Intervention Review

You have free access to this content

Cryotherapy for liver metastases

  1. Malgorzata M Bala1,*,
  2. Robert P Riemsma2,
  3. Robert Wolff2,
  4. Jos Kleijnen2,3

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 5 JUN 2013

Assessed as up-to-date: 31 DEC 2012

DOI: 10.1002/14651858.CD009058.pub2

How to Cite

Bala MM, Riemsma RP, Wolff R, Kleijnen J. Cryotherapy for liver metastases. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD009058. DOI: 10.1002/14651858.CD009058.pub2.

Author Information

  1. 1

    Jagiellonian University Medical College, 2nd Department of Internal Medicine, Krakow, Poland

  2. 2

    Kleijnen Systematic Reviews Ltd, York, UK

  3. 3

    School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, Netherlands

*Malgorzata M Bala, 2nd Department of Internal Medicine, Jagiellonian University Medical College, 8 Skawinska St, Krakow, 31-066, Poland.

Publication History

  1. Publication Status: New
  2. Published Online: 5 JUN 2013



References to studies included in this review

  1. References to studies included in this review
  2. Additional references
Korpan 1997 {published data only}

Additional references

  1. References to studies included in this review
  2. Additional references
Altekruse 2009
  • Altekruse SF, Kosary CL, Krapcho M, Neyman N, Aminou R, Waldron W, et al. SEER Cancer statistics review, 1975-2007. National Cancer Institute. Bethesda, MD, based on November 2009 SEER data submission, posted to the SEER web site, 2010 (accessed 17 April 2013).
  • Australian Safety, Efficacy Register of New Interventional Procedures - Surgical (ASERNIP-S). Radiofrequency ablation of liver tumours (update): A systematic review. ASERNIP-S Report No. 56. Adelaide, South Australia: ASERNIP-S ( 2006 (accessed 17 April 2013).
Bilchik 2000
  • Bilchik AJ, Wood TF, Allegra D, Tsioulias GJ, Chung M, Rose DM, et al. Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: A proposed algorithm. Archives of Surgery 2000;135(6):657-64.
Bipat 2007
  • Bipat S,  van Leeuwen MS,  Ijzermans JN,  Comans EF,  Planting AS,  Bossuyt PM,  et al. Evidence-based guideline on management of colorectal liver metastases in the Netherlands. Netherlands Journal of Medicine 2007;65(1):5-14.
Brok 2008
  • Brok J, Thorlund K, Gluud C, Wetterslev J. Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses . Journal of Clinical Epidemiology 2008;61:763–9.
Brok 2009
  • Brok J, Thorlund K, Wetterslev J, Gluud C. Apparently conclusive meta-analyses may be inconclusive - trial sequential analysis adjustment for random error risk in conclusive neonatal meta-analyses. International Journal of Epidemiology 2009;38(1):287-98.
Bruix 2001
  • Bruix J, Sherman M, Llovet JM, Beaugrand M, Lencioni R, Burroughs AK, et al. Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL Conference. Journal of Hepatology 2001;35(3):421-30.
Chan 2004
  • Chan AW, Hróbjartsson A, Haahr MT, Gøtzsche PC, Altman DG. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 2004;291:2457–65.
CTU 2011
  • Copenhagen Trial Unit. TSA - Trial Sequential Analysis. 2011 (accessed 17 April 2013).
Decadt 2004
DerSimonian 1986
Egger 1997
FDA 2013
  • U.S. Food, Drug Administration. FDA approvals and investigational device exemptions. (accessed 17 April 2013).
Fedorowicz 2008
Geoghegan 1999
Gluud 2008
  • Gluud LL, Thorlund K, Gluud C, Woods L, Harris R, Sterne JA. Correction: reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Annals of Internal Medicine 2008;149(3):219.
Gluud 2013
  • Gluud C, Nikolova D, Klingenberg SL, Alexakis N, Als-Nielsen B, Colli A, et al. Cochrane Hepato-Biliary Group. About The Cochrane Collaboration (Cochrane Review Groups (CRGs)). 2013, Issue 3. Art. No.: LIVER. [: Art. No.: LIVER]
Greenland 1985
Higgins 2011
  • Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from
Hugh 1997
IARC 2008
  • International Agency for Research on Cancer. GLOBOCAN 2008, cancer incidence and mortality worldwide: IARC CancerBase No. 10 [Internet] . 2008 (accessed 17 April 2013).
ICH-GCP 1997
  • International Conference on Harmonisation Expert Working Group. International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. Guideline for good clinical practice 1997 CFR & ICH Guidelines. Vol. 1, PA 19063-2043, USA: Barnett International/PAREXEL, 1997.
Jemal 2010
Kjaergaard 2001
Lau 2000
Llovet 2003
Lopez 2006
Lundh 2012
Mala 2006
Mantel 1959
Markovic 1998
  • Markovic S, Gadzijev E, Stabuc B, Croce L, Masutti F, Surlan M. Treatment options in Western hepatocellular carcinoma: a prospective study of 224 patients. Journal of Hepatology 1998;29(4):650-9.
McCarter 2000
McLoughlin 2006
  • McLoughlin JM, Jensen EH, Malafa M. Resection of colorectal liver metastases: current perspectives. Cancer Control 2006;13(1):32-41.
Michel 2002
  • Michel S, Sue B, Montpeyroux F, Hachemanne S, Blanc P, Domergue J. Liver resection or transplantation for hepatocellular carcinoma? Retrospective analysis of 215 patients with cirrhosis. Journal of Hepatology 2002;26(6):1274-80.
Moher 1998
  • Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M, et al. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses?. Lancet 1998;352:609-13.
NICE 2010
  • National Institute for Health and Clinical Excellence. Cryotherapy for the treatment of liver metastases. 2010 (accessed 17 April 2013).
Parkin 2002
Parmar 1998
Pathak 2011
Pearson 1999
  • Pearson AS, Izzo F, Fleming RYD, Ellis LM, Delrio P, Roh MS, et al. Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. American Journal of Surgery 1999;178(6):592-9.
Riemsma 2009
  • Riemsma R, Bala M, Wolff R, Kleijnen J. Non-surgical ablation methods for primary malignant liver tumours and liver metastases. The Dutch Health Care Insurance Board ( 2009 (accessed 17 April 2013).
Royle 2003
  • Royle P, Milne R. Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches. International Journal of Technology Assessment in Health Care 2003;19(4):591-603.
Savovic 2012
  • Savovic J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Health Technology Assessment 2012;16(35):1-82.
Savovic 2012a
  • Savovic J, Jones HE, Altman DG, Harris RJ, Jüni P, Pildal J, et al. Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Annals of Internal Medicine 2012;157(6):429-38.
Schoppmeyer 2009
Schulz 1995
  • Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 1995;273:408-12.
Schwartz 2004
  • Schwartz JD, Beutler AS. Therapy for unresectable hepatocellular carcinoma: review of the randomized clinical trials-II: systemic and local non-embolization-based therapies in unresectable and advanced hepatocellular carcinoma. Anti-Cancer Drugs 2004;15(5):439-52.
Sutherland 2006
Tandan 1997
  • Tandan VR, Harmantas A, Galliner S. Long-term survival after hepatic cryosurgery versus surgical resection for metastatic colorectal carcinoma: A critical review of the literature . Canadian Journal of Surgery 1997;40:175–81.
Thierney 2007
Thorlund 2009
  • Thorlund K, Devereaux PJ, Wetterslev J, Guyatt G, Ioannidis JPA, Thabane L, et al. Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?. International Journal of Epidemiology 2009;38(1):276-86.
Thorlund 2010
  • Thorlund K, Anema A, Mills E. Interpreting meta-analysis according to the adequacy of sample size. An example using isoniazid chemoprophylaxis for tuberculosis in purified protein derivative negative HIV-infected individuals. Clinical Epidemiology 2010;2:57–66.
Thorlund 2011
  • Thorlund K, Engstrøm J, Wetterslev J, Brok J, Imberger G, Gluud C. User manual for Trial Sequential Analysis (TSA). 2011 (accessed 17 April 2013).
Weiss 1986
Wetterslev 2008
  • Wetterslev J, Thorlund K, Brok J, Gluud C. Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis. Journal of Clinical Epidemiology 2008;61(1):64-75.
Wetterslev 2009
  • Wetterslev J, Thorlund K, Brok J, Gluud C. Estimating required information size by quantifying diversity in a random-effects meta-analysis. BMC Medical Research Methodology 2009;9:86.
WHO 2013
  • World Health Organization. International Clinical Trials Registry Platform (ICTRP). (accessed 17 April 2013).
Wood 1976
  • Wood C, Gillis C, Blumgart L. A retrospective study of patients with liver metastases from colorectal cancer. Clinical Oncology 1976;2(3):285-8.
Wood 2008
  • Wood L, Egger M, Gluud LL, Schulz KF, Jüni P, Altman DG, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ (Clinical Research Ed.) 2008;336(7644):601-5.