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Intermittent iron supplementation for reducing anaemia and its associated impairments in menstruating women

  1. Ana C Fernández-Gaxiola1,
  2. Luz Maria De-Regil2,*

Editorial Group: Cochrane Developmental, Psychosocial and Learning Problems Group

Published Online: 7 DEC 2011

Assessed as up-to-date: 4 NOV 2011

DOI: 10.1002/14651858.CD009218.pub2


How to Cite

Fernández-Gaxiola AC, De-Regil LM. Intermittent iron supplementation for reducing anaemia and its associated impairments in menstruating women. Cochrane Database of Systematic Reviews 2011, Issue 12. Art. No.: CD009218. DOI: 10.1002/14651858.CD009218.pub2.

Author Information

  1. 1

    Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico

  2. 2

    Micronutrient Initiative, Ottawa, ON, Canada

*Luz Maria De-Regil, Micronutrient Initiative, 180 Elgin Street, Suite 1000, Ottawa, ON, K2P 2K3, Canada. lderegil@micronutrient.org.

Publication History

  1. Publication Status: Edited (no change to conclusions)
  2. Published Online: 7 DEC 2011

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[Figure 1]
Figure 1. Study flow diagram.
[Figure 2]
Figure 2. Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
[Figure 3]
Figure 3. Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
[Analysis 1.1]
Analysis 1.1. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 1 Anaemia (All).
[Analysis 1.2]
Analysis 1.2. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 2 Anaemia (by supplement composition).
[Analysis 1.3]
Analysis 1.3. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 3 Anaemia (by anaemic status at baseline).
[Analysis 1.4]
Analysis 1.4. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 4 Anaemia (by iron deficiency status at baseline).
[Analysis 1.5]
Analysis 1.5. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 5 Anaemia (by iron dose per week in the intermittent group).
[Analysis 1.6]
Analysis 1.6. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 6 Anaemia (by duration of the intervention).
[Analysis 1.7]
Analysis 1.7. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 7 Anaemia (by malaria endemicity).
[Analysis 1.8]
Analysis 1.8. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 8 Haemoglobin in g/L (All).
[Analysis 1.9]
Analysis 1.9. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 9 Haemoglobin in g/L (by supplement composition).
[Analysis 1.10]
Analysis 1.10. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 10 Haemoglobin in g/L (by anaemic status at baseline).
[Analysis 1.11]
Analysis 1.11. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 11 Haemoglobin in g/L (by iron deficiency status at baseline).
[Analysis 1.12]
Analysis 1.12. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 12 Haemoglobin in g/L (by iron dose per week in the intermittent group).
[Analysis 1.13]
Analysis 1.13. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 13 Haemoglobin in g/L (by duration of the intervention).
[Analysis 1.14]
Analysis 1.14. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 14 Haemoglobin in g/L (by malaria endemicity).
[Analysis 1.15]
Analysis 1.15. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 15 Iron deficiency (All).
[Analysis 1.16]
Analysis 1.16. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 16 Ferritin in µg/L (All).
[Analysis 1.17]
Analysis 1.17. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 17 Ferritin in µg/L (by supplement composition).
[Analysis 1.18]
Analysis 1.18. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 18 Ferritin in µg/L (by anaemic status at baseline).
[Analysis 1.19]
Analysis 1.19. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 19 Ferritin in µg/L (by iron deficiency status at baseline).
[Analysis 1.20]
Analysis 1.20. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 20 Ferritin in µg/L (by iron dose per week in the intermittent group).
[Analysis 1.21]
Analysis 1.21. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 21 Ferritin in µg/L (by duration of the intervention).
[Analysis 1.22]
Analysis 1.22. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 22 Ferritin in µg/L (by malaria endemicity).
[Analysis 1.23]
Analysis 1.23. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 23 Iron deficiency anaemia (All).
[Analysis 1.24]
Analysis 1.24. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 24 All cause morbidity (All).
[Analysis 1.25]
Analysis 1.25. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 25 Diarrhoea.
[Analysis 1.26]
Analysis 1.26. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 26 Any adverse side effects.
[Analysis 1.27]
Analysis 1.27. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 27 Adherence.
[Analysis 1.28]
Analysis 1.28. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 28 Prevalence of malaria parasitaemia.
[Analysis 1.29]
Analysis 1.29. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 29 Any malaria parasitaemia (Incidence rate; per 1000 person months).
[Analysis 1.30]
Analysis 1.30. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 30 High density malaria parasitaemia (parasites 200/wbc).
[Analysis 1.31]
Analysis 1.31. Comparison 1 Intermittent iron supplementation vs. no supplementation/placebo, Outcome 31 Clinical malaria.
[Analysis 2.1]
Analysis 2.1. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 1 Anaemia (All).
[Analysis 2.2]
Analysis 2.2. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 2 Anaemia (by supplement composition).
[Analysis 2.3]
Analysis 2.3. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 3 Anaemia (by anaemic status at baseline).
[Analysis 2.4]
Analysis 2.4. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 4 Anaemia (by iron deficiency at baseline).
[Analysis 2.5]
Analysis 2.5. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 5 Anaemia (by iron dose per week in the intermittent group).
[Analysis 2.6]
Analysis 2.6. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 6 Anaemia (by duration of the intervention).
[Analysis 2.7]
Analysis 2.7. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 7 Anaemia (by malaria endemicity).
[Analysis 2.8]
Analysis 2.8. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 8 Haemoglobin g/L (All).
[Analysis 2.9]
Analysis 2.9. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 9 Haemoglobin g/L (by supplement composition).
[Analysis 2.10]
Analysis 2.10. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 10 Haemoglobin g/L (by anaemic status at baseline).
[Analysis 2.11]
Analysis 2.11. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 11 Haemoglobin in g/L (by iron deficiency at baseline).
[Analysis 2.12]
Analysis 2.12. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 12 Haemoglobin in g/L (by iron dose per week in the intermittent group).
[Analysis 2.13]
Analysis 2.13. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 13 Haemoglobin in g/L (by duration of the intervention).
[Analysis 2.14]
Analysis 2.14. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 14 Haemoglobin in g/L (by malaria endemicity).
[Analysis 2.15]
Analysis 2.15. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 15 Iron deficiency (All).
[Analysis 2.16]
Analysis 2.16. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 16 Ferritin in µg/L (All).
[Analysis 2.17]
Analysis 2.17. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 17 Diarrhoea.
[Analysis 2.18]
Analysis 2.18. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 18 Any side effects.
[Analysis 2.19]
Analysis 2.19. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 19 Depression.
[Analysis 2.20]
Analysis 2.20. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 20 Adherence.
[Analysis 2.21]
Analysis 2.21. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 21 Hospitalization (non prespecified outcome).
[Analysis 2.22]
Analysis 2.22. Comparison 2 Intermittent iron supplementation vs. daily iron supplementation, Outcome 22 Oxidative stress -FRAP (non prespecified outcome).