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Antispasmodics for labour

  1. Anke C Rohwer1,*,
  2. Oswell Khondowe1,
  3. Taryn Young1,2

Editorial Group: Cochrane Pregnancy and Childbirth Group

Published Online: 5 JUN 2013

Assessed as up-to-date: 10 APR 2013

DOI: 10.1002/14651858.CD009243.pub3


How to Cite

Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database of Systematic Reviews 2013, Issue 6. Art. No.: CD009243. DOI: 10.1002/14651858.CD009243.pub3.

Author Information

  1. 1

    Stellenbosch University, Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, Tygerberg, South Africa

  2. 2

    South African Medical Research Council, South African Cochrane Centre, Tygerberg, South Africa

*Anke C Rohwer, Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Francie van Zijl Drive, Tygerberg, 7505, South Africa. arohwer@sun.ac.za.

Publication History

  1. Publication Status: New search for studies and content updated (no change to conclusions)
  2. Published Online: 5 JUN 2013

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References

References to studies included in this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Ajmera 2006 {published data only}
  • Ajmera SK, Shah PK, Shinde GA. Comparative study of drotaverine vs. Valethamate in cervical phase of labour. Bombay Hospital Journal (http://www.bhj.org/journal/2006_4802_april/html/org_res_305-309.html) (accessed 16 December 2011).
Al Matari 2007 {published data only}
  • Al Matari F. Is buscopan (hyoscine-N-butylbromide) effective in shortening labor? [abstract]. 31st British International Congress of Obstetrics and Gynaecology; 2007 July 4-6; London, UK. 2007:114.
Al Qahtani 2011 {published data only}
  • Al Qahtani NH, Al Hajeri F. The effect of hyoscine butylbromide in shortening the first stage of labor: A double blind, randomized controlled trial. Therapeutics and Clinical Risk Management 2011;7:495-500.
Azari 2010 {published data only}
  • Azari M, Mardi A, Dargahi R. The effect of combination atropine and hyoscine progress of delivery in primiparous women in Ardabil - Alavi Hospital 2008. Journal of Maternal-Fetal and Neonatal Medicine 2010;23(S1):226.
Batukan 2006 {published data only}
  • Batukan AC, Ozgun MT, Turkyilmaz C, Dolanbay M, Muderris II. Effect of valethamate bromide in acceleration of labor: a double-blind, placebo-controlled trial [Valetamat bromurun dogum eylemini hizlandirmadaki etkisi: Plasebo kontrollu, cift kor bir calisma.]. Journal of the Turkish German Gynecology Association Artemis 2006;7(3):202-5.
Cromi 2011 {unpublished data only}
Dahal 2013 {published data only}
  • Dahal P, Banerjee B, Uprety DK, Das BP, Thakur A, Agrawal A. Comparative study of efficacy of drotaverine hydrochloride and valethamate bromide with control in first stage of labour. Health Renaissance 2013;11(1):38-42.
Gupta 2008 {published data only}
Khosla 2003 {published data only}
  • Khosla AH, Bala I, Dahiya K, Sangwan K. A comparative study of the efficacy of valethamate bromide with drotaverine in normal labor. Journal of Obstetrics and Gynecology of India 2003;53(6):568-70.
Kuruvila 1992 {published data only}
  • Kuruvila S, Jasper P, Peedicayil A, Mathai M. A randomized controlled trial of valethamate bromide in acceleration of labor. International Journal of Gynecology & Obstetrics 1992;38:93-6.
Madhu 2010 {published data only}
  • Madhu C, Mahavarkar S, Bhave S. A randomised controlled study comparing drotaverine hydrochloride and valethamate bromide in the augmentation of labour. Archives of Gynecology and Obstetrics 2010;282:11-5.
Makvandi 2010 {published data only}
  • Makvandi S. The effect of hyoscine - N - butyl bromide suppository on labor pain and process in nuliparous women. IRCT Iranian Registry of Clinical Trials (www.irct.ir) (accessed 6 December 2010) 2010.
Mukaindo 2010 {unpublished data only}
  • Mukaindo AM, Stones WR (Department of Obstetrics and Gynaecology, Aga Khan University Hospital Nairobi). Hyoscine-N-butylbromide for the acceleration of labor in first time parturients: a randomized, double-blind, placebo-controlled trial. Personal communication via email 24 October 2011.
Raghavan 2008 {published data only}
  • Raghavan R. The effect of hyoscine butyl bromide on the first stage of labour in term pregnancies. BJOG: an international journal of obstetrics and gynaecology 2008;115(8):1064-5.
Samuels 2007 {published data only}
Sekhavat 2012 {published data only}
  • Sekhavat L, Karbasi S, Fallah R, Mirowliai M. Effect of hyoscine butylbromide first stage of labour in multiparus women. African Health Sciences 2012;12(4):408-11.
Sharma 2001 {published data only}
Singh 2004 {published data only}
Taskin 1993 {published data only}
  • Taskin O, Saade G, Belfort M, Moise K. The effect of narcotics and spasmolytics on cervical dilatation in labor: a randomized placebo-controlled study. American Journal of Obstetrics and Gynecology 1993;168:362.
Warke 2003 {published data only}
  • Warke HS, Chauhan AR, Raut VS, Ingle KM. Efficacy of camylofin dihydrochloride in acceleration of labour: A randomised double blind trial. Bombay Hospital Journal 2003;45(3):420-3.
Yilmaz 2009 {published data only}
  • Yilmaz B, Kart C, Kelekci S, Gokturk U, Sut N, Tarlan N, et al. Meperidine versus valethamate bromide in shortening the duration of active labor. International Journal of Gynecology & Obstetrics 2009;107(2):126-9.

References to studies excluded from this review

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Aggarwal 2008 {published data only}
  • Aggarwal P, Zutshi V, Batra S. Role of hyoscine N-butyl bromide (HBB, Buscopan) as labor analgesic. Indian Journal of Medical Science 2008;62(5):179-84.
Akleh 2010 {published data only}
  • Akleh HE, Al-Jufairi ZA. Effect of hyoscine-N-bulyl bromide (Buscopan) in accelerating first stage of labor. Journal of the Bahrain Medical Society 2010;22(3):103-7.
Baracho 1982 {published data only}
  • Baracho HM, Kamat JR, Kunkalekar K, Jacob L. Hyoscine-N-Butylbromide (Buscopan) in acceleration of labour. Journal of Obstetrics and Gynaecology of India 1982;34:509-12.
Bhattacharaya 1984 {published data only}
  • Bhattacharaya P, Joshi SG. Acceleration of labour intramuscular "Buscopan" injection. Journal of Obstetrics and Gynaecology of India 1984;35:1014-7.
Chan 1963 {published data only}
  • Chan DPC. The use of Buscopan during the first stage of labour. The Bulletin of the Hong Kong Chinese Medical 1963;15:69-71.
Demory 1990 {published data only}
  • Demory JE, Firmin JM, Parot P. The value of magnesium pyrrolidone carboxylate in true cervix dystocia. A double blind vs placebo study. Revue Francaise de Gynecologie et d Obstetrique 1990;85:413-6.
De Nobrega-Correa 2010 {published data only}
  • De Nobrega-Correa H, Guerra-Velasquez M, Reyna-Villasmil E, Mejia-Montilla J, Reyna-Villasmil N, Torres-Cepeda D, et al. Effects of intravenous hyoscine butylbromide-oxytocin or oxytocin on the duration of labor in term pregnancies [Spanish] [Efectos del butil bromuro de hioscina-oxitocina u oxitocina intravenosos en la duracion del parto de embarazos a termino]. Progresos de Obstetricia y Ginecologia 2010;53(12):502-6.
Fouedjio 2012 {published data only}
  • Fouedjio JH, Ymele Fouelifack F, Kenfack B, Wache Sime LC, Nana NP, Temkou S, et al. Efficacité du phloroglucinol sur le raccourcissement de la phase active du travail à la maternité de l'Hôpital Central de Yaoundé, Cameroun. Clinics in Mother and Child Health 2012;9:C12502.
Guerresi 1981 {published data only}
  • Guerresi E, Gori G, Beccari A, Farro M, Mazzanti C. Influence of spasmolytic treatment and amniotomy on delivery times: a factorial clinical trial. Clinical Therapeutics 1981;3(5):382-8.
Hamann 1972 {published data only}
  • Hamann GO. Avacan vs fortral. A controlled double blind investigation on parturient patients. Ugeskrift for Laeger 1972;134:2261-5.
Hao 2004 {published data only}
  • Hao Y, Zhai GR, Duan AH. Effects of spasfon on course of labor. Chung-Hua Fu Chan Ko Tsa Chih [Chinese Journal of Obstetrics and Gynecology] 2004;39(9):606-8.
Kauppila 1970 {published data only}
  • Kauppila O, Koistinen O, Vaalamo P. Drug-induced acceleration of labour. Trials of an Indan derivative in childbirth. Annales Chirurgiae et Gynaecologiae Fenniae 1970;59:85-9.
Kaur 2003 {published data only}
  • Kaur D, Kaur R. Comparison of drotaverine and epidosin in the first stage of labor. Journal of Obstetrics and Gynecology of India 2003;53(5):449-52.
Kaur 2006 {published data only}
  • Kaur D, Kaur A. "Anafortan" an old drug with its newer use in acceleration of labour [abstract]. 49th All India Congress of Obstetrics and Gynaecology; 2006 January 6-9; Cochin, Kerala State, India. 2006:59.
Malensek 1985 {published data only}
  • Malensek B. The influence of spasmoanalgetics on uterine activity. Jugoslavenska Ginekologija i Perinatologija 1985;25:75-9.
Manpreet 2008 {published data only}
  • Manpreet K, Gouramba R, Jyothi K, Venkatesh S, Biradar R. A comparative study of hyoscine butylbromide versus drotaverine hydrochloride in first stage of labor. Journal of Obstetrics and Gynecology of India 2008;58(3):230-4.
Maritati 1986 {published data only}
  • Maritati V, Tanganelli E, Boccardo E, Camandona F, Pietrasanta R, Maganza C, et al. The use of sintropium bromide, a new spasmolytic, in obstetrics and gynecology. Minerva Ginecologica 1986;38(11):965-9.
Mishra 2002 {published data only}
  • Mishra SL, Toshniwal A, Banerjee R. Effect of drotaverine on cervical dilatation: a comparative study with epidosin (valethamate bromide). Journal of Obstetrics and Gynecology of India 2002;52(3):76-9.
Mortazavi 2004 {published data only}
  • Mortazavi F, Rakhshani MH. The effect of atropine, hyoscine and promethazine on the duration of labor stages and rate of labor progress in multiparous women. Journal of the Gorgan University of Medical Sciences 2004;6(2):92.
Rajkumar 2006 {published data only}
  • Rajkumar K, Vedavalli R. Drotaverine hydrochloride vs valethamate bromide for cervical dilatation in active phase of labour [abstract]. 49th All India Congress of Obstetrics and Gynaecology; 2006 January 6-9; Cochin, Kerala State, India. 2006:96.
Sirohiwal 2005 {published data only}
Tabassum 2005 {published data only}
  • Tabassum S, Afridi B, Aman Z. Phloroglucinol for acceleration of labour: double blind, randomized controlled trial. JPMA - Journal of the Pakistan Medical Association 2005;55(7):270-3.
Tripti 2009 {published data only}
  • Tripti N, Jyoti J. To compare and evaluate the efficacy and safety of drotaverine and valethamate bromide. Journal of Obstetrics and Gynaecology of India 2009;59(4):324-31.
Von Hagen 1965 {published data only}
  • Von Hagen H. Clinical trials with the spasmo-analgesic Spasdolsin in obstetrics (with application of a new methodology). Zentralblatt fur Gynakologie 1965;36:1201-9.

References to studies awaiting assessment

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Accinelli 1978 {published data only}
  • Accinelli G, Olivieri T, Vibelli C. The effectiveness of a new spasmolytic drug (DA 3177) during the active phase of labour. Acta Therapeutica 1978;4:19-27.
Ahmed 1982 {published data only}
  • Ahmed LT, Merouana A, Nait B, Souiah N, Chenntouf M, Larbi LO. Antispasmodics in obstetrics: myth or reality [Les antispasmodiques en obstetrique: mythe ou realite]. Journal de Gynecologie, Obstetrique et Biologie de la Reproduction 1982;11(2):281-4.
Georges 2007 {published data only}
  • Georges R, Aldahan F, Alwaeely F. The evaluation of the effect of buscopan (hyoscine-N-butyl bromide) on the duration of labour [abstract]. 31st British International Congress of Obstetrics and Gynaecology; 2007 July 4-6; London, UK. 2007:102.
Rajani 2011 {published data only}
  • Rajani M, Umadevi N, Jayasree S. Efficacy of valethamate bromide on cervical dilatation during the labour in comparison with placebo. 54th All India Congress of Obstetrics and Gynaecology; 2011 January 5-9; Hyderabad, Andhra Pradesh, India. 2011:141.
Ranka 2002 {published data only}
  • Ranka PR, Hishikar VA. Effect of drotaverine hydrochloride on normal labour - a randomised study. Journal of Obstetrics and Gynecology of India 2002;52(6):28-30.
Recto 1997 {published data only}
  • Recto CP, Co TV, Clemente V. The effect of hyoscine-n-butylbromide on the first stage of labor: a clinical trial. Acta Obstetricia et Gynecologica Scandinavica 1997;76 Suppl(167:1):45.
Roy 2007 {published data only}
  • Roy A, Patra KK, Mukhopadhyay S, Guha S. Study of drotaverine on first stage of labour and pregnancy outcome. Journal of the Indian Medical Association 2007;105(8):450.
Zagami 2012 {published data only}
  • Zagami SE, Golmakani N, Saadatjoo SAR, Dadgar S, Baghbani B. Comparison of effects of hyoscine N-butyl bromide and promethazine on length of active phase of first stage of labor. Iranian Journal of Obstetrics, Gynecology and Infertility 2012;15(6):16-21.

References to ongoing studies

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Movahed 2010 {published data only}
  • Movahed F. The effect of hyoscin on duration on the first stage of labor in term pregnancies. IRCT Iranian Registry of Clinical Trials (www.irct.ir) (accessed 6 December 2010) 2010.

Additional references

  1. References to studies included in this review
  2. References to studies excluded from this review
  3. References to studies awaiting assessment
  4. References to ongoing studies
  5. Additional references
  6. References to other published versions of this review
Brown 2008
Buhimschi 2003
  • Buhimschi CS, Buhimschi IA, Malinow AM, Saade GR, Garfield RE, Weiner CP. The forces of labour. Fetal and Maternal Medicine Review 2003;14(4):273-307.
Clark 2009
Daftary 2009
  • Daftary SN, Desai SV, Thanawala U, Bhide A, Levi J, Patki A, et al. Programmed labor - indegenous protocol to optimize labor outcome. South Asian Federation of Obstetrics and Gynecology 2009;1(1):61-4.
Dencker 2009
Egger 1997
Gibbon 2005
  • Gibbon CJ. South African Medicines Formulary. 6th Edition. Cape Town: Health and Medical Publishing, 2005.
Gitanjali 2010
  • Gitanjali B. Valethamate bromide: Is there any proof of efficacy and safety for its use in labor?. Journal of Pharmacology and Pharmacotherapeutics 2010;1(1):2-3.
Guyatt 2011
  • Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables. Journal of Clinical Epidemiology 2011;64:383-94.
Harbord 2006
Higgins 2011
  • Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
Khan 2006
Lavender 2009
  • Lavender T, Hart A, Smyth RMD. Effect of partogram use on outcomes for women in spontaneous labour at term. Cochrane Database of Systematic Reviews 2009, Issue 3. [DOI: 10.1002/14651858.CD005461.pub2]
Leppert 1995
Neal 2010
Neilson 2003
O'Driscoll 1973
O'Driscoll 1994
Ramsay 2003
  • Ramsay C. How do you include trials with more than two groups into a single meta-analysis?. FAQs: methodology in the Cochrane Effective Practice and Organisation of Care Group 2003.
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Romics 2003
Samuels 2009
  • Samuels L. Pharmacotherapy update: hyoscine butylbromide in the treatment of abdominal spasms. Clinical Medicine Insights: Therapeutics 2009;1:647-55.
Sommers 2002
  • Sommers De K. Sommers' Pharmacology. Pretoria: UP Drukkers, 2002.
Thirunavukkarasu 2010
  • Thirunavukkarasu AB, Vijayan S. Valethamate bromide: Conflicting evidence and continuing use. Journal of Pharmacology and Pharmacotherapeutics 2010.
Wei 2009
WHO 1994
  • World Health Organization maternal health and safe motherhood programme. World Health Organization partograph in management of labour. Lancet 4 June 1994;343(8910):1399-404.
WHO 2010
  • World Health Organization. Trends in maternal mortality: 1990-2008. Estimates developed by WHO, UNICEF, UNFPA and the World Bank. http://www.who.int/reproductivehealth/publications/monitoring/9789241500265/en/index.html (accessed 9 February 2010).
Yuel 2008
  • Yuel VI, Kaur V, Kaur D. Programmed labor for optimizing labor and delivery. JK Science 2008;10(2):62-4.