Intervention Review

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Psychological treatments for depression and anxiety in dementia and mild cognitive impairment

  1. Vasiliki Orgeta1,*,
  2. Afifa Qazi2,
  3. Aimee E Spector3,
  4. Martin Orrell1

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 22 JAN 2014

Assessed as up-to-date: 11 JAN 2013

DOI: 10.1002/14651858.CD009125.pub2

How to Cite

Orgeta V, Qazi A, Spector AE, Orrell M. Psychological treatments for depression and anxiety in dementia and mild cognitive impairment. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD009125. DOI: 10.1002/14651858.CD009125.pub2.

Author Information

  1. 1

    University College London, Mental Health Sciences Unit, London, UK

  2. 2

    North East London Foundation Trust, Goodmayes Hospital, Brentwood, Essex, UK

  3. 3

    University College, London, Research Department of Clinical, Educational and Health Psychology, London, UK

*Vasiliki Orgeta, Mental Health Sciences Unit, University College London, 67-73 Riding House Street, 2nd Floor, Charles Bell House, London, W1W 7EJ, UK.

Publication History

  1. Publication Status: New
  2. Published Online: 22 JAN 2014



References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Burgener 2008 {published data only}
  • Burgener SC, Yang Y, Gilbert R, Marsh-Yant S. The effects of a multimodal intervention on outcomes of persons with early-stage dementia. American Journal of Alzheimer’s Disease and Other Dementias 2008;23:382-94.
Burns 2005 {published data only}
  • Burns A, Guthrie E, Marino-Francis F, Busby C, Morris J, Russell E, et al. Brief psychotherapy in Alzheimer's disease: randomised controlled trial. The British Journal of Psychiatry 2005;187:143-7.
Spector 2012 {published data only}
  • Spector A, Orrell M, Lattimer M, Hoe J, King M, Harwood K, et al. Cognitive behavioural therapy (CBT) for anxiety in people with dementia: study protocol for a randomised controlled trial. Trials 2012;13:197.
Stanley 2012 {published data only}
  • Stanley MA, Calleo J, Bush AL, Wilson N, Snow AL, Kraus-Schuman C, et al. The Peaceful Mind Program: A pilot test of a cognitive–behavioral therapy–based intervention for anxious patients with dementia. American Journal of Geriatric Psychiatry 2012;21(7):696-708.
Tappen 2009 {published data only}
Waldorff 2012 {published data only}
  • Waldorff FB, Buss DV, Eckermann A, Rasmussen MLH, Keiding N, Rishøj S, et al. Efficacy of psychosocial intervention in patients with mild Alzheimer’s disease: the multicentre, rater blinded, randomised Danish Alzheimer Intervention Study (DAISY). BMJ 2012;345:1-14.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Abraham 1992 {published data only}
Beck 2002 {published data only}
  • Beck, C, Vogelpohl, T, Rasin, J, Topps, J, O’Sullivan, P, Walls, R, et al. Effects of behavioral interventions on disruptive behavior and affect in demented nursing home residents. Nursing Research 2002;51(4):219-28.
Brodaty 2003 {published data only}
  • Brodaty H, Draper BM, Millar J, Low L, Lie D, Sharah S, et al. Randomized controlled trial of different models of care for nursing home residents with dementia complicated by depression or psychosis. Journal of Clinical Psychiatry 2003;64:63-72.
Cheston 2003 {published data only}
  • Cheston R, Jones K, Gilliard J. Group psychotherapy and people with dementia. Aging and Mental Health 2003; Vol. 7:452-61.
Dartigues 2008 {published data only}
  • Dartigues JF. Efficacy Assessment of Three Non Pharmacological Therapies in Alzheimer's Disease (ETNA3). Trials Register.
Finnema 2005 {published data only}
  • Finnema E, Droës R, Ettema T, Ooms M, Adèr H, Miel Ribbe M, et al. The effect of integrated emotion-oriented care versus usual care on elderly persons with dementia in the nursing home and on nursing assistants: a randomised clinical trial. International Journal of Geriatric Psychiatry 2005;20:330-43.
Fischer-Terworth 2011 {published data only}
  • Fischer-Terworth C, Probst P. Evaluation of a TEACCH- and music therapy-based psychological intervention in mild to moderate dementia: a controlled trial. Geropsychology 2011;24:93-101.
Fossey 2006 {published data only}
  • Fossey J, Ballard C, Juszczak E, James I, Alder N, Jacoby R, et al. Effect of enhanced psychosocial care on antipsychotic use in nursing home residents with severe dementia: cluster randomised trial. BMJ 2006;332:756-8.
Garland 2007 {published data only}
  • Garland K, Beer E, Eppingstall B, O'Connor DW. A comparison of two treatments of agitated behavior in nursing home residents with dementia: Simulated family presence and preferred music. American Journal of Geriatric Psychiatry 2007;15:514-21.
Helcer 2012 {published data only}
  • Helcer J, Santorelli G, Choi J. Cognitive behavioral therapy to combat hopelessness and low self efficacy in Alzheimer's disease. Alzheimer's Association International Conference. 2012.
Hinchliffe 1997 {published data only}
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Hyer 2008 {published data only}
  • Hyer L, Yeager CA, Hilton N, Sacks A. Group, individual, and staff therapy: an efficient and effective cognitive behavioral therapy in long-term care. American Journal of Alzheimer’s Disease and Other Dementias 2008;23:528-39.
Joosten-Weyn Banningh2011 {published data only}
  • Joosten-Weyn Banningh LW, Prins JB, Vernooij-Dassen MJ, Wijnen HH, Olde Rikkert MG, Kessels RP. Group therapy for patients with mild cognitive impairment and their significant others: results of a waiting-list controlled trial. Gerontology 2011;57:444-54.
Kiosses 2010 {published data only}
  • Kiosses DN, Arean PA, Teri L, Alexopoulos GS. Home-delivered problem adaptation therapy (PATH) for depressed, cognitively impaired, disabled elders: A preliminary study. American Journal of Geriatric Psychiatry 2010;18:988-98.
Kiosses 2011 {published data only}
  • Kiosses DN. Home-delivered intervention for depressed, cognitively impaired elders. Trials Register 2011.
Kolanowski 2011 {published data only}
Konnert 2009 {published data only}
  • Konnert C, Dobson K, Stelmach L. The prevention of depression in nursing home residents: A randomised clinical trial of cognitive–behavioral therapy. Aging and Mental Health 2009;13:288-99.
Kurz 2012 {published data only}
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Laakkonen 2012 {published data only}
  • Laakkonen M-L, Holtta EH, Savikko N, Strandberg TE, Suominen M, Pitkala KH. Psychosocial group intervention to enhance self-management skills of people with dementia and their caregivers: study protocol for a randomized controlled trial. Trials 2012;13:133.
Lam 2010 {published data only}
  • Lam LCW, Lui VWC, Luk DNY, Chau R, So C, Poon V, et al. Effectiveness of an individualized functional training program on affective disturbances and functional skills in mild and moderate dementia—a randomised control trial. International Journal of Geriatric Psychiatry 2010;25:133–41.
Lichtenberg 2005 {published data only}
Logsdon 2010 {published data only}
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McSweeney 2012 {published data only}
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  • Mittelman MS, Ferris SH, Shulman E, Steinberg G, Levin B. A family intervention to delay nursing home placement of patients with Alzheimer disease. A randomized controlled trial. JAMA 1996;276:1725-31.
Onor 2007 {published data only}
  • Onor M L, Trevisiol M, Negro C, Signorini A, Saina M, Aguglia E. Impact of a multimodal rehabilitative intervention on demented patients and their caregivers. American Journal of Alzheimer's Disease and Other Dementias 2007;22:261-72.
Prick 2011 {published data only}
  • Prick AE, de Lange J, Scherder E, Pot AM. Home-based exercise and support programme for people with dementia and their caregivers: study protocol of a randomised controlled trial. BMC Public Health 2011;11:894.
Proctor 1999 {published data only}
  • Proctor R, Burns A, Powell HS, Tarrier N, Faragher B, Richardson G, et al. Behavioural management in nursing and residential homes: a randomised controlled trial. Lancet 1999;354:26–9.
Rovner 2012 {published data only}
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Selbaek 2010 {published data only}
  • Selbaek, G. Multidisciplinary intervention for challenging behaviour (agitation) in patients with dementia. Trial Register 2010.
Teri 2003 {published data only}
  • Terri L, Gibbons, LE, McCurry SM, Logsdon RG, Buchner DM, Barlow WE, et al. Exercise plus behavioral management in patients with Alzheimer disease: a randomized controlled trial. JAMA 2003;290:2015-22.
Vespa 2002 {published data only}
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Yesavage 1981 {published data only}

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Carreel 1990 {published data only}
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References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
Forstmeier 2011 {published data only}
  • Forstmeier S. Cognitive-behavioral treatment for mild Alzheimer's patients and their caregivers. Clinical Trials Register 2011.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
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