Intervention Review

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Pharmacological interventions for self-injurious behaviour in adults with intellectual disabilities

  1. Fareez Rana1,*,
  2. Aynur Gormez1,
  3. Susan Varghese2

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group

Published Online: 30 APR 2013

Assessed as up-to-date: 19 AUG 2012

DOI: 10.1002/14651858.CD009084.pub2

How to Cite

Rana F, Gormez A, Varghese S. Pharmacological interventions for self-injurious behaviour in adults with intellectual disabilities. Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD009084. DOI: 10.1002/14651858.CD009084.pub2.

Author Information

  1. 1

    Southern Health NHS Foundation Trust, Psychiatry of Intellectual Disability, Oxford, UK

  2. 2

    Black Country Partnership NHS Foundation Trust, Psychiatry of Intellectual Disability, Wolverhampton, West Midlands, UK

*Fareez Rana, Psychiatry of Intellectual Disability, Southern Health NHS Foundation Trust, Horspath Driftway, Oxford, OX3 7JH, UK.

Publication History

  1. Publication Status: New
  2. Published Online: 30 APR 2013



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Lewis 1996 {published data only (unpublished sought but not used)}
  • Lewis M, Bodfish J, Powell S, Parker D, Golden R. Clomipramine treatment for self-injurious behaviour of individuals with mental retardation: a double-blind comparison with placebo. American Journal on Mental Retardation 1996;100(6):654-65.
Sandman 1990 {published data only}
  • Sandman CA, Barron JL, Colman H. An orally administered opiate blocker, naltrexone, attenuates self-injurious behavior. American Journal on Mental Retardation 1990;95(1):93-102.
Symons 2001 {published data only}
  • Symons F, Wulfsberg A, Sutton K, Tapp J, Heeth W, Bodfish W. Sequential analysis of the effects of naltrexone on the environmental mediation of self injurious behaviour. Experimental and Clinical Psychopharmacology 2001;9:269-76.
Thompson 1994 {published data only}
  • Thompson T, Hackenberg T, Cerutti D, Baker D, Axtell S. Opioid antagonist effects on self-injury in adults with mental retardation: response form and location as determinants of medication effects. American Journal on Mental Retardation 1994;99(1):85-102.
Willemsen-Swinkels 1995 {published and unpublished data}
  • Willemsen-Swinkels S, Buitelaar J, Nijhof G, van Engeland H. Failure of naltrexone hydrochloride to reduce self injurious and autistic behaviour in mentally retarded adults. Archives General Psychiatry 1995;52:766-73.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
Bodfish 1997 {published data only}
  • Bodfish J, McCuller W, Madison J, Register M, Mailman R, Lewis M. Placebo, double-blind evaluation of long-term naltrexone treatment effects for adults with mental retardation and self-injury. Journal of Developmental and Physical Disabilities 1997;9(2):135-52.
Garcia 1999 {published data only}
Kars 1990 {published data only}
Sandman 1983 {published data only}
  • Sandman C, Datta P, Barron J, Hoehler F, Williams C, Swanson J. Naloxone attenuates self-abusive behaviour in developmentally disabled clients. Applied Research in Mental Retardation 1983;4:5-11.
Szymanski 1987 {published data only}
Zingarelli 1992 {published data only}
  • Zingarelli G, Ellman G, Wymore A, Heldron S, Chicz-Demet A. Clinical effects of naltrexone on autistic behaviour. American Journal on Mental Retardation 1992;97(1):57-63.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. Additional references
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Aman 1993
  • Aman M. Efficacy of psychotropic drugs for reducing self-injurious behavior in the developmental disabilities. Annals of Clinical Psychiatry 1993;5(3):171-88.
Beail 2007
  • Beail N. Staff Emotional Reactions to Service User Self Injury. Changing Practice Reducing the Risk. BILD Conference. 2007.
Bhaumik 2005
  • Bhaumik S, Branford D (editors). Chapter 5: Self-injurious behaviour. The Frith Prescribing Guidelines for Adults with Learning Disability. Abingdon, UK: Taylor & Francis, 2005:45.
Bhaumik 2010
  • Bhaumik S, Tyrer F, Barrett M, Tin N, McGrother CW, Kiani R. The relationship between carers report of autistic traits and clinical diagnoses of autism spectrum disorders in adults with intellectual disability. Research in Developmental Disabilities 2010;31(3):705-12.
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