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Medication review in hospitalised patients to reduce morbidity and mortality

  1. Mikkel Christensen1,*,
  2. Andreas Lundh2

Editorial Group: Cochrane Effective Practice and Organisation of Care Group

Published Online: 28 FEB 2013

Assessed as up-to-date: 10 AUG 2011

DOI: 10.1002/14651858.CD008986.pub2


How to Cite

Christensen M, Lundh A. Medication review in hospitalised patients to reduce morbidity and mortality. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD008986. DOI: 10.1002/14651858.CD008986.pub2.

Author Information

  1. 1

    Bispebjerg Hospital, Department of Clinical Pharmacology, Copenhagen, Denmark

  2. 2

    Rigshospitalet, The Nordic Cochrane Centre, Copenhagen, Denmark

*Mikkel Christensen, Department of Clinical Pharmacology, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen, 2400, Denmark. mch@dadlnet.dk.

Publication History

  1. Publication Status: New
  2. Published Online: 28 FEB 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Gallagher 2011 {published data only (unpublished sought but not used)}
  • Gallagher PF, O’Connor MN, O’Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clinical Pharmacology and Therapeutics 2011;89(6):845-54. [PUBMED: 21508941]
Gillespie 2009 {published and unpublished data}
  • Gillespie U, Alassaad A, Henrohn D, Garmo H, Hammarlund-Udenaes M, Toss H, et al. A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Archives of Internal Medicine 2009;169(9):894-900. [PUBMED: 19433702]
Lisby 2010 {published and unpublished data}
  • Lisby M, Thomsen A, Nielsen LP, Lyhne NM, Breum-Leer C, Fredberg U, et al. The effect of systematic medication review in elderly patients admitted to an acute ward of internal medicine. Basic and Clinical Pharmacology and Toxicology 2010;106(5):422-7. [PUBMED: 20059474]
Lisby 2011 {unpublished data only}
  • Lisby M, Bonnerup DK, Brock B, Gregersen PA, Jensen J, Rungby J, et al. Systematic medication review and clinically health-related outcome in elderly patients admitted acutely to an orthopedic ward: a randomised controlled study. Clinically Important Medication Errors [PhD Thesis by Marianne Lisby]. Aarhus, Denmark: Faculty of Health Sciences. Aarhus University, 2011:3-33.
Schnipper 2006 {published data only (unpublished sought but not used)}
  • Schnipper JL, Kirwin JL, Cotugno MC, Wahlstrom SA, Brown BA, Tarvin E, et al. Role of pharmacist counselling in preventing adverse drug events after hospitalization. Archives of Internal Medicine 2006;166(5):565-71. [PUBMED: 16534045]

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
[no author] 2001 {published data only}
  • [no author]. Hospital pharmacists and the NSF for CHD. Pharmaceutical Journal 2001;267(7169):518.
Allen 1986 {published data only}
  • Allen CM, Becker PM, McVey LJ, Saltz C, Feussner JR, Cohen HJ. A randomized, controlled clinical trial of a geriatric consultation team. Compliance with recommendations. JAMA 1986;255(19):2617-21. [PUBMED: 3517396]
Al Mazroui 2009 {published data only}
Al-Rashed 2002 {published data only}
Bolas 2004 {published data only}
  • Bolas H, Brookes K, Scott M, McElnay J. Evaluation of a hospital-based community liaison pharmacy service in Northern Ireland. Pharmacy World and Science 2004;26(2):114-20. [PUBMED: 15085948]
Burleson 2003 {published data only}
  • Burleson BS. Impact of pharmacist-conducted medication histories on number of pharmacist's interventions, drug cost, medication errors, re-admission rates, and mortality during hospitalization of medicine patients. ASHP Midyear Clinical Meeting. 2003; Vol. 38:P-610.
Burnett 2009 {published data only}
  • Burnett KM, Scott MG, Fleming GF, Clark CM, McElnay JC. Effects of an integrated medicines management program on medication appropriateness in hospitalized patients. American Journal of Health-System Pharmacy 2009;66(9):854-9.
Cardinale 1993 {published data only}
  • Cardinale V. Clinical R.Ph.s in a team prove to be cost-effective. Drug Topics 1993;Jan Suppl:1.
Ciechanover 1987 {published data only}
  • Ciechanover M, Kohn D. A drug-reduction trial in elderly patients. Harefuah 1987;112(11):543-5.
Crotty 2004 {published data only}
  • Crotty M, Rowett D, Spurling L, Giles LC, Phillips PA. Does the addition of a pharmacist transition coordinator improve evidence-based medication management and health outcomes in older adults moving from the hospital to a long-term care facility? Results of a randomized, controlled trial. American Journal of Geriatric Pharmacotherapy 2004;2(4):257-64. [PUBMED: 15903284]
Gattis 1999 {published data only}
  • Gattis WA, Hasselblad V, Whellan DJ, O'Connor CM. Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study. Archives of Internal Medicine 1999;159(16):1939-45. [PUBMED: 10493325]
Hellstrom 2011 {published data only}
  • Hellstrom LM, Bondesson A, Hoglund P, Midlov P, Holmdahl L, Rickhag E, et al. Impact of the Lund Integrated Medicines Management (LIMM) model on medication appropriateness and drug-related hospital revisits. European Journal of Clinical Pharmacology 2011;67(7):741-52. [PUBMED: 21318595]
Kelly 2011 {published data only}
  • Kelly DM, Frick EM, Hale LS. How the medication review can help to reduce risk of falls in older patients. JAAPA 2011;24(4):30-4, 55. [PUBMED: 21534380]
Koehler 2009 {published data only}
Lipton 1992 {published data only}
  • Lipton HL, Bero LA, Bird JA, McPhee SJ. The impact of clinical pharmacists' consultations on physicians' geriatric drug prescribing. A randomized controlled trial. Medical Care 1992;30(7):646-58. [PUBMED: 1614233]
McMullin 1999 {published data only}
  • McMullin ST, Hennenfent JA, Ritchie DJ, Huey WY, Lonergan TP, Schaiff RA, et al. A prospective, randomized trial to assess the cost impact of pharmacist-initiated interventions. Archives of Internal Medicine 1999;159(19):2306-9. [PUBMED: 10547170]
Naughton 1994 {published data only}
  • Naughton BJ, Moran MB, Feinglass J, Falconer J, Williams ME. Reducing hospital costs for the geriatric patient admitted from the emergency department: a randomized trial. Journal of the American Geriatrics Society 1994;42(10):1045-9. [PUBMED: 7930327]
Pope 2011 {published data only}
  • Pope G, Wall N, Peters CM, O'Connor M, Saunders J, O'Sullivan C, et al. Specialist medication review does not benefit short-term outcomes and net costs in continuing-care patients. Age and Ageing 2011;40(3):307–12. [PUBMED: 20817937]
Rainville 1999 {published data only}
  • Rainville EC. Impact of pharmacist interventions on hospital readmissions for heart failure. American Journal of Health-System Pharmacy 1999;56(13):1339-42. [PUBMED: 10683133]
Saltvedt 2005 {published data only}
  • Saltvedt I, Spigset O, Ruths S, Fayers P, Kaasa S, Sletvold O. Patterns of drug prescription in a geriatric evaluation and management unit as compared with the general medical wards: a randomised study. European Journal of Clinical Pharmacology 2005;61(12):921-8. [PUBMED: 16307267]
Schmader 1997 {published data only}
  • Schmader KE, Hanlon JT, Landsman PB, Samsa GP, Lewis IK, Weinberger M. Inappropriate prescribing and health outcomes in elderly veteran outpatients. The Annals of Pharmacotherapy 1997;31(5):529-33. [PUBMED: 9161643]
Schmader 2004 {published data only}
  • Schmader KE, Hanlon JT, Pieper CF, Sloane R, Ruby CM, Twersky J, et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. American Journal of Medicine 2004;116(6):394-401. [PUBMED: 15006588]
Scullin 2007 {published data only}
Smith 1996 {published data only}
  • Smith DM, Cox MR, Brizendine EJ, Hui SL, Freedman JA, Martin DK, et al. An intervention on discharge polypharmacy. Journal of the American Geriatrics Society 1996;44(4):416-9. [PUBMED: 8636588]
Spinewine 2007 {published data only (unpublished sought but not used)}
Stowasser 2002 {published data only}
  • Stowasser DA, Collins DM, Stowasser M. A randomised controlled trial of medication liaison services - patient outcomes. Journal of Pharmacy Practice and Research 2002;32:133-40.
Walker 2009 {published data only}
  • Walker PC, Bernstein SJ, Tucker Jones JN, Piersma J, Kim HW, Regal RE, et al. Impact of a pharmacist-facilitated hospital discharge program: A quasi-experimental study. Archives of Internal Medicine 2009;169(21):2003-10. [PUBMED: 19933963]

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
ISRCTN08043800 {unpublished data only}
  • ISRCTN08043800. Pharmaceutical optimization of the medication process during admission to hospital: A multicentre, randomised, controlled trial. controlled-trials.com/ISRCTN08043800 (accessed August 2011).
NCT00844025 {unpublished data only}
  • NCT00844025. Pharmaceutical Care and Clinical Outcomes for the Elderly Taking Potentially Inappropriate Medication. clinicaltrials.gov/show/NCT00844025 (accessed August 2011).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to ongoing studies
  4. Additional references
Aronson 2006
  • Aronson JK. Polypharmacy, appropriate and inappropriate. The British Journal of General Practice 2006; Vol. 56, issue 528:484-5. [PUBMED: 16834872]
Beers 1991
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Beers 1997
Bregnhøj 2009
  • Bregnhøj L, Thirstrup S, Kristensen MB, Bjerrum L, Sonne J. Combined intervention programme reduces inappropriate prescribing in elderly patients exposed to polypharmacy in primary care. European Journal of Clinical Pharmacology 2009;65(2):199-207. [PUBMED: 18807252]
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Chen 2007
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Christensen 2009
Classen 1997
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Ebbesen 2001
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