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Amitriptyline versus placebo for major depressive disorder

  1. Claudia Leucht*,
  2. Maximilian Huhn,
  3. Stefan Leucht

Editorial Group: Cochrane Common Mental Disorders Group

Published Online: 12 DEC 2012

Assessed as up-to-date: 30 AUG 2012

DOI: 10.1002/14651858.CD009138.pub2


How to Cite

Leucht C, Huhn M, Leucht S. Amitriptyline versus placebo for major depressive disorder. Cochrane Database of Systematic Reviews 2012, Issue 12. Art. No.: CD009138. DOI: 10.1002/14651858.CD009138.pub2.

Author Information

  1. Technische Universität München Klinikum rechts der Isar, Klinik und Poliklinik für Psychiatrie und Psychotherapie, München, Germany

*Claudia Leucht, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität München Klinikum rechts der Isar, Ismaningerstrasse 22, München, 81675, Germany. Claudia.Leucht@lrz.tu-muenchen.de. claudialeucht@gmx.de.

Publication History

  1. Publication Status: New
  2. Published Online: 12 DEC 2012

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. 'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. 'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Amitriptyline versus placebo, outcome: 1.1 Response.
[Figure 5]
Figure 5.
[Figure 6]
Figure 6. Funnel plot of comparison: 1 Amitriptyline versus placebo, outcome: 1.1 Response.
[Figure 7]
Figure 7.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Amitriptyline versus placebo, Outcome 1 Response.
[Analysis 1.2]
Analysis 1.2. Comparison 1 Amitriptyline versus placebo, Outcome 2 Remission.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Amitriptyline versus placebo, Outcome 3 Mean severity of depression - change scores.
[Analysis 1.4]
Analysis 1.4. Comparison 1 Amitriptyline versus placebo, Outcome 4 Mean severity of depression - endpoint scores.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Amitriptyline versus placebo, Outcome 5 Drop-out: total.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Amitriptyline versus placebo, Outcome 6 Drop-out: due to inefficacy.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Amitriptyline versus placebo, Outcome 7 Drop-out: due to adverse events.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Amitriptyline versus placebo, Outcome 8 Side effects - total number of patients experiencing at least one side effect.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Amitriptyline versus placebo, Outcome 9 Side effects - anticholinergic: any anticholinergic effects (dry mouth, constipation, visual disturbances).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Amitriptyline versus placebo, Outcome 10 Side effects - anticholinergic: constipation.
[Analysis 1.11]
Analysis 1.11. Comparison 1 Amitriptyline versus placebo, Outcome 11 Side effects - anticholinergic: dry mouth.
[Analysis 1.12]
Analysis 1.12. Comparison 1 Amitriptyline versus placebo, Outcome 12 Side effects - anticholinergic: nasal congestion.
[Analysis 1.13]
Analysis 1.13. Comparison 1 Amitriptyline versus placebo, Outcome 13 Side effects - anticholinergic: urination problems.
[Analysis 1.14]
Analysis 1.14. Comparison 1 Amitriptyline versus placebo, Outcome 14 Side effects - anticholinergic: vision problems (amblyopia, blurred vision).
[Analysis 1.15]
Analysis 1.15. Comparison 1 Amitriptyline versus placebo, Outcome 15 Side effects - cardiovascular: hypertension.
[Analysis 1.16]
Analysis 1.16. Comparison 1 Amitriptyline versus placebo, Outcome 16 Side effects - cardiovascular: hypotension.
[Analysis 1.17]
Analysis 1.17. Comparison 1 Amitriptyline versus placebo, Outcome 17 Side effects - cardiovascular: lightheadedness.
[Analysis 1.18]
Analysis 1.18. Comparison 1 Amitriptyline versus placebo, Outcome 18 Side effects - cardiovascular: palpitations.
[Analysis 1.19]
Analysis 1.19. Comparison 1 Amitriptyline versus placebo, Outcome 19 Side effects - cardiovascular: tachycardia.
[Analysis 1.20]
Analysis 1.20. Comparison 1 Amitriptyline versus placebo, Outcome 20 Side effects - central nervous: agitation.
[Analysis 1.21]
Analysis 1.21. Comparison 1 Amitriptyline versus placebo, Outcome 21 Side effects - central nervous: amnesia.
[Analysis 1.22]
Analysis 1.22. Comparison 1 Amitriptyline versus placebo, Outcome 22 Side effects - central nervous: confusion.
[Analysis 1.23]
Analysis 1.23. Comparison 1 Amitriptyline versus placebo, Outcome 23 Side effects - central nervous: disco-ordination.
[Analysis 1.24]
Analysis 1.24. Comparison 1 Amitriptyline versus placebo, Outcome 24 Side effects - central nervous: dizziness.
[Analysis 1.25]
Analysis 1.25. Comparison 1 Amitriptyline versus placebo, Outcome 25 Side effects - central nervous: headache.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Amitriptyline versus placebo, Outcome 26 Side effects - central nervous: increased activity.
[Analysis 1.27]
Analysis 1.27. Comparison 1 Amitriptyline versus placebo, Outcome 27 Side effects - central nervous: insomnia.
[Analysis 1.28]
Analysis 1.28. Comparison 1 Amitriptyline versus placebo, Outcome 28 Side effects - central nervous: nervousness.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Amitriptyline versus placebo, Outcome 29 Side effects - central nervous: sedation/sleepiness/somnolence/drowsiness.
[Analysis 1.30]
Analysis 1.30. Comparison 1 Amitriptyline versus placebo, Outcome 30 Side effects - central nervous: tremor.
[Analysis 1.31]
Analysis 1.31. Comparison 1 Amitriptyline versus placebo, Outcome 31 Side effects - dermal: rash.
[Analysis 1.32]
Analysis 1.32. Comparison 1 Amitriptyline versus placebo, Outcome 32 Side effects - dermal: sweating.
[Analysis 1.33]
Analysis 1.33. Comparison 1 Amitriptyline versus placebo, Outcome 33 Side effects - gastrointestinal: anorexia.
[Analysis 1.34]
Analysis 1.34. Comparison 1 Amitriptyline versus placebo, Outcome 34 Side effects - gastrointestinal: diarrhoea.
[Analysis 1.35]
Analysis 1.35. Comparison 1 Amitriptyline versus placebo, Outcome 35 Side effects - gastrointestinal: dyspepsia.
[Analysis 1.36]
Analysis 1.36. Comparison 1 Amitriptyline versus placebo, Outcome 36 Side effects - gastrointestinal: gastralgia.
[Analysis 1.37]
Analysis 1.37. Comparison 1 Amitriptyline versus placebo, Outcome 37 Side effects - gastrointestinal: increased appetite.
[Analysis 1.38]
Analysis 1.38. Comparison 1 Amitriptyline versus placebo, Outcome 38 Side effects - gastrointestinal: nausea.
[Analysis 1.39]
Analysis 1.39. Comparison 1 Amitriptyline versus placebo, Outcome 39 Side effects - gastrointestinal: vomiting.
[Analysis 1.40]
Analysis 1.40. Comparison 1 Amitriptyline versus placebo, Outcome 40 Side effects - gastrointestinal: weight gain.
[Analysis 1.41]
Analysis 1.41. Comparison 1 Amitriptyline versus placebo, Outcome 41 Side effects - general: fatigue/asthenia/slowed down.
[Analysis 1.42]
Analysis 1.42. Comparison 1 Amitriptyline versus placebo, Outcome 42 Side effects - sexual: impotence.
[Analysis 1.43]
Analysis 1.43. Comparison 1 Amitriptyline versus placebo, Outcome 43 Side effects - sexual: any sexual dysfunction.
[Analysis 1.44]
Analysis 1.44. Comparison 1 Amitriptyline versus placebo, Outcome 44 Subgroup analysis: industry sponsored - response to treatment.
[Analysis 1.45]
Analysis 1.45. Comparison 1 Amitriptyline versus placebo, Outcome 45 Subgroup analysis: inpatient versus outpatient studies - response to treatment.
[Analysis 1.46]
Analysis 1.46. Comparison 1 Amitriptyline versus placebo, Outcome 46 Subgroup analysis: two-arms versus three-arms studies - response to treatment.
[Analysis 1.47]
Analysis 1.47. Comparison 1 Amitriptyline versus placebo, Outcome 47 Sensitivity analysis: devoid of studies calculated with imputed statistic methods - response to treatment.
[Analysis 1.48]
Analysis 1.48. Comparison 1 Amitriptyline versus placebo, Outcome 48 Sensitivity analysis: fixed instead of random-effects model - response to treatment.