Intervention Review

You have free access to this content

Hydrocolloid dressings for healing diabetic foot ulcers

  1. Jo C Dumville1,*,
  2. Sohan Deshpande2,
  3. Susan O'Meara3,
  4. Katharine Speak4

Editorial Group: Cochrane Wounds Group

Published Online: 6 AUG 2013

Assessed as up-to-date: 11 APR 2013

DOI: 10.1002/14651858.CD009099.pub3


How to Cite

Dumville JC, Deshpande S, O'Meara S, Speak K. Hydrocolloid dressings for healing diabetic foot ulcers. Cochrane Database of Systematic Reviews 2013, Issue 8. Art. No.: CD009099. DOI: 10.1002/14651858.CD009099.pub3.

Author Information

  1. 1

    University of Manchester, Department of Nursing, Midwifery and Social Work, Manchester, UK

  2. 2

    Kleijnen Systematic Reviews, York, UK

  3. 3

    University of Leeds, School of Healthcare, Leeds, UK

  4. 4

    York, UK

*Jo C Dumville, Department of Nursing, Midwifery and Social Work, University of Manchester, Manchester, M13 9PL, UK. jo.dumville@manchester.ac.uk.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 6 AUG 2013

SEARCH

References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Clever 1995 {published data only}
  • Clever HU, Dreyer M. Comparing two wound dressings for the treatment of neuropathic diabetic foot ulcers. Proceedings of the 5th European Conference on Advances in Wound Management; 1995, 21-24 November; Harrogate, UK. 1995:201-3.
Jeffcoate 2009 {published data only}
  • Jeffcoate WJ, Price PE, Phillips CJ, Game FL, Mudge E, Davies S, et al. Randomised controlled trial of the use of three dressing preparations in the management of chronic ulceration of the foot in diabetes. Health Technology Assessment 2009;13(54):1-110.
Jude 2007 {published data only}
Kuo 2012 {published data only}
  • Kuo Y-S, Chien H-F, Lu W. Plectranthus amboinicus and Centella asiatica Creamforthe Treatment of Diabetic Foot Ulcers. Evidence-Based Complementary and Alternative Medicine 2012;418679:doi: 10.1155/2012/418679.
Piaggesi 2001 {published data only}

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Agas 2006 {published data only}
  • Agas CM, Bui TD, Driver VR, Gordon IL. Effect of window casts on healing rates of diabetic foot ulcers. Journal of Wound Care 2006;15(2):80-3.
Ahroni 1993 {published data only}
Altman 1993 {published data only}
  • Altman MI, Mulder GD. Multi-centre evaluation of Nu-Gel wound dressing in full-thickness chronic wounds of the lower extremities. 3rd European Conference on Advances in Wound Management; 1993, 19-22 October; Harrogate, UK. 1993:164-5.
Alvarez 2003 {published data only}
  • Alvarez OM, Roger RS, Booker JG, Patel M. Effect of non contact normothermic wound therapy on the healing of neuropathic (diabetic) foot ulcers: an interim analysis of 20 patients. Journal of Foot and Ankle Surgery 2003;42(1):30-5.
Apelqvist 1990 {published data only}
Apelqvist 1996 {published data only}
  • Apelqvist J, Ragnarson-Tennvall G. Cavity foot ulcers in diabetic patients: a comparative study of cadexomer iodine ointment and standard treatment. An economic analysis alongside a clinical trial. Acta Dermato-Venereologica 1996;76(3):321-5.
Apelqvist 2004 {published data only}
  • Apelqvist J, Piaggesi A. Enamel matrix protein in diabetic foot ulcers, a controlled multicentre study. 2nd World Union of Wound Healing Societies Meeting; 2004 ,8-13 July; Paris. 2004:8-13.
Armstrong 2004 {published data only}
  • Armstrong DG, Lavery LA, Frykberg RG, Andros G, Attinger CE, Boulton AJM. VAC therapy appears to heal complex DFU. 2nd World Union of Wound Healing Societies Meeting; 2004 ,8-13 July; Paris. 2004:22.
Baker 1993 {unpublished data only}
  • Baker NR, Creevy J. A randomised comparative pilot study to evaluate Allevyn hydrocellular dressings and Sorbsan calcium-alginate dressings in the treatment of diabetic foot ulcers. Unpublished 1993.
Belcaro 2010 {published data only}
  • Belcaro G, Cesarone MR, Errichi BM, Ricci A, Dugall M, Pellegrini L, et al. Venous and diabetic ulcerations: management with topical multivalent silver oxide ointment. Panminerva Medica 2010;52(2 (Suppl 1)):37-42.
Blackman 1994 {published data only}
  • Blackman JD, Senseng D, Quinn L, Mazzone T. Clinical evaluation of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers. Diabetic Care 1994;17(4):322-5.
Bogaert 2004 {published data only}
  • Bogaert T, Meert S, Derre B, Goethals E. Topical autologous platelet gel enhances healing of chronic diabetic ulcer: Preliminary report. 2nd World Union of Wound Healing Societies Meeting; 2004 ,8-13 July; Paris. 2004:114.
Bradshaw 1989 {published data only}
  • Bradshaw T, Gem J, Boulton A. The use of Kaltostat in the treatment of ulceration in the diabetic foot. Chiropodist 1989;44(9):204-7.
Caravaggi 2003 {published data only}
  • Caravaggi C, De Giglio R, Pritelli C, Sommaria M, Dalla Noce S, Faglia E, et al. HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers: a prospective, multicenter, controlled, randomized clinical trial. Diabetes Care 2006;10:2853-9.
Chang 2000 {published data only}
  • Chang DW, Sanchez LA, Veith FJ, Wain RA, Okhi T, Suggs WD. Can a tissue-engineered skin graft improve healing of lower extremity foot wounds after revascularization?. Annals of Vascular Surgery 2000;14(1):44-9.
Chauhan 2003 {published data only}
  • Chauhan VS, Rasheed MA, Pandley SS, Shukla VK. Nonhealing wounds - a therapeutic dilemma. International Journal of Lower Extremity Wounds 2003;2(1):40-5.
Chirwa 2010 {published and unpublished data}
  • Chirwa Z, Bhengu T, Litiane K. The cost effectiveness of using calcium alginate silver matrix in the treatment of wounds. European Wound Management Association Journal 2010;10(2):257, Abstract P299.
Cuevas 2007 {published data only}
  • Cuevas FR, Velázquez Méndez AA, Andrade IC. Zinc hyaluronate effects on ulcers in diabetic patients [Efecto delhialuronato de zinc sobre las úlceras en pacientes con diabetes]. Gerokomos 2007;18(2):91-105.
D'Hemecourt 1998 {published data only}
  • D'Hemecourt PA, Smiell JM, Karim MR. Sodium carboxymethyl cellulose aqueous-based gel vs becaplermin gel in patients with nonhealing lower extremity diabetic ulcers. Wounds 1998;10(3):69-75.
Dash 2009 {published data only}
  • Dash NR, Dash SN, Routray P, Mohapatra S, Mohapatra PC. Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells. Rejuvenation Research 2009;12(5):359-66.
Diehm 2005 {published data only}
Donaghue 1998 {published data only}
  • Donaghue VM, Chrzan JS, Rosenblum BI, Giurini JM, Habershaw GM, Veves A. Evaluation of a collagen-alginate wound dressing in the management of diabetic foot ulcers. Advances in Wound Care 1998;11(3):114-9.
Driver 2006 {published data only}
  • Driver VR, Hanft J, Fylling CP, Beriou JM, and Autologel Diabetic Foot Ulcer Study Group. A prospective randomized controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers. Ostomy/Wound Management 2006;52(6):68-70, 72, 74.
Edmonds 2009 {published data only}
Eginton 2003 {published data only}
  • Eginton MT, Brown KR, Seabrook GR, Towne JB, Cambria RA. A prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds. Annals of Vascular Surgery 2003;17(6):645-9.
Etoz 2003 {published data only}
  • Etoz A, Ozgenel Y, Ozcan M. The use of negative pressure wound therapy on diabetic foot ulcers: a preliminary controlled trial. Wounds: A Compendium of Clinical Research and Practice 2004;16(8):264-9.
Farac 1999 {published data only}
  • Farac KP, Grief R, Sessler DI. Radiant heat bandage speeds healing of diabetic-neuropathic foot ulcers. 31st Annual Wound, Ostomy and Continence Conference; 1999 June; Minneapolis, MN. 1999:488.
Foo 2004 {published data only}
  • Foo LSS, Chua BSY, Chia GT, Tan SB, Howe TS. Vacuum assisted closure vs moist gauze dressing in post-operative diabetic foot wounds: early results from a randomised controlled trial. 2nd World Union of Wound Healing Societies Meeting; 2004 ,8-13 July; Paris. 2004:8-9.
Foster 1994 {published data only}
  • Foster AVM. Comparing dressings for diabetic foot ulcers - letter. Journal of Wound Care 1995;4(1):10.
  • Foster AVM, Greenhill MT, Edmonds ME. A randomised comparative study to compare Allevyn hydrocellular dressings and Kaltostat calcium-sodium alginate dressings in the treatment of diabetic foot ulcers. 5th Annual Symposium on Advanced Wound Care; 1992, 23-25 April; New Orleans, Lousiana. 1992:146.
  • Foster AVM, Greenhill MT, Edmonds ME. A randomised comparative study to compatre Allevyn hydrocellular dressings and Kaltostat calcium-sodium alginate dressings in the treatment of diabetic foot ulcers. 2nd European Conference on Advances in Wound Management; 1992, 20-23 October; Harrogate, UK. 1993:77.
  • Foster AVM, Greenhill MT, Edmonds ME. Comparing two dressings in the treatment of diabetic foot ulcers. Journal of Wound Care 1994;3(5):224-8.
Foster 1999 {published data only}
  • Foster A, Bates M, Doxford M, Edmonds ME. Treatment of indolent neuropathic ulceration of the diabetic foot with Hyaff. The Diabetic Foot 1999;2(2):72.
Gao 2007 {published data only}
  • Gao L, Xu GX, Zhou HB. Efficacy evaluation of diabetic foot ulceration treated with iodophors dressings therapy. Journal of Clinical Nursing 2007;6(4):21-2.
Gentzkow 1996 {published data only}
Gottrup 2011 {published data only}
  • Gottrup F, Gibson M, Karlsmark T, Bishoff-Mikkelsen M, Nisbet L, Cullen B. Collagen/ORC/silver treatment of diabetic foot ulcers; a randomised controlled trial. Wound Repair and Regeneration  2011;19(2):A24.
  • Gottrup F, Karlsmark T, Cullen B, Gibson M, Nisbet L. Comparative clinical study to determine the effects of collagen/orc+silver therapy on wound healing of diabetic foot ulcers. EWMA Journal 2010;10(2):83 Abstract 126.
Hanft 2002 {published data only}
  • Hanft JR, Surprenant MS. Healing of chronic foot ulcers in diabetic patients treated with a human fibroblast-derived dermis. Journal of Foot and Ankle Surgery 2002;41(5):291-1.
Jeffery 2008 {published data only}
  • Jeffery S. A honey-based dressing for diabetic foot ulcers: a controlled study. Diabetic Foot Journal 2008;11(2):87-91.
Jensen 1998 {published data only}
  • Jensen JL, Seeley J, Gillin B. A controlled, randomized comparison of two moist wound healing protocols: Carrasyn hydrogel wound dressing and wet-to-moist saline gauze. Advances in Wound Care 1998;11(7 (Suppl)):1-4.
Kordestani 2008 {published data only}
  • Kordestani S, Shahrezaee M, Tahmasebi MN, Hajimahmodi H, Ghasemali DH, Abyaneh MS. A randomised controlled trial on the effectiveness of an advanced wound dressing used in Iran. Journal of Wound Care 2008;17(7):323-7.
Lalau 2002 {published data only}
  • Lalau JD, Bresson R, Charpentier P, Coliche V, Erlher S, Ha Van G, et al. Efficacy and tolerance of calcium alginate versus Vaseline gauze dressings in the treatment of diabetic foot lesions. Diabetes and Metabolism 2002;28(3):223-9.
  • Lalau JD, Samardzic M. Algoderm dressing versus Vaseline gauze for the treatment of diabetic foot lesions. First World Wound Healing Congress; 2000, 10-13 September; Melbourne, Australia. 2000:96.
Landsman 2010 {published data only}
  • Landsman A, Agnew P, Parish L, Joseph R, Galiano RD. Diabetic foot ulcers treated with becaplermin and TheraGauze, a moisture-controlling smart dressing: a randomized, multicenter, prospective analysis. Journal of the American Podiatric Medical Association 2010;100(3):155-60.
Lazaro-Martinez 2007 {published data only}
  • Lázaro-Martíneza JL, García-Moralesa E, Aragón-Sánchezc FJ. Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers. EWMA Journal 2008;8(2 (Suppl)):Poster 371.
  • Lázaro-Martíneza JL, García-Moralesa E, Beneit-Montesinosa JV, Martínez-de-Jesúsb FR, Aragón-Sánchezc FJ. Randomized comparative trial of a collagen/oxidized regenerated cellulose dressing in the treatment of neuropathic diabetic foot ulcers [Estudio aleatorizado y comparativo de unapósito de colágeno y celulosa oxidadaregenerada en el tratamiento de úlcerasneuropáticas de pie diabético]. Cirugia Espanola 2007;82(1):27-31.
Lipkin 2003 {published data only}
  • Lipkin S, Chaikof E, Isseroff Z, Silverstein P. Effectiveness of bilayered cellular matrix in healing of neuropathic diabetic foot ulcers: results of a multicenter pilot trial. Wounds: A Compendium of Clinical Research and Practice 2003;15(7):230-6.
Markevich 2000 {published data only}
  • Markevich YO, McLeod-Roberts J, Mousley M, Melloy E. Maggot therapy for diabetic neuropathic foot wounds. Diabetologia. Northampton, UK, 2000; Vol. 43, issue Suppl 1:A15.
Marston 2001 {published data only}
  • Marston W, Foushee K, Farber M. Prospective randomized study of a cryopreserved, human fibroblast-derived dermis in the treatment of chronic plantar foot ulcers associated with diabetes mellitus. 14th Annual Symposium on Advances in Wound Care and Medical Research Forum on Wound Repair; 2001 30 April - 3 May; Las Vegas, Nevada. 2001.
Mazzone 1993 {published data only}
  • Mazzone T, Blackman JD. Evaluation of a new loaded foam membrane on the healing rate of diabetic foot ulcers. 1st Joint Meeting of the Wound Healing Society and the European Tissue Repair Society; 1993, August; Amsterdam, the Netherlands 1993:88.
McCallon 2000 {published data only}
  • McCallon SK, Knight CA, Valiulus JP, Cunningham MW, McCulloch, Farinas LP. Vacuum-assisted closure versus saline moistened gauze in the healing of postoperative diabetic foot wounds. Ostomy/Wound Management 2000;46(8):28-34.
Mody 2008 {published data only}
  • Mody GN, Nirmal IA, Duraisamy S, Perakath B. A blinded, prospective, randomized controlled trial of topical negative pressure wound closure in India. Ostomy/Wound Management 2008;54(12):36-46.
Moretti 2009 {published data only}
  • Moretti B, Notarnicola A, Maggio G, Moretti L, Pascone M, Tafuri S, et al. The management of neuropathic ulcers of the foot in diabetes by shock wave therapy. BMC Musculoskeletal Disorders 2009; Vol. 10, issue 54. [DOI: 10.1186/1471-2474-10-54]
Mueller 1989 {published data only}
Mulder 1994 {published data only}
  • Mulder GD, Jensen JL, Seeley JE, Peak Andrews K. A controlled randomized study of an amorphous hydrogel to expedite closure of diabetic ulcers. 4th European Tissue Repair Society Meeting; 1994, 25-28 August; Oxford, England. 1994:130.
Munter 2006 {published data only}
  • Munter KC, Beele H, Russell L, Basse E, Grochenig E, Crespi A, et al. The CONTOP study: improved healing of delayed healing ulcers with sustained silver-releasing foam dressing versus other silver dressings. 16th Conference of the European Wound Management Association; 2006, 18-20 May; Prague, Czech Republic. 2006:210, Abstract No.P068.
  • Munter KC, Beele H, Russell L, Basse PB, Groechenig E, Crespi A, et al. The CONTOP study: a large-scale,comparative, randomized study in patients treated with a sustained silver-releasing foam dressing. SAWC; 30 April-3 May 2006; San Antonio,Texas. 2006:Poster 11.
  • Munter KC, Beele H, Russell L, Crespi A, Grocenig E, Basse P, et al. Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study. Journal of Wound Care 2006;15(5):199-205.
  • Russell L, Nebbioso G, Munter KC, Beele H, Basse PB, Dienst H. The Contop study: a hydro-activated silver containing foam dressing versus standard care. 2nd World Union of Wound Healing Societies Meeting; 2004 ,8-13 July; Paris. 2004:89.
  • Scalise A, Forma O, Happe M, Hahn TW. The Contop study: real life experiences from an international study comparing a silver containing hydro-activated foam dressing with standard wound care. 13th Conference of the European Wound Management Association; 2003, 22-24 May; Pisa, Italy. 2003:212.
Novinscak 2010 {published data only}
  • Novinscak T, Zvorc M, Trojko S, Jozinovic E, Filipovic M, Grudic R. Comparison of cost-benefit of the three methods of diabetic ulcer treatment: dry, moist and negative pressure. Acta Medica Croatica 2010;64(Suppl 1):113-5.
Palao i Domenech 2008 {published data only}
  • Palao i Domenech R, Romanelli M, Tsiftsis DD, Slonkova V, Jortikka A, Johannesen N, et al. Effect of an ibuprofen-releasing foam dressing on wound pain: a real-life RCT. Journal of Wound Care 2008;17(8):342, 344-8.
Parish 2009 {published data only}
  • Parish L, Routh H, Parish J. Diabetic foot ulcers: a randomized multicenter study comparing a moisture-controlling dressing with a topical growth factor. Journal of the American Academy of Dermatology 2009;60(Suppl 3):AB202.
Pham 1999 {published data only}
  • Pham HT, Rosenblum BI, Lyons TE, Giurini JM, Chrzan JS, Habershaw GM, et al. Evaluation of a human skin equivalent for the treatment of diabetic foot ulcers in a prospective, randomized, clinical trial. Wounds: A Compendium of Clinical Research and Practice 1999;11(4):76-86.
Piaggesi 1997 {published data only}
  • Piaggesi A. A thin hydrocolloid occlusive dressing in diabetic foot ulcerations. Journal of Wound Care 1997;6(3):10.
Reyzelman 2009 {published data only}
Roberts 2001 {published data only}
  • Roberts GH, Hammad LH, Haggan G, Baker N, Sandeman D, Mani R, et al. Hydrocellular against non-adherent dressings to treat diabetic foot ulcers - a randomised controlled study. 11th European Tissue Repair Society Annual Conference; 2001 5-8 September; Cardiff, Wales. 2001:50.
Robson 2005 {published data only}
  • Robson MC, Payne WG, Garner WL, Biundo J, Giacalone VF, Cooper DM, et al. Integrating the results of phase IV(post marketing) clinical trial with four previous trials reinforces the position that Regranex (Becaplermin) gel 0.01% is an effective adjunct to the treatment of diabetic foot ulcers. Journal of Applied Research 2005;5(1):35-45.
Robson 2009 {published data only}
  • Robson V, Dodd S, Thomas S. Standardized antibacterial honey (Medihoney) with standard therapy in wound care: randomized clinical trial. Journal of Advanced Nursing  2009 ;65 (3):565-75.
Sabolinski 2000 {published data only}
  • Sabolinski M, Giovino K, Graftskin Diabetic Foot Ulcer Study Group. Risk factors associated with the healing of diabetic foot ulcers. Wound Healing Society Educational Symposium; 2000, 4-6 June; Toronto, Canada. 2000:14.
  • Sabolinski M, Toole T, Giovino K, Apligraft Diabetic Foot Ulcer Study Group. Apligraf (Graftskin) bilayered living skin construct in the treatment of diabetic foot ulcers. First World Wound Healing Congress; 2000, 10-13 September; Melbourne, Australia. 2000:68-9.
  • Sabolinski ML, Veves A. Graftskin (Apligraf) in neuropathic diabetic foot ulcers. Wounds: A Compendium of Clinical Research and Practice 2000;12(5 (Suppl A)):33A-6A.
  • Sabolinski ML, Veves A. Graftskin bilayered living skin construct in the treatment of diabetic foot ulcers. 13th Annual Symposium on Advanced Wound Care and 10th Annual Medical Research Forum on Wound Repair; 2000, 1-4 April; Dallas, Texas. 2000:C72-C73.
  • Veves A, Falango V, Armstrong DG, Sabolinski ML. Graftskin (Apligraf) a human skin equivalent, promotes wound healing in diabetic foot ulcers in a prospective, randomized, multicenter clinical trial. Tenth Annual Meeting of the European Tissue Repair Society; 24–27 May 2000; Brussels, Belgium. 2000.
Sabolinski 2001 {published data only}
  • Sabolinski M, Falanga V. The healing of diabetic plantar foot ulcers of greater than two-month duration with Graftskin in a randomized prospective study. Eleventh Annual Meeting and Educational Symposuim Wound Healing Society; 2001, 16-18 May; Albuquerque, New Mexico. 2001:148.
Shaw 2010 {published data only}
  • Shaw J, Hughes CM, Lagan KM, Stevenson MR, Irwin CR, Bell PM. The effect of topical phenytoin on healing in diabetic foot ulcers: a randomised controlled trial. Diabetologia 2010;53(Suppl 1):S463.
Shukrimi 2008 {published data only}
  • Shukrimi A, Sulaiman AR, Halim AY, Azril A. A comparative study between honey and povidone iodine as dressing solution for Wagner type II diabetic foot ulcers. Medical Journal of Malaysia 2008;63(1):44-6.
Sibbald 2011 {published data only}
  • Sibbald RG, Coutts P, Woo KY. Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressing-clinical trial results. Advances in Skin and Wound Care  2011;24(2):78-84.
Solway 2011 {published data only}
Steed 1992 {published data only}
  • Holloway GA, Steed DL, DeMarco MJ, Matsumoto T, Moosa HH, Webster MW, et al. A randomized controlled multicenter dose response trial of activated platelet supernatant topical CT-102 in chronic nonhealing diabetic wounds. Wounds: A Compendium of Clinical Research and Practice 1993;5(4):198-206.
  • Steed DL. Growth factors in managing diabetic foot ulcers. 5th Annual Symposium on Advanced Wound Care; 1992, 23-25 April; New Orleans, Lousiana. 1992.
  • Steed DL, Goslen JB, Holloway GA, Malone JM, Bunt TJ, Webster MW. Randomized prospective double-blind trial in healing chronic diabetic foot ulcers. Diabetic Care 1992;15(11):1598-604.
Steed 1995 {published data only}
  • Steed DL, Ricotta JJ, Prendergast JJ, Kaplan RJ, Webstar MW, McGill JB. Promotion and acceleration of diabetic ulcer healing by arginine-glycine-aspartic acid (RGD) peptide matrix. RGD Study Group. Diabetes Care 1995;18(1):39-46.
Steed 1996 {published data only}
  • Steed DL, Edington HD, Webster MW. Recurrence rate of diabetic neurotrophic foot ulcers healed using topical application of growth factors released from platelets. Wound Repair and Regeneration 1996;4(2):230-3.
Subrahmanyam 1993 {published data only}
  • Subrahmanyam M. Honey as a surgical dressing for burns and ulcers. Indian Journal of Surgery 1993;55(9):468-73.
Trial 2010 {published data only}
  • Teot L, Trial C, Lavigne JP. Results of RCT on the antimicrobial effectiveness of a new silver alginate wound dressing. European Wound Management Association Journal 2008;8(Suppl 2):54 Abstract no. 69.
  • Trial C, Darbas H, Lavigne J. Assessment of the antimicrobial effectiveness of a new silver alginate wound dressing: a RCT. Journal of Wound Care 2010;19(1):20-6.
Turns 2012 {published data only}
  • Turns M. Evaluation of NOSF in neuropathic diabetic. Wounds UK 2012;8(1):100-6.
Urbaneie-Rovan 1999 {published data only}
  • Urbaneie-Rovan V. Efficacy and cost of different dressings. Practical Diabetes International 1999;16(2):S3.
Vandeputte 1997 {published data only}
  • Vandeputte J, Gryson L. Clinical trial on the control of diabetic foot infection by an immunomodulating hydrogel containing 65% glycerine. Proceedings of the 6th European Conference on Advances in Wound Management; 1-4 October, 1996; Amsterdam. 1996:50-3.
  • Vandeputte J, Gryson L. Diabetic foot infection controlled by immuno-modulating hydrogel containing 65% glycerine. Personal Communication: Presentation of a clinical trial. 1996.
Varma 2006 {published data only}
  • Varma AK, Bal A, Kumar H, Kesav R, Nair S. Efficacy of polyurethane foam dressing in debrided diabetic lower limb wounds. Wounds: A Compendium of Clinical Research and Practice 2006;18(10):300-6.
Veves 2001 {published data only}
Veves 2002 {published data only}
  • Sheehan P, Jones P,   Caselli A, Giurini JM, Veves A. Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Diabetes Care  2003;26(6):1879-82.
  • Veves A. Promogran clinical trial. The Diabetic Foot 2001;4(4):S4-S5.
  • Veves A. Wound care device expert meeting. Summary report. Promogran - clinical trial data. The Diabetic Foot  2001;4(3):S8-S10.
  • Veves A, Sheehan P, Pham HT. A randomized controlled trial of Promogran (a collagen / oxidised regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Archives of Surgery 2002;137:822-7.
Whalley 2001 {published data only}
  • Capillas R, Whalley A, Boulton AMJ, Dargis V, Harding K, Van Acker K. Performance characteristics and safety of hydrogels using a non-adhesive foam dressing as secondary dressing in the treatment of diabetic foot ulcers. 12th Conference of the European Wound Management Association;2002, 23-25 May; Granada, Spain. 2002:261.
  • Whalley A, Boulton AJM, Dargis V, Harding K, Van Acker K, Capillas R. Characteristics of the efficacy and safety of a hydrogen using a hydropolymer as the secondary dressing in the treatment of ulcers of the diabetic foot. 12th Conference of the European Wound Management Association;2002, 23-25 May; Granada, Spain. 2002:322.
  • Whalley A, Boulton AJM, Dargis V, Harding K, Van Acker K, Capillas R. Performance characteristics and safety of Purilon gel versus Intrasite using Biatain non-adhesive dressing as secondary dressing in the treatment of diabetic foot ulcers. 11th European Tissue Repair Society Annual Conference; 2001 5-8 September; Cardiff, Wales. 2001:49.
Woo 2010 {published data only}
  • Woo K, Sibbald G, Coutts P. Reduction of infection and pain in chronic wounds using a new antimicrobial foam dressing. EWMA Journal 2010;10(2):59 Abstract 78.
Yao 2007 {published data only}
  • Yao XZ, Chen W. Effectiveness of feet soaking with Chinese herbs combined with changing dressings in the treatment of diabetic foot ulceration. Journal of Nursing Science 2007;22(5):42-3.
Zimny 2003 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Ogce 2007 {published data only}
  • Ogce F, Dramali A. The treatment of diabetic foot ulcers. Sendrom 2007;19(12):79-81.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. Additional references
Abbott 2002
Apelqvist 2000a
Apelqvist 2000b
Becker 2011
  • Becker LA, Oxman AD. Chapter 22: Overviews of reviews. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Bergin 2006
BNF 2010
  • British Medical Association and Royal Pharmaceutical Society of Great Britain. British National Formulary Appendix 8: Wound management products and elastic hosiery. http://www.bnf.org.uk/bnf/bnf/current Sept 2010;60.
Cardinal 2009
Currie 1998
Deeks 2002
Diabetes UK 2011
  • Reports and statistics. http://www.diabetes.org.uk/Professionals/Publications-reports-and-resources/Reports-statistics-and-case-studies/Reports/. www.diabetes.org.uk, (accessed July 2011).
Dorresteijn 2001
  • Dorresteijn JA N, Kriegsman DM W, Assendelft WJJ, Valk GD. Patient education for preventing diabetic foot ulceration. Cochrane Database of Systematic Reviews 2001, Issue 4. [DOI: 10.1002/14651858.CD001488.pub2]
Dorresteijn 2010
Dumville 2011a
  • Dumville JC, Deshpande S, O'Meara S, Speak K. Foam dressings for healing diabetic foot ulcers. Cochrane Database of Systematic Reviews 2011, Issue 9. [DOI: 10.1002/14651858.CD009111.pub2.]
Dumville 2011b
  • Dumville JC, O'Meara S, Deshpande S, Speak K. Hydrogel dressings for healing diabetic foot ulcers. Cochrane Database of Systematic Reviews 2011, Issue 5. [DOI: 10.1002/14651858.CD009101.pub2]
Dumville 2012
  • Dumville JC, O'Meara S, Deshpande S, Speak K. Alginate dressings for healing diabetic foot ulcers. Cochrane Database of Systematic Reviews 2012, Issue 2. [DOI: 10.1002/14651858.CD009110]
Edwards 2010
Fiskin 1996
Gregg 2004
  • Gregg EW, Sorlie P, Paulose-Ram R, Gu Q, Eberhardt MS, Wolz M, et al. Prevalence of lower-extremity disease in the U.S. adult population >40 years of age with and without diabetes. Diabetes Care 2004;27(7):1591-7.
Higgins 2003
Higgins 2011
  • Higgins JPT, Altman DG, on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (Editors). Chapter 8:  Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Hinchliffe 2008
Kumar 1994
Lefebvre 2011
  • Lefebvre C, Manheimer E, Glanville J, on behalf of the Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Margolis 1999
Mason 1999
Moher 2010
  • Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG, for the CONSORT Group. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trial. BMJ 2010;340:c869.
Morris 1998
  • Morris AD, McAlpine R, Steinke D, Boyle DI, Ebrahim AR, Vasudev N, et al. Diabetes and lower limb amputations in the community. A retrospective cohort study. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside Scotland/Medicines Monitoring Unit. Diabetes Care 1998;21:738-43.
Murray 1996
Nelson 2006
O'Meara 2000
  • Meara S, Cullum N, Majid M, Sheldon T. Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration. Health Technology Assessment 2000;4(21):1-237.
Oyibo 2001
  • Oyibo SO, Jude EB, Tarawneh I, Nguyen HC, Harkless LB, Boulton AJ. A comparison of two diabetic foot ulcer classification systems: the Wagner and the University of Texas wound classification systems. Diabetes Care 2001;24(1):84-8.
Pecoraro 1990
Pound 2005
Reiber 1996
  • Reiber G. The epidemiology of diabetic foot problems. Diabetic Medicine 1996;13S:S6-11.
Reiber 1999
  • Reiber GE, Vileikyte L, Boyko EJ, del Aguila M, Smith DG, Lavery LA, et al. Causal pathways for incident lower extremity ulcers in patients with diabetes from two settings. Diabetes Care 1999;22:157-62.
RevMan 2011
  • The Nordic Cochrane Centre. Review Manager (RevMan) Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration 2011.
Schaper 2004
Schulz 2010
  • Schulz KF, Altman DG, Moher D, CONSORT Group. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. PLoS Medicine 2010;7(3):e1000251.
SIGN 2011
  • Scottish Intercollegiate Guidelines Network (SIGN). Search filters. http://www.sign.ac.uk/methodology/filters.html#random.
Singh 2005
Smith 2003
  • Smith J. A national survey of podiatry practice in the treatment of diabetic foot ulcers. Unpublished.
Spencer 2000
  • Spencer S. Pressure relieving interventions for preventing and treating diabetic foot ulcers. Cochrane Database of Systematic Reviews 2000, Issue 3. [DOI: 10.1002/14651858.CD002302]
Steed 2006
Storm-Versloot 2007
  • Storm-Versloot MN, Vos CG, Ubbink DT, Vermeulen H. Topical silver for preventing wound infection. Cochrane Database of Systematic Reviews 2007, Issue 2. [DOI: 10.1002/14651858.CD006478]
Tesfaye 1996
  • Tesfaye S, Stephens L, Stephenson J, Fuller J, Platter ME, Ionescu-Tirgoviste C, et al. The prevalence of diabetic neuropathy and its relationship to glycaemic control and potential risk factors: The EURODIAB IDDM complications study. Diabetalogia 1996;39:1377-84.
Tierney 2007
Van Gils 1999
  • Van Gils C, Wheeler LA, Mellsrom M, Brinton EA, Mason S, Wheeler CG. Amputation prevention by vascular surgery and podiatry collaboration in high risk diabetic and non-diabetic patients - the operation desert foot experience. Diabetes Care 1999;22(5):678-83.
Wagner 1981
  • Wagner FW. The dysvascular foot: a system of diagnosis and treatment. Foot and Ankle 1981;2:64-122.
WHO 2005
  • Diabetes estimates and projections. http//www.who.int/diabetes/facts/world-figures/en/index4.html (accessed 23 February 2011).
Wild 2004
Winter 1963
Wrobel 2001
  • Wrobel JS, Mayfield JA, Reiber GE. Geographic variation of lower limb extremity major amputation in individuals with and without diabetes in the Medicare population. Diabetes Care 2001;24:860-4.