MS, Fisher LD, Schoch HG, Wolford JL, Banaji M, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: a cohort study of 355 patients. Annals of Internal Medicine 1993;118:255-67.
Meacham 2010 {published data only}
  • Meacham LR, Chow EJ, Ness KK, Kamdar KY, Chen Y, Yasui Y, et al. Cardiovascular risk factors in adult survivors of pediatric cancer-a report from the childhood cancer survivor study. Cancer Epidemiology, Biomarkers and Prevention 2010;19:170-81.
Meadows 1985 {published data only}
Meck 2006 {published data only}
Mendez 2006 {published data only}
  • Mendez Romero A, Wunderink W, Hussain SM, De Pooter JA, Heijmen BJ, Nowak PC, et al. Stereotactic body radiation therapy for primary and metastatic liver tumors: a single institution phase I-II study. Acta Oncologica 2006;45:831-7.
Mertens 1997 {published data only}
Meyer 2006 {published data only}
  • Meyer JP, Delves GH, Sullivan ME, Keoghane SR. The effect of nephroureterectomy on glomerular filtration rate. British Journal of Urology International 2006;98:845-8.
Millar 2011 {published data only}
  • Millar AJ, Davidson A, Rode H, Numanoglu A, Hartley PS, Desai F. Nephron-sparing surgery for bilateral Wilms' tumours: a single-centre experience with 23 cases. African Journal of Paediatric Surgery 2011;8(1):49-56.
Miralbell 1996 {published data only}
  • Miralbell R, Bieri S, Mermillod B, Helg C, Sancho G, Pastoors B, et al. Renal toxicity after allogeneic bone marrow transplantation: the combined effects of total-body irradiation and graft-versus-host disease. Journal of Clinical Oncology 1996;14:579-85.
Miralbell 2004 {published data only}
  • Miralbell R, Sancho G, Bieri S, Carrio I, Helg C, Brunet S, et al. Renal insufficiency in patients with hematologic malignancies undergoing total body irradiation and bone marrow transplantation: a prospective assessment. International Journal of Radiation Oncology, Biology, Physics 2004;58:809-16.
Mitchell 2009 {published data only}
  • Mitchell C, Hall G, Clarke RT. Acute leukaemia in children: diagnosis and management. British Medical Journal 2009;338:1491-5.
Moghrabi 1998 {published data only}
  • Moghrabi A, Friedman HS, Ashley DM, Bottom KS, Kerby T, Stewart E, et al. Phase II study of carboplatin (CBDCA) in progressive low-grade gliomas. Neurosurgical Focus 1998;4:e3.
Mohammadianpanah 2004 {published data only}
Morris 1991 {published data only}
  • Morris Jones PH. The late effects of cancer therapy in childhood. British Journal of Cancer 1991;64:1-2.
Naguib 2008 {published data only}
  • Naguib SF, El Haddad A, El Badawy SA, Zaghloul AS. Multidisciplinary approach to wilms' tumor: a retrospective analytical study of 53 patients. Journal of the Egyptian National Cancer Institute 2008;20:410-23.
Nath 2007 {published data only}
Niethammer 1998 {published data only}
Nieto 2005 {published data only}
  • Nieto B, Martin Aguado MJ, Verdu J, Canals A, Martin Hortiguela ME, Mira J, et al. Study of renal function and compensatory changes in children with single kidney [Determinacion de funcion renal y cambios compensadores en ninos con rinon unico]. Cirugía Pediátrica 2005;18:151-5.
Nogueira 1998 {published data only}
  • Nogueira PCK, Hadj-Aissa A, Schell M, Dubourg L, Brunat-Mentigny M, Cochat P. Long-term nephrotoxicity of cisplatin, ifosfamide, and methotrexate in osteosarcoma. Pediatric Nephrology 1998;12:572-5.
Nunez 2007 {published data only}
  • Nunez SB, Mulrooney DA, Laverdiere C, Hudson MM. Risk-based health monitoring of childhood cancer survivors: a report from the Children's Oncology Group. Current Oncology Reports 2007;9:440-52.
Oeffinger 2001 {published data only}
  • Oeffinger KC, Buchanan GR, Eshelman DA, Denke MA, Andrews TC, Germak JA, et al. Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Pediatric Hematology/Oncology 2001;23:424-30.
Oeffinger 2009 {published data only}
  • Oeffinger KC, Adams-Huet B, Victor RG, Church TS, Snell PG, Dunn AL, et al. Insulin resistance and risk factors for cardiovascular disease in young adult survivors of childhood acute lymphoblastic leukemia. Journal of Clinical Oncology 2009;27:3698-704.
Ota 1993 {published data only}
  • Ota K. [Cisplatinum compounds]. Gan To Kagaku Ryoho 1993;20:50-8.
Pahernik 2007 {published data only}
Parigi 2003 {published data only}
  • Parigi GB, Beluffi G, Corbella F, Matteotti C, Ramella B, Bragheri R. Long-term follow-up in children treated for retroperitoneal malignant tumours. European Journal of Pediatric Surgery 2003;13:240-4.
Parisi 1999 {published data only}
Patte 1991 {published data only}
  • Patte C, Philip T, Rodary C, Zucker JM, Behrendt H, Gentet JC, et al. High survival rate in advanced-stage B-cell lymphomas and leukemias without CNS involvement with a short intensive polychemotherapy: results from the French Pediatric Oncology Society of a randomized trial of 216 children. Journal of Clinical Oncology 1991;9:123-32.
Patzer 1997 {published data only}
Paulides 2008 {published data only}
  • Paulides M, Mergenthaler A, Peeters J, Beck JD, Langer T, Kaatsch P. Major organ-related long-term effects of chemotherapy and secondary malignancies. Medizinische Welt 2008;59:105-9.
Pectasides 2010 {published data only}
  • Pectasides D, Pectasides E, Papaxoinis G, Xiros N, Kamposioras K, Tountas N, et al. Methotrexate, paclitaxel, ifosfamide, and cisplatin in poor-risk nonseminomatous germ cell tumors. Urologic Oncology 2010;28(6):617-23.
Pentheroudakis 2007 {published data only}
Pereira 2005 {published data only}
Petersen 1992 {published data only}
  • Petersen FB, Deeg HJ, Buckner CD, Appelbaum FR, Storb R, Clift RA, et al. Marrow transplantation following escalating doses of fractionated total body irradiation and cyclophosphamide-a phase I trial. International Journal of Radiation Oncology, Biology, Physics 1992;23:1027-32.
Petersen 1999 {published data only}
Phillips 2008 {published data only}
  • Phillips RS, Tyerman K, Al-Kassim MI, Picton S. A systematic review of the accuracy and utility of early markers of Ifosfamide-induced proximal tubulopathy in survivors of childhood cancers. Pediatric Hematology and Oncology 2008;25:107-13.
Pietila 2005 {published data only}
Pietila 2009 {published data only}
Pinter 2003 {published data only}
Plowman 1999 {published data only}
  • Plowman PN. Survivors of cancer: organ preservation and reducing the morbidity of treatment in paediatric genitourinary oncology. British Journal of Urology International 1999;83 Supp:51-60.
Pochedly 1973 {published data only}
Ponisch 2006 {published data only}
Poon 2007 {published data only}
  • Poon RT, Tso WK, Pang RW, Ng KK, Woo R, Tai KS, et al. A phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead. Clinical Gastroenterology and Hepatology 2007;5:1100-8.
Pratt 1981 {published data only}
  • Pratt CB, Hayes A, Green AA, Evans WE, Senzer N, Howarth CB, et al. Pharmacokinetic evaluation of cisplatin in children with malignant solid tumors: a phase II study. Cancer Treatment Reports 1981;65:1021-6.
Pratt 1991 {published data only}
  • Pratt CB, Meyer WH, Jenkins JJ, Avery L, McKay CP, Wyatt RJ, et al. Ifosfamide, Fanconi's syndrome, and rickets. Journal of Clinical Oncology 1991;9:1495-9.
Pratt 1996 {published data only}
Raney 1994 {published data only}
  • Raney B, Ensign LG, Foreman J, Khan F, Newton W, Ortega J, et al. Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor. American Journal of Pediatric Hematology/Oncology 1994;16:286-95.
Regazzoni 1998 {published data only}
  • Regazzoni BM, Genton N, Pelet J, Drukker A, Guignard JP. Long-term followup of renal functional reserve capacity after unilateral nephrectomy in childhood. Journal of Urology 1998;160:844-8.
Reisi 2009 {published data only}
  • Reisi N, Azhir A, Hashemipour M, Raeissi P, Amini A, Moafi A. The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran. Journal of Research in Medical Sciences 2009;14:111-6.
Renal tumours and hypertension {published data only}
  • No authors listed. Renal tumours and hypertension. British Medical Journal 1968;3(5614):327-8.
Ritchey 1996 {published data only}
Ritchey 2008 {published data only}
Roback 1971 {published data only}
  • Roback SA, Nesbit ME Jr, Sharp HL, D'Angio GJ, Leonard AS. Portal hypertension following surgery, x-radiation, and actinomycin D therapy of nephroblastoma. Journal of Pediatrics 1971;78:1031-4.
Robert 1995 {published data only}
Romanini 1981 {published data only}
  • Romanini A, Galli G, D'Errico G, Carlesimo M, De Renzis C. Radioisotopic study of some organs after radiotherapy of the upper abdomen (author's translation) [Studio radioisotopico di alcuni organi dopo radioterapia dell'addome superiore]. Radiologia Medica 1981;67:757-61.
Rossi 1999a {published data only}
Saddadi 2009 {published data only}
  • Saddadi F, Hakemi M, Najafi I, Moghadam K, Ghavamzadeh A, Jahani M, et al. Chronic kidney disease after hematopoietic cell transplantation: frequency, risk factors, and outcomes. Transplantation Proceedings 2009;41:2895-7.
Saez 1995 {published data only}
  • Saez RA, Slease RB, Strnad C, Selby GB, Confer DL, Epstein RB. High-dose carboplatin, etoposide and cyclophosphamide with autologous bone marrow transplantation for the treatment of advanced malignancies: a phase I study. Bone Marrow Transplantation 1995;16:507-14.
Sagerman 1969 {published data only}
  • Sagerman RH, Berdon WE, Baker DH. Renal atrophy without hypertension following abdominal irradiation in infants and children [Atrophie renale sans hypertension apres irradiation de l'abdomen chez le nourrisson et chez l'enfant]. Annales de Radiologie 1969;12:278-84.
Sagstuen 2005 {published data only}
Sakellari 2010a {published data only}
  • Sakellari I, Bamichas G, Barbouti A, Mallouri D, Fragidis S, Apostolou C, et al. Older age, the number of preceded events of acute kidney injury and the in vivo t cell depletion are risk factors for kidney injury after hematopoietic cell transplantation. Haematologica 2010:447.
Sastry 2005 {published data only}
Schenkein 1994 {published data only}
  • Schenkein DP, Dixon P, Desforges JF, Berkman E, Erban JK, Ascensao JL, et al. Phase I/II study of cyclophosphamide, carboplatin, and etoposide and autologous hematopoietic stem-cell transplantation with posttransplant interferon alfa-2b for patients with lymphoma and Hodgkin's disease. Journal of Clinical Oncology 1994;12:2423-31.
Schiff 1977 {published data only}
Schmidt 2010 {published data only}
  • Schmidt D, Anderson L, Bingen K, Hoag J, Kupst MJ, Warwick AB. Late effects in adult survivors of childhood cancer: considerations for the general practitioner. Wisconsin Medical Journal 2010;109:98-108.
Schmoll 2003 {published data only}
  • Schmoll HJ, Kollmannsberger C, Metzner B, Hartmann JT, Schleucher N, Schoffski P, et al. Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group. Journal of Clinical Oncology 2003;21:4083-91.
Schwartz 2007 {published data only}
Shamash 2000 {published data only}
  • Shamash J, O'Doherty CA, Oliver RT, Kelsey S, Gupta RK, Gallagher CJ, et al. Should high-dose chemotherapy be used to consolidate second or third line treatment in relapsing germ cell tumours?. Acta Oncologica 2000;39:857-63.
Shirasaki 2004 {published data only}
Shirasaki 2004a {published data only}
Shnorhavorian 2009 {published data only}
  • Shnorhavorian M, Friedman DL, Koyle MA. Genitourinary long-term outcomes for childhood cancer survivors. Current Urology Reports 2009;10:134-7.
Sieber 2004 {published data only}
  • Sieber M, Tesch H, Pfistner B, Rueffer U, Paulus U, Munker R, et al. Treatment of advanced Hodgkin's disease with COPP/ABV/IMEP versus COPP/ABVD and consolidating radiotherapy: final results of the German Hodgkin's Lymphoma Study Group HD6 trial. Annals of Oncology 2004;15:276-82.
Silberzweig 1992 {published data only}
Simpson 2002 {published data only}
  • Simpson AB, Calvert PM, Sludden JA, Boddy AV, Griffin MJ, Schatzlein A, et al. Topotecan in combination with carboplatin: Phase I trial evaluation of two treatment schedules. Annals of Oncology 2002;13:399-402.
Skinner 1991 {published data only}
  • Skinner R, Pearson AD, Coulthard MG, Skillen AW, Hodson AW, Goldfinch ME, et al. Assessment of chemotherapy-associated nephrotoxicity in children with cancer. Cancer Chemotherapy and Pharmacology 1991;28:81-92.
Skinner 1992 {published data only}
  • Skinner R, Pearson AD, Price L, Coulthard MG, Craft AW. The influence of age on nephrotoxicity following chemotherapy in children. British Journal of Cancer 1992;18:S30-5.
Skinner 1993 {published data only}
Skinner 2000 {published data only}
  • Skinner R, Cotterill SJ, Stevens MC. Risk factors for nephrotoxicity after ifosfamide treatment in children: a UKCCSG Late Effects Group study. United Kingdom Children's Cancer Study Group. British Journal of Cancer 2000;82:1636-45.
Skinner 2003 {published data only}
Skinner 2010a {published data only}
  • Skinner R. Nephrotoxicity of cancer treatment in children. Pediatric Health 2010;4:519-38.
Skinner 2011 {published data only}
Sloetjes 2000 {published data only}
  • Sloetjes KG, van den Bergh JP, Wesseling P, Otten BJ, Pieters GF, Hermus AR. Clinical presentation, treatment, and follow-up of 32 patients with a primary intracranial germinoma, registered during the previous 15 years in the Dutch Pathological-Anatomical National Automated Archive (PALGA) [Kliniek, behandeling en follow-up van 32 patienten met een primair intracranieel germinoom uit de afgelopen 15 jaar, geregistreerd in het Pathologisch-Anatomisch Landelijk Geautomatiseerd Archief (PALGA)]. Nederlands Tijdschrift voor Geneeskunde 2000;144:2264-8.
Smith 1998 {published data only}
  • Smith GR, Thomas PR, Ritchey M, Norkool P. Long-term renal function in patients with irradiated bilateral Wilms tumor. National Wilms' Tumor Study Group. American Journal of Clinical Oncology 1998;21(1):58-63.
Sonn 2008 {published data only}
Spira 2009 {published data only}
  • Spira EM, Jacobi C, Frankenschmidt A, Pohl M, von Schnakenburg C. Sonographic long-term study: paediatric growth charts for single kidneys. Archives of Disease in Childhood 2009;94:693-8.
Springate 1997 {published data only}
  • Springate JE. Toxic nephropathies. Current Opinion in Pediatrics 1997;9:166-9.
Stava 2007 {published data only}
  • Stava CJ, Jimenez C, Vassilopoulou-Sellin R. Endocrine sequelae of cancer and cancer treatments. Journal of Cancer Survivorship 2007;1:261-74.
Steinbach 1995 {published data only}
  • Steinbach F, Novick AC, Zincke H, Miller DP, Williams RD, Lund G, et al. Treatment of renal cell carcinoma in von Hippel-Lindau disease: a multicenter study. Journal of Urology 1995;153:1812-6.
Stern 2002 {published data only}
Suarez 1991 {published data only}
  • Suarez A, McDowell H, Niaudet P, Comoy E, Flamant F. Long-term follow-up of ifosfamide renal toxicity in children treated for malignant mesenchymal tumors: an International Society of Pediatric Oncology report. Journal of Clinical Oncology 1991;9(12):2177-82.
Sukarochana 1972 {published data only}
Talvensaari 1996 {published data only}
Talvensaari 1997 {published data only}
Tamaro 1997 {published data only}
  • Tamaro P. Wilms' tumor: reached progress and future prospects [Il tumore di Wilms: progressi ottenuti e prospettive future]. Archivio Italiano di Urologia, Andrologia 1997;69:227-32.
Taylor 1997 {published data only}
  • Taylor RE. Morbidity from abdominal radiotherapy in the First United Kingdom Children's Cancer Study Group Wilms' Tumour Study. United Kingdom Children's Cancer Study Group. Clinical Oncology 1997;9:381-4.
Taylor 2003 {published data only}
  • Taylor RE, Bailey CC, Robinson K, Weston CL, Ellison D, Ironside J, et al. Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: the International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study. Journal of Clinical Oncology 2003;21:1581-91.
Tefft 1977 {published data only}
Thomas 1983 {published data only}
Tichelli 1991 {published data only}
  • Tichelli A, Gratwohl A, Uhr M, Dazzi H, Hoffmann T, Stebler Gysi C, et al. [Health status and late complications following allogeneic bone marrow transplantation. A review] [Gesundheitszustand und Spatkomplikationen nach allogener Knochenmarktransplantation. Eine Ubersicht]. Schweizerische Medizinische Wochenschrift 1991;121:1473-81.
Tokuc 1997 {published data only}
  • Tokuc G, Yalciner A, Kebudi R, Dogan S, Gorgun O, Ayan I. Renal dysfunctions secondary to ifosfamide treatment in children. Journal of Experimental & Clinical Cancer Research 1997;16:227-30.
Trimis 2007 {published data only}
  • Trimis G, Moschovi M, Papassotiriou I, Chrousos G, Tzortzatou-Stathopoulou F. Early indicators of dysmetabolic syndrome in young survivors of acute lymphoblastic leukemia in childhood as a target for preventing disease. Journal of Pediatric Hematology/Oncology 2007;29:309-14.
Turna 2008 {published data only}
  • Turna B, Frota R, Kamoi K, Lin Y-C, Aron M, Desai MM, et al. Risk factor analysis of postoperative complications in laparoscopic partial nephrectomy. Journal of Urology 2008;179:1289-95.
van Waas 2010 {published data only}
  • van Waas M, Neggers SJ, Van Der Lelij A-J, Pieters R, Van Den Heuvel-Eibrink MM. The metabolic syndrome in adult survivors of childhood cancer, a review. Journal of Pediatric Hematology/Oncology 2010;32:171-9.
van Waas 2010a {published data only}
  • van Waas M, Neggers SJ, Pieters R, van den Heuvel-Eibrink MM. Components of the metabolic syndrome in 500 adult long-term survivors of childhood cancer. Annals of Oncology 2010;21:1121-6.
Veringa 2011 {published data only}
Vio 1970 {published data only}
  • Vio A, Reggiani A. Hypertension in Wilms' tumors [L'ipertensione nei tumori di Wilms]. Archivio Italiano di Urologia, Nefrologia, Andrologia 1970;43:155-62.
Von Der Weid 1999 {published data only}
  • Von Der Weid NX, Erni BM, Mamie C, Wagner HP, Bianchetti MG. Cisplatin therapy in childhood: renal follow up 3 years or more after treatment. Nephrology Dialysis Transplantation 1999;14:1441-4.
Voute 1992 {published data only}
  • Voute PA, de Kraker J. Ifosfamide in pediatric oncology. Seminars in Oncology 1992;19:2-6.
Voute 1996 {published data only}
  • Voute PA, van den Berg H, Behrendt H, Michiels E, de Kraker J. Ifosfamide in the treatment of pediatric malignancies. Seminars in Oncology 1996;23:8-11.
Weijl 2004 {published data only}
  • Weijl NI, Elsendoorn TJ, Lentjes EG, Hopman GD, Wipkink Bakker A, Zwinderman AH, et al. Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. European Journal of Cancer 2004;40:1713-23.
Welch 1987 {published data only}
Wistow 1979 {published data only}
  • Wistow BW, McAfee JG, Sagerman RH, Thomas FD, Grossman ZD. Renal uptake of Tc-99m methylene diphosphonate after radiation therapy. Journal of Nuclear Medicine 1979;20:32-4.
Womer 1985 {published data only}
Wright 2009 {published data only}
Wu 2005 {published data only}
Yanagisawa 2009 {published data only}
  • Yanagisawa R, Nakazawa Y, Sakashita K, Tanaka M, Shikama N, Kamijo T, et al. Low toxicity of a conditioning with 8-Gy total body irradiation, fludarabine and cyclophosphamide as preparative regimen for allogeneic hematopoietic stem cell transplantation in pediatric hematological malignancies. Pediatric Transplantation 2009;13:737-45.
Yao 1997 {published data only}
  • Yao MS, Mehta MP, Boyett JM, Li H, Donahue B, Rorke LB, et al. The effect of M-stage on patterns of failure in posterior fossa primitive neuroectodermal tumors treated on CCG-921: a phase III study in a high-risk patient population. International Journal of Radiation Oncology, Biology, Physics 1997;38:469-76.
Yaris 2005 {published data only}
  • Yaris N, Sozen E, Erduran E, Okten A, Orem A, Cakirbay H. Bone mineral metabolism and its relationship to leptin levels in survivors of childhood leukemia and lymphoma. Pediatric Hematology and Oncology 2005;22:489-98.
Yoshimura 1997 {published data only}
  • Yoshimura K, Yamauchi T, Maeda H, Kawai T. Cisplatin, vincristine, methotrexate, peplomycin, etoposide (COMPE) therapy for disseminated germ cell testicular tumors. International Journal of Urology 1997;4:47-51.
Zagars 1987 {published data only}
Zerin 1996 {published data only}
Zielinska 2003 {published data only}
  • Zielinska E, Zubowska M, Bodalski J. Polymorphism at the glutathione S-transferase pi locus as a risk factor for ifosfamide nephrotoxicity in children [Polimorfizm genu kodujacego transferaze S-glutationowa klasy P1 jako czynnik ryzyka nefrotoksycznego dzialania ifosfamidu u dzieci]. Polski Merkuriusz Lekarski 2003;14:295-8.
Zorn 2007 {published data only}
  • Zorn KC, Gong EM, Orvieto MA, Gofrit ON, Mikhail AA, Msezane LP, et al. Comparison of laparoscopic radical and partial nephrectomy: effects on long-term serum creatinine. Urology 2007;69:1035-40.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Bailey 2002 {published data only}
  • Bailey S,  Roberts A,  Brock C,  Price L,  Craft AW,  Kilkarni R,  et al. Nephrotoxicity in survivors of Wilms' tumours in the North of England. British Journal of Cancer 2002;87:1092-8.
Cohen 2010 {published data only}
  • Cohen E, Fish BL, Moulder J. Mitigation of radiation nephropathy. Radiotherapy and Oncology 2010:S109.
Cozzi 2010 {published data only}
  • Cozzi D, Ceccanti S, Mele E, Frediani S, Iaconelli R, Schiavetti A, et al. Renal function outcomes after nephrectomy or nephron-sparing surgery for unilateral renal tumor in childhood. Pediatric Blood and Cancer 2010:793.
D'Angio 1978 {published data only}
  • D'Angio GJ, Tefft M, Breslow N, Meyer JA. Radiation therapy of Wilms' tumor: results according to dose, field, post-operative timing and histology. International Journal of Radiation Oncology, Biology, Physics 1978;4:769-80.
Eckstein 2010 {published data only}
  • Eckstein OS, O'Hear CE, Chi S, Lehmann LE, Duncan CN. High-dose chemotherapy with autologous stem-cell rescue in pediatric patients with CNS tumors: toxicity and outcomes. Biology of Blood and Marrow Transplantation. 2010:S247.
Janda 1993 {published data only}
  • Janda J, Koutecky J, Lukes M, Lukesova M, Malis J. The solitary kidney in patients after nephrectomy in Wilm's tumor. Ceskoslovenska Pediatrie 1993;48:577-80.
Kieran 2010 {published data only}
  • Kieran K, Giel DW, Davidoff AM, Williams MA. Urolithiasis in patients treated for childhood cancer: does altered calcium metabolism play a role?. Journal of Urology. 2010:e409.
Li 2006 {published data only}
  • Li MJ, Huang Y, Tang DX, Zhou YB, Tang HF, Liang JF. [Treatment of advanced Wilms' tumor]. Zhonghua Zhong Liu Za Zhi 2006;28:791-5.
Madden 2010 {published data only}
  • Madden JR, Hemenway M, Dorneman L, Strecker R, Foreman N. Outpatient cisplatin for average risk medulloblastoma: 15 year experience. Neuro-Oncology. 2010:ii111.
Matsuyama 2002 {published data only}
  • Matsuyama T, Kato K, Hanada R, Kawa K, Okamura J, Tsuchida M, et al. [Hematopoietic stem cell transplantation with conditioning regimens containing melphalan in pediatric patients with acute lymphoblastic leukemia]. Rinsho Ketsueki 2002;43:527-37.
Pugachev 2004 {published data only}
  • Pugachev AG. Conservative surgery-a basic principle of childhood urology [Organosokhraniaiushchie Operatsii Osnovnoe Napravlenie v Detskoi Urologii]. Urologiia 2004;4:3-5.
Radvansky 2010 {published data only}
  • Radvansky J, Slaby K, Radvanska J, Malis J, Eckschalger T, Sulc J, et al. Late effect of treatment of nephroblastoma in patients treated in 1980-2001 in a single centre [Pozdni nasledky Wilmsova tumoru a jeho lecby u pacientu lecenych v letech 1980-2001 na jedinem pracovisti.]. Klinikal Onkologie 2010;23:245-55.
Sakellari 2010 {published data only}
  • Sakellari I, Bamichas G, Barbouti A, Mallouri D, Fragidis S, Yannaki E, et al. Kidney injury as an early complication after haematopoietic cell transplantation: incidence, risk factors and outcome. Bone Marrow Transplantation 2010:S107.
Schwartz 2001 {published data only}
Sierota 2005 {published data only}
  • Sierota D, Stefanowicz J, Aleszewicz-Baranowska J, Birkholz D, Kosiak W, Adamkiewicz-Drozynska E, et al. Late side-effects of treatment in patients with nephroblastoma [Odlegle nastepstwa leczenia przeciwnowotworowego u dzieci z rozpoznaniem nerczaka zarodkowego]. Medycyna Wieku Rozwojowego 2005;9:517-22.
Stronska 2003 {published data only}
  • Stronska E, Zwolinska D, Sawicz-Birkowska K, Makulska I, Magier K, Czernik J. Assessment of function of the only kidney in children after nephrectomy due to Wilms tumor [Ocena czynnosci jedynej nerki u dzieci po nefrektomii z powodu guza Wilmsa.]. Polski Merkuriusz Lekarski 2003;14:311-4.
Terenziani 2010 {published data only}
  • Terenziani M, Indolfi P, Ardissino G, Bianchi M, Biasoni D, Catania S, et al. Bilateralwilms tumour (stage V): a report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) Wilms Tumour 2003 Cooperative Protocol. Pediatric Blood and Cancer 2010:883.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Beevers 2007
  • Beevers G, Lip GY, O'Brien E. ABC of Hypertension. 5th Edition. London, United Kingdom: BMJ Books, 2007.
Breitz 2004
Butt 2009
De Graaf 1996
  • De Graaf SS, Van Gent H, Reitsma-Bierens WC, Van Luyk WH, Dolsma WV, Postma A. Renal function after unilateral nephrectomy for Wilms' tumour: the influence of radiation therapy. European Journal of Cancer 1996;32A(3):465-9.
Egger 1997
  • Egger M,  Zellweger-Zähner T,  Schneider M,  Junker C,  Lengeler C,  Antes G. Language bias in randomised controlled trials published in English and German. The Lancet 1997;350(9074):326-9.
Gatta 2009
  • Gatta G,  Zigon G,  Capocaccia R,  Coebergh JW,  Desandes E,  Kaatsch P,  et al. Survival of European children and young adults with cancer diagnosed 1995–2002. European Journal of Cancer 2009;45(6):992-1005.
Grimes 2002
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011.
Hoang 2003
Kremer 2002
  • Kremer LC, van Dalen EC, Offringa M, Voûte PA. Frequency and risk factors of anthracycline-induced clinical heart failure in children: a systematic review. Annals of Oncology 2002;13(4):503-12.
Lajer 1999
Laupacis 1994
  • Laupacis A, Wells G, Richardson WS, Tugwell P. Users' guides to the medical literature. V. How to use an article about prognosis. Evidence-Based Medicine Working Group. Journal of the American Medical Association 1994;272:234-7.
Liamis 2010
Matsushita 2010
  • Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, et al. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. The Lancet 2010;375:2073-81.
Mulder 2010
Nathan 2009
  • Nathan PC,  Ford JS,  Henderson TO,  Hudson MM,  Emmons KM,  Casillas JN, et al. Health behaviors, medical care, and interventions to promote healthy living in the Childhood Cancer Survivor Study cohort. Journal of Clinical Oncology 2009;27(14):2363-73.
National Kidney Foundation 2002
  • National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. American Journal of Kidney Disease 2002;39:S1-S266.
Oeffinger 2006
Pietilä 2005
van Dalen 2006
  • van Dalen EC,  van der Pal HJ,  Kok WE,  Caron HN,  Kremer LC. Clinical heart failure in a cohort of children treated with anthracyclines: a long-term follow-up study. European Journal of Cancer 2006;42(18):3191-8.
van der Pal 2012
  • van der Pal HJ,  van Dalen EC,  van Delden E,  van Dijk IW,  Kok WE,  Geskus RB,  et al. High risk of symptomatic cardiac events in childhood cancer survivors. Journal of Clinical Oncology 2012;30(13):1429-37.
von Elm 2007
  • von Elm E,  Altman DG,  Egger M,  Pocock SJ,  Gøtzsche PC,  Vandenbroucke JP,  STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Annals of Internal Medicine 2007;147(8):573-77.
Wasilewski-Masker 2010
  • Wasilewski-Masker K, Mertens AC, Patterson B, Meacham LR. Severity of health conditions identified in a pediatric cancer survivor program. Pediatric Blood and Cancer 2010;54(7):976-82.
World Health Organization 2002
  • World Health Organization. The World Health Report 2002: Reducing Risks, Promoting Healthy Life. Geneva, Switzerland: World Health Organization, 2002.