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Intermittent iron supplementation for improving nutrition and development in children under 12 years of age

  1. Luz Maria De-Regil1,*,
  2. Maria Elena D Jefferds2,
  3. Allison C Sylvetsky3,
  4. Therese Dowswell4

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group

Published Online: 7 DEC 2011

Assessed as up-to-date: 23 OCT 2011

DOI: 10.1002/14651858.CD009085.pub2


How to Cite

De-Regil LM, Jefferds MED, Sylvetsky AC, Dowswell T. Intermittent iron supplementation for improving nutrition and development in children under 12 years of age. Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD009085. DOI: 10.1002/14651858.CD009085.pub2.

Author Information

  1. 1

    Micronutrient Initiative, Ottawa, ON, Canada

  2. 2

    Centers for Disease Control and Prevention, International Micronutrient Malnutrition Prevention and Control Program, Nutrition Branch, Division of Nutrition, Physical Activity and Obesity, Atlanta, Georgia, USA

  3. 3

    Emory University, Graduate Division of Biological and Biomedical Sciences, Atlanta, Georgia, USA

  4. 4

    The University of Liverpool, Cochrane Pregnancy and Childbirth Group, Department of Women's and Children's Health, Liverpool, UK

*Luz Maria De-Regil, Micronutrient Initiative, 180 Elgin Street, Suite 1000, Ottawa, ON, K2P 2K3, Canada. lderegil@micronutrient.org.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 7 DEC 2011

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Aguayo 2000 {published data only}
  • Aguayo VM. School-administered weekly iron supplementation - effect on the growth and hemoglobin status of non-anemic Bolivian school-age children. A randomized placebo-controlled trial. European Journal of Nutrition 2000;39(6):263-9.
Arcanjo 2011 (C) {published data only}
  • Arcanjo FPN, Arcanjo CC, Amancio OMS, Braga JAP, Leite AJM. Weekly iron supplementation for the prevention of anemia in pre-school children: a randomized, double-blind, placebo-controlled trial. Journal of Tropical Pediatrics 2011 Feb 1 [Epub ahead of print].
Awasthi 2005 (C) {published data only}
  • Awasthi S, Verma T, Vir S. Effectiveness of biweekly versus daily iron-folic acid administration on anaemia status in preschool children. Journal of Tropical Pediatrics 2005;51(2):67-71.
Baqui 2003 {published data only}
  • Baqui AH, Walker CL, Zaman K, El Arifeen S, Chowdhury HR, Wahed MA, et al. Weekly iron supplementation does not block increases in serum zinc due to weekly zinc supplementation in Bangladeshi infants. Journal of Nutrition 2005;135(9):2187-91.
  • Baqui AH, Zaman K, Persson LA, El Arifeen S, Yunus M, Begum N, et al. Simultaneous weekly supplementation of iron and zinc is associated with lower morbidity due to diarrhea and acute lower respiratory infection in Bangladeshi infants. Journal of Nutrition 2003;133(12):4150-7.
  • Black MM, Baqui AH, Zaman K, Ake Persson L, El Arifeen S, Le K, et al. Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. American Journal of Clinical Nutrition 2004;80(4):903-10.
  • Fischer Walker CL, Baqui AH, Ahmed S, Zaman K, El Arifeen S, Begum N, et al. Low-dose weekly supplementation of iron and/or zinc does not affect growth among Bangladeshi infants. European Journal of Clinical Nutrition 2009;63(1):87-92.
Berger 1997 {published data only}
  • Berger J, Aguayo VM, Téllez W, Luján C, Traissac P, San Miguel JL. Weekly iron supplementation is as effective as 5 day per week iron supplementation in Bolivian school children living at high altitude. European Journal of Clinical Nutrition 1997;51(6):381-6.
Da Silva 2008 {published and unpublished data}
Desai 2004 (C) {published data only}
  • Desai MR, Dhar R, Rosen DH,  Kariuki SK, Shi YP, Kager PA, et al. Daily iron supplementation is more efficacious than twice weekly iron supplementation for the treatment of childhood anemia in western Kenya. Journal of Nutrition 2004;134(5):1167-74.
Ekvall 2000 {published data only}
Engstrom 2008 (C) {published data only}
  • Engstrom EM, Castro IR, Portela M, Cardoso LO, Monteiro CA. Effectiveness of daily and weekly iron supplementation in the prevention of anemia in infants. Revista de Saúde Pública 2008;42(5):786-95.
Ermis 2002 {published data only}
  • Ermis B, Demirel F, Demircan N, Gurel A. Effects of three different iron supplementations in term healthy infants after 5 months of life. Journal of Tropical Pediatrics 2002;48(5):280-4.
Evangelista-Salazar 2004 {published data only}
  • Evangelista-Salazar E. Evaluation of the preventive effect of the intermittent provision of iron and vitamin C on the reduction of the iron and neurodevelopment in infants [Evaluacion del efecto preventivo de la administracion intermitente de hierro y vitamina C sobre la disminucion de la reserva de hierro y el neurodesarrollo en lactantes]. Doctoral Thesis. Universidad de Colima, Mexico 2004.
  • Martínez H, Evangelista Salazar JJ, Avila Jiménez L. Iron supplementation for preventing anaemia in infants [Suplementación con hierro para prevenir anemia en la primera infancia]. In: Luis Durán Arenas, Onofre Muñoz Hernández editor(s). La traducción del conocimiento. del resultado de la investigación a la aplicación de los servicios de salud. México, D.F: CAMS, 2006:71-86.
Faqih 2006 {published data only}
  • Faqih AM, Kakish SB, Izzat M. Effectiveness of intermittent iron treatment of two- to six-year-old Jordanian children with iron-deficiency anemia. Food and Nutrition Bulletin 2006;27(3):220-7.
Hall 2002 (C) {published and unpublished data}
  • Hall A, Roschnik N, Ouattara F, Toure I, Maiga F, Sacko M, et al. A randomised trial in Mali of the effectiveness of weekly iron supplements given by teachers on the haemoglobin concentrations of schoolchildren. Public Health Nutrition 2002;5(3):413-8.
Khademloo 2009 {published data only}
  • Khademloo M, Karami H, Ajami A, Yasari M. Comparison of the effectiveness of weekly and daily iron supplementation in 6- to 24-months-old babies in urban health centers of Sari, Iran. Pakistan Journal of Biological Sciences 2009;12(2):195-7.
Liu 1995 (C) {published data only}
  • Liu X-N, Kang J, Zhao L, Viteri FE. Intermittent iron supplementation in Chinese pre-schoolchildren is efficient and safe. Food and Nutrition Bulletin 1995;16(2):139-46.
  • Liu XNA, Liu PY. The effectiveness of weekly iron supplementation regimen in improving the iron status of Chinese children and pregnant women. Biomedical and Environmental Sciences 1996;9(2-3):341-7.
Nguyen 2002 {published data only}
  • Nguyen XN, Berger J, Dao TQ, Nguyen CK, Traissac P, Ha HK. Efficacy of daily and weekly iron supplementation for the control of iron deficiency anaemia in infants in rural Vietnam [Efficacite de la supplementation en fer quotidienne et hebdomadaire pour le controle de l'anemie chez le nourrisson en milieu rural au Vietnam]. Santé (Montrouge, France) 2002;12(1):31-7.
Olsen 2000 {published data only}
  • Olsen A, Nawiri J, Friis H. The impact of iron supplementation on reinfection with intestinal helminths and Schistosoma mansoni in western Kenya. Transactions of the Royal Society of Tropical Medicine Hygene 2000;94(5):493-9.
  • Olsen A, Nawiri J, Magnussen P, Krarup H, Friis H. Failure of twice-weekly iron supplementation to increase blood haemoglobin and serum ferritin concentrations: results of a randomized controlled trial. Annals of Tropical Medicine and Parasitology 2006;100(3):251-63.
Palupi 1997 {published data only}
  • Palupi L, Schultink W, Achadi E, Gross R. Effective community intervention to improve hemoglobin status in preschoolers receiving once-weekly iron supplementation. American Journal of Clinical Nutrition 1997;65(4):1057-61.
Roschnik 2003 (C) {unpublished data only}
  • Roschnik N, Phiri V, Mukaka M. The impact of weekly school-based iron supplementation. Mangochi District, Malawi (Report). Save the Children, USA February 2003.
Roschnik 2004 (C) {published and unpublished data}
Schultink 1995 {published data only}
  • Schultink W, Gross R, Gliwitzki M, Karyadi D, Matulessi P. Effect of daily vs twice weekly iron supplementation in Indonesian preschool children with low iron status. American Journal of Clinical Nutrition 1995;61(1):111-5.
Sen 2009 (C) {published and unpublished data}
  • Sen A, Kanani SJ. Impact of iron-folic acid supplementation on cognitive abilities of school girls in Vadodara. Indian Pediatrics 2009;46(2):137-43.
  • Sen A, Kanani SJ. Physical work capacity of young underprivileged school girls impact of daily vs intermittent iron folic acid supplementation: a randomized controlled trial. Indian Pediatrics 2009;46(10):849-54.
Siddiqui 2004 {published data only}
  • Siddiqui IA, Jaleel A, Rahman MA. Preventive strategy to control iron deficiency anemia in children and adults. Journal of the Pakistan Medical Association 2003;53(4):131-3.
  • Siddiqui IA, Rahman MA, Jaleel A. Efficacy of daily vs. weekly supplementation of iron in schoolchildren with low iron status. Journal of Tropical Pediatrics 2004;5:276-8.
Sinisterra 1997 (C) {published data only}
  • Sinisterra OT, Valdes VE, Valverde C. Effect of supplementation with iron salts and knowledge, attitudes and practices in relation to anaemia among schoolchildren in the province of Cocle, Ministry of Health, Republic of Panama (report). [Efecto de la suplementacion con sales de hierro y de conocimientos, actitudes y practicas en relacion a la anemia en escolares de la provincia de Cocle, Republica de Panama: reporte]. Vol. DCE/18, Panama: INCAP, Ministry of Health, Republic of Panama, 1997.
Soemantri 1997 {published data only}
  • Soemantri AG, Hapsari DE, Susanto JC, Rohadi W, Tamam M, Irawan PW, et al. Daily and weekly iron supplementation and physical growth of school age Indonesian children. Southeast Asian Journal of Tropical Medicine and Public Health 1997;28 Suppl 2:69-74.
Sungthong 2002 {published data only}
  • Sungthong R, Mo-Suwan L, Chongsuvivatwong V, Geater AF. Once weekly is superior to daily iron supplementation on height gain but not on hematological improvement among schoolchildren in Thailand. Journal of Nutrition 2002;132(3):418-22.
  • Sungthong R, Mo-suwan L, Chongsuvivatwong V, Geater AF. Once-weekly and 5-days a week iron supplementation differentially affect cognitive function but not school performance in Thai children. Journal of Nutrition 2004;134(9):2349-54.
Tavil 2003 {published data only}
  • Tavil B, Sipahi T, Gökçe H, Akar N. Effect of twice weekly versus daily iron treatment in Turkish children with iron deficiency anemia. Pediatric Hematology and Oncology 2003;20(4):319-26.
Taylor 2001 {published data only}
  • Taylor M, Jinabhai CC, Couper I, Kleinschmidt I, Jogessar VB. The effect of different anthelmintic treatment regimens combined with iron supplementation on the nutritional status of schoolchildren in KwaZulu-Natal, South Africa: a randomized controlled trial. Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(2):211-6.
Thu 1999 {published data only}
  • Thu BD, Schultink W, Dillon D, Gross R, Leswara ND, Khoi HH. Effect of daily and weekly micronutrient supplementation on micronutrient deficiencies and growth in young Vietnamese children. American Journal of Clinical Nutrition 1999;69(1):80-6.
Verhoef 2002 {published data only}
  • Verhoef H, West CE, Kraaijenhagen R, Nzyuko SM, King R, Mbandi MM. Malarial anemia leads to adequately increased erythropoiesis in asymptomatic Kenyan children. Blood 2002;15(00(10)):489-94.
  • Verhoef H, West CE, Nzyuko SM, de Vogel S, van der Valk R, Wanga MA, et al. Intermittent administration of iron and sulfadoxine-pyrimethamine to control anaemia in Kenyan children: a randomised controlled trial. Lancet 2002;21(360(9337)):908-14.
Yang 2004 (C) {published data only}
  • Yang Q, Yin S, Zhao X, An J. Effect of daily or once weekly iron supplementation on growth and iron status of preschool children. Wei sheng yan jiu = Journal of Hygiene Research 2004;33(2):205-7.
Young 2001 {published data only}
  • Young MW. The effectiveness of weekly iron and vitamin supplementation of Malawian preschool children. South African Medical Journal = Suid-Afrikaanse tydskrif vir geneeskunde 2001;91(1):49-50.
Yurdakok 2004 {published data only}
  • Yurdakök K, Temiz F, Yalçin SS, Gümrük F. Efficacy of daily and weekly iron supplementation on iron status in exclusively breast-fed infants. Journal of Pediatric Hematology/Oncology 2004;26(5):284-8.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Agarwal 2003 {published data only}
  • Agarwal KN, Gomber S, Bisht H, Som M. Anemia prophylaxis in adolescent school girls by weekly or daily iron-folate supplementation. Indian Pediatrics 2003;40(4):296-301.
Ahmed 2001 {published data only}
  • Ahmed F, Khan MR, Jackson AA. Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh. American Journal of Clinical Nutrition 2001;74(1):108-15.
Ahmed 2005 {published data only}
  • Ahmed F, Khan MR, Akhtaruzzaman M, Karim R, Marks GC, Banu CP, et al. Efficacy of twice-weekly multiple micronutrient supplementation for improving the hemoglobin and micronutrient status of anemic adolescent schoolgirls in Bangladesh. American Journal of Clinical Nutrition 2005;82(4):829-35.
Avila-Jimenez 2011 {unpublished data only}
  • Ávila Jiménez L, Méndez, Villalpando-Hernández S, Martínez-Salgado H. Preventive iron supplementation and nutritional status of infants measured by anthropometry assigned to IMSS obligatory regimen [Suplementación preventiva con hierro y estado nutricio medido por antropometría de lactantes del régimen obligatorio del IMSS]. Unpublished article sent by Dr Homero Martinez.
  • Ávila-Jiménez L, Méndez I, Villalpando-Hernández S, Martínez-Salgado H. Effect of iron supplementation on growth velocity in infants [Efecto de una suplementación con hierro sobre la velocidad de crecimiento en lactantes]. Unpublished article sent by Dr Homero Martinez.
Azeredo 2010 {published data only}
  • Azeredo CM, Cotta RM, Sant'Ana LF, Franceschini Sdo C, Ribeiro Rde C, Lamounier JA, et al. Greater effectiveness of daily iron supplementation scheme in infants [Efectividad superior del esquema diario de suplementación de hierro en lactantes]. Revista de Saúde Pública  2010;44(2):230-9.
Beasley 2000 {published data only}
Briars 2003 {published data only}
  • Adank C, Green TJ, Skeaff CM, Briars B. Weekly high-dose folic acid supplementation is effective in lowering serum homocysteine concentrations in women. Annals of Nutrition and Metabolism 2003;47(2):55-9.
Februhartanty 2002 {published data only}
Hafeez 1998 {published data only}
  • Hafeez A, Ahmad P. Iron deficiency anaemia: continuous versus intermittent treatment in anaemic children. Journal of the Pakistan Medical Association 1998;48(9):269-72.
Hop 2005 {published data only}
  • Hop LT, Berger J. Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial. Journal of Nutrition 2005;135(3):660s-5s.
Jackson 2003 {published data only}
  • Jackson RT, Al-Mousa Z, Al-Raqua M, Prakash P. Effect of short-term weekly supplementation on anemia and symptoms in adolescent Kuwaiti girls. Kuwait Medical Journal 2003;35(4):275-80.
Jaleel 2004 {published data only}
Jayatissa 1999 {published data only}
  • Jayatissa R, Piyasena P. Adolescent schoolgirls: daily or weekly iron supplementation. Food and Nutrition Bulletin 1999;20(4):429-34.
Kanal 2005 {published data only}
  • Kanal K, Busch-Hallen J, Cavalli-Sforza T, Crape B, Smitasiri S, Cambodian Weekly Iron-Folic Acid Program Team. Weekly iron-folic acid supplements to prevent anemia among Cambodian women in three settings: process and outcomes of social marketing and community mobilization. Nutrition Reviews 2005;63(12 Pt 2):S126-33.
Kapur 2003 {published data only}
  • Kapur D, Sharma S, Agarwal KN. Effectiveness of nutrition education, iron supplementation or both on iron status in children. Indian Pediatrics 2003;40(12):1131-44.
Kianfar 2000 {published data only}
  • Kianfar H, Kimiagar M, Ghaffarpour M. Effect of daily and intermittent iron supplementation on iron status of high school girls. International Journal for Vitamin and Nutrition Research 2000;70(4):172-7.
Lechtig 2006 {published data only}
  • Lechtig A, Gross R, Vivanco OA, Gross U, López de Romaña D. Lessons learned from the scaling-up of a weekly multimicronutrient supplementation program in the integrated food security program (PISA). Food and Nutrition Bulletin 2006;27 Suppl Peru(4):160-5.
Leenstra 2009 {published data only}
  • Leenstra T, Kariuki SK, Kurtis JD, Oloo AJ, Kager PA, Ter Kuile FO. The effect of weekly iron and vitamin A supplementation on hemoglobin levels and iron status in adolescent schoolgirls in western Kenya. European Journal of Clinical Nutrition 2009;63(2):173-82.
Lima 2006 {published data only}
  • Lima AC, Lima MC, Guerra MQF, Romani SAM, Eickmann SH, Lira PIC. Impact of weekly treatment with ferrous sulfate on hemoglobin level, morbidity and nutritional status of anemic infants. Jornal de Pediatria 2006;82(6):452-7.
Lin 2001 {published data only}
  • Lin X, Tang Y, Long Z. Effects of vitamin A and iron supplementation on the improvement of iron status and immunological function in preschool children. Chinese Journal of Preventive Medicine - Zhonghua Yu Fang Yi Xue Za Zhi 2001;35(6):374-7.
López de Romaña 2005 {published data only}
  • López de Romaña G, Cusirramos S, López de Romaña D, Gross R. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants. Journal of Nutrition 2005;135(3):646s-52s.
López de Romaña 2006 {published data only}
  • López de Romaña D, Verona S, Vivanco OA, Gross R. Protective effect of multimicronutrient supplementation against anemia among children, women, and adolescent girls in lower-income areas of Chiclayo, Peru. Food and Nutrition Bulletin 2006;27 Suppl Peru(4):S143-50.
Menendez 1997 {published data only}
  • Menendez C, Kahigwa E, Hirt R, Vounatsou P, Aponte JJ, Font F, et al. Randomised placebo-controlled trial of iron supplementation and malaria chemoprophylaxis for prevention of severe anaemia and malaria in Tanzanian infants. Lancet 1997;350(9081):844-50.
Mwanakasale 2009 {published data only}
  • Mwanakasale V, Siziya S, Mwansa J, Koukounari A, Fenwick A. Impact of iron supplementation on schistosomiasis control in Zambian school children in a highly endemic area. Malawi Medical Journal 2009;21(1):12-8.
Perrin 2002 {published data only}
  • Perrin E, Rothman R, Coyne-Beasley T, Ford C, Bordley WC. Is weekly iron and folic acid supplementation as effective as daily supplementation for decreasing incidence of anemia in adolescent girls?. Archives of Pediatrics and Adolescent Medicine 2002;156(2):128-30.
Risonar 2008 {published data only}
  • Risonar MG, Tengco LW, Rayco-Solon P, Solon FS. The effect of a school-based weekly iron supplementation delivery system among anemic schoolchildren in the Philippines. European Journal of Clinical Nutrition 2008;62(8):991-6.
Rivera 1998 {published data only}
  • Rivera G, De Thomson M. Effect of ferrous salts supplementation on iron status of schoolchildren, Chiriqui, Panama, 1995-1997 [Efecto de la suplementacion con sales ferrosas en el estado nutricional de hierro de escolares, Chiriqui, Panama, 1995-1997]. Panama: Ministry of Health, Republic of Panama, 1998.
Schümann 2009 {published data only}
  • Schümann K, Longfils, P, Monchy D, von Xylander S, Weinheimer H,  Solomons NW. Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: a placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age. European Journal of Clinical Nutrition 2009;63(3):355-68.
Shah 2002 {published data only}
  • Shah BK, Gupta P. Weekly vs daily iron and folic acid supplementation in adolescent Nepalese girls. Archives of Pediatrics and Adolescent Medicine 2002;156(2):131-5.
Sharma 2000 {published data only}
  • Sharma A, Prasad K, Rao KV. Identification of an appropriate strategy to control anemia in adolescent girls of poor communities. Indian Pediatrics 2000;37(3):261-7.
Shobha 2003 {published data only}
  • Shobha S, Sharada D. Efficacy of twice weekly iron supplementation in anemic adolescent girls. Indian Pediatrics 2003;40(12):1186-90.
Smuts 2005 {published data only}
  • Smuts CM, Dhansay MA, Faber M, van Stuijvenberg ME, Swanevelder S, Gross R, et al. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, and growth in South African infants. Journal of Nutrition 2005;135(3):653s-9s.
Soekarjo 2004 {published data only}
  • Soekarjo DD, Pee S de, Kusin JA, Schreurs WH. Schultink W, Muhilal, et al. Effectiveness of weekly vitamin A (10,000 IU) and iron (60 mg) supplementation for adolescent boys and girls through schools in rural and urban East Java, Indonesia. European Journal of Clinical Nutrition 2004;58(6):927-37.
Sotelo-Cruz 2002 {published data only}
  • Sotelo-Cruz N, Gómez-Rivera N, Ferrá-Fragoso S, Pereyda-Galaz DE. Ferrous sulfate weekly dose for iron deficiency in preschool children. Gaceta Médica de México 2002;138(3):225-30.
Tee 1999 {published data only}
  • Tee ES, Kandiah M, Awin N, Chong SM, Satgunasingam N, Kamarudin L, et al. School-administered weekly iron-folate supplements improve hemoglobin and ferritin concentrations in Malaysian adolescent girls. American Journal of Clinical Nutrition 1999;69(6):1249-56.
Tomashek 2001 {published data only}
  • Tomashek KM, Woodruff BA, Gotway CA, Bloland P, Mbaruku G. Randomized intervention study comparing several regimens for the treatment of moderate anemia among refugee children in Kigoma Region,Tanzania. American Journal Tropical Medicine and Hygiene 2001;64(3-4):164-71.
UNICEF 2006 {published data only}
  • Ministry of Health Panama, UNICEF, PAHO. [Situacion de deficiencia de hierro y anemia]. Status of iron deficiency and anaemia. Panama: UNICEF, 2006.
Vir 2008 {published data only}
  • Vir SC, Singh N, Nigam AK, Jain R. Weekly iron and folic acid supplementation with counselling reduces anemia in adolescent girls: a large-scale effectiveness study in Uttar Pradesh, India. Food and Nutrition Bulletin 2008;29(3):186-94.
Wijaya-Erhardt 2007 {published data only}
  • Wijaya-Erhardt M, Erhardt JG, Untoro J, Karyadi E, Wibowo L, Gross R. Effect of daily or weekly multiple-micronutrient and iron foodlike tablets on body iron stores of Indonesian infants aged 6-12 mo: a double-blind, randomized, placebo-controlled trial. American Journal of Clinical Nutrition 2007;86(6):1680-6.
Zavaleta 2000 {published data only}
  • Zavaleta N, Respicio G, Garcia T. Efficacy and acceptability of two iron supplementation schedules in adolescent school girls in Lima, Peru. Journal of Nutrition 2000;130(2):462s-4s.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Husseini 1999 {unpublished data only}
  • Husseini T. Bagor, Indonesia Trial. Information included in Beaton 1999.
Kargarnovin 2010 {published data only}
  • Kargarnovin Z, Tamkins A, Jalaly M, Salavan K, Pam L. Effects of daily versus weekly iron therapy in infants between 6-24 months for iron deficiency anemia. Journal of Nursing and Midwifery 2010;20(69):48.
Reid 2001 {published data only}
  • Reid ED, Lopez P, Galaviz IA, Isoard F, Rosado JL, Allen LH. Hematological and biochemical responses of rural Mexican preschoolers to iron alone or iron plus micronutrients. FASEB Journal. 2001; Vol. 15:A731.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Zeeba Zaka-ur-Rab 2010 {published data only}
  • Dr. Zeeba Zaka-ur-Rab. A clinical trial to compare the effects of daily versus intermittent iron supplementation on markers of oxidative stress and anti-oxidant status in children with iron deficiency anemia . The Clinical Trials Registry- India (CTRI).

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
ACC/SCN 1991
  • Administrative Committee on Coordination/Subcommittee on Nutrition (United Nations). Controlling iron deficiency. ACC/SCN State of the Art Series. Vol. Nutrition Policy Discussion Paper No 9, Geneva: United Nations Administrative Committee on Coordination: Subcommittee on Nutrition, 1991.
Adetifa 2009
Balshem 2010
Baqui 2005
  • Baqui AH, Fischer Walker CL, Zaman K, Arifeen SE, Chowdhury HR, Wahed MA, et al. Weekly iron supplementation does not block increases in serum zinc due to weekly zinc supplementation in Bangladeshi infants. Journal of Nutrition 2005;135(9):2187-91.
Beard 2008
Beaton 1999
  • Beaton GH, McCabe GP. Efficacy of intermittent iron supplementation in the control of iron deficiency anaemia in developing countries. An analysis of experience (final report). Ottawa: The Micronutrient Initiative, 1999.
Bhutta 2009
  • Bhutta Z, Klemm R, Shahid F, Rizvi A, Rah JH, Christian P. Treatment response to iron and folic alone is the same as with multivitamins and/or anthelminthics in severely anemic 6 to 24-month-old children. Journal of Nutrition 2009;139(8):1568.
Borenstein 2008
  • Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to Meta-Analysis (Statistics in Practice). Chichester (UK): John Wiley & Sons, 2008.
Bothwell 2000
Casanueva 2003
Cole 2010
  • Cole CR, Grant FK, Swaby-Ellis ED, Smith JL, Jacques A, Northrop-Clewes CA, et al. Zinc and iron deficiency and their interrelations in low-income African American and Hispanic children in Atlanta. American Journal of Clinical Nutrition 2010;91(4):1027-34.
Davidsson 2003
De-Regil 2011
  • De-Regil LM, Pena-Rosas JP, Flores-Ayala R, Jefferds MED. WHO/CDC logic model for micronutrient interventions in public health. FASEB Journal March 17, 2011;25:108.1.
Fernández-Gaxiola 2011
  • Fernández-Gaxiola AC, De-Regil LM, Nasser M. Intermittent iron supplementation for reducing anaemia and its associated impairments in women of reproductive age. Cochrane Database of Systematic Reviews 2011, Issue 12. [DOI: 10.1002/14651858.CD009218]
Gera 2007
  • Gera T, Sachdev HP, Nestel P, Sachdev SS. Effect of iron supplementation on haemoglobin response in children: systematic review of randomised controlled trials. Journal of Pediatric Gastroenterology and Nutrition 2007;44(4):468-86.
GRADEpro 2008
  • Jan Brozek, Andrew Oxman, Holger Schünemann. GRADEpro Version 3.2 for Windows. Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group, 2008.
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: John Wiley & Sons, 2011.
Iannoti 2006
  • Iannotti LL, Tielsch JM, Black MM, Black RE. Iron supplementation in early childhood: health benefits and risks. American Journal of Clinical Nutrition 2006;84(6):1261-76.
Lozoff 2000
Lozoff 2007
Mills 2009
  • Mills RJ, Davies MW, McGuire W. Iron supplementation in enterally fed preterm infants. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD005095]
Moy 2006
NIH 2011
  • NIH Iron and Malaria Technical Working Group. Chapter 2: Mechanisms. In: Raiten D, Namaste S, Brabin B editor(s). Considerations for the Safe and Effective use of Iron Interventions. Bethesda: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), 2011 (in press):16-51.
Okebe 2011
Olsen 2006
  • Olsen A, Nawiri J, Magnussen P, Krarup H, Friis H. Failure of twice weekly iron supplementation to increase blood haemoglobin and serum ferritin concentrations: results of a randomized controlled trial. Annals of Tropical Medicine and Parasitology 2006;100(3):251-63.
Peña-Rosas 2009
RevMan 2011
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