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Influenza vaccines in immunosuppressed adults with cancer

  1. Noa Eliakim-Raz1,*,
  2. Inbal Vinograd2,
  3. Anca Zalmanovici Trestioreanu3,
  4. Leonard Leibovici1,
  5. Mical Paul4

Editorial Group: Cochrane Gynaecological, Neuro-oncology and Orphan Cancer Group

Published Online: 29 OCT 2013

Assessed as up-to-date: 20 AUG 2013

DOI: 10.1002/14651858.CD008983.pub2

How to Cite

Eliakim-Raz N, Vinograd I, Zalmanovici Trestioreanu A, Leibovici L, Paul M. Influenza vaccines in immunosuppressed adults with cancer. Cochrane Database of Systematic Reviews 2013, Issue 10. Art. No.: CD008983. DOI: 10.1002/14651858.CD008983.pub2.

Author Information

  1. 1

    Beilinson Hospital, Rabin Medical Center, Department of Medicine E, Petah Tikva, Israel

  2. 2

    Schneider Children's Medical Centre of Israel, Pharmacy, Petah-Tikva, Israel

  3. 3

    Beilinson Hospital, Rabin Medical Center, Department of Family Medicine, Petah Tikva, Israel

  4. 4

    Rambam Health Care Campus, Division of Infectious Diseases, Haifa, Israel

*Noa Eliakim-Raz, Department of Medicine E, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, 49100, Israel.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 29 OCT 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Earle 2003 {published data only}
Machado 2005 {published data only}
Musto 1997 {published data only}
  • Musto P, Carotenuto M. Vaccination against influenza in multiple myeloma. British Journal of Haematology 1997;97(2):504-10.
Vinograd 2013 {published data only}
  • Vinograd I, Eliakim-Raz N, Farbman L, Baslo R, Taha A, Sakhnini A, et al. Clinical effectiveness of seasonal influenza vaccine among adult cancer patients. Cancer 2013;16 SEP:Epub ahead of print. [10.1002/cncr.28351]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Adell 2002 {published data only}
  • Adell C, Bayas JM, Vilella A, Perales M, Vidal J, Bertran MJ, et al. Post-transplantation vaccination of bone-marrow transplant recipients [Vacunacion de pacientes receptores de trasplante de progenitores hematopoyeticos]. Medicina Clinica Journal 2002;119(11):405-9.
Anderson 1999 {published data only}
  • Anderson H, Petrie K, Berrisford C, Charlett A, Thatcher N, Zambon M. Seroconversion after influenza vaccination in patients with lung cancer. British Journal of Cancer 1999;80:219-20.
Avetisyan 2008 {published data only}
  • Avetisyan G, Aschan J, Hassan M, Ljungman P. Evaluation of immune responses to seasonal influenza vaccination in healthy volunteers and in patients after stem cell transplantation. Transplantation 2008;86(2):257-63.
Bedognetti 2009 {published data only}
  • Bedognetti D, Zoppoli G, Massucco C, Zupo S, Sertoli MR. Impaired humoral response to influenza vaccine and prolonged B memory cell depletion as a consequence of rituximab-based immunochemotherapy in non-hodgkin lymphoma patients. Journal of Immunotherapy 2009;32(9):992–3.
Bedognetti 2010 {published data only}
  • Bedognetti D, Zoppoli G, Zanardi E, Massucco C, Sertoli MR. Prolonged lack of humoral response to influenza vaccine associated with a persistent depletion of B memory cells in non-hodgkin’s lymphoma patients treated with rituximab-containing immunochemotherapy. Clinical Immunology 2010;135:84.
Brydak 1999 {published data only}
Brydak 2001 {published data only}
Brydak 2006 {published data only}
  • Brydak LB, Machala M, Centkowski P, Warzocha K, Bilinski P. Humoral response to hemagglutinin components of influenza vaccine inpatients with non-Hodgkin malignant lymphoma. Vaccine 2006;24:6620-23.
Buccalosi 1995 {published data only}
  • Bucalossi A, Marotta G, Galieni P, Bigazzi C, Valenzin PE, Dispensa E. Immunological response to influenza virus vaccine in B-cell chronic lymphocytic leukaemia patients. Acta Haematologica 1995;93(1):56.
Centkowski 2007 {published data only}
  • Centkowski P, Brydak L, Machala M, Kalinka-Warzocha E, Blasinska-Morawiec M, Federowicz I, et al. Immunogenicity of influenza vaccination in patients with non-Hodgkin lymphoma. Journal of Clinical Immunology 2007;27(3):339-46.
Chadha 2009 {published data only}
  • Chadha MK, Fakih MG, Tian L, Mashtare T, Nesline M. Effect of 25 hydroxy vitamin D status on serological response to influenza vaccine in cancer patients. Journal of Clinical Oncology 2009;27:e20575.
De Lavallade 2011 {published data only}
  • De Lavallade H, Garland P, Sekine T, Hoschler K, Marin D, Stringaris K, et al. Repeated vaccination is required to optimize seroprotection against H1N1 in the immunocompromised host. Haematologica 2011;96(2):307-14.
Engelhard 1993 {published data only}
  • Engelhard D, Nagler A, Hardan I, Morag A, Aker M, Baciu H, et al. Antibody response to a two-dose regimen of influenza vaccine in allogeneic T cell depleted and autologous BMT recipients. Bone Marrow Transplant 1993;11(1):1-5.
Feery 1977 {published data only}
  • Feery BJ, Sullivan JR, Hurley TH, Evered MG. Immunization with influenza vaccine in patients with haematological malignant disease. Medical Journal of Australia 1977;1:292-4.
Ganz 1978 {published data only}
Gribabis 1994 {published data only}
Hodges 1979 {published data only}
  • Hodges GR, Davis JW, Lewis HD Jr, Whittier FC Jr, Siegel CD, Chinn TD, et al. Response to influenza A vaccine among high-risk patients. Southern Medical Journal 1979;72(1):29–32.
Issa 2011 {published data only}
  • Issa NC, Marty FM, Gagne LS, Koo S, Verrill KA, Alvea EP, et al. Seroprotectivetiters against 2009 H1N1 influenza A virus after vaccination in allogeneic hematopoietic stem cell transplantation recipients. Biological Blood MarrowTransplant 2011;17(3):434–8.
Jo 2009 {published data only}
Lachenal 2010 {published data only}
  • Lachenal F, Sebban C, Duruisseaux M, Biron P, Blay JY, Ghesquières H. Influenza vaccination in patients with haematologic malignancies: analysis of practices in 200 patients in a single center. Bulletin du Cancer 2010;97(4):E33-6.
Lankes 2009 {published data only}
  • Lankes HA, Fought AJ, Evens AM, Weisenburger DD, Chiu BC. Vaccination history and risk of non-Hodgkin lymphoma: a population-based, case-control study. Cancer Causes and Control 2009;20(5):517-23.
Ljungman 2005 {published data only}
Lo 1993 {published data only}
  • Lo W, Whimbey E, Elting L, Couch R, Cabanillas F, Bodey G. Antibody response to a two-dose influenza vaccine regimen in adult lymphoma patients on chemotherapy. European Journal of Clinical Microbiology & Infectious Diseases 1993;12(10):778-82.
Mazza 2005 {published data only}
  • Mazza JJ, Yale SH, Arrowood JR, Reynolds CE, Glurich I, Chyou PH, et al. Efficacy of the influenza vaccine in patients with malignant lymphoma. Clinical Medicine and Research 2005;3(4):214-20.
Mulder 2009 {published data only}
  • Mulder SF, Jacobs JFM, Olde Nordkamp MAM, Kremer IK, Mulders PFA. Immunological response to influenza vaccine in cancer patients undergoing treatment with sunitinib or sorafenib. European Journal of Cancer 2009;7:116.
Nordoy 2002 {published data only}
  • Nordoy T, Aaberge IS, Husebekk A, Samdal HH, Steinert S, Melby H, et al. Cancer patients undergoing chemotherapy show adequate serological response to vaccinations against influenza virus and Streptococcus pneumoniae. Medical Oncology 2002;19(2):71-8.
Ortbals 1977 {published data only}
Puthillath 2011 {published data only}
  • Puthillath A, Trump DL, Andrews C, Bir A, Romano K, Wisniewski M, et al. Serological immune responses to influenza vaccine in patients with colorectal cancer. Cancer Chemotherapy and Pharmacology 2011;67(1):111-5.
Rapezzi 2003 {published data only}
Robertson 2000 {published data only}
  • Robertson JD, Nagesh K, Jowitt SN, Dougal M, Anderson H, Mutton K, et al. Immunogenicity of vaccination against influenza, Streptococcus pneumoniae and Haemophilus influenzae type B in patients with multiple myeloma. British Journal of Cancer 2000;82(7):1261-5.
Safdar 2006 {published data only}
  • Safdar A, Rodriguez MA, Fayad LE, Rodriguez GH, Pro B, Wang M, et al. Dose-related safety and immunogenicity of baculovirus-expressed trivalent influenza vaccine: a double-blind, controlled trial in adult patients with non-Hodgkin B cell lymphoma. Journal of Infectious Diseases 2006;194(10):1394-7.
Schafer 1979 {published data only}
Shildt 1979 {published data only}
Spies 2008 {published data only}
  • Spies CD, Kip M, Lau A, Sander M, Breuer JP, Meyerhoefer J, et al. Influence of vaccination and surgery on HLA-DR expression in patients with upper aerodigestive tract cancer. Journal of International Medical Research 2008;36:296-307.
Spitaleri 2010 {published data only}
  • Spitaleri G, Delmonte A, Toffalorio F, De Pas TM, Gregorc V. Safety of concomitant administration of seasonal and/or H1N1 flu vaccination in patients receiving erlotinib for advanced non-small cell lung cancer. Journal of Thoracic Oncology 2010;5(5):752-4.
Stiver 1978 {published data only}
  • Stiver HG, Weinerman BH. Impaired serum antibody response to inactivated influenza A and B vaccine in cancer patients. Canadian Medical Association Journal 1978;119(7):733-8.
Takata 2009 {published data only}
  • Takata T, Suzumiya J, Ishikawa T, Takamatsu Y, Ikematsu H, Tamura K. Attenuated antibody reaction for the primary antigen but not for the recall antigen of influenza vaccination in patients with non-Hodgkin B-cell lymphoma after the administration of rituximab-CHOP. Journal of Clinical Experimental Hematopathology 2009;49(1):9-13.
Van der Velden 2001 {published data only}
  • Van der Velden AM, Mulder AH, Hartkamp A, Diepersloot RJ, Van Velzen-Blad H, Biesma DH. Influenza virus vaccination and booster in B-cell chronic lymphocytic leukaemia patients. European Journal of Internal Medicine 2001;12(5):420-4.
Xu 2009 {published data only}
  • Xu Y, Methuku N, Coimbatore P, Fitzgerald T, Huang Y, Xiao YY, et al. A prospective study of the immunogenicity of inactivated influenza A (H1N1) 2009 monovalent vaccine in patients who have solid or hematologic malignancies. 48th Annual Meeting of the Infectious Diseases Society of America, 21–24 October 2010; Vancouver, Canada. 2010; Vol. Abstract 5075, posterLB-5013.
Yalc 2010 {published data only}
  • Yalçin SS, Kondolot M, Albayrak N, Altaş AB, Karacan Y, Kuşkonmaz B, et al. Serological response to influenza vaccine after hematopoetic stem cell transplantation. Annals of Hematology 2010;89(9):913-8.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Alistair 2002
Anema 2008
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