Intervention Review

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Psychological treatments for depression and anxiety in dementia and mild cognitive impairment

  1. Vasiliki Orgeta1,*,
  2. Afifa Qazi2,
  3. Aimee E Spector3,
  4. Martin Orrell1

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 22 JAN 2014

Assessed as up-to-date: 11 JAN 2013

DOI: 10.1002/14651858.CD009125.pub2


How to Cite

Orgeta V, Qazi A, Spector AE, Orrell M. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD009125. DOI: 10.1002/14651858.CD009125.pub2.

Author Information

  1. 1

    University College London, Mental Health Sciences Unit, London, UK

  2. 2

    North East London Foundation Trust, Goodmayes Hospital, Brentwood, Essex, UK

  3. 3

    University College, London, Research Department of Clinical, Educational and Health Psychology, London, UK

*Vasiliki Orgeta, Mental Health Sciences Unit, University College London, 67-73 Riding House Street, 2nd Floor, Charles Bell House, London, W1W 7EJ, UK. v.orgeta@ucl.ac.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 22 JAN 2014

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Burgener 2008 {published data only}
  • Burgener SC, Yang Y, Gilbert R, Marsh-Yant S. The effects of a multimodal intervention on outcomes of persons with early-stage dementia. American Journal of Alzheimer’s Disease and Other Dementias 2008;23:382-94.
Burns 2005 {published data only}
  • Burns A, Guthrie E, Marino-Francis F, Busby C, Morris J, Russell E, et al. Brief psychotherapy in Alzheimer's disease: randomised controlled trial. The British Journal of Psychiatry 2005;187:143-7.
Spector 2012 {published data only}
  • Spector A, Orrell M, Lattimer M, Hoe J, King M, Harwood K, et al. Cognitive behavioural therapy (CBT) for anxiety in people with dementia: study protocol for a randomised controlled trial. Trials 2012;13:197.
Stanley 2012 {published data only}
  • Stanley MA, Calleo J, Bush AL, Wilson N, Snow AL, Kraus-Schuman C, et al. The Peaceful Mind Program: A pilot test of a cognitive–behavioral therapy–based intervention for anxious patients with dementia. American Journal of Geriatric Psychiatry 2012;21(7):696-708.
Tappen 2009 {published data only}
Waldorff 2012 {published data only}
  • Waldorff FB, Buss DV, Eckermann A, Rasmussen MLH, Keiding N, Rishøj S, et al. Efficacy of psychosocial intervention in patients with mild Alzheimer’s disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY). BMJ 2012;345:1-14.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Abraham 1992 {published data only}
Beck 2002 {published data only}
  • Beck, C, Vogelpohl, T, Rasin, J, Topps, J, O’Sullivan, P, Walls, R, et al. Effects of behavioral interventions on disruptive behavior and affect in demented nursing home residents. Nursing Research 2002;51(4):219-28.
Brodaty 2003 {published data only}
  • Brodaty H, Draper BM, Millar J, Low L, Lie D, Sharah S, et al. Randomized controlled trial of different models of care for nursing home residents with dementia complicated by depression or psychosis. Journal of Clinical Psychiatry 2003;64:63-72.
Cheston 2003 {published data only}
  • Cheston R, Jones K, Gilliard J. Group psychotherapy and people with dementia. Aging and Mental Health 2003; Vol. 7:452-61.
Dartigues 2008 {published data only}
  • Dartigues JF. Efficacy Assessment of Three Non Pharmacological Therapies in Alzheimer's Disease (ETNA3). Trials Register.
Finnema 2005 {published data only}
  • Finnema E, Droës R, Ettema T, Ooms M, Adèr H, Miel Ribbe M, et al. The effect of integrated emotion-oriented care versus usual care on elderly persons with dementia in the nursing home and on nursing assistants: a randomised clinical trial. International Journal of Geriatric Psychiatry 2005;20:330-43.
Fischer-Terworth 2011 {published data only}
  • Fischer-Terworth C, Probst P. Evaluation of a TEACCH- and music therapy-based psychological intervention in mild to moderate dementia: a controlled trial. Geropsychology 2011;24:93-101.
Fossey 2006 {published data only}
  • Fossey J, Ballard C, Juszczak E, James I, Alder N, Jacoby R, et al. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial. BMJ 2006;332:756-8.
Garland 2007 {published data only}
  • Garland K, Beer E, Eppingstall B, O'Connor DW. A comparison of two treatments of agitated behavior in nursing home residents with dementia: Simulated family presence and preferred music. American Journal of Geriatric Psychiatry 2007;15:514-21.
Helcer 2012 {published data only}
  • Helcer J, Santorelli G, Choi J. Cognitive behavioral therapy to combat hopelessness and low self efficacy in Alzheimer's disease. Alzheimer's Association International Conference. 2012.
Hinchliffe 1997 {published data only}
  • Hinchliffe AC, Katone C, Livingston G. The assessment and management of behavioural manifestations of dementia: a review and results of a controlled trial. International Journal of Psychiatry in Clinical Practice 1997;1:157-68.
Hyer 2008 {published data only}
  • Hyer L, Yeager CA, Hilton N, Sacks A. Group, individual, and staff therapy: an efficient and effective cognitive behavioral therapy in long-term care. American Journal of Alzheimer’s Disease and Other Dementias 2008;23:528-39.
Joosten-Weyn Banningh2011 {published data only}
  • Joosten-Weyn Banningh LW, Prins JB, Vernooij-Dassen MJ, Wijnen HH, Olde Rikkert MG, Kessels RP. Group therapy for patients with mild cognitive impairment and their significant others: results of a waiting-list controlled trial. Gerontology 2011;57:444-54.
Kiosses 2010 {published data only}
  • Kiosses DN, Arean PA, Teri L, Alexopoulos GS. Home-delivered problem adaptation therapy (PATH) for depressed, cognitively impaired, disabled elders: A preliminary study. American Journal of Geriatric Psychiatry 2010;18:988-98.
Kiosses 2011 {published data only}
  • Kiosses DN. Home-delivered intervention for depressed, cognitively impaired elders. Trials Register 2011.
Kolanowski 2011 {published data only}
Konnert 2009 {published data only}
  • Konnert C, Dobson K, Stelmach L. The prevention of depression in nursing home residents: A randomised clinical trial of cognitive–behavioral therapy. Aging and Mental Health 2009;13:288-99.
Kurz 2012 {published data only}
  • Kurz A, Thone-Otto A, Cramer B, Egert S, Frolich L, Gertz HJ, et al. Cordial: cognitive rehabilitation and cognitive-behavioral treatment for early dementia in Alzheimer disease. Alzheimer Disease and Associated Disorders 2012;26:246-53.
Laakkonen 2012 {published data only}
  • Laakkonen M-L, Holtta EH, Savikko N, Strandberg TE, Suominen M, Pitkala KH. Psychosocial group intervention to enhance self-management skills of people with dementia and their caregivers: study protocol for a randomized controlled trial. Trials 2012;13:133.
Lam 2010 {published data only}
  • Lam LCW, Lui VWC, Luk DNY, Chau R, So C, Poon V, et al. Effectiveness of an individualized functional training program on affective disturbances and functional skills in mild and moderate dementia—a randomised control trial. International Journal of Geriatric Psychiatry 2010;25:133–41.
Lichtenberg 2005 {published data only}
Logsdon 2010 {published data only}
  • Logsdon RG, Pike KC, McCurry SM, Hunter P, Maher J, Snyder L, et al. Early-stage memory loss support groups: outcomes from a randomized controlled clinical trial. Journal of Gerontology: Psychological Sciences 2010;65B:691–7.
McSweeney 2012 {published data only}
Mittelman 1996 {published data only}
  • Mittelman MS, Ferris SH, Shulman E, Steinberg G, Levin B. A family intervention to delay nursing home placement of patients with Alzheimer disease. A randomized controlled trial. JAMA 1996;276:1725-31.
Onor 2007 {published data only}
  • Onor M L, Trevisiol M, Negro C, Signorini A, Saina M, Aguglia E. Impact of a multimodal rehabilitative intervention on demented patients and their caregivers. American Journal of Alzheimer's Disease and Other Dementias 2007;22:261-72.
Prick 2011 {published data only}
  • Prick AE, de Lange J, Scherder E, Pot AM. Home-based exercise and support programme for people with dementia and their caregivers: study protocol of a randomised controlled trial. BMC Public Health 2011;11:894.
Proctor 1999 {published data only}
  • Proctor R, Burns A, Powell HS, Tarrier N, Faragher B, Richardson G, et al. Behavioural management in nursing and residential homes: a randomised controlled trial. Lancet 1999;354:26–9.
Rovner 2012 {published data only}
  • Rovner BW, Casten RJ, Hegel MT, Leiby BE. Preventing cognitive decline in older African Americans with mild cognitive impairment: design and methods of a randomized clinical trial. Contemporary Clinical Trials 2012;33:712-20.
Selbaek 2010 {published data only}
  • Selbaek, G. Multidisciplinary intervention for challenging behaviour (agitation) in patients with dementia. Trial Register 2010.
Teri 2003 {published data only}
  • Terri L, Gibbons, LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA 2003;290:2015-22.
Vespa 2002 {published data only}
  • Vespa A, Gori G, Spazzafumo L. Evaluation of non-pharmacological intervention on antisocial behavior in patients suffering from Alzheimer's disease in a day care center. Archives of Gerontology and Geriatrics 2002;34:1-8.
Yesavage 1981 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Carreel 1990 {published data only}
  • Carreel C. Value of conversation groups in institutions for the elderly. Revue de Laryngologie 1990;111:319-23.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Forstmeier 2011 {published data only}
  • Forstmeier S. Cognitive-behavioral treatment for mild Alzheimer's patients and their caregivers. Clinical Trials Register 2011.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Absher 1994
  • Absher JR, Cummings JL. Cognitive and noncognitive aspects of dementia syndromes: An overview. In: Burns A, Levy R editor(s). Dementia. London: Chapman & Hall Medical, 1994.
Alexopoulos 1988
Alexopoulos 2005
  • Alexopoulos GS, Jeste DV, Chung H, Carpenter D, Ross R, Docherty JP. The expert consensus guideline series. Treatment of dementia and its behavioral disturbances. Introduction: methods, commentary, and summary. Postgraduate Medicine 2005;Spec No:6-22.
Areán 2010
  • Areán P A, Raue P, Mackin S, Kanellopoulos D, McCulloch C, Alexopoulos G S. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. American Journal of Psychiatry 2010;167:1391-8.
Azermai 2012
  • Azermai M, Petrovic M, Elseviers MM, Bourgeois J, Van Bortel LM, Vander Stichele RH. Systematic appraisal of dementia guidelines for the management of behavioural and psychological symptoms. Ageing Research Reviews 2012;11:78-86.
Bains 2009
  • Bains J, Birks J, Dening T. Antidepressants for treating depression in dementia. Cochrane Database of Systematic Reviews 2009, Issue Issue 4. Art. No.: CD003944. DOI: 10.1002/14651858.
Ballard 1996
Ballard 2000
  • Ballard C, Neill D, O'Brien J, McKeith IG, Ince P, Perry R. Anxiety, depression and psychosis in vascular dementia: prevalence and associations. Journal of Affective Disorders 2000;59(2):97-106.
Ballard 2001
  • Ballard C, O'Brien J, James I. Dementia: Management of Behavioural and Psychological Symptoms. Oxford: Oxford University Press, 2001.
Banerjee 2011
  • Banerjee S, Hellier J, Dewey M, Romeo R, Ballard C, Baldwin R, et al. Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial. Lancet 2011;378:403-11.
Beck 1961
Beck 1979
  • Beck AT, Rush AJ, Shaw BF, Emery G. Cognitive therapy of depression. New York: Guilford Press, 1979.
Borkovec 2001
  • Borkovec TD, Ruscio AM. Psychotherapy for generalized anxiety disorder. Journal of Clinical Psychiatry 2001;62:15-9.
Brierley 2003
  • Brierley E, Guthrie E, Busby C. Psychodynamic interpersonal therapy for early Alzheimer’s disease. British Journal of Psychotherapy 2003;19:435-46.
Brodaty 2012
Bucks 1996
Crittendon 2006
  • Crittendon J, Hopko DR. Assessing worry in older and younger adults: psychometric properties of an Abbreviated Penn StateWorry Questionnaire (PSWQ-A). Journal of Anxiety Disorders 2006;20:1036–54.
Cummings 1994
Deeks 2001
  • Deeks JJ, Altman DG, Bradburn MJ. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. Systematic Reviews in Health Care: Meta-analysis in Context. 2nd Edition. London UK: BMJ Pubication Group, 2001.
Devanand 2003
Doody 2001
  • Doody R S, Stevens J C, Beck C, Dubinsky R M, Kaye J A, Gwyther L, et al. Practice parameter: management of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001;56(9):1154-66.
Douglas 2004
  • Douglas S, James I, Ballard C. Non-pharmacological interventions in dementia. Advances in Psychiatric Treatment 2004;10:171-7.
Enache 2011
EuroQoL 1990
  • EuroQoL. EuroQol—a new facility for the measurement of health-related quality of life. Health Policy 1990;1:199-208.
Ferreti 2001
Folstein 1975
Gabryelewicz 2004
Galasko 1997
  • Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M. An inventory to assess activities of daily living for clinical trials in Alzheimer’s disease. The Alzheimer’s Disease Cooperative Study. Alzheimer Disease and Associated Disorders 1997;11:33-9.
Gellis 2009
  • Gellis ZD, McClive-Reed KP, Brown EL. Treatments for depression in older persons with dementia. Clinical Care and Aging 2009;17:29-36.
Gibbons 2002
  • Gibbons LE, Teri L, Logsdon R. Anxiety symptoms as predictors of nursing home placement in patients with Alzheimer's disease. Journal of Clinical Geropsychology 2002;8:335-42.
Gitlin 2003
  • Gitlin LN, Winter L, Corcoran M, Dennis MP, Schinfeld S, Hauck WW. Effects of the home environmental skill-building program on the caregiver-care recipient dyad: 6-month outcomes from the Philadelphia REACH Initiative. The Gerontologist 2003;43:532–546.
Gonzalez-Salvador 1999
Gould 1997
  • Gould RA, Otto MW, Pollack MH, Yap L. Cognitive behavioural and pharmacological treatment of generalized anxiety disorders: a preliminary meta-analysis. Behaviour Therapy 1997;28:285-305.
Gould 2012
Grant 1995
  • Grant RW, Casey DA. Adapting cognitive behavioural therapy for the frail elderly. International Psychogeriatrics 1995;7(4):561-71.
Groves 2000
  • Groves WC, Brandt J, Steinberg M, Warren A, Rosenblatt A, Baker A, et al. Vascular dementia and Alzheimer's disease: Is there a difference?. The Journal of Neuropsychiatry and Clinical Neurosciences 2000;12:305-15.
Hersen 1992
Hobson 1985
  • Hobson RF. Forms of Feeling:The Heart of Psychotherapy. London: Tavistock Publications, 1985.
Hogan 2008
  • Hogan DB, Bailey P, Black S, Carswell A, Chertkow H, Clarke B, et al. Diagnosis and treatment of dementia: Nonpharmacologic and pharmacologic therapy for mild to moderate dementia. Canadian Medical Association Journal 2008;179(10):1019-26.
Hughes 1982
Hwang 2004
  • Hwang TJ, Masterman DL, Ortiz F, Fairbanks LA, Cummings JL. Mild cognitive impairment is associated with characteristic neuropsychiatric symptoms. Alzheimer Disease and Associated Disorders 2004;18(1):17-21.
Li 2001
Livingston 2005
  • Livingston G, Johnston K, Katona C, Paton J, Lyketsos CG, Old Age Task Force of the World Federation of Biological Psychiatry. Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia. The American Journal of Psychiatry 2005;162:1996-2021.
Logsdon 1999
  • Logsdon RG, Gibbons LE, McCurry S, Teri L. Quality of life in Alzheimer’s disease: patient and caregiver report (QoL-AD). Journal of Mental Health and Aging 1999;5:21–32.
Lopez 2003
  • Lopez O L, Becker J T, Sweet R A, Klunk, W, Kaufer D I, Saxton J, et al. Psychiatric symptoms vary with the severity of dementia in probable Alzheimer’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences 2003;15:346-53.
Lopez 2005
Lu 2009
Lyketsos 1997
  • Lyketsos CG, Steele C, Baker L, Galik E, Kopunek S, Steinberg M, et al. Major and minor depression in Alzheimer's disease: prevalence and impact. Journal of Neuropsychiatry and Clinical Neurosciences 1997;9(4):556-61.
Lyketsos 2002a
Margallo-Lana 2001
McKeith 1996
  • McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996;47:1113-24.
McKhann 1984
  • McKhann G, Drachman D, Folstein M. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS & ADRDA Work Group under the auspices of Department of Health and Human ServicesTask Force on Alzheimer’s Disease. Neurology 1984;34:939-44.
Mohlman 2005
Monastero 2009
  • Rozzini L, Chilovi BV, Peli M, Conti M, Rozzini R, Trabucchi M, et al. A systematic review of neuropsychiatric symptoms in mild cognitive impairment. Journal of Alzheimers Disorders 2009;18:11-30.
Montgomery 1979
Morris 1993
Novalis 1993
  • Novalis P, Rojcewicz S, Peele R. Clinical manual of supportive psychotherapy. American Psychiatric Publishing, 1993.
Olazarán 2010
  • Olazarán J, Reisberg B, Clare L, Cruz I, Peña-Casanova J, del Ser T, et al. Nonpharmacological therapies in Alzheimer’s disease: A systematic review of efficacy. Dementia and Geriatric Cognitive Disorders 2010;30:161-78.
Olin 2002
  • Olin JT, Schneider LS, Katz IR, Meyers BS, Alexopoulos GS, Breitner JC, et al. Provisional diagnostic criteria for depression of Alzheimer disease. American Journal of Geriatric Psychiatry 2002;10:125-8.
Pachana 2007
Pai 2006
  • Pai ALH, Drotar D, Zebracki K, Moore M, Youngstrom E. A meta-analysis of the effects of psychological interventions in pediatric oncology on outcomes of psychological distress and adjustment. Journal of Pediatric Psychology 2006;31:978-88.
Palmer 2007
Paukert 2010
  • Paukert AL, Calleo J, Kraus-Schuman C, Snow L, Wilson N, Petersen NJ, et al. Peaceful Mind: an open trial of cognitive-behavioral therapy for anxiety in persons with dementia. International Psychogeriatrics 2010;22:1012-21.
Peavey 1997
  • Peavey VR. Sociodynamic Counselling: A Constructivist Perspective for the Practice of Counselling in the 21st Century. Victoria: Trafford Publishing, 1997.
Peplau 1991
  • Peplau HE. Interpersonal relations in nursing: A conceptual frame of reference for psychodynamic nursing. New York: Springer, 1991.
Petersen 1999
Petersen 2003
  • Petersen RC. Conceptual Overview. In: Petersen R C editor(s). Cognitive Impairment: Aging to Alzheimer's Disease. New York: Oxford University Press, 2003:1-14.
Pinquart 2001
  • Pinquart M, Soerensen S. How effective are psychotherapeutic and other psychosocial interventions with older adults? A meta-analysis. Journal of Mental Health and Aging 2001;7:207–43.
Robie 1999
  • Robie KJ. An exploration of psychologists' perceptions of the process of psychotherapy for the treatment of psychological concerns and mental disorders in elders who have concomitant dementia. Dissertation Abstracts International 1999; Vol. 59:5108.
Rolland 2007
Rosenthal 1999
  • Rosenthal RN, Muran JC, Pinsker H, Hellerstein D, Winston A. Interpersonal change in brief supportive psychotherapy. Journal of Psychotherapy Practice and Research 1999;8(1):55-63.
Rozzini 2009
Salzman 2008
  • Salzman C, Jeste DV, Meyer RE, Cohen-Mansfield J, Cummings J, Grossberg GT, et al. Elderly patients with dementia-related symptoms of severe agitation and aggression: consensus statement on treatment options, clinical trials methodology, and policy. Journal of Clinical Psychiatry 2008;69:889-98.
Schultz 2004
  • Schultz SK, Hoth A, Buckwalter K. Anxiety and impaired social function in the elderly. Annals of Clinical Psychiatry 2004;16(1):47-51.
Seignourel 2008
Shankar 1999
Shapiro 1993
  • Shapiro DA, Startup M. Measuring therapist adherence in exploratory therapy. Journal of Psychotherapy Practice and Research 1993;2:193-203.
Solfrizzi 2007
  • Solfrizzi V, D'Introno A, Colacicco AM, Capurso C, Del Parigi A, Caselli RJ, et al. Incident occurrence of depressive symptoms among patients with mild cognitive impairment - the Italian longitudinal study on aging. Dementia and Geriatric Cognitive Disorders 2007;24(1):55-64.
Spruytte 2002
  • Spruytte N, Van Audenhove C, Lammertyn F, Storms G. The quality of the caregiving relationship in informal care for older adults with dementia and chronic psychiatric patients. Psychology and Psychotherapy: Theory, Research and Practice 2002;75:295-311.
Stanley 2004
  • Stanley MA, Diefenbach GJ, Hopko DR. Cognitive behavioral treatment for older adults with generalized anxiety disorder. A therapist manual for primary care settings. Behaviour Modification 2004;28:73-117.
Starkstein 2007
Stern 1997
Sultzer 1993
Sunderland 1988
Tappen 1997
  • Tappen RM, Williams-Burgess C, Edelstein J, Touhy T, Fishman S. Communicating with individuals with Alzheimer’s disease: Examination of recommended strategies. Archives of Psychiatric Nursing 1997;11:249-56.
Tappen 2001
  • Tappen RM, Williams CL, Barry C, DiSesa D. Conversation intervention with Alzheimer’s patients: Increasing the relevance of communication. Clinical Gerontologist 2001;24:63-75.
Tappen 2008
  • Tappen RM, Williams CL. Development and testing of the Alzheimer’s Disease and Related Dementias Mood Scale. Nursing Research 2008;57:426-35.
Teng 1987
Teri 1991
Teri 1992
  • Teri L, Truax R, Logsdon R. Assessment of behavioural problems in dementia: the Revised Memory and Behavior Problems Checklist. Psychology and Aging 1992;4:622-31.
van der Hooft 2008
Visser 2005
  • Visser PJ, Scheltens P, Verhey FR. Do MCI criteria in drug trials accurately identify subjects with predementia Alzheimer's disease?. Journal of Neurology, Neurosurgery, and Psychiatry 2005;76:1348-54.
Weiner 2002
  • Weiner MF, Doody RS, Sairam R. Prevalence and incidence of major depressive disorder in Alzheimer’s disease: findings from two databases. Dementia and Geriatric Cognitive Disorders 2002;13:8-12.
WHO 2007
  • WHO. World Health Organisation, Regional Office for Europe, Health Evidence Network. Evidence for decision makers. http://www.euro.who.int/HEN/ 2007 2007.
Wilson 2008
  • Wilson KC, Mottram PG, Vassilas CA. Psychotherapeutic treatments for older depressed people. Cochrane Database Systematic Reviews 2008;23:doi: 10.1002/14651858.CD004853.pub2.
Woods 2012
  • Woods RT, Spector AE, Jones CA, Orrell M, Davies SP. Reminiscence therapy for dementia. Cochrane Database of Systematic Reviews 2009, Issue 2 Art. No.: CD001120. DOI: 10.1002/14651858.
Yale 1995
  • Yale R. Developing Support Groups for Individuals With Early-Stage Alzheimer’s Disease: Planning, Implementation, and Evaluation. Baltimore, MD: Health Professions Press, 1995.
Yesavage 1983
Yesavage 1984
Yost 1986
  • Yost E, Beutler L, Corbishley A, Allender J. Group Cognitive therapy: A treatment approach for depressed older adults. New York: Pergamon Press, 1986.
Zigmond 1983