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Pharmacotherapies for sleep disturbances in Alzheimer's disease

  1. Jenny McCleery1,*,
  2. Daniel A. Cohen2,
  3. Ann L Sharpley3

Editorial Group: Cochrane Dementia and Cognitive Improvement Group

Published Online: 21 MAR 2014

Assessed as up-to-date: 31 MAR 2013

DOI: 10.1002/14651858.CD009178.pub2


How to Cite

McCleery J, Cohen DA, Sharpley AL. Pharmacotherapies for sleep disturbances in Alzheimer's disease. Cochrane Database of Systematic Reviews 2014, Issue 3. Art. No.: CD009178. DOI: 10.1002/14651858.CD009178.pub2.

Author Information

  1. 1

    Oxford Health NHS Foundation Trust, Banbury, Oxfordshire, UK

  2. 2

    Division of Sleep Medicine, Research Fellow in Sleep and Circadian Neurobiology, Boston, MA, USA

  3. 3

    Oxford University, Department of Psychiatry, Oxford, UK

*Jenny McCleery, Oxford Health NHS Foundation Trust, Elms Centre, Oxford Road, Banbury, Oxfordshire, OX16 9AL, UK. jenny.mccleery@oxfordhealth.nhs.uk.

Publication History

  1. Publication Status: New
  2. Published Online: 21 MAR 2014

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[Figure 1]
Figure 1. Study flow diagram
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Figure 4]
Figure 4. Forest plot of comparison: 1 Melatonin versus placebo, outcome: 1.1 total night-time sleep time (minutes)
[Figure 5]
Figure 5. Forest plot of comparison: 1 Melatonin versus placebo, outcome: 1.5 ratio of daytime sleep to night-time sleep
[Analysis 1.1]
Analysis 1.1. Comparison 1 Melatonin versus placebo: efficacy, Outcome 1 total nocturnal sleep time (minutes).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Melatonin versus placebo: efficacy, Outcome 2 sleep efficiency.
[Analysis 1.3]
Analysis 1.3. Comparison 1 Melatonin versus placebo: efficacy, Outcome 3 nocturnal time awake (minutes).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Melatonin versus placebo: efficacy, Outcome 4 number of night-time awakenings.
[Analysis 1.5]
Analysis 1.5. Comparison 1 Melatonin versus placebo: efficacy, Outcome 5 ratio of daytime sleep to night-time sleep.
[Analysis 1.6]
Analysis 1.6. Comparison 1 Melatonin versus placebo: efficacy, Outcome 6 carer-rated sleep quality, change from baseline.
[Analysis 1.7]
Analysis 1.7. Comparison 1 Melatonin versus placebo: efficacy, Outcome 7 MMSE, change from baseline.
[Analysis 1.8]
Analysis 1.8. Comparison 1 Melatonin versus placebo: efficacy, Outcome 8 ADAS-cog, change from baseline.
[Analysis 1.9]
Analysis 1.9. Comparison 1 Melatonin versus placebo: efficacy, Outcome 9 ADL, change from baseline.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Melatonin versus placebo: safety, Outcome 1 number of adverse event reports per person.
[Analysis 2.2]
Analysis 2.2. Comparison 2 Melatonin versus placebo: safety, Outcome 2 adverse event severity.