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Eplerenone for hypertension

  • Protocol
  • Intervention

Authors


Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows:

  1. To determine the effect of eplerenone as monotherapy compared to placebo in adults (of varying age and race) with essential hypertension (with and without co-morbidities) on:

    1. All cause mortality

    2. Cardiovascular events (fatal or non-fatal myocardial infarction)

    3. Cerebrovascular events (fatal or non fatal strokes)

    4. Systolic and diastolic blood pressure

  2. To determine whether eplerenone is associated with an increased incidence of adverse events or withdrawals due to adverse events compared to placebo.

  1. All cause mortality

  2. Cardiovascular events (fatal or non-fatal myocardial infarction)

  3. Cerebrovascular events (fatal or non fatal strokes)

  4. Systolic and diastolic blood pressure