Plain language summary
Dietary supplements for preventing postnatal depression
Postnatal depression is a common condition that affects women and may impact on their babies. Common symptoms of postnatal depression include fluctuations in mood, mood changes, suicidal ideation and preoccupation with infant well-being ranging from over-concern to frank delusions. There is currently not much evidence regarding interventions that might prevent or treat postnatal depression. A diet lacking in certain vitamins, minerals or other nutrients may cause postnatal depression in some women. Correcting this deficiency with dietary supplements might therefore prevent postnatal depression. Examples of possible dietary supplements aimed at preventing postnatal depression include omega-3 fatty acids, iron, folate, s-adenosyl-L-methionine, vitamin B12 (cobalamin), B6 (pyridoxine), B2 (riboflavin), vitamin D and calcium.
This review identified two randomised controlled studies. One study examined the effect of selenium supplements taken by women from the first trimester to birth in preventing postnatal depression. This study had a high risk of bias because of women withdrawing or not completing their self-scoring system for depression (Edinburgh Postnatal Depression Scale). It may also have been difficult to ensure that the women took their supplements because of concerns that exist about taking supplements during pregnancy. More high-quality studies would be required to confirm any benefit in preventing postnatal depression using selenium.
This review also identified one randomised controlled study that compared docosahexanoic and eicosapentaenoic acid to placebo in women at risk of postpartum depression. This study found that neither docosahexanoic acid nor eicosapentaenoic acid prevented postpartum depression.
Overall, there is not enough evidence at this stage to recommend selenium, docosahexanoic acid, eicosapentaenoic acid or any other dietary supplement for the prevention of postnatal depression. Unfortunately there were no other studies of other dietary supplements that met our selection criteria. Other dietary supplements need to be studied in trials where depressed women are excluded from entry to determine if supplements prevent postnatal depression.
Compléments alimentaires pour la prévention de la dépression post-natale
La dépression postnatale est une pathologie courante qui affecte les femmes et peut avoir un impact sur leurs bébés. Les symptômes courants de la dépression postnatale comprennent les fluctuations de l'humeur, les changements d'humeur, des idées et des préoccupations sur le bien-être de l’enfant, allant d’un investissement exagéré jusqu’à des idées délirantes à ce sujet. Il n'existe pas actuellement beaucoup de preuves concernant les interventions qui pourraient permettre de prévenir ou traiter la dépression postnatale. Un régime alimentaire pauvre en certaines vitamines et minéraux ou d'autres nutriments peut entraîner une dépression postnatale chez certaines femmes. La correction de ces carences avec compléments alimentaires pourrait donc prévenir la dépression postnatale. Exemples de possibles compléments alimentaires visant à prévenir la dépression postnatale sont des acides gras oméga-3, du fer, de l'acide folique, s-adénosyl-L-méthionine, de la vitamine B12 (cobalamine), B6 (pyridoxine), B2 (riboflavine), D et du calcium.
Cette revue a identifié deux études contrôlées randomisées. Une étude a examiné l'effet de suppléments de sélénium pris par les femmes à partir du premier trimestre et la naissance dans la prévention de la dépression post-natale. Cette étude présentait un risque élevé de biais en raison du nombre de femmes qui arrêtaient ou ne terminaient pas leur système d’auto rapport pour le traitement de la dépression (Echelle de dépression postnatale d’Edimbourg). Il pourrait avoir été difficile de s'assurer que les femmes prenaient leur suppléments en raison de doutes que subsistent quant à la prise de compléments alimentaires pendant la grossesse. D'autres études de qualité seraient nécessaires pour confirmer un éventuel bénéfice dans la prévention de la dépression post-natale à l'aide de sélénium.
Cette revue a également identifié une étude contrôlée randomisée qui comparaient l’acide docosahexanéoïque et l'acide eicosapentaénoïque à un placebo chez les femmes présentant un risque de dépression post-partum. Cette étude a trouvé que ni l’acide docosahexanéoïque ni l'acide eicosapentaénoïque prévenaient la dépression post-partum.
Dans l'ensemble, il n'existe pas suffisamment de preuves à ce stade pour recommander le sélénium, l’acide docosahexanéoïque, l'acide eicosapentaénoïque ou d'autres compléments alimentaires pour la prévention de la dépression postnatale. Malheureusement, il n'y avait pas d'autres études portant sur d'autres suppléments alimentaires qui remplissaient nos critères de sélection. D'autres compléments alimentaires doivent être étudiés dans les essais dans lesquels les femmes déprimées sont exclues d’emblée et déterminer si les compléments préviennent la dépression post-natale.
Notes de traduction
Traduit par: French Cochrane Centre 9th January, 2014
Traduction financée par: Financeurs pour le Canada : Instituts de Recherche en Sant� du Canada, Minist�re de la Sant� et des Services Sociaux du Qu�bec, Fonds de recherche du Qu�bec-Sant� et Institut National d'Excellence en Sant� et en Services Sociaux; pour la France : Minist�re en charge de la Sant�
Dodaci prehrani za sprječavanje depresije nakon porođaja
Poslijeporođajna depresija je često stanje koje pogađa žene i može utjecati na njihovu djecu. Najčešći simptomi poslijeporođajne depresije uključuju promjene raspoloženja, samoubilačke ideje i pretjeranu zaokupljenost novorođenčetom u rasponu od pretjerane brige do doslovnih zabluda. Trenutno nema mnogo dokaza u učinkovitosti postupaka koji bi mogli spriječiti ili liječiti poslijeporođajnu depresiju. Ako u prehrani žene nedostaje manjka nekih vitamina, minerala i drugih hranjivih tvari, to može dovesti do poslijeporođajne depresije kod nekih žena. Stoga bi se ispravljanjem takvih nedostataka pomoću dodataka prehrani moglo spriječili nastanak poslijeporođajne depresije. Primjeri mogućih dodataka prehrani s ciljem sprječavanja poslijeporođajne depresije su omega-3 masne kiseline, željezo, folna kiselina, e-adenozil-L-metionin, vitamin B12 (kobalamin), B6 (piridoksin), B2 (riboflavin), vitamin D i kalcij.
Ovaj Cochrane sustavni pregled je pronašao dvije nasumične kontrolirane studije na tu temu. Jedna studija ispitala je učinak dodatka selena koje su uzimale žene od prvog tromjesečja do rođenja djeteta na sprečavanje poslijeporođajne depresije. Ta studija ima visok rizik od pristranosti zbog velikog broja žena koje su odustale od sudjelovanja u istraživanju ili jer nisu potpuno ispunile upitnik za depresiju (Edinburgh ljestvica poslijeporođajne depresije). Također može biti teško osigurati da žene zaista uzimaju propisane dodatke zbog moguće brige o štetnosti uzimanja takvih dodataka tijekom trudnoće. Potrebno je provesti više studija visoke kvalitete kako bi potvrdili bilo kakve koristi od selena za sprječavanje poslijeporođajne depresije.
Ovaj pregled je također pronašao jedno nasumično kontrolirano ispitivanje koje uspoređuje dokozaheksanoičnu i eikozapentaensku kiselinu s placebom u žena koje imaju rizik od poslijeporođajne depresije. To istraživanje pokazalo je da nijedna od tih kiselina ne sprječava poslijeporođajnu depresiju.
Sve u svemu, ne postoji dovoljno dokaza u ovom trenutku za preporučiti selen, dokozaheksanoičnu kiselinu, eikozapentaensku kiselinu ili bilo koji drugi dodatak prehrani za sprječavanje poslije porođajnedepresije. Nažalost, nije bilo drugih studija o drugim dodatcima prehrani koje bi udovoljile kriterijima uključenja studija u ovaj sustavni pregled. Ostali dodatci prehrani trebaju se istražiti u pokusima u kojima se neće uključiti depresivne žene, da bi utvrdili da li dodatci sprječavaju poslije porođajnu depresiju.
Prevela: Božena Armanda
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Description of the condition
Postnatal mood disorders are heterogeneous (Brockington 2004) and range from postnatal blues that affect 15% to 80% of postnatal women (Beck 2006; Pitt 1973), to postpartum psychosis that affects one in 2000 women (Kendell 1987). The Diagnostic and Statistical Manual of Mental Disorders (DSM) (APA 2000) defines postnatal depression as a major depressive episode with postpartum onset if the onset is within four weeks postpartum. It distinguishes postpartum depressive episodes from the 'baby blues', which affect up to 80% of women during the first 10 days postpartum, but are transient and do not impair functioning (APA 2000; Cox 2003). The DSM IV and International Classification of Diseases (ICD-10) criteria concur that postnatal depression can last for any length of time between two weeks and one year postpartum, and is differentiated from normal postpartum emotional adjustment by the pattern of symptoms, and the severity and consistency with which they occur (Cox 1987a; Cox 2003; Gibbon 2004). The DSM is published by the American Psychiatric Association (APA) and provides a common language and standards for classification of mental disorders. It is used mostly in the United States. The ICD-10, produced by the World Health Organization, is another standard of classification and is mainly used in Europe. Symptoms of postnatal depression include mood lability, sleep disturbances such as waking at night or early rising not related to the baby, appetite disturbances and weight loss, ‘thought blocking’ and mental sluggishness, suicidal ideation, and preoccupation with infant well-being ranging from over-concern to frank delusions. Delusions are associated with an increased risk of harm to the infant (Austin 2008; Brockington 2004). Although not classified as a distinct syndrome, the ICD10 classifies depression after childbirth as “mild (four symptoms), moderate (five symptoms) or severe (five symptoms or more, plus agitation, feelings of worthlessness or guilt or suicidal thoughts or acts)” (Fisher 2009).
Whether postnatal depression is distinct from major depression, or just coincidental timing of a major depressive episode with the postnatal period is an area of speculation (Brockington 1996; Steiner 1990). The major life changes associated with the transition to motherhood are an obvious potential stressor, and cause emotional disruption in even the most resilient of women (Beck 2006). However, it is unlikely that the most important precipitating factors of an episode of postnatal depression are particular to pregnancy and its aftermath (Brockington 1996; Hanley 2009). Whilst the prevalence of depression in postnatal women is similar to the incidence in the general female population, there is a three-fold increase in the incidence of depression in the first five weeks postpartum (Cox 1993). Approximately one-third of women who develop postnatal depression may experience symptoms in the first four weeks; two-thirds will develop them between 10 and 14 weeks; and cases who present later are often misdiagnosed or missed altogether (Hanley 2009). Three longitudinal studies from both high-income countries (US and UK) and low- and middle-income countries (Brazil) have found an increase in the incidence and symptoms of postnatal depression around three months postpartum, with a second peak occurring around nine months postpartum (Gjerdingen 2011; Lobato 2011; Nott 1987). Nott 1987 even suggests that the incidence of new cases of postnatal depression was highest three to nine months postpartum, which is outside of the period when women would have regular contact with postpartum clinical services and depression screening.
The problem for prevention and treatment lies in the lack of consensus regarding the aetiology, definition, and tools for detection of this condition. Consequently, the study and management of women with "melancholia" after childbirth (Brockington 1996) has fallen between several disciplines - that of primary care, obstetrics, and psychiatry. Also, there are multiple pathways towards an episode of postnatal depression, and different women will find alternative modes of treatment and/or support to be effective (Austin 2008; NHMRC 1999).
Description of the intervention
The overall hypothesis of this review is that certain dietary deficiencies in a pregnant or postnatal woman's diet may cause postnatal depression. Hence, correcting these deficiencies with dietary supplements could prevent postnatal depression.
The intervention considered was dietary supplements given before the onset or diagnosis of postnatal depression. Examples include omega-3 fatty acids, iron, calcium, vitamin B12 (cobalamin), riboflavin (B2), vitamin B6 (pyridoxine), folate, S-adenosyl-methionine (SAMe) and vitamin D (Freeman 2009). Dietary supplements were defined as any vitamin, mineral or compound that exists naturally and could be reasonably expected to be part of the normal human diet. Intervention with supplementation would be expected to correct a current or potential deficit in these vitamins, minerals or other compounds.
Omega-3 polyunsaturated fatty acids are found in oily fish and seafood as docosahexanoic acid (DHA) and eicosapentaenoic acid (EPA). During the last century, the diets of industrialised societies have contained significantly lower amounts of omega-3 fatty acids, and relatively higher levels of omega-6 polyunsaturated fatty acids Simopoulos 2008). There also appears to be a correlation between fish consumption rates and depression, with lower reported incidence of depression in people from Hong Kong, China, and Japan compared with Western countries (Hibbeln 2002). Lower rates of fish consumption have also been correlated with higher rates of postnatal depression (Rees 2005). Women have been found to be depleted in omega-3 polyunsaturated fatty acids during gestation and breastfeeding as there is preferential diversion of omega-3 fats to the baby (Huang 2013). It has been hypothesised that if low omega-3 levels are associated with depression, one reason women are more vulnerable to depression postnatally is due to depletion of their omega-3 fatty acids (Rees 2005). A previous non-Cochrane systematic review (Wojcicki 2011) looked at the association between omega-3 fatty acid supplementation and the risk of perinatal depression. It reviewed 10 articles and found that six found no association, two found mixed results and two found a positive association between omega-3 supplementation and reduced risk of perinatal depression. This review included longitudinal cohort studies, randomised controlled trials and pilot trials. All of the randomised controlled trials included mixed populations of depressed and non-depressed women on entry into the studies so none of these studies could be classified as purely investigating a prevention effect of omega-3 fatty acids on postnatal depression. One of the pilot studies in which women were excluded at entry if they were depressed showed no preventive effect of omega-3 fatty acids on perinatal depression (Marangell 2004).
Other dietary deficiencies may play a part in postnatal depression. In one study, iron treatment resulted in a 25% improvement in previously iron-deficient mothers’ depression and stress scales, whereas anaemic mothers who received placebo did not improve (Beard 2005). Anaemia is a risk factor for postnatal depression (Corwin 2003), hence postpartum haemorrhage may also be a cause of postnatal depression. Albacar (Albacar 2011) found an association between low ferritin 48 hours after delivery and postpartum depression. S-adenosyl-L-methionine, alone or in combination with pharmacologic antidepressants, has been effective in the treatment of major depression (Mischoulon 2002). One prospective study examined the relationship of dietary consumption of folate and B vitamins during pregnancy with the risk of postpartum depression (Miyake 2006). There was no measurable association between intake of folate, cobalamin, or pyridoxine and the risk of postpartum depression. Compared with riboflavin intake in the first quartile, only riboflavin consumption in the third quartile was independently related to a decreased risk of postpartum depression. In another study, nulliparous women, between 11 and 21 weeks' gestation, were randomised to receive either placebo or 2000 mg elemental calcium per day as participants in the NIH-sponsored Calcium for Preeclampsia Prevention (CPEP) trial. The study found there was a trend toward less depression in calcium-supplemented women (Harrison-Hohner 2001). An association has been found between low vitamin D serum levels and depression in older persons (Hoogendijk 2008). If reduced vitamin D levels are linked to depression then it is not unreasonable that correcting a deficiency may be helpful for postnatally depression women.
Hence, certain nutritional deficiencies such as low levels of DHA found in seafood, calcium, B vitamins, vitamin D, and iron have been investigated in relation to postnatal depression but so far this research has been inconclusive (Hanley 2009; Miller 2002). Further research into the biological aetiology of postnatal depression is required, as studies to date have been quasi-experimental, or randomised controlled trials with small sample sizes of varying methodological quality (Dennis 2009; Miller 2002).
How the intervention might work
Dietary supplementation individually or in combination could be shown to indicate a significant effect in preventing postnatal depression.
Specific hypotheses for how each intervention works are related to the particular intervention. For instance, iron supplements may prevent iron deficiency anaemia, hence preventing maternal lethargy and concomitant depression. But iron deficiency also affects electrophysiological recordings and neurotransmitter metabolism with no direct association to anaemia (Beard 2005). Correcting iron deficiency may normalise neural functioning through direct electrochemical mechanisms. S-adenosyl-L-methionine is involved in methylation of biological proteins which are integral to neural functioning of neurotransmitters, phospholipids, and cellular receptors and channels (Mischoulon 2002). Folate also is involved in methylation of homocysteine and a deficiency may have a similar effect biochemically to a deficiency of S-adenosyl-L-methionine (Freeman 2009). Omega-3 fatty acids are known to affect neurotransmitters, peptides, releasing factors, hormones, and a variety of physiological and cognitive processes. Fatty acids also may exert a controlling function in the modulation of neuronal membrane fluidity (Yehuda 1999). Nuclear receptors for vitamin D exist in neurons and glial cells. Vitamin D is involved in the biosynthesis of neurotrophic factors, and at least one enzyme involved in neurotransmitter synthesis. Vitamin D can also inhibit the synthesis of inducible nitric oxide synthase and increase glutathione levels, suggesting a role for the hormone in brain detoxification pathways (Garcion 2002).
The hypothesis upon which this review is based is that postnatal depression can be linked to, or contributed to by a dietary deficiency in one or more compounds, and that replacement of these compounds can prevent postnatal depression. It is also likely that women undergoing pregnancy and childbirth require increased amounts of these compounds compared with non-pregnant women. What is regarded as normal intake outside of pregnancy and childbirth would be insufficient for the extra dietary requirements of pregnancy and childbirth.
Why it is important to do this review
Postnatal depression is the most common complication of childbirth, which not only impacts maternal well-being, but also infant and child development, and family cohesion (Fisher 2009; Harpham 2005). A large systematic review of postnatal depression in low- and middle-income countries identified a pooled prevalence of common postnatal mental disorders of 19.8% (Fisher 2012). Prevalence of postnatal depression has been estimated to be between 10% and 20% worldwide, although rates vary within and between countries (Affonso 2000; O'Hara 1996). Furthermore, the recurrence rate of postnatal depression is significant (25% to 68%) (Dalton 1982; Wisner 2004). Women who have suffered from postnatal depression are also twice as likely to suffer from further episodes of depression over a five-year period (Cooper 1995).
Postnatal depression can cause impaired maternal-infant interactions (Cooper 1998; Murray 1996) and negative perceptions of infant behaviour (Mayberry 1993) that have been linked to attachment insecurity (Hipwell 2000; Murray 1992). Other effects on the infant include cognitive developmental delay (Deave 2008; Hipwell 2000), social/interaction difficulties (Cummings 1994; Murray 1999), impaired expressive language development (Cox 1987), attention- (Breznitz 1988), and long-term behavioural problems (Beck 1999). Infants of depressed mothers have been shown to have a statistically significant poorer growth than infants of non-depressed mothers at the third month postpartum (Adewuya 2008). Child abuse/neglect (Buist 1998) and marital stress resulting in separation or divorce (Boyce 1994; Holden 1991) are other reported outcomes. Effective treatment for postnatal depression may not be sufficient to improve the developing mother-child relationship (Forman 2007). Hence in this aspect, prevention is better than treatment.
Several Cochrane reviews have considered various strategies for the prevention and treatment of postnatal depression. However, to date there appears to be no effective strategy for the prevention of postnatal depression among these reviews. One intervention that might be effective in preventing postnatal depression is telephone-based peer support among women at high risk (Dennis 2009).
Intensive, professionally-based postpartum support for at-risk women appears promising (Dennis 2004); however, antenatal interventions do not appear to be effective (Austin 2008). One review reported that synthetic progestogens could double the incidence of postnatal depression (Dennis 2008a). Oestrogens and natural progesterone have not been tested in a randomised trial. In terms of other alternative therapies, massage and/or acupuncture have not been demonstrated to improve antenatal depression immediately after treatment or prevent postnatal depression (Dennis 2008b). One systematic review found that some psychosocial and psychological interventions for treating postpartum depression appear to be effective in reducing Edinburgh Postnatal Depression Scale (EPDS) scores; however, the methodological quality of the included trials was not strong, and the long-term effectiveness is unclear (Dennis 2007a). There is not enough evidence to demonstrate that these interventions can treat antenatal depression (Dennis 2007b). This is despite the fact that women prefer to have counselling with someone who was non-judgmental, rather than receive pharmacological interventions (Dennis 2006).
Antidepressants given postpartum cannot be recommended for prevention of postnatal depression as there is a lack of clear evidence (Howard 2005). There is also little evidence for using antidepressants for the treatment of postnatal depression (Hoffbrand 2001), although this is certainly the current standard accepted practice among clinicians. Another issue regarding the acceptability of antidepressants as a treatment for postnatal depression is their transfer from mother to infant through breastfeeding, although most antidepressants are believed to be safe with breastfeeding (Kendall-Tackett 2007). Antidepressants given in the third trimester have been associated with transient neonatal withdrawal syndrome, which includes jitteriness, muscle weakness, and respiratory difficulties (Oberlander 2004). There are concerns regarding unknown effects of antidepressants on the fetus and infant as well. There is a paucity of information on the concentrations of different drugs that are excreted in breast milk and their associated toxicity profiles (Fortinguerra 2009; Hanley 2009). Some significant areas of concern exist with antidepressant use in pregnancy, particularly some evidence of higher risk of preterm birth, neonatal adaptation difficulties, and congenital cardiac malformations with paroxetine (Udechuku 2010).
Compared to other treatments, dietary supplements are an inexpensive, readily available form of intervention and are generally free of side effects. Furthermore, there is marketing of over-the-counter dietary supplements in pharmacies and supermarkets for the purpose of preventing postnatal depression, without clear evidence of benefit. On examining the literature there appear to be no concerns mentioned with regard to micronutrient supplementation in pregnancy where it is recommended to correct specific deficiencies (Shah 2009). Concerns have been raised concerning excessive consumption of vitamin A. However, excessive dietary intake of vitamin A has been associated with teratogenicity in humans in less than 20 reported cases over 30 years (Azaïs-Braesco 2000). This review is not intended to address the effects of excessive or supra-physiological doses of dietary supplements. It is intended only to address the effects of correcting dietary deficiencies.
Postnatal depression has a high recurrence rate and treatments may not improve the mother-infant relationship. The symptoms of postnatal depression are generally assumed to have a deleterious effect on mother-infant interaction, as mothers experience low energy levels and ambivalence towards the baby. This in turn inhibits their ability to provide a nurturing, responsive environment for their infants and children (Hanley 2009; Pedros-Rosello 2007). Hence the focus of this review will be on interventions that may prevent this condition.
To assess the effects of dietary supplements used either alone or in combination with pharmacological and non-pharmacological interventions on the incidence of postnatal depression up to 12 months postpartum.
Description of studies
Results of the search
The search of the Cochrane Pregnancy and Childbirth Group's Trials Register retrieved 23 trial reports. Of these, we included six reports (relating to two studies) and excluded 16 reports (relating to 14 studies). One report is awaiting classification. (Figure 1).
Two trials fulfilled our eligibility criteria (Mokhber 2011; Mozurkewich 2013).
The first randomised controlled study (Mokhber 2011) involved 179 Iranian pregnant primigravid women who were randomised to either 100 µg selenium yeast tablets or placebo tablets. Women were screened at recruitment with a Beck Depression Inventory (BDI) test, and those with results indicative of moderate to severe depression were excluded from the study and referred to a psychiatrist. The tablets were given from the first trimester of pregnancy until delivery. Eighty-three were randomised to each arm of the trial. Sixty-one women completed the selenium arm, 44 of whom completed an EPDS test. Sixty-four women completed the placebo arm of the trial, 41 of whom completed an EPDS test.
The second randomised controlled study (Mozurkewich 2013) compared docosahexanoic acid (DHA) and eicosapentaenoic acid (EPA) with placebo. The trial randomised 126 women at risk of postpartum depression to three arms of the trial: 42 were allocated to EPA, 42 to DHA and 42 to placebo. Three women in the EPA arm, four in the DHA arm, and one woman in the placebo arm were lost to follow-up. Women who were found to have major depressive disorder, bipolar disorder, current substance abuse or dependence, suicidal ideation, schizophrenia, coagulation disorders, or known to have a multiple gestation at recruitment were excluded from the study. The women who discontinued the intervention (five in the EPA arm, four in the DHA arm and seven in the placebo arm) were included in the intention-to-treat analysis, while those who were lost to follow-up were not. Women received supplements or placebo from recruitment at gestational age of 12 to 20 weeks until their final review visit at six to eight weeks postpartum. The primary outcome measure was the BDI score at the fifth visit (six to eight weeks postpartum).
We excluded 14 studies. We have described reasons for exclusion in the Characteristics of excluded studies tables. We excluded some studies because they included only participants who were depressed at recruitment and hence were looking at treatment rather than prevention. We also excluded studies if at time of recruitment they did not exclude depressed women and hence had a mixed population of depressed and non-depressed women. Furthermore, the proportion of women with depression at recruitment was high in these studies. It was the opinion of the review authors that including a mixed population of depressed and non-depressed women would confuse the issue of prevention and treatment of postnatal depression.
Risk of bias in included studies
We described the risk of bias of the included studies in the ’Risk of bias tables’ attached to the Characteristics of included studies.
It was ascertained that the study Mokhber 2011 had a high risk of incomplete outcome data due to attrition of participants in the trial. Despite emailing the study authors for more information there was also unclear risk of bias with regard to allocation concealment. Risk of bias was deemed to be low in the areas of random sequence generation, blinding of participants and personnel, blinding of outcome assessment and selective reporting. Another potential area of unclear risk of bias lies in the timing of the administration of the EPDS since true postnatal depression might be confounded with "baby blues" if one arm of the study had a larger proportion of women completing the EPDS during the first 10 days postpartum.
Mozurkewich 2013 had a low risk of bias in the areas of random sequence generation, allocation concealment, blinding of participants and personnel, attrition, blinding of outcome assessment and selective reporting.
Effects of interventions
One included trial in this review (Mokhber 2011) compared daily supplementation with selenium tablets (100 µg) versus a placebo control.
The other included trial (Mozurkewich 2013) compared daily supplementation with EPA capsules with both supplementation with DHA capsules and placebo.
Selenium versus control
Self-reported Edinburgh Postnatal Depression Scale (EPDS)
In Mokhber 2011, selenium tablets had an effect compared with placebo on self-reported EPDS scores in favour of a lower risk of postnatal depression among those women who completed their EPDS (mean difference (MD) -1.90, 95% confidence interval (CI) -3.92 to 0.12), see Analysis 1.1. This effect has a P value of 0.07 and hence does not reach statistical significance.
Mokhber 2011 did not report on any of our secondary outcome measures.
EPA versus control
Beck Depression Inventory Score (BDI)
In Mozurkewich 2013, EPA had no significant effect on BDI scores compared with placebo on prevention of postnatal depression at six to eight weeks postpartum (MD 0.70, 95% CI -1.78 to 3.18) see Analysis 2.1.
Mozurkewich 2013 looked at a number of secondary outcomes. Of the outcomes that are the subject of this review, in Mozurkewich 2013, none of the secondary outcomes showed a significant effect of EPA compared with placebo. In terms of rates of development of major depressive disorder (risk ratio (RR) 1.58, 95% CI 0.28 to 8.94) (Analysis 2.2); rates of commencement of antidepressants (RR 1.58, 95% CI 0.48 to 5.71) (Analysis 2.3); and estimated maternal blood loss at delivery (MD 53.00, 95% CI -123.06 to 229.06) (Analysis 2.4). For rates of neonatal intensive care admissions of the neonates (RR 1.50, 95% CI 0.46 to 4.91) see Analysis 2.5.
DHA versus control
Beck Depression Inventory Score (BDI)
In Mozurkewich 2013, DHA has no significant effect on BDI scores compared with placebo on prevention of postnatal depression at six to eight weeks postpartum (MD -0.20, 95% CI -2.61 to 2.21) see Analysis 3.1.
In Mozurkewich 2013, of the outcomes that are the subject of this review, none of the secondary outcomes showed a significant effect of DHA compared with placebo. In terms of rates of development of major depressive disorder (RR 1.08, 95% CI 0.16 to 7.28) (Analysis 3.2); rates of commencement of antidepressants (RR 1.89, 95% CI 0.60 to 5.94) (Analysis 3.3); and estimated maternal blood loss at delivery (MD 54.00, 95% CI -83.43 to 191.43) (Analysis 3.4). For rates of neonatal intensive care admissions of neonates (RR 0.53, 95% CI 0.10 to 2.71) see Analysis 3.5.
EPA versus DHA
Beck Depression Inventory Score (BDI)
In Mozurkewich 2013, EPA has no significant effect on BDI scores compared with DHA on prevention of postnatal depression at six to eight weeks postpartum (MD 0.90, 95% CI -1.33 to 3.13) see Analysis 4.1.
In Mozurkewich 2013, of the outcomes that are the subject of this review, none of the secondary outcomes showed a significant effect of EPA compared with DHA. In terms of rates of development of major depressive disorder (RR 1.46, 95% CI 0.26 to 8.26) (Analysis 4.2); rates of commencement of antidepressants (RR 0.84, 95% CI 0.31 to 2.26) (Analysis 4.3); and estimated maternal blood loss at delivery (MD -1.00, 95% CI -183.94 to 181.94) (Analysis 4.4). For rates of neonatal intensive care admissions of the neonates (RR 2.85, 95% CI 0.61 to 13.26) see Analysis 4.5.
Summary of main results
The study by Mokhber et al (Mokhber 2011), showed a favourable effect on mean EPDS scores in women in taking selenium 100 µg daily tablets compared with placebo for the prevention of postnatal depression. However this effect did not reach statistical significance.
Mozurkewich 2013 showed no significant effect of EPA or DHA on BDI scores compared with placebo. It also showed no significant effect of EPA or DHA compared with placebo on the secondary outcomes of rates of diagnosis of major depressive disorder, initiation of antidepressants, maternal estimated blood loss at delivery or neonatal intensive care admissions of neonates.
Overall completeness and applicability of evidence
Mokhber 2011 does not provide enough evidence to meet the objectives of this review. As well as not giving a result that reached statistical significance, it also did not report on any of the secondary outcomes of this review.
A number of trials of omega-3 fatty acids have now been performed but all have been excluded from this review because they included depressed women at recruitment. Mozurkewich 2013 is the first published study of omega-3 fatty acids where depressed women are clearly excluded from recruitment. Its results have important implications for practice, even though no effect on postnatal depression was found. Given that the population of women being investigated was a group at risk of depression, it is surprising that the actual rates of women diagnosed with major depressive disorder across the three arms of the study (EPA 8%, DHA 5% and placebo 5%) or the number of women commenced on antidepressants (EPA 15%, DHA 18% and placebo 10% ) are lower than previously published rates in a population at risk of depression (25% to 68%, Dalton 1982; Wisner 2004). Perhaps if this study had continued further into the postpartum period higher rates would have been detected. It is possible a significant effect of the intervention could have been detected with more follow-up visits into the postpartum period.
Many other potential interventions need to be studied. Among the excluded trials calcium (Harrison-Hohner 2001) and iron for iron-deficient anaemic mothers (Beard 2005) seemed promising but included both depressed and non-depressed women at recruitment. Trials where women who are depressed at entry are excluded from recruitment would be needed for more evidence of a preventive effect. Many other dietary supplements are worthy of testing to see if they can prevent postnatal depression.
Quality of the evidence
Mokhber 2011 has a high risk of bias due to large numbers of attrition, both in the numbers that withdrew from the study prior to completion, and in those that completed the study but failed to complete their Edinburgh Postnatal Depression Scale (EPDS) test. It is also unclear how randomisation or allocation concealment was performed, or when in the postnatal period the majority of EPDS questionnaires were completed.
In addition, the report for this study suggests there was difficulty in ensuring participants were compliant with taking their supplements because of concerns that exist about taking supplements during pregnancy. Conversely, the report states that there was a statistically significant higher selenium concentration in the selenium-supplemented group than the control group and this may imply that compliance was satisfactory.
Another strength and weakness of Mokhber 2011 is that it recruited a homogeneous population of women in Iran. While making the results more reliable they are less likely to be generalisable to other locations. The authors of this study recommend a larger multicentre trial.
Given the issues with this study, a robust conclusion regarding the efficacy of selenium for prevention of postnatal depression cannot be made.
Overall, Mozurkewich 2013 had a low risk of bias. It was a well-designed study that followed its previously published protocol and there were low numbers of women who were lost to follow-up. As postnatal depression can take up to 12 months postpartum to appear, one criticism of this study is that six to eight weeks postpartum may be too early to detect an effect of omega-3 supplementation. Perhaps looking for the presence of depression at the time-points of three- and six-month postpartum may show more of an effect, particularly if the population being studied is breastfeeding. Another weakness of this study was that it had the statistical power to detect differences in depressive symptoms, but not in the diagnoses of major depressive disorder.
Potential biases in the review process
A potential source of bias of this review may originate from the search strategy. The search strategy utilised is more likely to detect English language publications. Efforts have been made to identify publications in languages other than English, however, it is possible that relevant publications have not been identified.
Agreements and disagreements with other studies or reviews
No other studies of selenium for prevention of postnatal depression have been found.
The results of Mozurkewich 2013 are consistent with the findings of the study by Makrides et al (Makrides 2010), which found no benefit for DHA-rich fish oil for prevention of depressive symptoms among women who were not selected based on predisposition for depression. They are also consistent with the study by Freeman et al (Freeman 2008), which found no additional benefit for EPA-predominant fish oil compared with interpersonal psychotherapy alone. The findings of this study disagree with those of Su et al (Su 2008) and earlier studies by Freeman et al (Freeman 2006), which were suggestive of benefit. It has been suggested by Mozurkewich et al (Mozurkewich 2013) that one possible reason that the results differ from Freeman 2006 and Su 2008 is that lower doses of EPA and DHA were used in this study compared with the earlier studies. However, Freeman's dose-ranging trial found that higher doses of EPA plus DHA were not more effective than lower doses (Freeman 2006)
We would like to acknowledge the assistance of Dr Vicky Flenady and the Mater Research Support Centre (Mater Health Services Brisbane) in the initial development of this research question.
As part of the pre-publication editorial process, this review has been commented on by three peers (an editor and two referees who are external to the editorial team) and the Group's Statistical Adviser.
The National Institute for Health Research (NIHR) is the largest single funder of the Cochrane Pregnancy and Childbirth Group. The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR, NHS or the Department of Health.
Contributions of authors
Brendan Miller was the main author of this protocol and is the guarantor of the review. Bonnie Macfarlane assisted with the initial registration of the title and defining of the question being addressed. Linda Murray, Michael Beckmann and Terry Kent provided assistance with the main body of the protocol and with editing the protocol.
Brendan Miller and Terry Kent selected eligible studies from those identified in the search strategy and they completed the 'Risk of bias' assessment. Michael Beckmann and Linda Murray provided advice on the inclusion of eligible studies. Brendan Miller and Terry Kent performed data extraction from the one included study. Brendan Miller and Linda Murray performed the data analysis. Linda Murray provided Brendan Miller assistance with editing the review.