This is the protocol for a review and there is no abstract. The objectives are as follows:
To determine the effectiveness of ACE inhibitor administration in people with SCD for preserving renal function by decreasing intraglomerular pressure and proteinuria thus maintaining current GFR or slowing the decline in GFR. A secondary objective is to assess the safety of ACE inhibitors as pertains to their side effects (hyperkalemia, hypotension, etc.).