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Herbal medicines for fatty liver diseases

  1. Zhao Lan Liu1,
  2. Liang Zhen Xie2,
  3. Jiang Zhu3,
  4. George Q Li4,
  5. Suzanne J Grant5,
  6. Jian Ping Liu1,*

Editorial Group: Cochrane Hepato-Biliary Group

Published Online: 24 AUG 2013

Assessed as up-to-date: 31 MAY 2012

DOI: 10.1002/14651858.CD009059.pub2


How to Cite

Liu ZL, Xie LZ, Zhu J, Li GQ, Grant SJ, Liu JP. Herbal medicines for fatty liver diseases. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD009059. DOI: 10.1002/14651858.CD009059.pub2.

Author Information

  1. 1

    Beijing University of Chinese Medicine, Centre for Evidence-Based Chinese Medicine, Beijing, China

  2. 2

    First Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine, Haerbin, Heilongjiang Province, Heilongjiang Province, China

  3. 3

    Beijing University of Chinese Medicine, College of Humanities, Beijing, China

  4. 4

    University of Sydney, Faculty of Pharmacy, Sydney, NSW, Australia

  5. 5

    University of Western Sydney, Center for Complementary Medicine Research, Sydney, New South Wales, Australia

*Jian Ping Liu, Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Chaoyang District, Beijing, 100029, China. jianping_l@hotmail.com.

Publication History

  1. Publication Status: New
  2. Published Online: 24 AUG 2013

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[Figure 1]
Figure 1. Prevalence of nonalcoholic fatty liver disease (NAFLD) in general population. (Adapted from Lazo M, Clark JM. The epidemiology of non-alcoholic fatty liver disease: a global perspective. Seminars in Liver Disease 2008;28:339-50.)
[Figure 2]
Figure 2. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow-chart of study selection.
[Figure 3]
Figure 3. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 4]
Figure 4. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Medicinal herbs versus placebo, Outcome 1 ALT (U/L).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Medicinal herbs versus placebo, Outcome 2 AST (U/L).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Medicinal herbs versus placebo, Outcome 3 Liver/spleen CT ratio.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Herbal medicines plus lifestyle intervention versus placebo plus lifestyle intervention, Outcome 1 AST (U/L).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Herbal medicines plus lifestyle intervention versus placebo plus lifestyle intervention, Outcome 2 ALT (U/L).
[Analysis 2.3]
Analysis 2.3. Comparison 2 Herbal medicines plus lifestyle intervention versus placebo plus lifestyle intervention, Outcome 3 ALP (U/L).
[Analysis 2.4]
Analysis 2.4. Comparison 2 Herbal medicines plus lifestyle intervention versus placebo plus lifestyle intervention, Outcome 4 Liver/spleen CT ratio.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Herbal medicines plus lifestyle intervention versus lifestyle intervention, Outcome 1 ALT (IU/L).
[Analysis 3.2]
Analysis 3.2. Comparison 3 Herbal medicines plus lifestyle intervention versus lifestyle intervention, Outcome 2 AST (IU/L).
[Analysis 3.3]
Analysis 3.3. Comparison 3 Herbal medicines plus lifestyle intervention versus lifestyle intervention, Outcome 3 Ultrasound: liver score.
[Analysis 3.4]
Analysis 3.4. Comparison 3 Herbal medicines plus lifestyle intervention versus lifestyle intervention, Outcome 4 Liver CT without improvement.
[Analysis 3.5]
Analysis 3.5. Comparison 3 Herbal medicines plus lifestyle intervention versus lifestyle intervention, Outcome 5 Adverse events.
[Analysis 3.6]
Analysis 3.6. Comparison 3 Herbal medicines plus lifestyle intervention versus lifestyle intervention, Outcome 6 GGT (U/L).
[Analysis 4.1]
Analysis 4.1. Comparison 4 Herbal medicines versus conventional therapy, Outcome 1 ALT (IU/L).
[Analysis 4.2]
Analysis 4.2. Comparison 4 Herbal medicines versus conventional therapy, Outcome 2 AST (IU/L).
[Analysis 4.3]
Analysis 4.3. Comparison 4 Herbal medicines versus conventional therapy, Outcome 3 GGT (U/L).
[Analysis 4.4]
Analysis 4.4. Comparison 4 Herbal medicines versus conventional therapy, Outcome 4 ALP (U/L).
[Analysis 4.5]
Analysis 4.5. Comparison 4 Herbal medicines versus conventional therapy, Outcome 5 Abnormal ultrasound.
[Analysis 4.6]
Analysis 4.6. Comparison 4 Herbal medicines versus conventional therapy, Outcome 6 Abnormal AST (> 50 U/L).
[Analysis 4.7]
Analysis 4.7. Comparison 4 Herbal medicines versus conventional therapy, Outcome 7 Abnormal ALT (> 50 U/L).
[Analysis 4.8]
Analysis 4.8. Comparison 4 Herbal medicines versus conventional therapy, Outcome 8 Adverse events.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Herbal medicines plus conventional therapy versus conventional therapy, Outcome 1 ALT (IU/L).
[Analysis 5.2]
Analysis 5.2. Comparison 5 Herbal medicines plus conventional therapy versus conventional therapy, Outcome 2 AST (IU/L).
[Analysis 5.3]
Analysis 5.3. Comparison 5 Herbal medicines plus conventional therapy versus conventional therapy, Outcome 3 GGT (IU/L).
[Analysis 5.4]
Analysis 5.4. Comparison 5 Herbal medicines plus conventional therapy versus conventional therapy, Outcome 4 Hepatic ultrasound without improvement.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 1 ALT (IU/L).
[Analysis 6.2]
Analysis 6.2. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 2 AST (IU/L).
[Analysis 6.3]
Analysis 6.3. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 3 GGT (IU/L).
[Analysis 6.4]
Analysis 6.4. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 4 L/S CT ratio.
[Analysis 6.5]
Analysis 6.5. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 5 Ultrasound without improvement.
[Analysis 6.6]
Analysis 6.6. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 6 Ultrasound: proximal diffuse high echogenic dots.
[Analysis 6.7]
Analysis 6.7. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 7 Ultrasound: distal end echo attenuation.
[Analysis 6.8]
Analysis 6.8. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 8 Ultrasound: unclear hepatic vessel structure.
[Analysis 6.9]
Analysis 6.9. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 9 Ultrasound: reduction of blood flow.
[Analysis 6.10]
Analysis 6.10. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 10 Liver CT without improvement.
[Analysis 6.11]
Analysis 6.11. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 11 Adverse events.
[Analysis 6.12]
Analysis 6.12. Comparison 6 Herbal medicines plus lifestyle intervention versus conventional therapy plus lifestyle intervention, Outcome 12 Ultrasound: liver score.
[Analysis 7.1]
Analysis 7.1. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 1 Liver/spleen CT ratio.
[Analysis 7.2]
Analysis 7.2. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 2 ALT (U/L).
[Analysis 7.3]
Analysis 7.3. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 3 AST (U/L).
[Analysis 7.4]
Analysis 7.4. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 4 GGT (U/L).
[Analysis 7.5]
Analysis 7.5. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 5 Ultrasound: liver echo intensity.
[Analysis 7.6]
Analysis 7.6. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 6 Abnormal ultrasound.
[Analysis 7.7]
Analysis 7.7. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 7 Liver CT value.
[Analysis 7.8]
Analysis 7.8. Comparison 7 Herbal medicines plus lifestyle intervention plus conventional therapy versus lifestyle intervention plus conventional therapy, Outcome 8 Adverse events.