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Intermittent iron supplementation for improving nutrition and development in children under 12 years of age

  1. Luz Maria De-Regil1,*,
  2. Maria Elena D Jefferds2,
  3. Allison C Sylvetsky3,
  4. Therese Dowswell4

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group

Published Online: 7 DEC 2011

Assessed as up-to-date: 23 OCT 2011

DOI: 10.1002/14651858.CD009085.pub2

How to Cite

De-Regil LM, Jefferds MED, Sylvetsky AC, Dowswell T. Intermittent iron supplementation for improving nutrition and development in children under 12 years of age. Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD009085. DOI: 10.1002/14651858.CD009085.pub2.

Author Information

  1. 1

    Micronutrient Initiative, Ottawa, ON, Canada

  2. 2

    Centers for Disease Control and Prevention, International Micronutrient Malnutrition Prevention and Control Program, Nutrition Branch, Division of Nutrition, Physical Activity and Obesity, Atlanta, Georgia, USA

  3. 3

    Emory University, Graduate Division of Biological and Biomedical Sciences, Atlanta, Georgia, USA

  4. 4

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

*Luz Maria De-Regil, Micronutrient Initiative, 180 Elgin Street, Suite 1000, Ottawa, ON, K2P 2K3, Canada. lderegil@micronutrient.org.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 7 DEC 2011

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[Figure 1]
Figure 1. WHO/CDC logic model for micronutrients interventions in public health (with permission from WHO)
[Figure 2]
Figure 2. Study flow diagram.
[Figure 3]
Figure 3. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 4]
Figure 4. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 1 Anaemia (ALL).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 2 Anaemia (by dose of elemental iron in the intermittent group).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 3 Anaemia (by duration of the intervention).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 4 Anaemia (by type of compound).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 5 Anaemia (by anaemia status at baseline).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 6 Anaemia (by intermittent regimen).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 7 Anaemia (by sex).
[Analysis 1.8]
Analysis 1.8. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 8 Anaemia (by nutrient).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 9 Haemoglobin (ALL).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 10 Haemoglobin (by by dose of elemental iron in the intermittent group).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 11 Haemoglobin (by duration of the intervention).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 12 Haemoglobin (by type of compound).
[Analysis 1.13]
Analysis 1.13. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 13 Haemoglobin (by anaemia status at baseline).
[Analysis 1.14]
Analysis 1.14. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 14 Haemoglobin (by intermittent regimen).
[Analysis 1.15]
Analysis 1.15. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 15 Haemoglobin (by sex).
[Analysis 1.16]
Analysis 1.16. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 16 Haemoglobin (by nutrient).
[Analysis 1.17]
Analysis 1.17. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 17 Iron deficiency (ALL).
[Analysis 1.18]
Analysis 1.18. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 18 Ferritin (ALL).
[Analysis 1.19]
Analysis 1.19. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 19 Ferritin (by dose of elemental iron in the intermittent group).
[Analysis 1.20]
Analysis 1.20. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 20 Ferritin (by duration of the supplementation).
[Analysis 1.21]
Analysis 1.21. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 21 Ferritin (by type of compound).
[Analysis 1.22]
Analysis 1.22. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 22 Ferritin (by anaemia status at baseline).
[Analysis 1.23]
Analysis 1.23. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 23 Ferritin (by supplementation regimen).
[Analysis 1.24]
Analysis 1.24. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 24 Ferritin (by sex).
[Analysis 1.25]
Analysis 1.25. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 25 Ferritin (by nutrient).
[Analysis 1.26]
Analysis 1.26. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 26 All cause morbidity (ALL).
[Analysis 1.27]
Analysis 1.27. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 27 Any side effects (ALL).
[Analysis 1.28]
Analysis 1.28. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 28 Nausea.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 29 Adherence (ALL).
[Analysis 1.30]
Analysis 1.30. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 30 Mental development scale (ALL).
[Analysis 1.31]
Analysis 1.31. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 31 Orientation engagement (ALL).
[Analysis 1.32]
Analysis 1.32. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 32 Emotional regulation (ALL).
[Analysis 1.33]
Analysis 1.33. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 33 Motor quality (ALL).
[Analysis 1.34]
Analysis 1.34. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 34 Psychomotor development index (ALL).
[Analysis 1.35]
Analysis 1.35. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 35 IQ (ALL).
[Analysis 1.36]
Analysis 1.36. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 36 Thai language (ALL).
[Analysis 1.37]
Analysis 1.37. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 37 Mathematics (ALL).
[Analysis 1.38]
Analysis 1.38. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 38 WAZ.
[Analysis 1.39]
Analysis 1.39. Comparison 1 Intermittent iron supplementation versus placebo or no intervention: children 0 - 12 years, Outcome 39 HAZ.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 1 Anaemia (ALL).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 2 Anaemia (by dose of elemental iron in the intermittent group).
[Analysis 2.3]
Analysis 2.3. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 3 Anaemia (by duration of the supplementation).
[Analysis 2.4]
Analysis 2.4. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 4 Anaemia (by type of compound).
[Analysis 2.5]
Analysis 2.5. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 5 Anaemia (by anaemia status at baseline).
[Analysis 2.6]
Analysis 2.6. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 6 Anaemia (by supplementation regimen).
[Analysis 2.7]
Analysis 2.7. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 7 Anaemia (by sex).
[Analysis 2.8]
Analysis 2.8. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 8 Anaemia (by nutrient).
[Analysis 2.9]
Analysis 2.9. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 9 Haemoglobin (ALL).
[Analysis 2.10]
Analysis 2.10. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 10 Haemoglobin (by dose of elemental iron in the intermittent group).
[Analysis 2.11]
Analysis 2.11. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 11 Haemoglobin (by duration of the supplementation).
[Analysis 2.12]
Analysis 2.12. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 12 Haemoglobin (by type of compound).
[Analysis 2.13]
Analysis 2.13. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 13 Haemoglobin (by anaemia status at baseline).
[Analysis 2.14]
Analysis 2.14. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 14 Haemoglobin (by supplementation regimen).
[Analysis 2.15]
Analysis 2.15. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 15 Haemoglobin (by sex).
[Analysis 2.16]
Analysis 2.16. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 16 Haemoglobin (by nutrient).
[Analysis 2.17]
Analysis 2.17. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 17 Iron deficiency (ALL).
[Analysis 2.18]
Analysis 2.18. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 18 Ferritin (ALL).
[Analysis 2.19]
Analysis 2.19. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 19 Ferritin (by dose of elemental iron in the intermittent group).
[Analysis 2.20]
Analysis 2.20. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 20 Ferritin (by duration of the supplementation).
[Analysis 2.21]
Analysis 2.21. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 21 Ferritin (by type of compound).
[Analysis 2.22]
Analysis 2.22. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 22 Ferritin (by anaemia status at baseline).
[Analysis 2.23]
Analysis 2.23. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 23 Ferritin (by supplementation regimen).
[Analysis 2.24]
Analysis 2.24. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 24 Ferritin (by sex).
[Analysis 2.25]
Analysis 2.25. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 25 Ferritin (by nutrient).
[Analysis 2.26]
Analysis 2.26. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 26 Increase in steps climbed (ALL).
[Analysis 2.27]
Analysis 2.27. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 27 All cause morbidity (ALL).
[Analysis 2.28]
Analysis 2.28. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 28 Diarrhoea (ALL).
[Analysis 2.29]
Analysis 2.29. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 29 Any side effects (ALL).
[Analysis 2.30]
Analysis 2.30. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 30 Adherence (ALL).
[Analysis 2.31]
Analysis 2.31. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 31 IQ (ALL).
[Analysis 2.32]
Analysis 2.32. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 32 Thai language (ALL).
[Analysis 2.33]
Analysis 2.33. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 33 Mathematics (ALL).
[Analysis 2.34]
Analysis 2.34. Comparison 2 Intermittent iron supplementation versus daily iron supplementation: children 0 - 12 years, Outcome 34 HAZ.
[Analysis 3.1]
Analysis 3.1. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 1 Anaemia (ALL).
[Analysis 3.2]
Analysis 3.2. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 2 Anaemia (by dose of elemental iron in the intermittent group).
[Analysis 3.3]
Analysis 3.3. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 3 Anaemia (by duration of the supplementation).
[Analysis 3.4]
Analysis 3.4. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 4 Anaemia (by type of compound).
[Analysis 3.5]
Analysis 3.5. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 5 Anaemia (by anaemia status at baseline).
[Analysis 3.6]
Analysis 3.6. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 6 Anaemia (by intermittent regimen).
[Analysis 3.7]
Analysis 3.7. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 7 Anaemia (by sex).
[Analysis 3.8]
Analysis 3.8. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 8 Anaemia (by nutrient).
[Analysis 3.9]
Analysis 3.9. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 9 Haemoglobin (ALL).
[Analysis 3.10]
Analysis 3.10. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 10 Haemoglobin (by dose of elemental iron in the intermittent group).
[Analysis 3.11]
Analysis 3.11. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 11 Haemoglobin (by duration of the supplementation).
[Analysis 3.12]
Analysis 3.12. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 12 Haemoglobin (by type of iron compound).
[Analysis 3.13]
Analysis 3.13. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 13 Haemoglobin (by anaemia status at baseline).
[Analysis 3.14]
Analysis 3.14. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 14 Haemoglobin (by supplementation regimen).
[Analysis 3.15]
Analysis 3.15. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 15 Haemoglobin (by sex).
[Analysis 3.16]
Analysis 3.16. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 16 Haemoglobin (by nutrient).
[Analysis 3.17]
Analysis 3.17. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 17 Iron deficiency (ALL).
[Analysis 3.18]
Analysis 3.18. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 18 Ferritin (ALL).
[Analysis 3.19]
Analysis 3.19. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 19 Ferritin (by dose of iron in the intermittent group).
[Analysis 3.20]
Analysis 3.20. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 20 Ferritin (by duration of the supplementation).
[Analysis 3.21]
Analysis 3.21. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 21 Ferritin (by type of iron compound).
[Analysis 3.22]
Analysis 3.22. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 22 Ferritin (by anaemia status at baseline).
[Analysis 3.23]
Analysis 3.23. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 23 Ferritin (by supplementation regimen).
[Analysis 3.24]
Analysis 3.24. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 24 Ferritin (by sex).
[Analysis 3.25]
Analysis 3.25. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 25 Ferritin (by nutrient).
[Analysis 3.26]
Analysis 3.26. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 26 All cause morbidity (ALL).
[Analysis 3.27]
Analysis 3.27. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 27 Any side effects (ALL).
[Analysis 3.28]
Analysis 3.28. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 28 Adherence (ALL).
[Analysis 3.29]
Analysis 3.29. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 29 Mental development scale (ALL).
[Analysis 3.30]
Analysis 3.30. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 30 Orientation engagement (ALL).
[Analysis 3.31]
Analysis 3.31. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 31 Emotional regulation (ALL).
[Analysis 3.32]
Analysis 3.32. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 32 Motor quality (ALL).
[Analysis 3.33]
Analysis 3.33. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 33 Psychomotor development index (ALL).
[Analysis 3.34]
Analysis 3.34. Comparison 3 Intermittent iron supplementation versus placebo or no intervention: children 0 - 59 months, Outcome 34 HAZ.
[Analysis 4.1]
Analysis 4.1. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 1 Anaemia (ALL).
[Analysis 4.2]
Analysis 4.2. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 2 Haemoglobin (ALL).
[Analysis 4.3]
Analysis 4.3. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 3 Haemoglobin (by dose of elemental iron in the intermittent group).
[Analysis 4.4]
Analysis 4.4. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 4 Haemoglobin (by duration of supplementation).
[Analysis 4.5]
Analysis 4.5. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 5 Haemoglobin (by type of compound).
[Analysis 4.6]
Analysis 4.6. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 6 Haemoglobin (by anaemia status at baseline).
[Analysis 4.7]
Analysis 4.7. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 7 Haemoglobin (by supplementation regimen).
[Analysis 4.8]
Analysis 4.8. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 8 Haemoglobin (by sex).
[Analysis 4.9]
Analysis 4.9. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 9 Haemoglobin (by nutrient).
[Analysis 4.10]
Analysis 4.10. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 10 Iron deficiency (ALL).
[Analysis 4.11]
Analysis 4.11. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 11 Ferritin (ALL).
[Analysis 4.12]
Analysis 4.12. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 12 Ferritin (by dose of elemental iron in the intermittent subgroup).
[Analysis 4.13]
Analysis 4.13. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 13 Ferritin (by duration of supplementation).
[Analysis 4.14]
Analysis 4.14. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 14 Ferritin (by type of compound).
[Analysis 4.15]
Analysis 4.15. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 15 Ferritin (by anaemia status at baseline).
[Analysis 4.16]
Analysis 4.16. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 16 Ferritin (by supplementation regimen).
[Analysis 4.17]
Analysis 4.17. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 17 Ferritin (by sex).
[Analysis 4.18]
Analysis 4.18. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 18 Ferritin (by nutrient).
[Analysis 4.19]
Analysis 4.19. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 19 All cause morbidity (ALL).
[Analysis 4.20]
Analysis 4.20. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 20 Diarrhoea (ALL).
[Analysis 4.21]
Analysis 4.21. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 21 Any side effects (ALL).
[Analysis 4.22]
Analysis 4.22. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 22 Adherence (ALL).
[Analysis 4.23]
Analysis 4.23. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 23 HAZ.
[Analysis 4.24]
Analysis 4.24. Comparison 4 Intermittent iron supplementation versus daily iron supplementation: children 0 - 59 months, Outcome 24 WAZ.
[Analysis 5.1]
Analysis 5.1. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 1 Anaemia (ALL).
[Analysis 5.2]
Analysis 5.2. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 2 Anaemia (by dose).
[Analysis 5.3]
Analysis 5.3. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 3 Anaemia (by duration).
[Analysis 5.4]
Analysis 5.4. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 4 Anaemia (by type of compound).
[Analysis 5.5]
Analysis 5.5. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 5 Anaemia (by anaemia status at baseline).
[Analysis 5.6]
Analysis 5.6. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 6 Anaemia (by intermittent regimen).
[Analysis 5.7]
Analysis 5.7. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 7 Anaemia (by sex).
[Analysis 5.8]
Analysis 5.8. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 8 Anaemia (by nutrient).
[Analysis 5.9]
Analysis 5.9. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 9 Haemoglobin (ALL).
[Analysis 5.10]
Analysis 5.10. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 10 Haemoglobin (by dose of elemental iron in the intermittent group).
[Analysis 5.11]
Analysis 5.11. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 11 Haemoglobin (by duration of the supplementation).
[Analysis 5.12]
Analysis 5.12. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 12 Haemoglobin (by type of iron compound).
[Analysis 5.13]
Analysis 5.13. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 13 Haemoglobin (by anaemia status at baseline).
[Analysis 5.14]
Analysis 5.14. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 14 Haemoglobin (by supplementation regimen).
[Analysis 5.15]
Analysis 5.15. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 15 Haemoglobin (by sex).
[Analysis 5.16]
Analysis 5.16. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 16 Haemoglobin (by nutrient).
[Analysis 5.17]
Analysis 5.17. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 17 Ferritin (ALL).
[Analysis 5.18]
Analysis 5.18. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 18 All cause morbidity (ALL).
[Analysis 5.19]
Analysis 5.19. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 19 Any side effects (ALL).
[Analysis 5.20]
Analysis 5.20. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 20 Nausea.
[Analysis 5.21]
Analysis 5.21. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 21 IQ (ALL).
[Analysis 5.22]
Analysis 5.22. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 22 Thai language (ALL).
[Analysis 5.23]
Analysis 5.23. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 23 Mathematics (ALL).
[Analysis 5.24]
Analysis 5.24. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 24 Increase in steps climbed (ALL).
[Analysis 5.25]
Analysis 5.25. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 25 WAZ.
[Analysis 5.26]
Analysis 5.26. Comparison 5 Intermittent iron supplementation versus placebo or no intervention: children 5 - 12 years, Outcome 26 HAZ.
[Analysis 6.1]
Analysis 6.1. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 1 Anaemia (ALL).
[Analysis 6.2]
Analysis 6.2. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 2 Haemoglobin (ALL).
[Analysis 6.3]
Analysis 6.3. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 3 Haemoglobin (by dose of elemental iron).
[Analysis 6.4]
Analysis 6.4. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 4 Haemoglobin (by duration of the supplementation).
[Analysis 6.5]
Analysis 6.5. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 5 Haemoglobin (by type of compound).
[Analysis 6.6]
Analysis 6.6. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 6 Haemoglobin (by baseline prevalence of anaemia).
[Analysis 6.7]
Analysis 6.7. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 7 Haemoglobin (by supplementation regimen).
[Analysis 6.8]
Analysis 6.8. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 8 Haemoglobin (by sex).
[Analysis 6.9]
Analysis 6.9. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 9 Haemoglobin (by nutrient).
[Analysis 6.10]
Analysis 6.10. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 10 Ferritin (ALL).
[Analysis 6.11]
Analysis 6.11. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 11 All cause morbidity (ALL).
[Analysis 6.12]
Analysis 6.12. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 12 Diarrhoea (ALL).
[Analysis 6.13]
Analysis 6.13. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 13 Adherence (ALL).
[Analysis 6.14]
Analysis 6.14. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 14 IQ (ALL).
[Analysis 6.15]
Analysis 6.15. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 15 Thai language (ALL).
[Analysis 6.16]
Analysis 6.16. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 16 Mathematics (ALL).
[Analysis 6.17]
Analysis 6.17. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 17 Increase in steps climbed (ALL).
[Analysis 6.18]
Analysis 6.18. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 18 HAZ.
[Analysis 6.19]
Analysis 6.19. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 19 WAZ.
[Analysis 6.20]
Analysis 6.20. Comparison 6 Intermittent iron supplementation versus daily iron supplementation: children 5 - 12 years, Outcome 20 WAZ.